CN106473268A - A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use - Google Patents

A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use Download PDF

Info

Publication number
CN106473268A
CN106473268A CN201610675870.8A CN201610675870A CN106473268A CN 106473268 A CN106473268 A CN 106473268A CN 201610675870 A CN201610675870 A CN 201610675870A CN 106473268 A CN106473268 A CN 106473268A
Authority
CN
China
Prior art keywords
weight portion
weight
extract
root
grass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610675870.8A
Other languages
Chinese (zh)
Inventor
王玮
董培智
刘兴隆
陈云慧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chengdu Bo Biological Technology Co Ltd
Original Assignee
Chengdu Bo Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Bo Biological Technology Co Ltd filed Critical Chengdu Bo Biological Technology Co Ltd
Priority to CN201610675870.8A priority Critical patent/CN106473268A/en
Publication of CN106473268A publication Critical patent/CN106473268A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A41WEARING APPAREL
    • A41DOUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A41D13/1192Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532Agastache, e.g. giant hyssop
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Textile Engineering (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to technical field of traditional Chinese medicines, specifically provide a kind of pre- anti-virus, the Herb medicine gauze mask of allergic rhinitis, bulk drug is made up of the root of large-flowered skullcap, grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon and peppermint, and its weight proportion scope is 10 50 weight portion of the root of large-flowered skullcap, 5 40 weight portion of grass-leaved sweetflag, 5 40 weight portion of rhizoma atractylodis, 3 20 weight portion of the flower bud of lily magnolia, 3 20 weight portion of wrinkled giant hyssop, 3 20 weight portion of tarragon, 1 10 weight portion of peppermint.Present invention also offers the preparation method of the Herb medicine gauze mask and particular use.Drug regimen of the present invention proves there is substantially suppression influenza virus effect and resisting allergic rhinitis, pharyngitis effect through effect experiment.

Description

A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use
Technical field
The present invention relates to a kind of Herb medicine gauze mask, especially relates to the Chinese medicine of a kind of pre- anti-virus, allergic rhinitis and pharyngitis Mouth mask and its production and use, belongs to technical field of traditional Chinese medicines.
Background technology
Influenza (abbreviation influenza) is the ARI that influenza virus causes, and a kind of infection The property fast disease of strong, spread speed.Its spittle main through the air, interpersonal contact or with contaminated article Contact transmission.Its typical Clinical symptoms is:The anxious nosotoxicosis such as hyperpyrexia, headache, weak, eye conjunctivitis and muscular soreness of whole body Shape is obvious and respiratory tract catarrh symptom is lighter.General autumn and winter season is its high-incidence season.The disease is caused by influenza virus, can be divided For first, second, the third three types.In the traditional Chinese medicine traditional literature of China, the symptom to influenza, feature, epidemic status are already on the books. Influenza belongs to plague class (i.e. infectious disease) as which is widely current referred to as " influenza " in traditional Chinese medicine.Early in 610 years Christian eras Sui For written by physician's Chao Yuanfang (550-630 A.D.)《The General Treatise on the Cause and Symptoms of Diseases》In, just propose " gas patient during husband, this all because year when do not conform to, temperature is cool to forfeit one's integrity, people Feel epidemic pathogenic factor and raw patient, multiphase dye is easily ".Period of Ming and Qing epidemic febrile disease of Chinese medicine theory and practice is gradually ripe, that includes many Plant acute infectious disease, the pathology rule of infectious diseases, diagnostic method and systemic control knowledge so that traditional Chinese medicine and pharmacy is to influenza Diagnosis and treatment are constantly substantial, perfect.After liberation Chinese scholar has made numerous studies work in terms of Chinese medicine resisiting influenza virus, as a result shows Traditional Chinese medicine has good therapeutic action, Radix Isatidis, folium isatidis, giant knotweed, the capsule of weeping forsythia, the root of large-flowered skullcap, ox to viral illness, particularly influenza The Chinese medicines such as burdock, rhizome of cyrtomium, radix bupleuri, cordate houttuynia, notopterygium root, tarragon, infected by influenza all have certain inhibitory action.
Allergic rhinitis (allergic rhinitis), also known as allergic rhinitis, is the allergic disease of nasal membrane, and Multiple complications can be caused.Separately there is a type induced, participated in nothing specific allergen by nonspecific stimulation, be not that immunity is anti- Process is answered, but clinical manifestation is similar to above-mentioned amphitypy allergic rhinitis, claim vasomotor rhinitis or claim neural reflex rhinitis, Stimulate and may be from external (physics, chemistry aspect), or ex vivo (endocrine, spirit aspect), therefore it is allergic effect that someone regards as Property rhinitis.Clinic often appears as sneeze, rhiocnesmus, runny nose and nasal obstruction, and modern medicine usually adopts valence of desensitization treatment.Traditional Chinese medicine Think this disease category " allergic rhinitis " category, how made by internal organs are deficient, the different gas of instability of surface, chill is taken advantage of a weak point lung qi logical adjust, aqueous are stopped Poly-, pathogen conflicting with vital QI is caused by nose key.《Bier Benshen's piece》Think " Lung Qi deficiency then nasal obstruction ".The traditional Chinese medical science thinks allergic rhinitis Pathogenesis basis be interior in body because this, outer because mark, endexoteric is combined and is caused.Chinese traditional treatment is constantly clinical The sick paracmasis is proposed in practice how based on internal organs virtual loss, stage of attack mostly simulataneous insufficiency and excessive disease, lung spleen kidney three is dirty deficient for sending out Disease is basic, and thus proposes four kinds of partings:Deficiency-weakness of spleen-QI, lucid yang failing to raise;Kidney yang virtual loss, warm dereliction of duty;The lung qi cold of insufficiency type, defends table Not solid;Lung channel is hot and suffocating, upper criminal's nose key.
Chronic pharyngitis is to swallow under mucous membrane, mucous membrane and adenoid chronic inflammation.Diffusivity pharyngeal inflammation is often upper breathing A part for road chronic inflammation.Modern medicine thinks to cause the cause of disease of chronic pharyngitis to be mainly:Acpuei pharyngitis recurrent exerbation switchs to Chronic, upper respiratory tract chronic inflammation stimulates, long term physical and chemical factor stimulate and as professional reason causes to use throat mistake Degree.The traditional Chinese medical science thinks that chronic pharyngitis can be treated not thoroughly by anemopyretic laryngalgia, or remaining heresy is clear after warm heat disease, or overfeeding is pungent, pharyngeal Become homeless and support and fall ill.Modern Chinese medicine is broadly divided into:The type such as fire excess from yin deficiency, the lung-dryness syndrome due to yin deficiency, insufficiency of the spleen soil is weak.
We adopt the Chinese medicine such as the root of large-flowered skullcap, grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon and peppermint, expelling wind to resolve the exterior, aromatization Turbid, clearing heat and expelling damp, sensible inducing resuscitation.Pharmacological research shows that our Effective Component of Chinese Medicine has difference to various bacteria and virus, mould Function is killed in the suppression of degree.Especially its volatile oil by respiratory tract enter human body after, can excitor nerve system, stimulate machine Body immune system, promotes antibody tormation, improves the resistance against diseases of body.Additionally, glandula digestive activity is may additionally facilitate, increase secretion, The activity of digestive ferment is improved, is whetted the appetite, promote metabolism, reduce inflammation.Experiment is shown, is obtained using the preparation process of the present invention Chinese medical extract can effective flu-prevention, prevent and treat allergic rhinitis and pharyngitis, protect health.
Content of the invention
It is an object of the invention to the deficiencies in the prior art are solved, a kind of with low cost, evident in efficacy, security is provided good Herb medicine gauze mask.The Herb medicine gauze mask is made up of the root of large-flowered skullcap, grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon and peppermint, is cured the disease with anti- Poison, allergic rhinitis, the effect of pharyngitis.
It is an object of the invention to provide a kind of preventing and treating virus, allergic rhinitis, the Chinese medicine composition of pharyngitis, said composition Can be placed in mouth mask interlayer, be prepared into a kind of Herb medicine gauze mask.
The purpose of the present invention is achieved by the following technical solution:
The Chinese medicine of the Herb medicine gauze mask is made up of following raw material and weight ratio:Root of large-flowered skullcap 10-50 weight portion, grass-leaved sweetflag 5-40 weight Amount part, rhizoma atractylodis 5-40 weight portion, flower bud of lily magnolia 3-20 weight portion, wrinkled giant hyssop 3-20 weight portion, tarragon 3-20 weight portion, peppermint 1-10 weight Part.Preferably, root of large-flowered skullcap 15-45 weight portion, grass-leaved sweetflag 10-35 weight portion, rhizoma atractylodis 10-35 weight portion, flower bud of lily magnolia 5-18 weight portion, the leaves of pulse plants Fragrant 5-18 weight portion, tarragon 5-18 weight portion, peppermint 2-8 weight portion.Preferably, root of large-flowered skullcap 20-40 weight portion, grass-leaved sweetflag 15-30 Weight portion, rhizoma atractylodis 15-30 weight portion, flower bud of lily magnolia 8-15 weight portion, wrinkled giant hyssop 8-15 weight portion, tarragon 8-15 weight portion, peppermint 3-7 weight Amount part.Preferably, root of large-flowered skullcap 25-35 weight portion, grass-leaved sweetflag 18-25 weight portion, rhizoma atractylodis 18-25 weight portion, flower bud of lily magnolia 9-12 weight portion, Wrinkled giant hyssop 9-12 weight portion, tarragon 9-12 weight portion, peppermint 4-6 weight portion.Preferably, 18 weight portion of the root of large-flowered skullcap, 12 weight of grass-leaved sweetflag Part, 10 weight portion of rhizoma atractylodis, 12 weight portion of the flower bud of lily magnolia, 6 weight portion of wrinkled giant hyssop, 6 weight portion of tarragon, 6 weight portion of peppermint.Preferably, the root of large-flowered skullcap 30 weight portions, 20 weight portion of grass-leaved sweetflag, 10 weight portion of rhizoma atractylodis, 5 weight portion of the flower bud of lily magnolia, 5 weight portion of wrinkled giant hyssop, 5 weight portion of tarragon, peppermint 5 weight portions.
The Chinese medicine of the Herb medicine gauze mask is made up of following raw material and weight ratio:Baical Skullcap root P.E 10-50 weight portion, grass-leaved sweetflag Extract 5-40 weight portion, atractylodes chinensis 5-40 weight portion, Flos Magnoliae extract 3-20 weight portion, agastache extract 3-20 weight Part, Folium Artemisiae Argyi extract 3-20 weight portion, mint extract 1-10 weight portion.Preferably, 30 weight portion of Baical Skullcap root P.E, grass-leaved sweetflag 20 weight portion of extract, 10 weight portion of atractylodes chinensis, 5 weight portion of Flos Magnoliae extract, 5 weight portion of agastache extract, tarragon carry Take 5 weight portion of thing, 5 weight portion of mint extract.The extract is ethanol extract or water extract.
Concrete preparation method step is as follows:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, The flower bud of lily magnolia, wrinkled giant hyssop, tarragon, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby; S3:Take the dregs of a decoction that the root of large-flowered skullcap walked with S2 to mix, add the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, second, Three times each 1 hour, and filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become leaching Then medicinal extract be spray-dried to obtain extract powder by cream;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is mixed After obtain volatile oil extract powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains traditional Chinese medicine mouth Cover.
Manufacture-yellow a kind of reed mentioned in ancient books of the present invention, grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon and peppermint are 2015 editions《Chinese Pharmacopoeia》The One Chinese medicine for recording or Chinese medicine preparation product.
The beneficial effect that Herb medicine gauze mask of the present invention is verified through pharmacodynamics is:Chinese medicine of the present invention to various bacteria and virus, Mould has different degrees of suppression or kills function, especially its volatile oil after respiratory tract enters human body, can excitor nerve System, stimulates body immune system, promotes antibody tormation, improves the resistance against diseases of body.Additionally, may additionally facilitate glandula digestive work Dynamic, increase secretion, the activity of digestive ferment is improved, is whetted the appetite, promote metabolism, reduce inflammation.Chinese medicine infected by influenza of the present invention With prevention effect, there is preventive and therapeutic action to allergic rhinitis, pharyngitis.Chinese medicine of the present invention can be using oral, intranasal Or the various ways drug treatment such as percutaneous absorbtion.
Specific embodiment
Technical scheme is described in further detail with reference to specific embodiment, but protection scope of the present invention is not It is confined to described below.
Embodiment 1
Weigh raw material root of large-flowered skullcap 10kg, grass-leaved sweetflag 5kg, rhizoma atractylodis 5kg, flower bud of lily magnolia 3kg, wrinkled giant hyssop 3kg, tarragon 3kg, peppermint 1kg.
Embodiment 2
Weigh raw material root of large-flowered skullcap 15kg, grass-leaved sweetflag 10kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 5kg, wrinkled giant hyssop 5kg, tarragon 5kg, peppermint 2kg.
Embodiment 3
Weigh raw material root of large-flowered skullcap 20kg, grass-leaved sweetflag 15kg, rhizoma atractylodis 15kg, flower bud of lily magnolia 8kg, wrinkled giant hyssop 8kg, tarragon 8kg, peppermint 2kg.
Embodiment 4
Weigh raw material root of large-flowered skullcap 25kg, grass-leaved sweetflag 18kg, rhizoma atractylodis 18kg, flower bud of lily magnolia 9kg, wrinkled giant hyssop 9kg, tarragon 9kg, peppermint 4kg.
Embodiment 5
Weigh raw material root of large-flowered skullcap 18kg, grass-leaved sweetflag 12kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 12kg, wrinkled giant hyssop 6kg, tarragon 6kg, peppermint 6kg.
Embodiment 6
Weigh raw material root of large-flowered skullcap 35kg, grass-leaved sweetflag 25kg, rhizoma atractylodis 25kg, flower bud of lily magnolia 12kg, wrinkled giant hyssop 12kg, tarragon 12kg, peppermint 6kg.
Embodiment 7
Weigh raw material root of large-flowered skullcap 40kg, grass-leaved sweetflag 30kg, rhizoma atractylodis 30kg, flower bud of lily magnolia 15kg, wrinkled giant hyssop 15kg, tarragon 15kg, peppermint 7kg.
Embodiment 8
Weigh raw material root of large-flowered skullcap 45kg, grass-leaved sweetflag 35kg, rhizoma atractylodis 35kg, flower bud of lily magnolia 35kg, wrinkled giant hyssop 18kg, tarragon 18kg, peppermint 8kg.
Embodiment 9
Weigh raw material root of large-flowered skullcap 50kg, grass-leaved sweetflag 40kg, rhizoma atractylodis 40kg, flower bud of lily magnolia 20kg, wrinkled giant hyssop 20kg, tarragon 20kg, peppermint 10kg.
Embodiment 10
Weigh raw material root of large-flowered skullcap 18kg, grass-leaved sweetflag 12kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 12kg, wrinkled giant hyssop 6kg, tarragon 6kg, peppermint 6kg.
Embodiment 11
Weigh raw material root of large-flowered skullcap 30kg, grass-leaved sweetflag 20kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 5kg, wrinkled giant hyssop 5kg, tarragon 5kg, peppermint 5kg.
Embodiment 12
Weigh raw material root of large-flowered skullcap ethanol extract 30kg, grass-leaved sweetflag ethanol extract 20kg, rhizoma atractylodis ethanol extract 10kg, pungent Smooth ethanol extract 5kg, wrinkled giant hyssop ethanol extract 5kg, tarragon ethanol extract 5kg, peppermint ethanol extract 5kg.
Embodiment 13
Weigh raw material root of large-flowered skullcap water extract 30kg, grass-leaved sweetflag water extract 20kg, rhizoma atractylodis water extract 10kg, flower bud of lily magnolia water extraction Take thing 5kg, wrinkled giant hyssop water extract 5kg, tarragon water extract 5kg, peppermint water extract 5kg.
Embodiment 14
Weigh raw material root of large-flowered skullcap water extract 10kg, grass-leaved sweetflag water extract 5kg, rhizoma atractylodis water extract 5kg, flower bud of lily magnolia water to extract Thing 3kg, wrinkled giant hyssop water extract 3kg, tarragon water extract 3kg, peppermint water extract 1kg.
Embodiment 15
Weigh raw material root of large-flowered skullcap water extract 15kg, grass-leaved sweetflag water extract 10kg, rhizoma atractylodis water extract 10kg, flower bud of lily magnolia water extraction Take thing 5kg, wrinkled giant hyssop water extract 5kg, tarragon water extract 5kg, peppermint water extract 2kg.
Embodiment 16
Weigh raw material root of large-flowered skullcap ethanol extract 20kg, grass-leaved sweetflag ethanol extract 15kg, rhizoma atractylodis ethanol extract 15kg, pungent Smooth ethanol extract 8kg, wrinkled giant hyssop ethanol extract 8kg, tarragon ethanol extract 8kg, peppermint ethanol extract 2kg.
Embodiment 17
Weigh raw material root of large-flowered skullcap 25kg, grass-leaved sweetflag 18kg, rhizoma atractylodis 18kg, flower bud of lily magnolia 9kg, wrinkled giant hyssop 9kg, tarragon 9kg, peppermint 4kg.
Embodiment 18
Weigh raw material root of large-flowered skullcap ethanol extract 18kg, grass-leaved sweetflag ethanol extract 12kg, rhizoma atractylodis ethanol extract 10kg, pungent Smooth ethanol extract 12kg, wrinkled giant hyssop ethanol extract 6kg, tarragon ethanol extract 6kg, peppermint ethanol extract 6kg.
Embodiment 19
Weigh raw material root of large-flowered skullcap 10kg, grass-leaved sweetflag 5kg, rhizoma atractylodis 5kg, flower bud of lily magnolia 3kg, wrinkled giant hyssop 3kg, tarragon 3kg, peppermint 1kg.Tool Preparation:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon, peppermint Six medicaments mix, and use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the medicine of the root of large-flowered skullcap and S2 step Slag mixes, and adds the decocting of quality of medicinal material 5-8 times amount to boil three times, and 1.5 hours for the first time, second and third time each 1 hour, has decocted After becoming, filtration merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then medicinal extract is sprayed Dry extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, after mixing, obtains the oil extractum that volatilizees Powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 20
Weigh raw material root of large-flowered skullcap 15kg, grass-leaved sweetflag 10kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 5kg, wrinkled giant hyssop 5kg, tarragon 5kg, peppermint 2kg. Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon, thin Lotus six medicaments mix, and use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:The root of large-flowered skullcap is taken with S2 step The dregs of a decoction mix, and add the decocting of quality of medicinal material 5-8 times amount to boil three times, and 1.5 hours for the first time, second and third time each 1 hour, decocts After the completion of filtration merge decocting liquid, the dregs of a decoction discard;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then medicinal extract is sprayed Mist dry extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, after mixing, obtains the oil extractum that volatilizees Powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 21
Weigh raw material root of large-flowered skullcap 20kg, grass-leaved sweetflag 15kg, rhizoma atractylodis 15kg, flower bud of lily magnolia 8kg, wrinkled giant hyssop 8kg, tarragon 8kg, peppermint 2kg. Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon, thin Lotus six medicaments mix, and use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:The root of large-flowered skullcap is taken with S2 step The dregs of a decoction mix, and add the decocting of quality of medicinal material 5-8 times amount to boil three times, and 1.5 hours for the first time, second and third time each 1 hour, decocts After the completion of filtration merge decocting liquid, the dregs of a decoction discard;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then medicinal extract is sprayed Mist dry extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, after mixing, obtains the oil extractum that volatilizees Powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 22
Weigh raw material root of large-flowered skullcap 25kg, grass-leaved sweetflag 18kg, rhizoma atractylodis 18kg, flower bud of lily magnolia 9kg, wrinkled giant hyssop 9kg, tarragon 9kg, peppermint 4kg. Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon, thin Lotus six medicaments mix, and use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:The root of large-flowered skullcap is taken with S2 step The dregs of a decoction mix, and add the decocting of quality of medicinal material 5-8 times amount to boil three times, and 1.5 hours for the first time, second and third time each 1 hour, decocts After the completion of filtration merge decocting liquid, the dregs of a decoction discard;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then medicinal extract is sprayed Mist dry extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, after mixing, obtains the oil extractum that volatilizees Powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 23
Weigh raw material root of large-flowered skullcap 18kg, grass-leaved sweetflag 12kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 12kg, wrinkled giant hyssop 6kg, tarragon 6kg, peppermint 6kg.Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 24
Weigh raw material root of large-flowered skullcap 35kg, grass-leaved sweetflag 25kg, rhizoma atractylodis 25kg, flower bud of lily magnolia 12kg, wrinkled giant hyssop 12kg, tarragon 12kg, peppermint 6kg.Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 25
Weigh raw material root of large-flowered skullcap 40kg, grass-leaved sweetflag 30kg, rhizoma atractylodis 30kg, flower bud of lily magnolia 15kg, wrinkled giant hyssop 15kg, tarragon 15kg, peppermint 7kg.Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 26
Weigh raw material root of large-flowered skullcap 45kg, grass-leaved sweetflag 35kg, rhizoma atractylodis 35kg, flower bud of lily magnolia 35kg, wrinkled giant hyssop 18kg, tarragon 18kg, peppermint 8kg.Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 27
Weigh raw material root of large-flowered skullcap 50kg, grass-leaved sweetflag 40kg, rhizoma atractylodis 40kg, flower bud of lily magnolia 20kg, wrinkled giant hyssop 20kg, tarragon 20kg, peppermint 10kg.Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 28
Weigh raw material root of large-flowered skullcap 18kg, grass-leaved sweetflag 12kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 12kg, wrinkled giant hyssop 6kg, tarragon 6kg, peppermint 6kg.Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 29
Weigh raw material root of large-flowered skullcap 30kg, grass-leaved sweetflag 20kg, rhizoma atractylodis 10kg, flower bud of lily magnolia 5kg, wrinkled giant hyssop 5kg, tarragon 5kg, peppermint 5kg. Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon, thin Lotus six medicaments mix, and use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:The root of large-flowered skullcap is taken with S2 step The dregs of a decoction mix, and add the decocting of quality of medicinal material 5-8 times amount to boil three times, and 1.5 hours for the first time, second and third time each 1 hour, decocts After the completion of filtration merge decocting liquid, the dregs of a decoction discard;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then medicinal extract is sprayed Mist dry extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, after mixing, obtains the oil extractum that volatilizees Powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Embodiment 30
Weigh raw material root of large-flowered skullcap 50kg, grass-leaved sweetflag 40kg, rhizoma atractylodis 40kg, flower bud of lily magnolia 20kg, wrinkled giant hyssop 20kg, tarragon 20kg, peppermint 10kg;Concrete preparation method:S1:Chinese medicine material is weighed by component and weight ratio;S2:Take grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, Chinese mugwort Leaf, the mixing of peppermint six medicaments, use extraction by steam distillation volatile oil, collect volatile oil, and the dregs of a decoction are standby;S3:Take the root of large-flowered skullcap with The dregs of a decoction mixing of S2 step, adds the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, and second and third time each 1 little When, filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then will Medicinal extract is spray-dried to obtain extract powder;S5:The volatile oil of S2 step is injected to the extract powder in S4 step, is volatilized after mixing Oil extractum powder;S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
Beneficial effects of the present invention are proved below by specific test:
First, the prevention effect of Chinese medicine infected by influenza of the present invention
Using Balb/c mouse as experimental animal, male and female half and half, it is divided into 3 groups by sex, body weight stratified random, per group 10 Only, it is divided into negative control group, model group, administration group.Model group and administration group animal use influenza virus under ether light anesthesia A/FM/1/47 (H1N1) mouse lung adapted strain collunarium infects, and virus quantity is 15 times of median lethal dose (15LD50), drip per mouse 4, about 0.05mL.Virus infection is administered one week before attacking premise, continues administration 5 days after infection, using nebulizer administration, will during use Medicine is suspended in 20mL distilled water, filtering with microporous membrane.Negative control group and model group give physiological saline 1.5mL/kg, give Medicine group is 1.5g/kg (raw medicinal herbs).It is administered 12 days altogether, qd.Off-test, mouse are weighed, and put to death, and weigh lung weight, determine lung Index (table 1).
1 each group mouse Lung Exponent of table and inhibiting rate
Note:Compared with model group, *:P < 0.05, * *:P < 0.01;Lung Exponent=(mouse lung weight/Mouse Weight) × 100;Lung index=(model group Lung Exponent average-atomization group Lung Exponent average)/model group Lung Exponent average × 100
2nd, Chinese medicine infected by influenza infected mice death protective effect of the present invention
Using Balb/c mouse as experimental animal, male and female half and half, it is divided into 3 groups by sex, body weight stratified random, per group 10 Only, it is divided into negative control group, model group, administration group.Model group and administration group animal use influenza virus under ether light anesthesia A/FM/1/47 (H1N1) mouse lung adapted strain collunarium infects, and virus quantity is 2 times of median lethal doses (2LD50), drips per mouse 4, about 0.05mL.Virus infection is administered one week before attacking premise, and medicine, using nebulizer administration, is suspended in 20mL during use by qd In distilled water, filtering with microporous membrane.Negative control group and model group give physiological saline 1.5mL/kg, and administration group is 1.5g/kg (raw medicinal herbs).Virus stops being administered after infecting, and observes 2 weeks, records death time of animal, survival number, the calculating death rate, average life Deposit the time (table 2).
The 2 each group mouse survival time of table
Note:Compared with model group, *:P < 0.05, * *:P < 0.01;Extending life rate=(atomization group life span average- Model group life span average)/model group life span average × 100.
The viral pneumonia of influenza virus collunarium infecting mouse, mainly causes lung tissue to occur based on monocyte infiltration Inflammation performance.Severity of inflammation certainly will cause lung with its institute's virus infection being proportionate property of weight, pulmonary inflammatory formation The increase of weight, and the body weight of virus infected mice often declines, thus in resisiting influenza virus body evaluating drug effect many with Lung Exponent value i.e. with The percentage of mouse lung weight percentage of liveweight is passing judgment on pharmaceutically-active index.
Result of the test shows:Compare with normal group, model group Lung Exponent significantly raises (P < 0.01), shows modeling success. This fogging group is compared with model group, and Lung Exponent is remarkably decreased, difference statistically significant (P < 0.05 or P < 0.01), table Bright preparation can reduce Lung Exponent.From Table 2, it can be seen that the model group animal mean survival time was at 7.5 days or so.And be atomized The group animal mean survival time extends, and about at 10~14 days or so, extends animal life rate more than 70%, with virus control Group is compared, difference statistically significant (P < 0.01).The studies above shows, Chinese medicine of the present invention shows good pre- in vivo Anti- influenza virus effect.
3rd, Chinese medicine of the present invention is to allergic rhinitis preventive and therapeutic effect
Take cavy 30, male and female half and half, it is divided into 3 groups by sex, body weight stratified random, per group 10, is divided into negative control Group, model group, administration group.Model group and administration group micro sample adding appliance are by the olive of 10%TDI (Toluene-2,4-diisocyanate, 4- diisocyanate) Before olive oil solution instillation cavy bilateral in nasal cavity, 5 μ of every side nasal cavity instillation L/ time, once a day, totally 7 days;The next day of being changed to after 7th day 1 time, excite 4 times, totally 8 days.Negative control group cavy replaces TDI process with isopyknic olive oil solution, and process time is identical. Started each group animal atomized medicine introducing from the 7th day, medicine is suspended in 20mL distilled water during use, filtering with microporous membrane.Negative Control group and model group are physiological saline 1.5mL/kg, administration group 1.5g/kg (raw medicinal herbs), and one time a day, successive administration 15 days.
From the beginning of administration the 1st day, in 30min after TDI collunarium, observe the nose outward appearance symptom of cavy and score (rhiocnesmus, Dab nose several times, 1 point;Scratching nose, face are more than, rub everywhere, 2 points;Sneeze, 1~3,1 point;4~10,2 points;11 with On, 3 points;Clear tears, flow to anterior naris, 1 point;More than anterior naris, 2 points;Runny nose is had one's face covered with, 3 points).After last dose observation, globefish is put to death Mouse, opens nasal cavity, takes mucous membrane of nasal septum, and 10% neutral formalin is fixed, FFPE, conventional section, and H.E is dyeed, light microscopy checking, And with MIAS2000 type computer picture work system survey calculation inflammatory cell area, AO, integral optical density and Average blackness.
Compare with Normal group, model control group cavy 2 weeks interior, rhiocnesmus, sneeze and clear tears before administration and after administration Symptom substantially increase, symptom score is more than 6 points.Compare with model group, administration group starts on the 5th, cavy rhiocnesmus, sneeze and Clear tears symptom all substantially mitigates, as the prolongation allergic symptom scoring for the treatment of time is gradually lowered (table 3).
Table 3 to TDI cause cavy allergic rhinitis model symptom score impact (±s)
Note:Compared with model group, *:P < 0.05, * *:P < 0.01
Continued 3 to TDI cause cavy allergic rhinitis model symptom score impact (±s)
Note:Compared with model group, *:P < 0.05, * *:P < 0.01
Light Microscopic observation, TDI cause the inflammatory of the visible a large amount of infiltrations of cavy allergic rhinitis model mucous membrane of nasal septum epithelium thin Born of the same parents, inflammatory cell is based on acidophilia, neutrocyte, and infiltrates into mucosal epithelium.Compare with negative control group, model group Mucous membrane of nasal septum inflammatory cell sum, inflammatory cell area summation, inflammatory cell AO summation, inflammatory cell integral light Density summation and the average blackness summation of inflammatory cell have and significantly increase.Compare with model group, administration group shows can These parameters Write and reduce, point out administration group significantly mitigate the infiltration degree (being shown in Table 4) of schneiderian membrance epithelium inflammatory cell.
Table 4 to TDI cause cavy allergic rhinitis model inflammatory cell impact (±s)
Note:Compared with model group, * *:P < 0.01
Continued 4 to TDI cause cavy allergic rhinitis model inflammatory cell impact (±s)
Note:Compared with model group, * *:P < 0.01
Experimental result shows that Chinese medicine of the present invention can mitigate cavy allergic rhinitis model rhiocnesmus, sneeze and clear tears symptom, make Inflammatory cell sum, inflammatory cell area summation, inflammatory cell AO summation, inflammatory cell integral optical density summation, The average blackness summation of inflammatory cell all substantially reduces, and points out substantially mitigate the infiltration degree of schneiderian membrance epithelium inflammatory cell, right Allergic rhinitis may be acted on preferable prophylactic treatment.The studies above shows that Chinese medicine of the present invention is shown well in vivo The effect for preventing and treating allergic rhinitis.
4th, Chinese medicine of the present invention is to pharyngitis preventive and therapeutic effect
40 Japan large ear rabbits (male and female half and half) are taken, is randomly selected 10 (male and female half and half) and makees Normal group, remaining 30 (male and female half and half) modelings.Modeling starts, with the ammoniacal liquor that concentration is 2.5% to Japan large ear rabbit spray pharynx.Every morning, under Noon is each 1 time, and spray 3 every time is lifted.Continuous spray 16 days.Turpentine oil is injected in rabbit with tonsil needle by the 8th day wherein in modeling Under pharyngeal mucosa, every animal 0.5mL.Normal group animal physiological saline spray pharynx and injection, method of operating and modeling group Identical.Animal pharyngeal mucous membrane form, color and luster and secretion situation etc. are observed daily.
Modeling terminated at the 16th day.And at random put to death 10 animals (male and female half and half), from after animal model occur symptom, Sign, and the change of the aspect such as pharyngeal Pathomorphology evaluates modeling whether success to investigate.
By 20, successful for modeling Japan large ear rabbit chronic pharyngitis model (male and female half and half), be randomly divided into model group and to Medicine group.Negative control group, model group, administration group each group animal atomized medicine introducing, during use are suspended in medicine in 20mL distilled water, Filtering with microporous membrane.Negative control group and model group are physiological saline 1.5mL/kg, administration group 1.5g/kg (raw medicinal herbs), daily 1 Secondary, successive administration 15 days.The ordinary circumstance such as the active state of daily observed and recorded animal, body temperature and the pharyngeal disease of animal during experiment Shape, with the frontal mirror dynamic pharyngeal situation of observed and recorded animal (such as mucous membrane color and luster, have or not swelling and pharyngeal secretion etc.).
Impact of the table 5 to the pharyngeal Pathomorphology of chronic pharyngitis rabbit
Note:Compared with model group, *:P < 0.01, * *:P < 0.01
Impact of the continued 5 to the pharyngeal Pathomorphology of chronic pharyngitis rabbit
Note:Compared with model group, *:P < 0.01, * *:P < 0.01
Result of the test shows that (inflammatory cell is mainly lymph for the visible stove of intracutaneous or diffusivity cell infiltration in model group Cell, monocyte);Hyperplasia that epithelial layer is slight, blood vessel dilatation, hyperemia, proliferation of fibrous tissue, nail suddenly extend length, above-mentioned pathology with Normal group relatively has significant difference, shows that modeling is successful.By the treatment of Chinese medicine compound prescription, pharyngeal chronic of animal Inflammation substantially mitigates or tends to normal, and inflammatory cell infiltration degree mitigates, (P < statistically significant with model group comparing difference 0.01).The studies above shows that Chinese medicine of the present invention shows the good effect for preventing and treating chronic pharyngitis in vivo.
Chinese medicine of the present invention shows through clinical and experimental study that after Herb medicine gauze mask is prepared into Herb medicine gauze mask of the present invention can be effective Flu-prevention, can be obviously improved the clinical symptoms of allergic rhinitis and pharyngitis, allergic rhinitis and pharyngitis are had and is preferably controlled Treatment is acted on.In addition, Chinese medicine of the present invention through respiratory tract enter human body after, can excitor nerve system, stimulate body immune system, promote Enter antibody tormation, improve the resistance against diseases of body.

Claims (9)

1. a kind of pre- anti-virus, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:The Chinese medicine be by following raw material and weight Than composition:Root of large-flowered skullcap 10-50 weight portion, grass-leaved sweetflag 5-40 weight portion, rhizoma atractylodis 5-40 weight portion, flower bud of lily magnolia 3-20 weight portion, wrinkled giant hyssop 3- 20 weight portions, tarragon 3-20 weight portion, peppermint 1-10 weight portion.
2. a kind of pre- anti-virus according to claim 1, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:In described The ratio of weight and number of each raw material of medicine is:Root of large-flowered skullcap 15-45 weight portion, grass-leaved sweetflag 10-35 weight portion, rhizoma atractylodis 10-35 weight portion, pungent Smooth 5-18 weight portion, wrinkled giant hyssop 5-18 weight portion, tarragon 5-18 weight portion, peppermint 2-8 weight portion.
3. a kind of pre- anti-virus according to claim 1, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:In described The ratio of weight and number of each raw material of medicine is:Root of large-flowered skullcap 20-40 weight portion, grass-leaved sweetflag 15-30 weight portion, rhizoma atractylodis 15-30 weight portion, pungent Smooth 8-15 weight portion, wrinkled giant hyssop 8-15 weight portion, tarragon 8-15 weight portion, peppermint 3-7 weight portion.
4. a kind of pre- anti-virus according to claim 1, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:In described The ratio of weight and number of each raw material of medicine is:Root of large-flowered skullcap 25-35 weight portion, grass-leaved sweetflag 18-25 weight portion, rhizoma atractylodis 18-25 weight portion, pungent Smooth 9-12 weight portion, wrinkled giant hyssop 9-12 weight portion, tarragon 9-12 weight portion, peppermint 4-6 weight portion.
5. a kind of pre- anti-virus according to claim 1, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:In described The ratio of weight and number of each raw material of medicine is:18 weight portion of the root of large-flowered skullcap, 12 weight portion of grass-leaved sweetflag, 10 weight portion of rhizoma atractylodis, 12 weight of the flower bud of lily magnolia Part, 6 weight portion of wrinkled giant hyssop, 6 weight portion of tarragon, 6 weight portion of peppermint.
6. a kind of pre- anti-virus according to claim 1, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:In described The ratio of weight and number of each raw material of medicine is:30 weight portion of the root of large-flowered skullcap, 20 weight portion of grass-leaved sweetflag, 10 weight portion of rhizoma atractylodis, 5 weight of the flower bud of lily magnolia Part, 5 weight portion of wrinkled giant hyssop, 5 weight portion of tarragon, 5 weight portion of peppermint.
7. a kind of pre- anti-virus, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:The Chinese medicine be by following raw material and weight Than composition:Baical Skullcap root P.E 10-50 weight portion, Rhizoma Acori Graminei extract 5-40 weight portion, atractylodes chinensis 5-40 weight portion, the flower bud of lily magnolia Extract 3-20 weight portion, agastache extract 3-20 weight portion, Folium Artemisiae Argyi extract 3-20 weight portion, mint extract 1-10 weight Part.
8. a kind of pre- anti-virus according to claim 7, the Herb medicine gauze mask of allergic rhinitis, it is characterised in that:In described The ratio of weight and number of each raw material of medicine is:30 weight portion of Baical Skullcap root P.E, 20 weight portion of Rhizoma Acori Graminei extract, atractylodes chinensis 10 Weight portion, 5 weight portion of Flos Magnoliae extract, 5 weight portion of agastache extract, 5 weight portion of Folium Artemisiae Argyi extract, 5 weight of mint extract Part.
9. a kind of pre- anti-virus prepared in claim 1-6 described in any one claim, allergic rhinitis and pharyngitis The method of Herb medicine gauze mask, it is characterised in that:It comprises the following steps:
S1:Chinese medicine material is weighed by component and weight ratio;
S2:Grass-leaved sweetflag, rhizoma atractylodis, the flower bud of lily magnolia, wrinkled giant hyssop, tarragon, the mixing of peppermint six medicaments is taken, is volatilized with extraction by steam distillation Oil, collects volatile oil, and the dregs of a decoction are standby;
S3:Take the dregs of a decoction that the root of large-flowered skullcap walked with S2 to mix, add the decocting of quality of medicinal material 5-8 times amount to boil three times, 1.5 hours for the first time, Second and third time each 1 hour, and filtration after the completion of decoction merges decocting liquid, and the dregs of a decoction are discarded;
S4:The decocting liquid reduced pressure concentration of S3 step is become medicinal extract, then medicinal extract is spray-dried to obtain extract powder;
S5:The volatile oil of S2 step is injected to the extract powder in S4 step, after mixing, obtains volatile oil extract powder;
S6:The volatile oil extract powder that S5 step is obtained is placed in mouth mask interlayer and obtains Herb medicine gauze mask.
CN201610675870.8A 2016-08-17 2016-08-17 A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use Pending CN106473268A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610675870.8A CN106473268A (en) 2016-08-17 2016-08-17 A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610675870.8A CN106473268A (en) 2016-08-17 2016-08-17 A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use

Publications (1)

Publication Number Publication Date
CN106473268A true CN106473268A (en) 2017-03-08

Family

ID=58273396

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610675870.8A Pending CN106473268A (en) 2016-08-17 2016-08-17 A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use

Country Status (1)

Country Link
CN (1) CN106473268A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050195A (en) * 2017-04-27 2017-08-18 石家庄市中医院 A kind of mouth mask filter core humidification decoction and preparation method thereof
CN109045218A (en) * 2018-10-25 2018-12-21 广西中医药大学 A kind of Yao medicinal composition and preparation method thereof for preventing and treating inflammation of upper respiratory tract
CN111280525A (en) * 2020-03-17 2020-06-16 时圣运 Mask with protective medicine film and preparation method thereof
CN111789925A (en) * 2020-06-15 2020-10-20 湖北邹子书坊健康科技有限公司 Novel traditional Chinese medicine antiviral epidemic prevention patch and preparation method thereof
CN111904059A (en) * 2020-06-20 2020-11-10 南方医科大学中西医结合医院 Epidemic prevention traditional Chinese medicine mask
CN113767938A (en) * 2021-08-30 2021-12-10 柳州市中医医院(柳州市壮医医院) Zhuang nationality medicine air disinfectant
CN115475203A (en) * 2022-09-07 2022-12-16 甘肃中医药大学 Preparation and application of traditional Chinese medicine aromatherapy spray and paste extract with multiple activities

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1531939A (en) * 2003-03-19 2004-09-29 王璐林 Medicine for promoting wound healing
CN101081247A (en) * 2006-05-29 2007-12-05 吕连祥 Bag infusion for drinking and for smoking to treat nose disease
CN201216754Y (en) * 2008-03-14 2009-04-08 张留印 Health-care fragrant pillow of traditional Chinese medicine for neck
CN102349991A (en) * 2011-05-29 2012-02-15 王红芳 Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition
CN102727690A (en) * 2012-07-23 2012-10-17 太仓市伟基生物科技有限公司 Chinese medicinal snorted powder for preventing allergic rhinitis
CN202566389U (en) * 2012-03-18 2012-12-05 宋启增 Medicinal treatment mask
CN102988518A (en) * 2012-11-19 2013-03-27 王玮 Traditional Chinese medicine for treating rhinitis
CN104338133A (en) * 2013-07-24 2015-02-11 陆媛 Chewing medicine composition for preventing and treating mouth, nose and throat upper respiratory infecting and application thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1531939A (en) * 2003-03-19 2004-09-29 王璐林 Medicine for promoting wound healing
CN101081247A (en) * 2006-05-29 2007-12-05 吕连祥 Bag infusion for drinking and for smoking to treat nose disease
CN201216754Y (en) * 2008-03-14 2009-04-08 张留印 Health-care fragrant pillow of traditional Chinese medicine for neck
CN102349991A (en) * 2011-05-29 2012-02-15 王红芳 Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition
CN202566389U (en) * 2012-03-18 2012-12-05 宋启增 Medicinal treatment mask
CN102727690A (en) * 2012-07-23 2012-10-17 太仓市伟基生物科技有限公司 Chinese medicinal snorted powder for preventing allergic rhinitis
CN102988518A (en) * 2012-11-19 2013-03-27 王玮 Traditional Chinese medicine for treating rhinitis
CN104338133A (en) * 2013-07-24 2015-02-11 陆媛 Chewing medicine composition for preventing and treating mouth, nose and throat upper respiratory infecting and application thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050195A (en) * 2017-04-27 2017-08-18 石家庄市中医院 A kind of mouth mask filter core humidification decoction and preparation method thereof
CN109045218A (en) * 2018-10-25 2018-12-21 广西中医药大学 A kind of Yao medicinal composition and preparation method thereof for preventing and treating inflammation of upper respiratory tract
CN109045218B (en) * 2018-10-25 2021-03-02 广西中医药大学 Yao medicine composition for preventing and treating upper respiratory inflammation and preparation method thereof
CN111280525A (en) * 2020-03-17 2020-06-16 时圣运 Mask with protective medicine film and preparation method thereof
CN111789925A (en) * 2020-06-15 2020-10-20 湖北邹子书坊健康科技有限公司 Novel traditional Chinese medicine antiviral epidemic prevention patch and preparation method thereof
CN111904059A (en) * 2020-06-20 2020-11-10 南方医科大学中西医结合医院 Epidemic prevention traditional Chinese medicine mask
CN113767938A (en) * 2021-08-30 2021-12-10 柳州市中医医院(柳州市壮医医院) Zhuang nationality medicine air disinfectant
CN115475203A (en) * 2022-09-07 2022-12-16 甘肃中医药大学 Preparation and application of traditional Chinese medicine aromatherapy spray and paste extract with multiple activities
CN115475203B (en) * 2022-09-07 2024-03-08 甘肃中医药大学 Preparation and application of traditional Chinese medicine aromatherapy spray and ointment extracts with multiple activities

Similar Documents

Publication Publication Date Title
CN106473268A (en) A kind of pre- anti-virus, Herb medicine gauze mask of allergic rhinitis and its production and use
CN103463609B (en) The preparation method of the Chinese herbal oral decoction Chinese patent drug of the treatment infection of the upper respiratory tract
CN104042814A (en) Traditional Chinese medicinal composition for treating anaphylactic rhinitis
CN103110730B (en) Perillaseed-radix scutellariae-almond decoction for treating asthma and preparation method thereof
CN104474104B (en) A kind of Chinese medicine composition for preventing and treating infectious coryza of chicken and preparation method thereof
CN103830636A (en) Pharmaceutical composition for treating bronchitis and asthma
CN102772651B (en) Chinese medicine composition for the treatment of wind-dryness impairing the lung type cough and preparation method thereof
CN102772652B (en) Traditional Chinese medicine composition for treating cough and preparation method thereof
CN106620097A (en) Cough-relieving plaster prepared from traditional Chinese medicine composition, and preparation method of cough-relieving plaster
CN102772650A (en) Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof
CN104721665A (en) Traditional Chinese medicine composition for treating cough and preparation method thereof
CN101244101B (en) Chinese medicine composition for curing rhinitis
CN102772717A (en) Traditional Chinese medicine composition for treating cough and preparation method thereof
CN103405722B (en) Chinese herba preparation for preventing and treating infantile cough
CN105998725A (en) Traditional Chinese medicine preparation for treating silicosis
CN105833034A (en) Traditional Chinese medicine composition
CN110013507A (en) A kind of Chinese medicine composition for treating mixed type rhinitis
CN105796746B (en) Traditional Chinese medicine for preventing and treating recurrent upper respiratory tract infection
CN104173716A (en) Traditional Chinese medicine decoction treating acute and chronic pharyngitis
CN103251701B (en) Traditional Chinese medicine composition for treating rhinitis
CN103623369B (en) A kind of Chinese medicinal formulae for the treatment of tonsillitis, chronic pharyngitis
CN106237061A (en) A kind of Chinese medicine formula of clearing away lung-heat to relieve cough yin nourishing
CN101229338A (en) Heat cough oral liquid
CN104758710A (en) External application traditional Chinese medicine used for treating allergic rhinitis
CN104800460A (en) Traditional Chinese medicine composition for treating allergic rhinitis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20170308

RJ01 Rejection of invention patent application after publication