CN114366779A - Antiviral traditional Chinese medicine composition and mask - Google Patents
Antiviral traditional Chinese medicine composition and mask Download PDFInfo
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- CN114366779A CN114366779A CN202210051756.3A CN202210051756A CN114366779A CN 114366779 A CN114366779 A CN 114366779A CN 202210051756 A CN202210051756 A CN 202210051756A CN 114366779 A CN114366779 A CN 114366779A
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- Physical Education & Sports Medicine (AREA)
- Textile Engineering (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of personal hygiene and occupational protection, and particularly relates to an antiviral traditional Chinese medicine composition and a mask. The traditional Chinese medicine composition comprises the following medicines in parts by weight: 150 parts of folium artemisiae argyi 120-. As one application mode of the external medicine, the invention also discloses a novel mask prepared from the traditional Chinese medicine composition. The mask can effectively block the spread of epidemic diseases caused by viruses when being worn for a long time. The traditional Chinese medicine composition and the mask have good application prospects. Therefore, the traditional Chinese medicine composition and the mask have good application prospects.
Description
Technical Field
The invention belongs to the technical field of personal hygiene and occupational protection, and particularly relates to an antiviral traditional Chinese medicine composition and a mask.
Background
The pathogen of the novel coronavirus pneumonia is SARS-CoV-2, and the disease is formally named as 2019 coronavirus disease (COVID-19) by the world health organization. COVID-19 belongs to the family of coronaviridae, and is a single-stranded positive-strand RNA virus with an envelope. The transmission routes of COVID-19 are mainly direct transmission, aerosol transmission and contact transmission, and the large-scale prevalence has appeared on the global scale since the outbreak of the COVID-19 epidemic.
The emergence and the popularity of the new coronary pneumonia greatly change personal hygiene protection habits of people, and the mask is a necessary product for people to go out recently. In crowded places, people have become accustomed to wearing masks to prevent the spread of new coronary pneumonia. Although the existing mask products can greatly reduce the infection probability of epidemic diseases, the mask plays a role as a simple physical block, and the person wearing the mask can still be infected. Therefore, there is a need for improved products for masks that increase their probability of preventing the transmission of epidemic disease.
The Chinese patent application 'CN 202010225317.0 mask for preventing pneumonia caused by influenza virus and/or novel coronavirus and a preparation method thereof' provides a mask made of patchouli, raw argy wormwood leaf, fortune eupatorium herb, mint, swordlike atractylodes rhizome, grassleaf sweelflag rhizome, clove bud, dahurian angelica root, perilla leaf, notopterygium root, turmeric and costustoot as medicine cores, and the mask has a prevention effect on pneumonia caused by influenza virus, novel coronavirus and the like. However, the medicine core of the mask adopts a large amount of medicines and has complex formula, so the production cost is high. In addition, some traditional Chinese medicine extracts have certain water solubility or volatility, and the technology of stably attaching the traditional Chinese medicine extracts to the mask material is difficult to realize at present. Therefore, in order to apply the traditional Chinese medicine to the mask, the application must make various medicinal materials into powder and put the powder into the interlayer. The structure design enables the traditional Chinese medicine powder to be easily combined with moisture generated by breathing or inhaled by breathing, and influences the function of the mask.
Therefore, there is a need to develop new antiviral Chinese medicinal composition for external use which can be used for making products such as masks, etc., and provide more choices for daily antiviral protective products.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides an antiviral traditional Chinese medicine composition and a mask. Aims to provide an antiviral traditional Chinese medicine composition and a non-woven fabric on the outer layer of a mask added with the traditional Chinese medicine composition, which can be used for resisting viruses, can enhance the effect of the mask on resisting epidemic diseases caused by new coronavirus and the like, and simultaneously can be inhaled less.
A traditional Chinese medicine composition for external use comprises the following medicines in parts by weight:
150 parts of folium artemisiae argyi 120-.
Preferably, the medicine comprises the following medicines in parts by weight:
120 parts of folium artemisiae argyi, 180 parts of fortune eupatorium herb, 180 parts of rhizoma atractylodis, 60 parts of calamus, 120 parts of clove and 60 parts of mint.
The invention also provides application of the traditional Chinese medicine composition in preparing an antibacterial or antiviral protective device.
Preferably, the antibacterial or antiviral protection device is an antiviral mask.
Preferably, the antibacterial or antiviral shield is a shield against gram-positive bacteria, gram-negative bacteria, influenza virus or neocoronavirus.
The invention also provides an antibacterial and antiviral mask, which comprises a mask body and a structure for fixing the mask body on the face of a wearer, wherein the mask body comprises an outer sleeve layer, a medicine attachment layer and a moisture absorption layer which are sequentially arranged, and the medicine attachment layer is attached with the extract of the traditional Chinese medicine composition.
Preferably, the drug attachment layer is prepared from the following raw materials in parts by weight:
50-60 parts of polypropylene,
1-2 parts of surface treating agent,
20-25 parts of extract of the traditional Chinese medicine composition as claimed in claim 1 or 2,
6-9 parts of essential oil,
10-15 parts of potato starch,
60-90 parts of heavy calcium carbonate.
Preferably, the drug attachment layer is prepared from the following raw materials in parts by weight:
60 portions of polypropylene,
2 parts of surface treating agent,
25 parts of extract of the traditional Chinese medicine composition,
8 parts of essential oil,
15 portions of potato starch,
80 parts of ground calcium carbonate.
Preferably, the surface treatment agent is selected from potassium myristoyl glycinate and the essential oil is selected from peppermint essential oil.
The invention also provides a preparation method of the non-woven fabric containing the traditional Chinese medicine extract, the non-woven fabric is used for preparing the medicine adhesion layer of the mask, and the preparation method comprises the following steps:
step 1, mixing heavy calcium carbonate, potato starch, extracts of the traditional Chinese medicine composition and essential oil, and uniformly stirring at 35-45 ℃;
step 2, sequentially adding a surface treating agent and polypropylene, and standing at 50-55 ℃ to prepare a powder material;
and 3, preparing the powder material obtained in the step 2 into non-woven fabric.
Preferably, the extract of the traditional Chinese medicine composition is prepared according to the following steps: decocting folium Artemisiae Argyi, herba Eupatorii, rhizoma Atractylodis, rhizoma Acori Calami, flos Caryophylli and herba Menthae with 0.6-0.8L water respectively, filtering, mixing filtrates, and concentrating.
The invention provides an external traditional Chinese medicine composition with antibacterial and antiviral effects, which has a simpler formula and fewer medicinal ingredients. The whole formula is precise and appropriate in compatibility, and has the effects of aromatizing, eliminating dampness, removing plague and avoiding plague. Wherein cang Zhu is pungent and bitter in flavor, warm in nature, pungent can disperse, bitter can purge and warm can remove cold, Ben Cao gang mu: for retained fluid due to damp phlegm or blood stasis, it can form a nest bag, and it can lead to downward flow of spleen dampness, turbid and draining leucorrhea, and diarrhea with intestinal wind. The new coronavirus pneumonia belongs to the category of cold-dampness plague in the traditional Chinese medicine, so the formula takes the rhizoma atractylodis as a monarch drug to warm and resolve cold-dampness, relieve exterior syndrome and remove cold. Folium artemisiae argyi is bitter and pungent, and its nature is warm, so the book ben zheng: "Pirani-dispelling cold-evil and malaria. "Eupatorium has pungent flavor and mild property, Shen nong Ben Cao Jing: "mainly induce diuresis and kill poison parasitic tympanties. "clove is pungent in flavor and warm in nature, and" Kaibao Ben Cao "(herbal medicine for Kaibao): to warm the spleen and stomach and stop cholera. For (treatment of) congestion and distension, wind-toxicity and swelling, malnutrition of the teeth and malnutrition. All the three can warm and resolve cold-dampness, avoid virus and miasma, strengthen spleen and replenish qi, so they are used as ministerial drugs. The calamus has warm nature and pungent taste, has the effects of resolving dampness and stimulating appetite, inducing resuscitation and eliminating phlegm, refreshing mind and benefiting intelligence, and can enhance the effect of eliminating dampness of monarch drugs. The mint is cool in nature and pungent in taste, has the effects of dispelling wind, dissipating heat, removing dirt and detoxifying, and can increase the effects of dispelling wind and relieving exterior syndrome in the whole formula. Therefore, they are used as adjuvant drugs.
As one application mode of the external medicine, the extract of the traditional Chinese medicine composition can be effectively attached to non-woven fabrics, and then the non-woven fabrics are utilized to prepare a novel mask. Compared with the defect that the existing similar products need to be filled with medicinal powder, the mask has the same structure as the conventional mask (such as N95 and the like), so that the mask is convenient to use, low in cost and suitable for large-scale popularization. The mask can effectively block the spread of infectious diseases caused by viruses when worn, and can effectively prevent new coronavirus when worn for a long time.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
EXAMPLE 1 Chinese medicinal composition and extract thereof
This example provides a Chinese medicinal composition comprising mugwort, eupatorium, atractylodes rhizome, calamus, clove and mint, which is made into an extract.
The preparation method comprises the following steps:
1) the raw materials are proportioned according to the weight parts of the raw material medicaments,
2) respectively adding 9 times of water into folium Artemisiae Argyi, herba Eupatorii, rhizoma Atractylodis, rhizoma Acori Calami, flos Caryophylli and herba Menthae, decocting for two times, the first time for 90-120 min and the second time for 60-90 min, filtering the decoction, mixing the filtrates, and concentrating at 70 deg.C to relative density of 1.2 to obtain soft extract;
3) drying the soft extract to obtain dry powder, and grinding to obtain Chinese medicinal extract powder.
The formulation of the specific composition of group 5 is shown in the following table:
TABLE 1 Chinese medicinal composition formula (g)
| Raw material | Formulation 1 | Formulation 2 | Formulation 3 | Formulation 4 | Formulation 5 |
| Folium Artemisiae Argyi | 130 | 120 | 120 | 128 | 135 |
| Herba Eupatorii | 180 | 180 | 130 | 124 | 170 |
| Rhizoma Atractylodis | 250 | 180 | 220 | 200 | 220 |
| Acorus calamus | 170 | 60 | 156 | 165 | 170 |
| Lilac | 125 | 120 | 132 | 125 | 140 |
| Mint | 75 | 60 | 66 | 75 | 80 |
Example 2 antibacterial and antiviral mask
The mask that this embodiment provided includes the gauze mask body and is used for being fixed in the facial structure of wearer with the gauze mask body, the structure that is used for being fixed in the facial structure of wearer can refer to prior art and realize, for example can adopt rope or the area that has elasticity.
The mask body comprises an outer sleeve layer, a drug attachment layer and a moisture absorption layer which are sequentially arranged, wherein the outer sleeve layer is made of a spray-melting cloth material, and faces the outside when being worn, and the moisture absorption layer is in contact with the face of a wearer.
The drug attachment layer is made of cotton cloth or non-woven fabric, and as a specific preferred mode, the drug attachment layer of the embodiment is made through the following steps:
the first step is as follows: mixing ground calcium carbonate, potato starch, formula 2 and peppermint essential oil, and stirring uniformly at 40 ℃ until the water content is less than 2%; sequentially adding surface treating agent (potassium myristoyl glycinate) and polypropylene (Korea Xiaoxing: R530A), standing in water bath at 50-55 deg.C for 8-10 hr, and making into powder.
The second step is that: the materials prepared in the above steps are processed by the conventional procedures: the large screw rods are melted and extruded at high temperature, filtered, quantitatively conveyed by a metering pump, stretched and sucked up and down at a spinning inlet, cooled, pulled by air flow, formed into a net by a net curtain, reinforced by an upper pressing roller and a lower pressing roller, and hot rolled and reinforced by a rolling mill to prepare the spunbonded non-woven fabric.
The specific proportioning mode of each raw material is shown in the following table:
TABLE 2 drug attachment layer formulation (g)
In this example, the drug is attached only in the drug attachment layer. In other preferred embodiments, the outer jacket layer may be treated as in step S2, and then bonded to the drug attachment layer after the drug is attached to the outer jacket layer.
In order to illustrate the advantageous effects of the present invention, the following experimental examples are provided to further illustrate the technical solution of the present invention.
Experimental example 3 drug attachment layer ratio screening
The method of example 2 was used to prepare 5 drug attachment layers from the 5 formulations of the extracts of the herbal composition provided in example 1. Dissolving the drug attachment layers by using ethanol respectively, and weighing after extraction to obtain the following formula percentage results of the extract of the traditional Chinese medicine composition in the total extract:
TABLE 3 drug attachment layer formulation screening
As can be seen from the above table, the different formulas have different adsorption capacities to the nonwoven fabric, wherein formula 3 can be adsorbed on the nonwoven fabric to the maximum extent.
Experimental example 4 screening of Chinese medicinal composition
A natural bacteriostasis plate method is adopted, the bacteriostasis difference between the single use and the compound of the traditional Chinese medicine extracting solution is inspected, and the optimal curative effect of the formula is determined by screening the proportion.
1. Experimental Material
1.1 the experimental materials are 6 traditional Chinese medicines: folium Artemisiae Argyi, herba Eupatorii, rhizoma Atractylodis, rhizoma Acori Calami, flos Caryophylli, and herba Menthae.
1.2 experimental equipment: beaker, electronic balance, electric stove, filter screen, centrifuging tube, culture dish.
2. Experimental methods
1) The above Chinese medicinal materials are respectively 5g, placed in corresponding beaker, and immersed in distilled water.
2) Boil on a hotplate for 20 minutes.
3) After filtration through a filter screen, the mixture was concentrated to 15ml again.
4) Cooling at room temperature, and refrigerating in refrigerator for 6 hr.
5) All the filtrates were centrifuged (6000r/min, 4 ℃ C., 10min) and the supernatants were poured into corresponding petri dishes.
Placing the water extract in normal environment, and observing the natural bacteria growth condition every day.
The drug dose for each experimental group is shown in the following table:
TABLE 4 screening of Chinese medicinal composition
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
| Folium Artemisiae Argyi | Herba Eupatorii | Rhizoma Atractylodis | Acorus calamus | Lilac | Mint | Water (W) | |
| Quadrature 1 | 1 | 3 | 3 | 1 | 2 | 1 | 6 |
| Quadrature 2 | 2 | 3 | 3 | 1 | 2 | 1 | 8 |
| Quadrature 3 | 2 | 1 | 3 | 1 | 2 | 1 | 4 |
| Quadrature 4 | 2 | 3 | 2 | 1 | 2 | 2 | 5 |
| Quadrature 5 | 2 | 1 | 2 | 3 | 2 | 1 | 4 |
| Quadrature 6 | 1 | 3 | 2 | 2 | 3 | 1 | 3 |
| Quadrature 7 | 2 | 3 | 3 | 2 | 2 | 2 | 6 |
Note that "1 part" in the table represents 5g of the drug substance
TABLE 5 score for growth
Scoring for long bacterium condition:
when no bacteria is detected, the value is 0
The total number of colonies is less than or equal to 20 cfu/ml-1
The total number of colonies is less than or equal to 50 cfu/ml-2
The total number of colonies is less than or equal to 100cfu/ml and 3
The total number of colonies is less than or equal to 200 cfu/ml-4
The total number of colonies is less than or equal to 500 cfu/ml-5
Scoring of long bacterium condition: (0-5 points, the higher the score, the more the growing bacteria)
3. The experimental results are as follows:
as can be seen from the above table, Quadrature 2 (the ratio of each herb is equivalent to formula 3 in example 1) is the most effective and has no bacteria growth.
Experiment 5 anti-neocoronaviruses test
This experimental example tested the anti-neocoronaviral effect of the drug attachment layer prepared from the formulation polypropylene of example 3 of 60 parts, the surface treatment agent of 2 parts, the extract of formulation 2 of 25 parts, the peppermint essential oil of 8 parts, the potato starch of 15 parts, and the ground calcium carbonate of 80 parts.
1. And (3) inspecting equipment:
model 3111 CO2 incubator (Thermofisiher Co.);
CKX41 type inverted phase contrast microscope (OLYMPUS).
2. And (3) testing reagents:
SARS-CoV-2 virus (batch No.: P6; titer 2X 105PFU/ML)；
Fetal bovine serum (Hyclone corporation);
trypsin (Roche);
DMEM cell culture medium (Invitrogen);
EBSS (Brand: Gibico: cat # 14155063)
Mouse mononuclear macrophage RAW 264.7 (Kunming cell bank of Chinese academy of sciences, accession number KCB200603 YJ);
l-monomethyl arginine (L-NMMA, Biyuntian Biotechnology Co., Ltd.).
Contrast cotton fabric: 20mm x 20mm
The mask fabric made of the plant fibers comprises the following steps: 60 parts of formula polypropylene, 2 parts of surface treating agent, 25 parts of formula 2 extract, 8 parts of peppermint essential oil, 15 parts of potato starch and 80 parts of ground calcium carbonate of example 3.
3. The experimental method comprises the following steps:
1) putting the sterilized contrast cotton cloth fabric and the sterilized plant fiber mask fabric into 50 mu l of virus suspension; then placing in CO at 25 DEG C2The incubator is used for 30 min; measuring the virus infection titer by a plaque method;
2) adding 0.1ml of the prepared virus suspension into the control cotton and plant fiber mask fabric in 5 points, and standing at 25 deg.C for 0, 10, and 30 min;
3) the vial was filled with 10ml of EBSS medium, and the sample at the above time point was added to the vial. Oscillating for 60 seconds by a vortex oscillator to obtain basic virus eluent;
4) preparing a series of diluents of the eluent;
5) dilutions were assayed by plaque assay.
4. Plaque assay
1) The 96-well culture plate (cell density of 3X 104 cell holes) is laid 12-24 hours in advance to grow the cells to 90%
2) Washing the cells once by using PBS, and adding diluents with different concentrations;
3)5％CO2incubating the incubator for one hour, and observing the formation of voids;
4) adding 2% paraformaldehyde, fixing for half an hour, removing supernatant, adding crystal violet for 2min, washing with water for 5 times, calculating the number of plaques, and calculating titer.
5. Test results
The results are shown in tables 6 and 7:
table 6 titer of virus exposure to control cotton fabric:
table 7 titers of virus exposure to plant fiber mask fabric:
as can be seen from the data in the above table, the viral titer significantly decreased within 30 minutes after the new coronavirus was exposed to the drug attachment layer of the present application, and the rate of decrease was much higher than that of the existing cotton cloth fabric. Therefore, the mask of the present invention can effectively block infection of new coronavirus.
As can be seen from the above examples and experimental examples, the traditional Chinese medicine composition provided by the invention has antibacterial and antiviral effects. The mask prepared by wearing the traditional Chinese medicine composition for a long time can effectively block the spread of epidemic diseases caused by viruses. The traditional Chinese medicine composition and the mask have good application prospects.
Claims (10)
1. A traditional Chinese medicine composition for external use is characterized by comprising the following medicines in parts by weight:
150 parts of folium artemisiae argyi 120-.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following medicines in parts by weight:
120 parts of folium artemisiae argyi, 180 parts of fortune eupatorium herb, 180 parts of rhizoma atractylodis, 60 parts of calamus, 120 parts of clove and 60 parts of mint.
3. Use of a Chinese medicinal composition according to claim 1 or 2 for the preparation of an antibacterial or antiviral protective device.
4. Use according to claim 3, characterized in that: the antibacterial or antiviral protective device is an antiviral mask.
5. Use according to claim 3, characterized in that: the antibacterial or antiviral protective device is a protective device for resisting gram-positive bacteria, gram-negative bacteria, influenza viruses or new corona viruses.
6. The utility model provides an antibiotic and antiviral gauze mask, includes the gauze mask body and is used for being fixed in the facial structure of wearer with the gauze mask body, its characterized in that: the mask body comprises an outer sleeve layer, a drug attachment layer and a moisture absorption layer which are sequentially arranged, wherein the drug attachment layer is attached with the extract of the traditional Chinese medicine composition of claim 1 or 2.
7. The mask of claim 6 wherein: the drug attachment layer is prepared from the following raw materials in parts by weight:
50-60 parts of polypropylene,
1-2 parts of surface treating agent,
20-25 parts of extract of the traditional Chinese medicine composition as claimed in claim 1 or 2,
6-9 parts of essential oil,
10-15 parts of potato starch,
60-90 parts of heavy calcium carbonate.
8. The mask of claim 6 wherein: the surface treating agent is selected from potassium myristoyl glycinate, and the essential oil is selected from mint essential oil.
9. A method for preparing a non-woven fabric containing a herbal extract for preparing a drug attachment layer of the mask of claims 6-8, comprising the steps of:
step 1, mixing heavy calcium carbonate, potato starch, the extract of the traditional Chinese medicine composition of claim 1 or 2 and essential oil, and uniformly stirring at 35-45 ℃;
step 2, sequentially adding a surface treating agent and polypropylene, and standing at 50-55 ℃ to prepare a powder material;
and 3, preparing the powder material obtained in the step 2 into non-woven fabric.
10. The method of claim 9, wherein the extract of the herbal composition is prepared by the steps of: decocting folium Artemisiae Argyi, herba Eupatorii, rhizoma Atractylodis, rhizoma Acori Calami, flos Caryophylli and herba Menthae with 0.6-0.8L water respectively, filtering, mixing filtrates, and concentrating.
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