CN118078880A - Preparation and application of traditional Chinese medicine aromatherapy spray and ointment extracts with multiple activities - Google Patents

Preparation and application of traditional Chinese medicine aromatherapy spray and ointment extracts with multiple activities Download PDF

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Publication number
CN118078880A
CN118078880A CN202410181652.3A CN202410181652A CN118078880A CN 118078880 A CN118078880 A CN 118078880A CN 202410181652 A CN202410181652 A CN 202410181652A CN 118078880 A CN118078880 A CN 118078880A
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China
Prior art keywords
traditional chinese
chinese medicine
aromatherapy
parts
spray
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CN202410181652.3A
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Chinese (zh)
Inventor
李越峰
严兴科
张育贵
边甜甜
辛二旦
李国峰
李咸慰
杨新荣
王彦钧
严李云天
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Gansu University of Chinese Medicine
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Gansu University of Chinese Medicine
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Priority to CN202410181652.3A priority Critical patent/CN118078880A/en
Publication of CN118078880A publication Critical patent/CN118078880A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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    • A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • A—HUMAN NECESSITIES
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    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to preparation and application of traditional Chinese medicine aromatherapy spray/paste based on multiple effects. The Chinese medicinal aromatherapy comprises at least 8 of herba Menthae, rhizoma Acori Graminei, flos Caryophylli, herba Agastaches, flos Jasmini sambac, rhizoma Atractylodis, herba Artemisiae Scopariae, herba Eupatorii, rhizoma Ligustici, lavender, folium Canarii albi, flos Rosae Rugosae, folium Artemisiae Argyi, semen Myristicae, flos Sophorae Immaturus, flos Lonicerae, scutellariae radix, herba Menthae, and cortex Cinnamomi Japonici; the traditional Chinese medicine combination extract has obvious effect of inhibiting staphylococcus aureus and streptococcus albus; according to application investigation, the composition has obvious pharmacological activities of air freshening, mosquito killing, insect expelling, antibacterial, refreshing in the morning and soothing in the evening. Moreover, the traditional Chinese medicine composition extraction greatly shortens the dosage of the traditional Chinese medicine, and increases the release efficiency and the action effect of the spray/paste. The traditional Chinese medicine raw materials are cheap and easy to obtain, and the prepared traditional Chinese medicine combined extract is easy to store, simple in production process, obvious in effect, simple and convenient to operate, environment-friendly and sanitary, easy to clean and free of pollution.

Description

Preparation and application of traditional Chinese medicine aromatherapy spray and ointment extracts with multiple activities
The scheme is a divisional application of the original application, and the original patent number is as follows: 2022110874247; original patent name: preparation and application of Chinese medicinal aromatherapy spray and paste extract with various activities are provided; the original application date: 2022, 9 and 7.
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method and application of a traditional Chinese medicine aromatherapy spray and ointment extract with multiple activities.
Background
Under the influence of the large social background of the accelerated pace of life at present, the life pressure of people is increased, and the problems of low organism immunity, deficiency, difficulty in falling asleep, amnesia and the like are caused by long-term stay up and the like, and the problems of poor sleep quality, headache, heavy body and incapability of waking up quickly are caused. Meanwhile, mosquito bites at night cause great interference to patients with poor sleep quality. Although the modern mosquito eradication products have various forms, most of the products mainly use chemical reagents, and the long-term use of the chemical reagents can cause mosquito resistance, are difficult to eradicate, are easy to cause various infectious diseases, and cause great harm to physical and mental health of people.
The aromatherapy culture has been carried out from ancient times in China to date, has the effects of accelerating cell metabolism, enhancing immune system, eliminating cell endotoxin, purifying air, expelling mosquito, sterilizing and the like, and is often matched with relaxed music to relax human body and heart, relieve fatigue, stabilize endocrine system, refresh natural spirit and improve vitality greatly. Based on the above, the invention closely connects ancient aromatherapy culture with modern traditional Chinese medicine theory, takes the lamp as a carrier, blends the traditional Chinese medicine aromatherapy elements, and invents the traditional Chinese medicine aromatherapy spray traditional Chinese medicine aromatherapy cream with the main functions of inducing resuscitation and refreshing mind for early use, evade, soothing nerves for late use, helping sleep, and improving intelligence for aromatic use and evade.
Therefore, based on epidemic prevention, the traditional Chinese medicine aromatherapy formula is improved, the traditional Chinese medicines with the functions of removing plague and avoiding dirt, such as eupatorium, ligusticum sinense and wrinkled gianthyssop herb, and the antibacterial activities, such as scutellaria baicalensis, honeysuckle flower, are added, and a certain preparation process is adopted, so that the aromatherapy cream is the traditional Chinese medicine aromatherapy spray or the traditional Chinese medicine aromatherapy cream which integrates the functions of removing plague and avoiding dirt, inducing resuscitation and refreshing mind, tranquilizing mind, expelling parasites and killing mosquitoes, purifying air and resisting bacteria.
The invention provides a traditional Chinese medicine composition for removing plague and avoiding dirt, inducing resuscitation and refreshing mind, tranquilizing mind, expelling parasites and killing mosquitoes, purifying air and resisting bacteria, wherein the traditional Chinese medicine composition comprises peppermint, grassleaf sweetflag rhizome, clove, wrinkled gianthyssop herb, jasmine flower, swordlike atractylodes rhizome, white wormwood, eupatorium herb, chinese ligusticum rhizome, lavender, olive leaf, rose, mugwort leaf, nutmeg, pagodatree flower, honeysuckle flower, baical skullcap root, peppermint and cassia bark; the traditional Chinese medicine composition has remarkable pharmacological activity and additional use effect, and is beneficial to reducing the use dosage of medicines. The traditional Chinese medicine raw materials are cheap and easy to obtain, and the prepared traditional Chinese medicine combined extract is easy to store, simple in production process, obvious in effect, simple and convenient to operate, environment-friendly and sanitary, easy to clean and free of pollution.
Disclosure of Invention
The invention provides the traditional Chinese medicine aromatherapy spray extract and the traditional Chinese medicine solid aromatherapy cream, which are simple in production process, obvious in action effect, simple and convenient to operate, environment-friendly and sanitary, easy to clean and fragrant in smell, aiming at the defects of the current prevalence of aromatherapy spray and the development of solid aromatherapy technology under the background of the large pressure of the current society.
The invention solves the technical problems by the following scheme:
The Chinese ancient aromatherapy culture principle is followed, the Chinese medicine theory is used as a support, and the remarkable problem of the current society is solved: the traditional Chinese medicine formula is selected from the following raw materials: peppermint, grassleaf sweetflag rhizome, clove, wrinkled gianthyssop herb, jasmine flower, swordlike atractylodes rhizome, white wormwood herb, fortune eupatorium herb, chinese ligusticum rhizome, lavender, olive leaf, rose, mugwort leaf, nutmeg, pagodatree flower, honeysuckle flower, baical skullcap root, peppermint and cassia bark are combined with the research of modern pharmacological action, and are prepared into corresponding Chinese medicinal aromatherapy spray extracts and Chinese medicinal solid aromatherapy cream according to a certain proportion.
In a first aspect, the invention provides a traditional Chinese medicine composition with multiple activities, wherein the traditional Chinese medicine composition is prepared from the following components in parts by mass: 3-5 parts of peppermint, 1-2 parts of grassleaf sweelflag rhizome, 0.5-1 part of clove, 2-3 parts of agastache rugosus, 3-5 parts of jasmine flower, 1-2 parts of rhizoma atractylodis, 1-2 parts of artemisia alba, 1-2 parts of eupatorium, 1-2 parts of ligusticum, 2-3 parts of lavender, 3-5 parts of olive leaf, 1-2 parts of rose, 1-2 parts of mugwort leaf, 0.5-1 part of nutmeg, 2-3 parts of pagodatree flower, 1-2 parts of honeysuckle flower, 1-2 parts of baikal skullcap root and 0.5-1 part of cassia bark.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by mass: 5 parts of peppermint, 2 parts of grassleaf sweelflag rhizome, 0.5 part of clove, 2 parts of wrinkled gianthyssop herb, 3 parts of jasmine flower, 1 part of swordlike atractylodes rhizome, 1 part of white wormwood, 1 part of eupatorium and 1 part of Chinese ligusticum.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by mass: 3 parts of lavender, 3 parts of olive leaf, 1 part of rose, 1 part of mugwort leaf, 1 part of artemisia alba, 0.5 part of cassia bark, 0.5 part of nutmeg, 1 part of eupatorium and 1 part of ligusticum.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by mass: 3 parts of mint, 3 parts of wrinkled giant hyssop, 3 parts of lavender, 2 parts of mugwort leaf, 3 parts of pagodatree flower, 2 parts of honeysuckle, 2 parts of baical skullcap root and 0.5 part of cassia bark.
In a second aspect, the invention provides a Chinese medicinal composition extract with multiple activities, wherein the preparation method of the Chinese medicinal composition extract comprises the following steps of: pulverizing the above Chinese medicinal composition according to the first aspect, reflux-extracting with 70% ethanol solution for 2 times, mixing extractive solutions, filtering, and concentrating the filtrate under reduced pressure.
Preferably, the method comprises the steps of:
(1) Pulverizing the Chinese medicinal composition at high speed, sieving with 60 mesh sieve, and collecting the sieved powder;
(2) Adding 6-8 times of 70% ethanol solution into the powder obtained in the step (1), and heating and reflux-extracting with slow fire for 6h to obtain an extract; filtering and collecting filtrate;
(3) Repeating the step (2) on the filter residue obtained in the step (2);
(4) Combining the filtrates obtained in the step (2) and the step (3), and concentrating under reduced pressure in vacuum to recover ethanol to obtain the traditional Chinese medicine composition extract.
In a third aspect, the invention provides an application of the traditional Chinese medicine composition in the first aspect and the traditional Chinese medicine composition extract in the second aspect in preparing a product for removing plague and avoiding dirt, and/or inducing resuscitation and refreshing, and/or tranquilizing, and/or expelling parasites and killing mosquitoes, and/or purifying air, and/or resisting bacteria.
Preferably, the product comprises the application of a traditional Chinese medicine aromatherapy cream, a spray, a skin-moistening soap and a hand cleanser product.
In a fourth aspect, the invention provides a traditional Chinese medicine aromatherapy paste, which is prepared by the following steps: repeatedly grinding the adhesive, excipient, buffer and neutralizer in a mortar until the adhesive, excipient, buffer and neutralizer are mixed uniformly and the particle size is uniform, adding purified water at 50-70 ℃, heating in a water bath at 65 ℃ for at least 30 minutes, and continuously stirring until the solution in the beaker is gel white and nearly transparent; and adding the traditional Chinese medicine composition extract, the preservative and the traditional Chinese medicine volatile oil in the second aspect, repeatedly stirring and mixing uniformly, and standing at room temperature until the mixture is in a solid paste form.
In a fifth aspect, the invention provides a traditional Chinese medicine aromatherapy spray, and the preparation method of the traditional Chinese medicine aromatherapy spray comprises the following steps: adding the extract of the traditional Chinese medicine composition in the second aspect into spray emission equipment to obtain the traditional Chinese medicine aromatherapy spray.
The beneficial effects of the invention are as follows: (1) The traditional Chinese medicine composition is safe and nontoxic, has no obvious contraindication, and is suitable for all people to use; (2) The mosquito killing product which gets rid of chemical reagents on the market at present is safer and more effective; (3) Aiming at the condition that the pressure is too great in the current life, the people are difficult to sleep in the evening and can not wake in the morning, and the health care pillow is especially suitable for sub-health people; (4) adding antiviral traditional Chinese medicines; (5) The traditional Chinese medicine and the matrix are both green and environment-friendly, and the preparation process is simple; (6) The prepared traditional Chinese medicine composition extract has good stability of spray and paste, is not easy to decompose and can be stored for a long time; (7) The prepared traditional Chinese medicine composition extract spray and paste can be divided into various functions of purifying air, removing mosquitoes and killing insects, resisting epidemic, clearing head and eyes, calming and hypnotizing and the like, and can be used according to requirements; (8) The product has reasonable formula, mellow fragrance and wide acceptance range, and meets the general demands of the masses.
Drawings
The traditional Chinese medicine aromatherapy spray prepared in the figure 1 and the implementation mode thereof; wherein, 1: extracting solution of traditional Chinese medicine composition; 2: sucking 1mL;3: diluting to 10mL;4: a sample adding port; 5: spray emission equipment; 6: a spray emission tube; 7: a spray emission port; 8: spraying; 9: multifunctional aromatherapy lamp [ application (patent) No.: CN 201930453622.3';
The prepared traditional Chinese medicine aromatherapy solid paste shown in fig. 2 and the implementation mode thereof; wherein, 1: extracting solution of traditional Chinese medicine composition; 2: chinese medicine aromatherapy ointment; 3: multifunctional aromatherapy lamp [ application (patent) No.: CN 201930453622.3';
FIG. 3 shows the results of the effective head and eye clearing rate of the aromatherapy sprays F1 and F2, * shows P < 0.05, ** shows P < 0.01;
FIG. 4 shows the sedative hypnotic effective results of formulas F1 and F3, * representing P < 0.05 and *** representing P < 0.001, compared to ZH group;
FIG. 5 shows the results of the air freshening effectiveness of the fragrance sprays F1, F2, F3, * for P < 0.05 compared to the XJ group;
FIG. 6 shows that formulas F1, F2 and F3 are effective in mosquito and insect killing, and * represents P <0.05 and ** represents P <0.01 compared with CH group;
FIG. 7 shows the results of the formula F1 and F2 fragrance paste for improving the head and eyes, wherein ** represents P < 0.01 and *** represents P < 0.001 compared with the BM group;
FIG. 8 shows that formulas F1 and F3 aromatherapy pastes have sedative-hypnotic effective rate, ** shows P < 0.01, *** shows P < 0.001 compared with BM group;
FIG. 9 shows that formulas F1, F2 and F3 are effective in freshening air, * represents P < 0.05, ** represents P < 0.01, and *** represents P < 0.001 compared with XJ group;
In the figure 10, the formulas F1, F2 and F3 are shown as mosquito-repellent and insecticidal effective rates, ** is shown as P < 0.01, and *** is shown as P < 0.001 compared with the CH group.
Detailed Description
For a detailed description of the technical solutions of the present invention, the inventors have described a part of examples. The inventor has the right to carry out patent protection on similar traditional Chinese medicine aromatherapy spray and solid paste products. It should be noted that all technical solutions obtained by logic analysis, inference and experiments in the prior art according to the concept of the present invention by those skilled in the art are all included in the scope of the present invention as claimed.
Example 1 Chinese herbal formulation and efficacy evaluation
1. The traditional Chinese medicine formula in the embodiment is as follows:
traditional Chinese medicine formula 1 (F1): 3 parts of peppermint, 2 parts of grassleaf sweelflag rhizome, 0.5 part of clove, 2 parts of wrinkled giant hyssop, 3 parts of jasmine flower, 1 part of rhizoma atractylodis, 1 part of tarragon, 1 part of eupatorium, 1 part of ligusticum, 3 parts of lavender, 3 parts of olive leaf, 1 part of rose, 1 part of mugwort leaf, 0.5 part of nutmeg, 3 parts of pagodatree flower, 2 parts of honeysuckle flower, 2 parts of baical skullcap root and 0.5 part of cassia bark;
traditional Chinese medicine formula 2 (F2): 3 parts of peppermint, 2 parts of grassleaf sweelflag rhizome, 0.5 part of clove, 2 parts of wrinkled gianthyssop herb, 3 parts of jasmine flower, 1 part of swordlike atractylodes rhizome, 1 part of white wormwood, 1 part of eupatorium and 1 part of Chinese ligusticum.
Traditional Chinese medicine formula 3 (F3): 3 parts of lavender, 3 parts of olive leaf, 1 part of rose, 1 part of mugwort leaf, 1 part of artemisia alba, 0.5 part of cassia bark, 0.5 part of nutmeg, 1 part of eupatorium and 1 part of ligusticum.
Traditional Chinese medicine formula 4 (F4): 3 parts of mint, 3 parts of wrinkled giant hyssop, 3 parts of lavender, 2 parts of mugwort leaf, 3 parts of pagodatree flower, 2 parts of honeysuckle, 2 parts of baical skullcap root and 0.5 part of cassia bark.
Chinese medicine prescription 1-Chinese medicine prescription 4 four prescriptions respectively take 5 parts; preparing into Chinese medicinal aromatherapy spray and Chinese medicinal aromatherapy paste respectively; the preparation method of the traditional Chinese medicine aromatherapy spray comprises the following steps: (1) preparing a traditional Chinese medicine composition extract: ① Pulverizing the Chinese medicinal composition at high speed, sieving with 60 mesh sieve, and collecting the sieved powder; ② Adding 6-8 times of 70% ethanol solution into the powder, and reflux-extracting with slow fire for 6 hr; filtering and collecting the extracting solution; ③ Collecting the residue, repeating step ②;④, collecting the extractive solution twice, vacuum concentrating under reduced pressure, recovering ethanol until the extractive solution has no obvious ethanol taste, sterilizing at high temperature, sealing, standing to room temperature, and storing at 4deg.C; the preparation of the traditional Chinese medicine aromatherapy spray comprises the following steps: sucking 1mL of the above Chinese medicinal composition extract, diluting with purified water to 10mL, and adding spray emitting device to obtain the final product, wherein the final product can be stably and permanently released for 2-5h, and its preparation process is shown in figure 1.
The preparation method of the traditional Chinese medicine aromatherapy ointment comprises the following steps: (1) preparing a traditional Chinese medicine composition extract: the same as in (1) above; the preparation of the traditional Chinese medicine aromatherapy ointment comprises the following steps: adding an adhesive and an excipient according to the proportion of 11:7 (namely, 7 parts of excipient is needed when 11 parts of adhesive are needed according to the mass parts), adding 2 parts of buffer and 0.8 part of neutralizer, repeatedly grinding in a mortar until the mixture is uniform and the particle size is uniform, adding 50mL of purified water (kept between 50 and 70 ℃), heating in a water bath kettle at 65 ℃ for more than 30 minutes, continuously stirring until the solution in the beaker is gel white and nearly transparent, repeatedly stirring and uniformly mixing 10mL of Chinese medicinal composition extract, 0.2 part of preservative and one or more Chinese medicinal volatile oils, standing at room temperature until the solution in the beaker is solid paste, has uniform color and is in the color of a liquid medicine, and obtaining a Chinese medicinal solid aromatherapy paste; cooling at room temperature, packaging with vacuum sealed packaging bag, and refrigerating at 4deg.C. When in use, the multifunctional aromatherapy lamp is matched for use, and the multifunctional aromatherapy lamp can be stably used for 0.5-5h, as shown in figure 2.
2. In vitro experiments
Respectively carrying out experiments of inducing resuscitation, refreshing mind, tranquilizing mind, expelling parasites, killing mosquitoes, purifying air and resisting bacteria on the traditional Chinese medicine formula 1 (F1) aromatherapy spray and the traditional Chinese medicine aromatherapy paste; performing experiments on the Chinese medicinal composition 2 (F2) aromatherapy spray and Chinese medicinal aromatherapy paste for refreshing head and eyes, refreshing air, killing mosquitoes and insects and antibacterial activity; performing sedative hypnotic, air freshening, mosquito killing and antibacterial activity experiments on the traditional Chinese medicine formula 3 (F3) aromatherapy spray and the traditional Chinese medicine aromatherapy paste; antibacterial activity tests were performed on the traditional Chinese medicine formulation 4 (F4) aromatherapy sprays and the traditional Chinese medicine aromatherapy pastes. 5 parts of each square are selected in parallel (the numbers are F1-1 to F1-5, F2-1 to F2-5, F3-1 to F3-5 and F4-1 to F4-5) for testing.
The head-clearing and eye-refreshing ratio is 4ml of a commercial product, namely a Bai Mei Yi person (Baimiss) refreshing rod energy rod, and 5 parts (serial numbers: BM-1 to BM-5)) are selected in parallel for testing, and 5 parallel samples are taken for each test; the sedative hypnotic comparison is 200ml of Liushen floral water which is a commercial product, 5 parts (serial numbers: ZH-1 to ZH-5) are selected in parallel for testing, and 5 parallel samples are taken for each test; the fresh air is compared with 70g of a commercial finished product of fresh solid aromatic, 5 parts (serial numbers: XJ-1 to XJ-5) are selected in parallel for testing, and 5 parallel samples are taken for each test; the comparison of mosquito and insect killing is that the commercial product Liushen floral water is 200ml, and 5 parts (serial numbers: CH-1 to CH-5) are selected in parallel for testing; 5 replicates were taken for each trial.
The usage amount is as follows: twice a day (once in the morning and evening), and the treatment course is 7 days. The number of the test cases was 50. And (5) judging whether the corresponding symptoms of the subject are obviously reduced or whether the evaluation of the subject is effective or not by taking the main subject as a standard for judging whether the evaluation is effective or not. Effective rate (%) = (number of test cases/total number of test cases) ×100%.
As shown in table 1 and fig. 3, the total effective rate of the formula F1 aromatherapy spray for clearing head reaches 84.91 ±11.97, the total effective rate of the comparison group BM reaches 74.34±11.92, and the effective rate of the formula F1 aromatherapy spray for clearing head is significantly higher than that of the comparison group (P < 0.01); the total effective rate of the formula F2 aromatherapy spray for clearing head reaches 82.74 +/-12.03, and the total effective rate of the comparison group BM reaches 74.34+/-11.92 (P is less than 0.05), and the effective rate of the formula F2 aromatherapy spray for clearing head is higher than that of the comparison group; the formula F1 aromatherapy spray and the formula F2 aromatherapy spray have obvious activities of clearing head and eyes, and the formula F1 is superior to the formula F2. Wherein * represents P < 0.05, ** represents P < 0.01, compared with BM group.
TABLE 1 effective results of formulations F1 and F2 fragrance spray for clearing the head and eyes
As shown in table 2 and fig. 4, the total effective rate of the formula F1 aromatherapy spray for sedative hypnotic reaches 85.60 ±8.78, while the total effective rate of the control group ZH reaches 75.94 ±10.08, and the effective rate of the formula F1 for sedative hypnotic is higher than that of the control group; the total effective rate of the formula F3 aromatherapy spray for sedative hypnotic reaches 81.33 +/-10.29, and the total effective rate of the control group ZH reaches 75.94 +/-10.08, and the effective rate of the formula F3 aromatherapy spray for sedative hypnotic is higher than that of the control group; the formula F1 aromatherapy spray and the formula F3 aromatherapy spray are obvious in head-refreshing activity, and the formula F1 is superior to the formula F3, wherein * represents P < 0.05 and *** represents P < 0.001 compared with the ZH group.
TABLE 2 effective results of F1 and F3 fragrance spray for sedative hypnotic
Referring to fig. 5, the result of the air freshening efficiency of the formula F1 aromatherapy spray is shown in table 3, the total effective rate reaches 90.51 ±7.35, the total effective rate of the control group XJ reaches 85.83 ±8.90, and the air freshening effect of the formula F1 aromatherapy spray is significantly better than that of the control group (P < 0.05); the effective air freshening efficiency result of the formula F2 aromatherapy spray is shown in table 4, the total effective efficiency reaches 87.49+/-7.88, the air freshening effect of the formula F2 aromatherapy spray is better than that of the control group, but the air freshening effect of the formula F2 aromatherapy spray is not obviously different, and the effect of the formula F2 aromatherapy spray is equivalent to that of the control XJ; the effective air freshening efficiency results of the formula F3 aromatherapy sprays are shown in table 5, the total effective efficiency reaches 89.71 +/-6.75, and the air freshening effect of the formula F3 aromatherapy sprays is better than that of the control group, but the effect of the formula F3 aromatherapy sprays is not obviously different, so that the effect of the formula F2 aromatherapy sprays is equivalent to that of the control XJ. The experimental results show that the compositions F1, F2 and F3 aromatherapy sprays have the effect of freshening air, the effect of the F1 aromatherapy sprays on freshening air is better, the effects of F2 and F3 are basically equivalent to those of the market contrast, and compared with the XJ group, * represents that P is less than 0.05.
Table 3 results of effective air freshening rates for formula F1 fragrance spray
Table 4 results of effective air freshening rates for formula F2 fragrance sprays
Table 5 results of effective air freshening rates for formula F3 fragrance sprays
Referring to FIG. 6, the mosquito-killing and insecticidal effective rate results of the formula F1 aromatherapy spray are shown in Table 6, the total effective rate reaches 78.17+ -12.25, the total effective rate of the control group CH reaches 74.80 + -12.08, and the mosquito-killing and insecticidal effect of the formula F1 aromatherapy spray is obviously better than that of the control group (P < 0.05); the effective rate results of the formula F2 aromatherapy spray for killing mosquitoes and insects are shown in the table 7, the total effective rate reaches 83.20 +/-8.40, and the effect of the formula F2 aromatherapy spray for killing mosquitoes and insects is extremely superior to that of a control group (P is less than 0.01); the effective mosquito-killing and insect-killing results of the formula F3 aromatherapy spray are shown in table 8, the total effective rate reaches 79.83 +/-10.31, the mosquito-killing and insect-killing effect of the formula F3 is better than that of a control group, but no obvious difference exists, and the formula F3 aromatherapy spray has the same mosquito-killing and insect-killing effect as the control CH. The experimental results show that the components F1, F2 and F3 aromatherapy sprays have obvious mosquito and insect killing effects, the components F1 and F2 aromatherapy sprays have better mosquito and insect killing effects, and the F3 aromatherapy sprays have basically the same effects as the control. Wherein, annotate: * represents P < 0.05, ** represents P < 0.01, compared to CH group.
Table 6 effective results of formula F1 fragrance spray for mosquito and insect control
Table 7 effective results of the formula F2 fragrance spray for mosquito and insect control
Table 8 effective results of formula F3 fragrance spray for mosquito and insect control
As shown in table 9 and fig. 7, the total effective rate of the formula F1 aromatherapy cream for clearing head reaches 84.97 ±9.04, while the total effective rate of the control group BM reaches 76.80±7.43, the effective rate of the formula F1 aromatherapy cream for clearing head is obviously better than that of the control group (P < 0.01); the total effective rate of the formula F2 aromatherapy cream for clearing head reaches 86.51+/-7.49, and the effective rate of the formula F2 aromatherapy spray for clearing head is extremely superior to that of a control group (P is less than 0.001); the formula F1 aromatherapy paste and the formula F2 aromatherapy paste have obvious activities of clearing the head and eyes. Wherein ** represents P < 0.01, *** represents P < 0.001, compared with the BM group.
TABLE 9 effective results of formula F1, F2 fragrance paste for clearing head and eyes
As shown in table 10 and fig. 8, the total effective rate of the formula F1 aromatherapy ointment for sedation and hypnosis reaches 88.79 ±6.21, while the total effective rate of the control group ZH reaches 80.46±9.80, and the effective rate of the formula F1 aromatherapy ointment for sedation and hypnosis is obviously higher than that of the control group (P < 0.001); the total effective rate of the formula F3 aromatherapy paste for sedative hypnotic reaches 89.71 +/-5.72, and the total effective rate of the control group ZH reaches 80.46+/-9.80, and the effective rate of the formula F3 aromatherapy paste for sedative hypnotic is obviously higher than that of the control group (P is less than 0.001); the formula F1 and the formula F3 aromatherapy paste have obvious activities of clearing the head and eyes. Wherein *** represents P < 0.01 compared with BM group.
Table 10 effective rate of F1 and F3 fragrance ointments for sedative hypnotic
Referring to FIG. 9, the result of the air freshening efficiency of the formula F1 fragrance paste is shown in Table 11, the total effective rate reaches 90.17+ -5.40, the total effective rate of the control group XJ reaches 83.94 + -7.89, and the air freshening effect of the formula F1 fragrance paste is significantly better than that of the control group (P < 0.001); the effective rate of the fresh air of the aromatherapy cream of the formula F2 is shown in the table 12, the total effective rate reaches 89.31 +/-4.87, and the effect of the fresh air of the aromatherapy cream of the formula F2 is obviously better than that of a control group (P is less than 0.01); the effective rate of the air freshening agent of the formula F3 is shown in a table 13, the total effective rate reaches 89.14+/-5.08, and the effect of the air freshening agent of the formula F3 is better than that of a control group (P is less than 0.05). The experimental results show that the aromatherapy ointments of the formulas F1, F2 and F3 have obvious effect of refreshing air. Wherein * represents P < 0.05, ** represents P < 0.01, and *** represents P < 0.001, as compared with XJ group.
Table 11 formulation F1 fragrance paste air freshening efficacy
Table 12 formula F2 fragrance paste fresh air effective rate
TABLE 13 effective rate of F3 fragrance paste for freshening air
Referring to FIG. 10, the mosquito-killing and insecticidal effective rate results of the formula F1 aromatherapy cream are shown in Table 14, the total effective rate reaches 78.17+ -12.25, the total effective rate of the control group CH reaches 74.80 + -12.07, and the mosquito-killing and insecticidal effect of the formula F1 aromatherapy cream is significantly better than that of the control group (P < 0.001); the effective rate results of the formula F2 aromatherapy paste for killing mosquitoes and insects are shown in table 15, the total effective rate reaches 85.49 +/-9.12, and the effect of the formula F2 aromatherapy paste for killing mosquitoes and insects is obviously better than that of a control group (P is less than 0.01); the effective mosquito-killing and insecticidal results of the formula F3 aromatherapy paste are shown in Table 16, the total effective rate reaches 86.00 +/-8.64, the mosquito-killing and insecticidal effects of the formula F3 aromatherapy paste are stronger than those of the control group, but no obvious difference exists, and the mosquito-killing and insecticidal effects of the formula F3 aromatherapy paste are equal to those of the control CH. The experimental results show that the formula F1 and the formula F2 aromatherapy pastes have obvious mosquito-killing and insect-killing effects, and the formula F3 aromatherapy paste has the mosquito-killing and insect-killing effects consistent with those of a control. Wherein ** represents P < 0.01, *** represents P < 0.001, compared with CH group.
Table 14 effective rate of mosquito-repellent and insecticidal by F1 aromatherapy cream
Table 15 effective rate of F2 aromatherapy ointment for killing mosquito and insect
Table 16 formula F3 aromatherapy ointment effective rate of mosquito and insect killing
3. Animal experiment
The preparation method of the traditional Chinese medicine formula extract comprises the following steps:
Mixing the components of the F1-F4 traditional Chinese medicines, adding 10 times of purified water, decocting for 1h, decocting twice, collecting the two decoction extract, and heating and reflux-extracting with slow fire for 6h; extracting for 2 times. Collecting the two extractive solutions, concentrating at low temperature until the crude drug content is 0.5g mL, and storing in refrigerator at 4deg.C.
(1) Experiment for clearing head and eyes: the evaluation index of the experiment mainly comprises Norepinephrine (NA) and dopamine (Dopamine, da) in brain tissues. Norepinephrine is a neurotransmitter, is a chemical substance responsible for transmitting nerve impulses between neurons, can be found in the central and sympathetic nervous systems, is also secreted by adrenal glands, has the effect of stress hormone, can play a role in exciting the heart, and is helpful for people to wake and become active quickly; dopamine is a cerebral endocrine, is the most abundant catecholamine neurotransmitter in the brain, can regulate and control various physiological functions of the central nervous system, is related to the emotion and feeling of a person, and can transmit excitation and happy information; NA and Da were therefore used as index of action for evaluation of the Fang Qingli mesh of the experiment.
The experimental method comprises the following steps: 90 SD rats (180+ -20 g) were randomly divided into 9 groups of blank group, model group, noradrenal group, dopamine group, noradrenal+dopamine group, F1-administered group, F2-administered group, F3-administered group, and F4-administered group. In addition to the blank group, rats in other groups were modeled for hypoxic ischemic encephalopathy, and the specific method was as follows: the skin is cut at the middle of the rat anesthetic neck, after the common carotid artery is separated, double ligation is carried out by using a 5-0 noninvasive suture line, a blood vessel is cut off from the middle of the ligature line, the suture is carried out after disinfection, the operation is recovered for 2 hours, the recovered rat is placed in an anoxic cabin, and mixed gas of 92% nitrogen and 8% oxygen is introduced into the cabin for continuously hypoxia for 2 hours. After successful molding, each group of stomach-lavage drug administration intervenes for 7 days, and the drug administration amount is 20mL/kg. After the end of the administration, the rat brain tissue fluid was subjected to NA and Da level detection using ELISA kit, the results are shown in Table 17, wherein ### represents P < 0.001 compared with the blank group; * represents P < 0.05, ** represents P < 0.01, and *** represents P < 0.001, compared to the model group.
As can be seen from the results shown in Table 17, the model group showed significantly lower NA and Da levels (P < 0.001) compared to the blank group, and the F1-F4 administration groups showed significantly higher NA and Da levels (P < 0.05 or P < 0.01) after the administration treatment, and the compositions each had an effect of promoting the elevation of NA and Da in brain tissues, and the F1-F4 groups had similar effects to those of NA and Da hormone. The research results show that F1-F4 has the functions of clearing the head and eyes, and can play an exciting role after being used, thereby being beneficial to people to be quickly awake and full of vitality.
TABLE 17 expression levels of NA and Da in rat brain tissue fluids of groups
Group of NA(μg/L) Da(μg/L)
Blank group 16.79±1.44 0.38±0.04
Model group 7.10±0.92### 0.14±0.03###
Noradrenal gland group 18.84±1.60** 0.13±0.01
Dopamine group 8.95±0.85 0.41±0.03***
Noradrenal + dopamine group 19.59±1.92*** 0.40±0.01***
F1 dosing group 17.88±1.39*** 0.36±0.02***
F2 dosing group 16.96±1.58** 0.31±0.03***
F3 dosing group 9.87±1.24* 0.22±0.02*
F4 dosing group 10.60±1.48* 0.27±0.03**
(2) Sedative hypnotic experiment: the evaluation index of the experiment is mainly based on 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) in brain tissues. 5-hydroxytryptamine, also known as serotonin, is a widely distributed biological indoleamine, which is both a neurotransmitter and a vasoactive substance; the 5-hydroxytryptamine transmitter system distributed in the brain is concentrated, the neurons of the 5-hydroxytryptamine transmitter system are mainly positioned in the middle joint nucleus of the low-level brainstem near-midline region, and a large number of researches show that the 5-HT serving as an important monoamine neurotransmitter in the brain can not replace the substitution in improving insomnia symptoms, and the 5-HT has the effect of obviously promoting fast wave sleep and slow wave sleep; the insomnia rat model is prepared by microinjection of p-chlorophenylalanine capable of reducing 5-HT synthesis into the middle slit dorsal nucleus of the rat, so that insomnia symptoms are generated in the rat. Thus, 5-HT was used as an effective index for assessing sedative hypnotic effects.
The experimental method comprises the following steps: building an insomnia animal model: after 1w of adaptive feeding of 70 Kunming mice (16+ -2 g), they were randomly divided into 7 groups by body mass, which were a blank group, a model group, and diazepam 2.6mg/kg group, F1-administered group, F2-administered group, F3-administered group, and F4-administered group, respectively. Except for the blank group, the normal saline solution with the concentration of 30mg/mL is injected into the abdominal cavity, and the other groups are fully and evenly shaken, and the injection volume is 10mL/kg for 2d for 1 time per day, compared with the blank group, the initial success of modeling is indicated when the mice are subjected to the phenomena of dysphoria, continuous activity, disappearance of circadian rhythm, appetite reduction, obvious weight reduction and the like. After successful molding, the corresponding drug was administered by gavage at a dose of 0.4mL/20g/d for 6 days, 30mg/kg sodium pentobarbital was administered to each group of mice after 30min of last gavage, and the number of times each group of mice was observed to fall asleep within 20min, and the results are shown in Table 18. And the time when the specular reflection of each group of mice disappeared and the time when the specular reflection appeared were recorded, the mice were put to sleep after the specular reflection disappeared for more than 30s, the time from falling asleep to specular reflection reproduction was the sleep time, and finally the sleep latency and the sleep duration of each group of mice were calculated, and the results are shown in table 19. After the experiment, the cerebrospinal fluid was taken and subjected to 5-HT level detection by ELISA kit, and the results are shown in Table 20; wherein #### represents P < 0.0001 compared to the blank; * represents P < 0.05, ** represents P < 0.01, and *** represents P < 0.001, compared to the model group.
As shown in the influence results of all traditional Chinese medicine formulas shown in Table 18 on the number of falling asleep of PCPA mice with insomnia models, F1-F4 can obviously increase the sleep rate of PCPA mice with insomnia models, but the effect is inferior to that of diazepam, wherein the best effect is F1, next F3, next F4 and worst F2; as shown in Table 19, the effect of each Chinese medicinal formula on the sleep of PCPA model mice is shown, compared with a blank group, the sleep latency of the model group is obviously prolonged (P < 0.0001), the sleep duration is obviously reduced (P < 0.0001), the sleep latency after administration of each administration group is obviously shortened (P < 0.01 or P < 0.001), the sleep duration is obviously prolonged (P < 0.01 or P < 0.001), and the Chinese medicinal formulas F1-F4 have obvious effect of improving the sleep, can effectively reduce the sleep latency and increase the sleep duration, wherein the effect is the most obvious F1, the next F3, the next F4 and the worst F2.
Influence of each traditional Chinese medicine formula in Table 18 on sleep onset number of PCPA insomnia model mice (n=10)
Group of Sleeping number (only) Sleep rate (%)
Blank group 0 0％
Model group 0 0％
Diazepam 2.6mg/kg group 7 70％
F1 dosing group 6 60％
F2 dosing group 2 20％
F3 dosing group 5 50％
F4 dosing group 4 40％
Influence of each Chinese medicinal formulation of Table 19 on sleep of PCPA Insomnia model mice
Group of Sleep latency (min) Sleep time (min)
Blank group 3.33±1.18 72.50±5.63
Model group 9.36±1.29#### 16.60±2.41####
Diazepam 2.6mg/kg group 1.95±0.74*** 80.40±5.95***
F1 dosing group 3.07±0.70*** 65.00±5.98***
F2 dosing group 6.91±0.84** 35.44±5.78***
F3 dosing group 3.20±0.58*** 60.60±6.92***
F4 dosing group 7.46±0.50** 50.00±7.31***
TABLE 20 expression levels of 5-HT in rat brain tissue fluid from each group
(3) Antibacterial experiment:
Examples: the preparation method of the traditional Chinese medicine composition extract comprises the following steps: mixing the components of F1-F4 traditional Chinese medicines, pulverizing at high speed, sieving with 60 mesh sieve, and collecting sieving powder; adding 6-8 times of 70% ethanol solution, and reflux-extracting with slow fire for 6 hr; extracting for 2 times. Collecting the two extractive solutions, vacuum concentrating under reduced pressure to recover ethanol until the extractive solution has no obvious ethanol taste, sterilizing at high temperature, sealing, standing to room temperature, and storing at 4deg.C.
Comparative example:
The preparation method of the single Chinese medicine extract comprises the following steps: respectively weighing 30g of peppermint, grassleaf sweelflag rhizome, clove, agastache rugosus, jasmine flower, rhizoma atractylodis, artemisia annua, eupatorium fortunei, ligusticum, lavender, olive leaf, rose, mugwort leaf, nutmeg, pagodatree flower, honeysuckle, baical skullcap root and cassia bark; the preparation method is the same as that of the traditional Chinese medicine composition extract in the embodiment;
Comparative composition 1 (Z1): 30g of pagodatree flower, 20g of honeysuckle, 20g of baikal skullcap root and 5g of cassia bark; comparative composition 2 (Z2): 30g of mint, 30g of wrinkled giant hyssop, 20g of lavender and 20g of mugwort leaf; comparative composition 3 (Z3): 20g of grassleaf sweelflag rhizome, 5g of clove, 30g of jasmine flower, 10g of rhizoma atractylodis, 10g of artemisia annua, 10g of eupatorium fortunei and 10g of ligusticum; comparative composition 4 (Z4): 30g of olive leaves, 10g of roses, 10g of mugwort leaves and 5g of nutmeg; the preparation method is the same as that of the traditional Chinese medicine composition extract.
And (3) detection of a bacteriostasis zone: the method comprises the steps of adopting an agar plate punching method, uniformly coating 100 mu L of test bacteria on nutrient agar, placing for 15min, uniformly punching on the nutrient agar by using a puncher with the diameter of 6mm, removing agar blocks, adding 1mL of traditional Chinese medicine extracting solution into holes on the principle that liquid medicine is not overflowed completely, setting distilled water as negative control at the center of each plate with the hole spacing of more than 20mm, setting positive control, culturing for 24h at 37 ℃, measuring the diameter of a bacteriostasis ring, observing the result, and repeating the test for 3 times. The antibacterial diameter is more than or equal to 20mm, the antibacterial diameter is extremely sensitive, 15-20 mm is highly sensitive, 10-15 mm is moderately sensitive, and the antibacterial diameter is less than 10mm is lowly sensitive.
As can be seen from the antibacterial results shown in table 21, each single Chinese medicine extract has certain antibacterial activity against staphylococcus aureus, such as grassleaf sweelflag rhizome, swordlike atractylodes rhizome, white artemisia, eupatorium, lavender, olive leaf, rose, mugwort leaf, pagodatree flower, honeysuckle, baical skullcap root, cassia bark and the like, wherein only the white artemisia and the baical skullcap root have high antibacterial activity against staphylococcus aureus; the artemisia annua, the ligusticum, the olive leaves, the roses, the mugwort leaves, the sophora flowers, the baikal skullcap roots and the like have certain antibacterial activity on the streptococcus albus, wherein only the roses and the mugwort leaves have high antibacterial activity on the streptococcus albus; flos Caryophylli, rhizoma Atractylodis, semen Myristicae, flos Sophorae Immaturus, scutellariae radix, cortex Cinnamomi Japonici have certain antibacterial activity on Escherichia coli, wherein only rhizoma Atractylodis has high antibacterial activity on Escherichia coli. As can be seen from the antibacterial results shown in Table 22, the antibacterial experimental results of the traditional Chinese medicine extract solutions of the formulas F1-F4 show that; F1-F4 have obvious inhibitory activity on staphylococcus aureus, streptococcus albus and escherichia coli, wherein F1, F2 and F4 show extremely sensitive antibacterial activity on staphylococcus aureus, and F3 shows highly sensitive antibacterial activity; f1 and F4 show extremely sensitive bacteriostatic activity against streptococcus leucotrichia, while F2 and F3 show highly sensitive bacteriostatic activity; f1, F2, F3 and F4 all showed extremely sensitive bacteriostatic activity against escherichia coli. The results show that the bacteriostatic effect of F1 and F4 is excellent. As can be seen from the comparison of the antibacterial results shown in tables 21 and 22, the antibacterial effect of the single medicine is obviously weaker, and the traditional Chinese medicines (F1, F2, F3 and F4) respectively have obvious antibacterial activity; f1 is a traditional Chinese medicine composition with main antibacterial activity of F4 based on F2 and F3, has extremely strong antibacterial activity, and the traditional Chinese medicine composition of F2 and F3 has quite high antibacterial activity, but the four formulas have high antibacterial activity, and the overall antibacterial activity is obviously stronger than that of each single medicine, so that the traditional Chinese medicine composition can be used for developing related antibacterial products in future.
Table 21 diameter (mm) of antibacterial zone of Chinese medicinal extractive solutions of different formulations against detection bacteria
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Table 22 diameter (mm) of antibacterial zone of Chinese medicinal extract with different formulations for detecting bacteria
As can be seen from Table 23, the four comparative composition extracts all have a certain antibacterial effect on the detected bacteria, but the antibacterial effect is significantly lower than that of the traditional Chinese medicine composition.
Table 23 compares the diameter (mm) of the zone of inhibition of the detection of bacteria by the extract of the composition
Description: the present disclosure is not intended to limit the scope of the invention, but is merely illustrative of the embodiments of the present disclosure, and the invention is not limited to the details of the technology, spirit, principle of the present disclosure, and any modification, equivalent replacement, and improvement based on the present disclosure.

Claims (6)

1. The traditional Chinese medicine composition with multiple activities is characterized by comprising the following components in parts by mass: 3 parts of mint, 3 parts of wrinkled giant hyssop, 3 parts of lavender, 2 parts of mugwort leaf, 3 parts of pagodatree flower, 2 parts of honeysuckle, 2 parts of baical skullcap root and 0.5 part of cassia bark; the preparation method of the traditional Chinese medicine composition comprises the following steps: pulverizing the Chinese medicinal composition, reflux extracting with 70% ethanol solution for 2 times, mixing extractive solutions, filtering, and concentrating the filtrate under reduced pressure.
2. The traditional Chinese medicine composition according to claim 1, wherein the method comprises the following steps:
(1) Pulverizing the Chinese medicinal composition at high speed, sieving with 60 mesh sieve, and collecting the sieved powder;
(2) Adding 6-8 times of 70% ethanol solution into the powder obtained in the step (1), and heating and reflux-extracting with slow fire for 6h to obtain an extract; filtering and collecting filtrate;
(3) Repeating the step (2) on the filter residue obtained in the step (2);
(4) Combining the filtrates obtained in the step (2) and the step (3), and concentrating under reduced pressure in vacuum to recover ethanol to obtain the traditional Chinese medicine composition extract.
3. The use of a Chinese medicinal composition according to claim 1 for the preparation of a pestilence-removing and dirt-avoiding, and/or resuscitation-inducing and refreshing, and/or tranquillizing, and/or insect-repelling and mosquito-killing, and/or air-purifying, and/or antibacterial product.
4. The use according to claim 3, wherein said product comprises a traditional Chinese medicine fragrance, a spray, a skin-moisturizing soap, a hand cleanser.
5. The traditional Chinese medicine aromatherapy paste is characterized by comprising the following preparation method: repeatedly grinding the adhesive, excipient, buffer and neutralizer in a mortar until the adhesive, excipient, buffer and neutralizer are mixed uniformly and the particle size is uniform, adding purified water at 50-70 ℃, heating in a water bath at 65 ℃ for at least 30 minutes, and continuously stirring until the solution in the beaker is gel white and nearly transparent; adding the traditional Chinese medicine composition, the preservative and the traditional Chinese medicine volatile oil according to claim 1, repeatedly stirring and mixing uniformly, and standing at room temperature until the mixture is in a solid paste form.
6. The traditional Chinese medicine aromatherapy spray is characterized by comprising the following steps of: adding the Chinese medicinal composition of claim 1 into spray emission equipment to obtain Chinese medicinal aromatherapy spray.
CN202410181652.3A 2022-09-07 2022-09-07 Preparation and application of traditional Chinese medicine aromatherapy spray and ointment extracts with multiple activities Pending CN118078880A (en)

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