CN113797266A - Antiviral traditional Chinese medicine composition and application thereof - Google Patents

Antiviral traditional Chinese medicine composition and application thereof Download PDF

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Publication number
CN113797266A
CN113797266A CN202010531863.7A CN202010531863A CN113797266A CN 113797266 A CN113797266 A CN 113797266A CN 202010531863 A CN202010531863 A CN 202010531863A CN 113797266 A CN113797266 A CN 113797266A
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chinese medicine
traditional chinese
medicine composition
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陈国瑞
辛远航
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Shanghai Guankrypton Pharmaceutical Technology Development Co ltd
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Shanghai Guankrypton Pharmaceutical Technology Development Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532Agastache, e.g. giant hyssop
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009Sachets, pouches characterised by the material or function of the envelope
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

The invention relates to an antiviral traditional Chinese medicine composition which is prepared from the following raw material medicines: the whole formula has the effects of relieving exterior syndrome and expelling pathogenic factors, and eliminating dampness and regulating the middle warmer, and is suitable for preparing sachets, fragrant pillows, hanging decorations and the like. Researches show that the Chinese medicinal composition has an antiviral effect and can reduce the incidence rate of influenza of people. The traditional Chinese medicine (medicinal plant) raw materials selected by the traditional Chinese medicine composition are mostly medicinal and edible varieties, have no toxic or side effect, high safety, low cost and obvious advantages, and have good popularization and application prospects.

Description

Antiviral traditional Chinese medicine composition and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an antiviral traditional Chinese medicine composition and application thereof.
Background
In recent years, serious Acute Respiratory Syndrome (SARS, commonly known as atypical pneumonia), Middle East Respiratory Syndrome (MERS), ebola and other epidemic outbreaks occur in sequence, and the human life safety is continuously faced with a major challenge brought by epidemic diseases. Currently, new coronavirus infection pneumonia epidemic situation spreads all over the world, and specific drugs, vaccines and treatment methods are lacked so far. The traditional Chinese medicine has a long history of epidemic prevention and treatment, accumulates abundant experience, and supports the continuation of Chinese nationality. The traditional Chinese medicine will be of various naturesInfectious diseases and epidemic pathogens are called pestilence qi, pestilence qi, toxic gas, grumpy qi, etc., which are abnormal qi in various seasons and specific areas, and diseases caused by pestilence qi attacking human body are called epidemic diseases or pestilence diseases, such as dysentery, smallpox, plague, cholera, etc., and SARS, MERS, Ebola, new crown pneumonia, etc. are also caused by pestilence qi. The sachet is also called sachet, wearing sachet, pouch, etc. under the guidance of the theory of traditional Chinese medicine, combines the nature of pathogenic factors, selects the Chinese herbal medicine with aromatic smell, and is filled in the embroidered sachet. The aromatic smell emitted by the aromatic medicine contains chemical components, has the function of aromatic and avoiding dirty, and can kill and eliminate pathogens by regulating the functions of human bodies, so that people can avoid pathogen attack and have difficulty. Research reports that the aromatic odor component of the aromatic medicine can improve the spleen index and the respiratory SIgA content of a model animal and up-regulate CD3+、CD4+Cell number, CD4+/CD8+The ratio and the serum INF-7 can also improve the immune level of mice with low immune function, in particular improve the immune function of respiratory mucosa. It is also reported that wearing sachets has significant immunoregulation effect on children with recurrent respiratory tract infection, and can up-regulate the levels of sIgA, serum IgA, IgG and IgM to different degrees. Some aromatic components of the medicine have certain inhibitory effect on influenza virus, respiratory syncytial virus and respiratory pathogenic bacteria, and are reported. It should be said that, combining history and modern scientific research, the sachet is as the means of preventing epidemic situations such as influenza, simple and easy, easily promotes. However, due to different epidemic situations and different properties of pestilence qi, the prepared specific anti-epidemic sachet with good curative effect can exert better anti-epidemic effect by blending different Chinese medicinal components. However, due to the wide variety of aromatic drugs, great difference in drug properties and good traditional Chinese medicine formula, the aromatic Chinese medicine can be finally formed only by screening according to the traditional Chinese medicine theory, expert experience and a large amount of modern scientific research.
Disclosure of Invention
The invention aims to provide an antiviral traditional Chinese medicine composition for preventing influenza and the like, which is suitable for preparing sachets, fragrant pillows, hanging decorations and the like, and is particularly suitable for preparing sachets.
The antiviral traditional Chinese medicine composition provided by the invention is prepared from mint, agastache rugosus, eupatorium fortunei, rhizoma acori graminei, folium artemisiae argyi, radix angelicae, rhizoma atractylodis, clove and borneol. The herba Menthae is dry aerial part of Mentha haplocalyx Briq. of Labiatae, has pungent and cool nature and taste, and enters lung and liver channels, and has effects of dispelling pathogenic wind and heat, refreshing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Herba Agastaches is dry aerial part of herba Agastaches Pogostemon cablin (Blanco) Benth of Labiatae, has pungent and mild nature and taste, and has effects of invigorating spleen, stomach and lung channels, eliminating turbid pathogen with aromatics, regulating stomach, relieving vomit, relieving exterior syndrome and clearing summerheat. The Eupatorium fortunei Turcz is dry aerial part of Eupatorium fortunei Turcz of Compositae, has pungent and mild taste, and has effects of invigorating spleen, stomach and lung channels, eliminating dampness with aromatics, activating spleen, promoting appetite, relieving exterior syndrome and relieving summer-heat. Rhizoma Acori Graminei is dried rhizome of Acorus tatarinowii Schott of Araceae, has pungent, bitter, and warm properties, and has effects of inducing resuscitation, eliminating phlegm, refreshing mind, improving intelligence, eliminating dampness, and promoting appetite. The folium Artemisiae Argyi is dry leaf of Artemisia argyi L.et Vant. of Compositae, is pungent, bitter and warm in nature, and enters liver, spleen and kidney channels, and has effects of warming channels, stopping bleeding, dispelling cold, relieving pain, eliminating dampness and relieving itching for external use. The radix Angelicae Dahuricae is dry root of Angelica dahurica (Fisch. ex Hoffm.) Benth.et hook.f. or Angelica dahurica (Fisch. ex Hoffm.) Benth.et hook.f. var.fortmosana (Boiss.) Shann et Yuan, and has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, and relieving swelling and discharging pus. The rhizoma Atractylodis is dried rhizome of Atractylodes lancea DC (Thunb.) or Atractylodes chinensis Koidz (DC.) of Compositae, is pungent, bitter, and warm in nature, and has effects of eliminating dampness spleen, dispelling pathogenic wind, dispelling cold, and improving eyesight. Flos Caryophylli is the dried flower bud of Eugenia caryophyllata Thunb of Myrtaceae, has pungent and warm nature and taste, and has effects of warming middle-jiao, lowering adverse qi, invigorating kidney and tonifying yang. The borneol is prepared by extracting and processing fresh branches and leaves of Cinnamomum camphora (L.) Presl of Lauraceae, has pungent, bitter and cool nature, and has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. The whole formula has the effects of relieving exterior syndrome and expelling pathogenic factors, and resolving dampness and regulating the middle warmer, is mainly composed of aromatic medicines, and is suitable for preparing sachets, fragrant pillows, hanging decorations and the like.
According to an embodiment, the antiviral traditional Chinese medicine composition provided by the invention is prepared from the following raw material medicines in parts by weight: 1-50 parts of mint, 1-50 parts of wrinkled gianthyssop herb, 1-50 parts of fortune eupatorium herb, 1-50 parts of grassleaf sweelflag rhizome, 1-50 parts of Chinese mugwort leaf, 1-50 parts of dahurian angelica root, 1-50 parts of swordlike atractylodes rhizome, 1-50 parts of clove and 1-50 parts of borneol. Preferably: 1-30 parts of mint, 1-30 parts of wrinkled gianthyssop herb, 1-30 parts of fortune eupatorium herb, 1-30 parts of grassleaf sweelflag rhizome, 1-30 parts of Chinese mugwort leaf, 1-30 parts of dahurian angelica root, 1-30 parts of swordlike atractylodes rhizome, 1-30 parts of clove and 1-20 parts of borneol. Further preferably: 1-10 parts of mint, 1-10 parts of wrinkled gianthyssop herb, 1-10 parts of fortune eupatorium herb, 1-10 parts of grassleaf sweelflag rhizome, 1-10 parts of Chinese mugwort leaf, 1-10 parts of dahurian angelica root, 1-10 parts of swordlike atractylodes rhizome, 1-10 parts of clove and 1-5 parts of borneol. Most preferably: 5 parts of mint, 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 5 parts of grassleaf sweelflag rhizome, 5 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 5 parts of swordlike atractylodes rhizome, 5 parts of clove and 2 parts of borneol.
The common preparation method of the traditional Chinese medicine composition comprises the following steps: weighing the raw materials in parts by weight, and directly crushing the raw materials into proper granularity according to a common method in the field to prepare sachets, fragrant pillows or hanging decorations.
Subsequent experimental studies showed that: the traditional Chinese medicine composition has the pharmacological action of obviously inhibiting common viruses which can cause respiratory tract infection, and can reduce the incidence rate of influenza of people. The traditional Chinese medicine (medicinal plant) raw materials selected by the traditional Chinese medicine composition are mainly medicinal and edible varieties, have no toxic or side effect, high safety, low cost and obvious advantages, are added with traditional culture carriers such as sachets, fragrant pillows and hanging ornaments, and have good popularization and application prospects.
Detailed Description
The following detailed description of the present invention will be provided in conjunction with examples, which are to be construed as merely illustrative, and not limitative of the remainder of the disclosure. Various changes and modifications may be effected therein by one skilled in the art, and such equivalent changes and modifications also fall within the scope of the invention as defined in the appended claims.
EXAMPLE 1 preparation of Chinese medicinal composition powder
The traditional Chinese medicine composition powder is prepared by crushing 500g of mint, 500g of wrinkled gianthyssop herb, 500g of fortune eupatorium herb, 500g of grassleaf sweelflag rhizome, 500g of Chinese mugwort leaf, 500g of dahurian angelica root, 500g of swordlike atractylodes rhizome, 500g of clove and 200g of borneol and sieving the crushed materials with a 24-mesh sieve.
EXAMPLE 2 preparation of Chinese medicinal composition powder
Selecting 1000g of mint, 50g of wrinkled gianthyssop herb, 100g of fortune eupatorium herb, 50g of grassleaf sweelflag rhizome, 100g of Chinese mugwort leaf, 100g of dahurian angelica root, 300g of swordlike atractylodes rhizome, 200g of clove and 50g of borneol, crushing, and sieving by a 24-mesh sieve to obtain the traditional Chinese medicine composition powder.
EXAMPLE 3 preparation of Chinese medicinal composition powder
Selecting 50g of mint, 1000g of wrinkled gianthyssop herb, 1000g of fortune eupatorium herb, 200g of grassleaf sweelflag rhizome, 1000g of Chinese mugwort leaf, 300g of dahurian angelica root, 100g of swordlike atractylodes rhizome, 50g of clove and 200g of borneol, crushing, and sieving by a 24-mesh sieve to obtain the traditional Chinese medicine composition powder.
EXAMPLE 4 preparation of Chinese medicinal composition powder
Selecting 50g of mint, 100g of wrinkled gianthyssop herb, 50g of fortune eupatorium herb, 1000g of grassleaf sweelflag rhizome, 300g of Chinese mugwort leaf, 100g of dahurian angelica root, 100g of swordlike atractylodes rhizome, 50g of clove and 1000g of borneol, crushing, and sieving by a 24-mesh sieve to obtain the traditional Chinese medicine composition powder.
EXAMPLE 5 preparation of Chinese medicinal composition powder
Selecting 300g of mint, 50g of wrinkled gianthyssop herb, 50g of fortune eupatorium herb, 1000g of grassleaf sweelflag rhizome, 300g of Chinese mugwort leaf, 100g of dahurian angelica root, 100g of swordlike atractylodes rhizome, 50g of clove and 10g of borneol, crushing, and sieving by a 24-mesh sieve to obtain the traditional Chinese medicine composition powder.
EXAMPLE 6 preparation of Chinese medicinal composition powder
2000g of mint, 3000g of wrinkled gianthyssop herb, 50g of fortune eupatorium herb, 200g of grassleaf sweelflag rhizome, 100g of Chinese mugwort leaf, 50g of dahurian angelica root, 100g of swordlike atractylodes rhizome, 50g of clove and 100g of borneol are selected, crushed and sieved by a 24-mesh sieve to obtain the traditional Chinese medicine composition powder.
EXAMPLE 7 sachet manufacture
The powder of the Chinese medicinal composition described in any one of embodiments 1 to 6 is packaged in filter paper bags with 10g of each bag, sealed into inner bags, and then packaged in 7cm × 12cm brocade bags to form sachets, which are sealed and packaged in plastic bags for later use.
EXAMPLE 8 fragrant pillow preparation
The powder of the traditional Chinese medicine composition in any one of embodiments 1 to 6 is packaged into a textile bag with 200g of powder, a proper amount of cotton auxiliary material is added, the textile bag is sealed into an inner bag, a 20cm × 40cm brocade bag is used as an outer package, and the fragrant pillow is obtained and sealed and packaged by a plastic bag for standby.
EXAMPLE 9 preparation of hanging ornament
The powder of the Chinese medicinal composition described in any one of embodiments 1 to 6 is packaged into an inner bag in an amount of 20 g per bag, the inner bag is placed into a fan-shaped craft brocade bag, and then the fan-shaped craft brocade bag is connected with Chinese knots in series, and is sealed and packaged by a plastic bag for later use.
EXAMPLE 10 antiviral pharmacological test
1. Purpose of experiment
The traditional Chinese medicine composition has the effect of inhibiting common viruses causing respiratory tract infection, including influenza virus A1 and A3, and adenovirus 3 and 7.
2. Experimental Material
2.1 reagent: DMEM medium (TBD10565, tertiary Tianjin), double antibody (mixed solution of streptomycin, batch number: BL-XB-0197, Boguan), phosphate buffer (PBS, PB2004Y, tertiary Tianjin), fetal bovine serum (FBS, 10099-141, Gibco, USA), EDTA-0.25% pancreatin (BL-XB-0168, Boguan), and thiazole blue dye solution (MTT, BL-SJ-0717, Boguan).
2.2, test article: examples 1 and 3A Chinese medicinal composition is prepared by ultrasonic extracting with 10 times of 75% ethanol for 2 hr, concentrating the extractive solution under reduced pressure to 1g/ml to obtain Chinese medicinal composition extractive solutions 1 and 3, and filtering with microporous membrane.
3. Experimental methods
Influenza virus A1, A3, adenovirus 3, and 7 virus strains are selected for testing, and the inhibiting effect of the Chinese medicinal composition extractive solution is observed. Diluting all virus strains by 100 times, mixing with Chinese medicinal composition extractive solution, inoculating into human embryonic kidney cell, adsorbing for 40min, adding lactoprotein cell maintaining solution, setting virus and cell control tubes, standing at 37 deg.C and 5% CO2And (3) culturing and killing for 1 week in an incubator, observing cytopathic conditions, and judging the cytopathic conditions according to the following standards: +: the cells grow normally, no lesion appears or cytopathic effect accounts for less than 25% of the whole monolayer of cells; ++: cytopathic effectLess than about 50% of the total monolayer of cells; +++: cytopathic effects account for the typical pathology of an entire monolayer of cells. The results show that the traditional Chinese medicine composition has obvious antiviral effect, and the results are shown in table 1.
TABLE 1 results of antiviral tests
Figure BDA0002535708400000051
Example 11 trial of the population (prevention experiment)
1. General data
The observation target was preschool children in a kindergarten. The observation time is from 12 months 1 days in 2019 to 12 months 31 days in 2019 (flu season). The sex and age of children in the observation group and the control group are not statistically different from each other in 6 classes, and the children in the two groups have comparability.
2. Diagnostic criteria
The disease diagnosis refers to the clinical diagnosis and treatment guidelines for influenza (draft) made by the respiratory disease society of the Chinese medical society, as follows: (1) there is a history of cold exposure; (2) the symptoms of acute fever, chills, dry, itchy and painful throat, cough, nasal obstruction, watery nasal discharge and other symptoms or digestive tract symptoms are shown: (3) checking the obvious congestion of pharynx or tonsil swelling and congestion: (4) white blood cell counts were normal or low and lymphocyte cell ratios were elevated.
3. Inclusion criteria
The child is determined to be healthy after a comprehensive examination by the medical school.
4. Exclusion criteria
The method comprises the following specific steps: (1) children suffering from other chronic respiratory diseases such as influenza and allergic asthma, or children who cannot be taken into or kept in observation for any reason. (2) For this reason, children who accumulate more than 5 days cannot be reached.
5. Method of treatment
Observation group: 120 persons in 6 classes, the classroom wall of the class is 1/m2The sachets were hung and replaced 1 time per week.
Control group: the number of people is 120 in 6 classes of the same age as that of the observation group, and the rest of the observation group is the same except that the sachet is not hung in the classroom.
6. Observation index
After the infants are grouped, the chief and the officer in each class are responsible for reporting the morbidity of the infants in real time. And after observation is finished, summarizing the results and calculating the incidence rate of the cold.
The incidence rate of common cold is the number of people who have common cold/the total number of experimental people in the group
7. Observation results
After one month observation, the observation group shows the conditions of appetite increase, better mental state and immunity enhancement, the incidence rate of the cold of the observation group is obviously lower than that of a control group (P is less than 0.01), and the results are shown in a table 2, which shows that the traditional Chinese medicine composition has the effect of obviously reducing the incidence rate of the influenza of the crowd.
TABLE 2 trial results for the population
Figure BDA0002535708400000061

Claims (6)

1. The antiviral traditional Chinese medicine composition is characterized by being prepared from the following raw material medicines in parts by weight: 1-50 parts of mint, 1-50 parts of wrinkled gianthyssop herb, 1-50 parts of fortune eupatorium herb, 1-50 parts of grassleaf sweelflag rhizome, 1-50 parts of Chinese mugwort leaf, 1-50 parts of dahurian angelica root, 1-50 parts of swordlike atractylodes rhizome, 1-50 parts of clove and 1-50 parts of borneol.
2. The antiviral traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1-30 parts of mint, 1-30 parts of wrinkled gianthyssop herb, 1-30 parts of fortune eupatorium herb, 1-30 parts of grassleaf sweelflag rhizome, 1-30 parts of Chinese mugwort leaf, 1-30 parts of dahurian angelica root, 1-30 parts of swordlike atractylodes rhizome, 1-30 parts of clove and 1-20 parts of borneol.
3. The antiviral traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1-10 parts of mint, 1-10 parts of wrinkled gianthyssop herb, 1-10 parts of fortune eupatorium herb, 1-10 parts of grassleaf sweelflag rhizome, 1-10 parts of Chinese mugwort leaf, 1-10 parts of dahurian angelica root, 1-10 parts of swordlike atractylodes rhizome, 1-10 parts of clove and 1-5 parts of borneol.
4. The antiviral traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 parts of mint, 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 5 parts of grassleaf sweelflag rhizome, 5 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 5 parts of swordlike atractylodes rhizome, 5 parts of clove and 2 parts of borneol.
5. Use of the antiviral traditional Chinese medicine composition of any one of claims 1 to 4 in the preparation of sachets, pillows or hangers.
6. Use according to claim 5, characterized in that antiviral traditional Chinese medicine compositions are used for the preparation of sachets.
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CN101721618A (en) * 2009-11-24 2010-06-09 中国人民解放军第二军医大学 External Chinese medicinal health-care bag for dispelling filth and preventing and treating influenza
CN105477218A (en) * 2015-12-11 2016-04-13 中国人民解放军第二军医大学 Traditional Chinese medicine composition for preventing influenza and application thereof
CN107362324A (en) * 2017-09-06 2017-11-21 南京苏新智慧社区服务有限公司 A kind of Chinese medicine sachet of preventing cold strengthening the spleen and stomach and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115475203A (en) * 2022-09-07 2022-12-16 甘肃中医药大学 Preparation and application of traditional Chinese medicine aromatherapy spray and paste extract with multiple activities
CN115475203B (en) * 2022-09-07 2024-03-08 甘肃中医药大学 Preparation and application of traditional Chinese medicine aromatherapy spray and ointment extracts with multiple activities

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Application publication date: 20211217