CN1181075C - 新型嘧啶-4-酮化合物、其制备方法和含有它们的药物组合物 - Google Patents

新型嘧啶-4-酮化合物、其制备方法和含有它们的药物组合物 Download PDF

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Publication number
CN1181075C
CN1181075C CNB021161038A CN02116103A CN1181075C CN 1181075 C CN1181075 C CN 1181075C CN B021161038 A CNB021161038 A CN B021161038A CN 02116103 A CN02116103 A CN 02116103A CN 1181075 C CN1181075 C CN 1181075C
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China
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compound
general formula
salt
methyl
branched
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Expired - Fee Related
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CNB021161038A
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English (en)
Chinese (zh)
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CN1381456A (zh
Inventor
G������
G·拉维勒
T·杜巴夫特
O·马勒
M·米兰
A·德克尼
M·布罗克
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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Publication of CN1381456A publication Critical patent/CN1381456A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB021161038A 2001-04-18 2002-04-18 新型嘧啶-4-酮化合物、其制备方法和含有它们的药物组合物 Expired - Fee Related CN1181075C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0105216A FR2823752B1 (fr) 2001-04-18 2001-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR01/05216 2001-04-18
FR0105216 2001-04-18

Publications (2)

Publication Number Publication Date
CN1381456A CN1381456A (zh) 2002-11-27
CN1181075C true CN1181075C (zh) 2004-12-22

Family

ID=8862407

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB021161038A Expired - Fee Related CN1181075C (zh) 2001-04-18 2002-04-18 新型嘧啶-4-酮化合物、其制备方法和含有它们的药物组合物

Country Status (22)

Country Link
US (1) US6747032B2 (https=)
EP (1) EP1256583B1 (https=)
JP (1) JP3781698B2 (https=)
CN (1) CN1181075C (https=)
AR (1) AR034308A1 (https=)
AT (1) ATE301662T1 (https=)
AU (1) AU781663B2 (https=)
BR (1) BR0201312A (https=)
CA (1) CA2383315C (https=)
DE (1) DE60205424T2 (https=)
DK (1) DK1256583T3 (https=)
EA (1) EA005402B1 (https=)
ES (1) ES2246380T3 (https=)
FR (1) FR2823752B1 (https=)
HU (1) HUP0201255A3 (https=)
MX (1) MXPA02003849A (https=)
NO (1) NO328014B1 (https=)
NZ (1) NZ518425A (https=)
PL (1) PL207047B1 (https=)
PT (1) PT1256583E (https=)
SI (1) SI1256583T1 (https=)
ZA (1) ZA200203086B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2010505B1 (en) * 2006-03-28 2012-12-05 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
WO2012140642A1 (en) 2011-04-10 2012-10-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
US9708337B2 (en) * 2013-02-22 2017-07-18 Bristol-Myers Squibb Company Aryl amide-based kinase inhibitors
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
FR2764890B1 (fr) * 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1390217A (zh) * 1999-11-12 2003-01-08 神经原公司 二环和三环杂芳族化合物

Also Published As

Publication number Publication date
EP1256583B1 (fr) 2005-08-10
HUP0201255A3 (en) 2003-02-28
ATE301662T1 (de) 2005-08-15
US6747032B2 (en) 2004-06-08
DE60205424T2 (de) 2006-07-13
FR2823752A1 (fr) 2002-10-25
ES2246380T3 (es) 2006-02-16
MXPA02003849A (es) 2003-07-14
US20030087916A1 (en) 2003-05-08
PL207047B1 (pl) 2010-10-29
EP1256583A1 (fr) 2002-11-13
JP3781698B2 (ja) 2006-05-31
HUP0201255A2 (hu) 2002-12-28
NO328014B1 (no) 2009-11-09
BR0201312A (pt) 2003-06-10
PT1256583E (pt) 2005-10-31
CA2383315C (fr) 2008-02-05
EA200200379A2 (ru) 2002-10-31
CN1381456A (zh) 2002-11-27
NZ518425A (en) 2003-08-29
JP2002356486A (ja) 2002-12-13
AU781663B2 (en) 2005-06-02
AU3440602A (en) 2002-10-24
FR2823752B1 (fr) 2004-10-22
EA200200379A3 (ru) 2002-12-26
AR034308A1 (es) 2004-02-18
SI1256583T1 (sl) 2005-12-31
ZA200203086B (en) 2002-10-28
NO20021806L (no) 2002-10-21
PL353511A1 (en) 2002-10-21
HU0201255D0 (https=) 2002-06-29
HK1049669A1 (en) 2003-05-23
EA005402B1 (ru) 2005-02-24
DK1256583T3 (da) 2005-10-31
DE60205424D1 (de) 2005-09-15
NO20021806D0 (no) 2002-04-17
CA2383315A1 (fr) 2002-10-18

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Granted publication date: 20041222

Termination date: 20110418