CN108888675B - Tranquilizing traditional Chinese medicine composition, traditional Chinese medicine slow-release sachet and preparation method thereof - Google Patents

Tranquilizing traditional Chinese medicine composition, traditional Chinese medicine slow-release sachet and preparation method thereof Download PDF

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CN108888675B
CN108888675B CN201810912903.5A CN201810912903A CN108888675B CN 108888675 B CN108888675 B CN 108888675B CN 201810912903 A CN201810912903 A CN 201810912903A CN 108888675 B CN108888675 B CN 108888675B
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伍振峰
黄小英
杨明
谢老智
王学成
王雅琪
万娜
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Jiangxi University of Traditional Chinese Medicine
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Abstract

The invention relates to the technical field of sachets, and particularly provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, a traditional Chinese medicine slow-release sachet and a preparation method thereof. The traditional Chinese medicine composition provided by the invention comprises spina date seed, gardenia, sandalwood, arborvitae, melissa officinalis, lavender, chamomile, orange flower, sweet orange and grapefruit. The traditional Chinese medicine composition can effectively improve insomnia by reasonably and scientifically mixing various traditional Chinese medicine active ingredients. The Chinese medicinal composition volatilizes and transmits odor through air, achieves the purposes of tranquilizing and allaying excitement and improving sleep quality, is safe, has no toxic or side effect, and can be used for a long time. The invention provides a traditional Chinese medicine slow-release sachet and a preparation method thereof.

Description

Tranquilizing traditional Chinese medicine composition, traditional Chinese medicine slow-release sachet and preparation method thereof
Technical Field
The invention relates to the technical field of sachets, and particularly relates to a traditional Chinese medicine composition for tranquilizing and allaying excitement, a traditional Chinese medicine slow-release sachet and a preparation method thereof.
Background
Due to the change of life rhythm, more and more people suffer from insomnia with different degrees, and the insomnia is one of main diseases which affect the physical and mental health of the people and reduce the life quality of the people. According to the results of epidemiological investigation, the prevalence rate of chronic insomnia is between 6% and 30%. The prevalence rate of insomnia in common adult people in China is between 9.2 and 11.2 percent.
At present, insomnia treatment mainly stays in the stage of artificially synthesized sedative and hypnotic drugs, and the drugs are easy to generate drug resistance, addiction and withdrawal reaction and the adverse reaction of the drugs, so that the traditional Chinese medicine has great disadvantages. The traditional Chinese medicine for treating insomnia has the defects of complex formula, large dosage, poor taste, need of patients to remember to take medicines and the like.
Therefore, it is important to provide a product with the functions of tranquilizing and allaying excitement, which is safe and effective, has no toxic and side effects, is low in cost and is convenient to use.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a traditional Chinese medicine composition for tranquilizing and allaying excitement, so as to relieve the lack of a composition for effectively treating insomnia in the prior art.
The second purpose of the invention is to provide a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which is used for relieving the lack of a product which can effectively treat insomnia without oral administration, and has the advantages of low cost, convenient use and long service life in the prior art.
The third purpose of the invention is to provide a preparation method of the traditional Chinese medicine volatile oil slow-release sachet for tranquilizing and allaying excitement.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the invention provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 15-25 parts of spina date seed, 3-10 parts of gardenia, 1-6 parts of sandalwood, 6-15 parts of horse buckwheat, 3-10 parts of melissa officinalis, 10-20 parts of lavender, 3-10 parts of chamomile, 5-15 parts of orange flower, 3-10 parts of sweet orange and 1-8 parts of grapefruit.
Further, the beverage comprises, by weight, 17-24 parts of spina date seeds, 3-8 parts of gardenia, 1-5 parts of sandalwood, 6-13 parts of horse-tree lotus, 3-8 parts of balm, 10-17 parts of lavender, 3-8 parts of chamomile, 7-13 parts of orange flowers, 5-10 parts of sweet oranges and 3-8 parts of grapefruit;
preferably, the traditional Chinese medicine composition comprises, by weight, 18-22 parts of spina date seeds, 3-6 parts of gardenia, 2-5 parts of sandalwood, 6-10 parts of horse-tree lotus, 3-6 parts of melissa officinalis, 10-15 parts of lavender, 3-6 parts of chamomile, 8-12 parts of orange flowers, 6-9 parts of sweet oranges and 3-7 parts of grapefruit.
Further, the traditional Chinese medicine composition comprises volatile oil extracted from all raw materials.
Further, the preparation method of the volatile oil of each raw material in the traditional Chinese medicine composition independently comprises a steam distillation method or a vacuum extraction method;
preferably, the raw materials are pretreated, wherein the pretreatment comprises cleaning and naturally airing the traditional Chinese medicine;
preferably, the vacuum extraction conditions include: extracting under the conditions of pressure of 30-50kPa and temperature of 65-85 deg.C for 2-8 h.
The invention also provides a slow-release sachet containing the traditional Chinese medicine composition.
Further, the composition also comprises a slow release carrier;
preferably, the slow release carrier comprises one or more of graphene oxide, activated carbon or zeolite molecular sieve;
preferably, the slow release carrier is graphene oxide.
The invention finally provides a preparation method of the traditional Chinese medicine slow-release sachet, which comprises the following steps: mixing the raw materials uniformly, and bagging to obtain the traditional Chinese medicine slow-release sachet.
Further, mixing the traditional Chinese medicine composition with a slow release carrier to obtain solidified powder, and subpackaging into bags to obtain the traditional Chinese medicine slow release sachet;
preferably, the slow release carrier comprises one or more of graphene oxide, activated carbon or zeolite molecular sieve;
preferably, the slow release carrier is graphene oxide;
preferably, the mass ratio of the traditional Chinese medicine composition to the sustained-release carrier is 1:0.5-1.2, preferably 1:0.7-1.2, and further preferably 1: 0.8-1.1.
Further, the mixing conditions include: mixing for 3-8min under the conditions of 150-300 r/min.
Further, the preparation method of the volatile oil of each raw material in the traditional Chinese medicine composition independently comprises a steam distillation method or a vacuum extraction method;
preferably, the raw materials are pretreated, wherein the pretreatment comprises cleaning and naturally airing the traditional Chinese medicine;
preferably, the vacuum extraction conditions include: extracting under the conditions of pressure of 30-50kPa and temperature of 65-85 deg.C for 2-8 h.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition for tranquilizing and allaying excitement provided by the invention comprises, by weight, 15-25 parts of spina date seeds, 3-10 parts of gardenia, 1-6 parts of sandalwood, 6-15 parts of horse and arbor lotus, 3-10 parts of melissa officinalis, 10-20 parts of lavender, 3-10 parts of chamomile, 5-15 parts of orange flowers, 3-10 parts of sweet oranges and 1-8 parts of grapefruit. The traditional Chinese medicine composition can effectively improve insomnia by reasonably and scientifically mixing various traditional Chinese medicine active ingredients. The traditional Chinese medicine composition volatilizes and transmits smell through air, has fresh smell, is refreshing, avoids the defects of poor taste, need of taking medicine on time and difficulty in taking medicine by patients, and achieves the purposes of tranquilizing and allaying excitement and improving sleep quality by breathing into human body constantly. The traditional Chinese medicine composition is safe, has no toxic or side effect, can be used for a long time, can treat insomnia, and is suitable for daily sleep-aiding requirements.
The traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement provided by the invention comprises the traditional Chinese medicine composition. The traditional Chinese medicine slow-release sachet has the advantages of convenience in carrying, convenience in use, wide application places and remarkable slow-release effect besides the beneficial effects of the traditional Chinese medicine composition, so that the traditional Chinese medicine slow-release sachet is long in service life and low in cost.
The preparation method of the traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement provided by the invention comprises the steps of mixing the traditional Chinese medicine composition, and subpackaging into bags to obtain the sachet. The method has simple preparation process, and can be used for large-scale mass production, and the prepared sachet can effectively improve sleep, and has long release time and uniform product quality.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer.
A traditional Chinese medicine composition for tranquilizing and allaying excitement comprises, by weight, 15-25 parts of spina date seeds, 3-10 parts of gardenia, 1-6 parts of sandalwood, 6-15 parts of horse-tree lotus, 3-10 parts of melissa officinalis, 10-20 parts of lavender, 3-10 parts of chamomile, 5-15 parts of orange flowers, 3-10 parts of sweet oranges and 1-8 parts of grapefruit.
The traditional Chinese medicine composition can effectively improve insomnia by reasonably and scientifically mixing various traditional Chinese medicine active ingredients. The traditional Chinese medicine composition volatilizes and transmits smell through air, has fresh smell, is refreshing, avoids the defects of poor taste, need of taking medicine on time and difficulty in taking medicine by patients, and achieves the purposes of tranquilizing and allaying excitement and improving sleep quality by breathing into human body constantly. The traditional Chinese medicine composition is safe, has no toxic or side effect, can be used for a long time, can treat insomnia, and is suitable for daily sleep-aiding requirements. The spina date seed is dry mature seed kernel of wild jujube of jujube genus of Rhamnaceae family, and is considered by traditional Chinese medicine to have sweet and mild nature and taste and enter heart, spleen, liver and gallbladder meridians. Has effects of nourishing heart, tranquilizing mind, arresting sweating, nourishing liver, and promoting fluid production, and can be used for treating vexation, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid consumption, and thirst. The volatile oil is one of the main active components of semen Ziziphi Spinosae, and has tranquilizing and hypnotic effects. The semen Ziziphi Spinosae volatile oil contains various lipid compounds, acid compounds, alcohol compounds and ether compounds, such as capric acid, lauric acid, eugenol, caryophyllene and eucalyptus essential oil. Typical, but not limiting, parts by weight of the spine date seeds are 15 parts, 17 parts, 19 parts, 20 parts, 21 parts, 23 parts or 25 parts.
The gardenia is a flower of gardenia jasminoides ellis of rubiaceae, and is considered to be cold in nature, sweet and bitter in taste, and enters lung and liver channels by traditional Chinese medicine. The functions are mainly used for tranquilizing and allaying excitement, protecting liver and benefiting gallbladder, and treating vexation and insomnia, high fever and dysphoria. The gardenia volatile oil mainly contains linalool, geraniol, alpha-caryophyllene, camphene and the like. Typical, but not limiting, gardenia is 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts by weight.
The sandalwood is a trunk heartwood of sandalwood of santalaceae, and the traditional Chinese medicine believes that the sandalwood is warm in nature and pungent in flavor, enters spleen, stomach and lung channels, and has the effects of regulating qi, warming middle-jiao, stimulating appetite and relieving pain. The lignum Santali albi has effects of tranquilizing mind, resisting bacteria, and promoting urination. The sandalwood volatile oil contains many sesquiterpene compounds, such as alpha-santalol, beta-santalol, alpha-santalene, beta-santalene, alpha-curcumol and tricyclic santal. Sandalwood is typically, but not limited to, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, or 6 parts by weight.
The herba Eichhorniae is a Labiatae plant, and has effects of promoting skin blood circulation, relieving pain, tranquilizing mind, and resisting depression. The radix et rhizoma Fagopyri Dibotryis volatile oil has warm smell and penetrating power. Arborescent typically, but not by way of limitation, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 parts by weight.
Melissa officinalis is a Labiatae plant, can be used as mild sedative, spasmolytic and antibacterial agent, and has effects of tranquilizing mind, dispelling pathogenic wind, relieving spasm, resisting bacteria, resisting virus, resisting tumor, resisting oxidation, resisting formation of fat tissue, and improving blood sugar tolerance level. The Melissa officinalis volatile oil contains citral a (geranial), citral b (neral), caryophyllene oxide and caryophyllene. Typical but not limiting examples of melissa officinalis are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts by weight.
Lavender belongs to Lavender of Labiatae, and has effects of treating chest and abdomen distending pain, common cold and cough with asthma, dizziness and headache, cardiopalmus and short breath, joint rheumatism, etc. The Lavender volatile oil has tranquilizing, blood pressure lowering, blood lipid reducing, brain refreshing, antibacterial, healing and anti-inflammatory effects. Typical, but not limiting, lavender is 10 parts, 12 parts, 14 parts, 15 parts, 16 parts, 18 parts or 20 parts by weight.
Chamomile is a plant of the family Compositae, slightly bitter and sweet in taste. Has effects of improving eyesight, clearing liver fire, treating insomnia, and lowering blood pressure. The volatile oil of flos Matricariae Chamomillae is distilled from flowers, and can relieve anxiety, tension, anger and fear, relax people, and make people feel patience and peaceful. The flos Matricariae Chamomillae volatile oil contains terpenes, pinene, camphene, sabinene, myrcene, cineol and caryophyllene. Typical but not limiting parts by weight of chamomile are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts.
The orange flower is white petal of bitter orange, and has effects of resisting depression, resisting bacteria, resisting spasm, killing bacteria, promoting cell activity, deodorizing, softening skin and calming. The neroli essential oil is extracted from white petals of bitter oranges, and the neroli volatile oil contains alpha-pinene, camphene, beta-pinene, alpha-terpinene, nerol acetate, farnesol, acid ester, indole and the like. Typical but not limiting parts by weight of orange blossom are 5 parts, 7 parts, 9 parts, 10 parts, 11 parts, 13 parts or 15 parts.
The sweet orange volatile oil has sweet orange fragrance, and can be used for dispelling tension and stress, relieving insomnia caused by anxiety, promoting perspiration, and promoting discharge of toxin from blocked skin, and is helpful for oily skin, acne skin or dry skin. Sweet oranges are typically, but not limited to, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts by weight.
Grapefruit typically, but not by way of limitation, is 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, or 8 parts by weight.
In a preferred embodiment of the invention, the traditional Chinese medicine composition for tranquilizing and allaying excitement comprises, by weight, 17-24 parts of spina date seeds, 3-8 parts of gardenia, 1-5 parts of sandalwood, 6-13 parts of horse buckwheat, 3-8 parts of melissa officinalis, 10-17 parts of lavender, 3-8 parts of chamomile, 7-13 parts of orange flowers, 5-10 parts of sweet oranges and 3-8 parts of grapefruit. The traditional Chinese medicine composition has the advantages of further optimized component proportion, fresher smell, wide universality and easy favor of more consumers, and the compatibility effect of various traditional Chinese medicines is more beneficial to improving the sleep.
In a preferred embodiment of the invention, the traditional Chinese medicine composition for tranquilizing and allaying excitement comprises, by weight, 18-22 parts of spina date seeds, 3-6 parts of gardenia, 2-5 parts of sandalwood, 6-10 parts of horse arbor lotus, 3-6 parts of melissa officinalis, 10-15 parts of lavender, 3-6 parts of chamomile, 8-12 parts of orange flowers, 6-9 parts of sweet oranges and 3-7 parts of grapefruit. The component proportion of the traditional Chinese medicine composition is further optimized, and the compatibility effect of various traditional Chinese medicines is further improved.
In a preferred embodiment of the present invention, the Chinese medicinal composition comprises volatile oil extracted from each raw material. The volatile oil contains plant effective components in traditional Chinese medicine, removes redundant impurities, has higher bioavailability, more obvious volatilization of smell, safety and no toxic or side effect.
In a preferred embodiment of the present invention, the preparation method of the volatile oil of each raw material in the Chinese medicinal composition independently comprises steam distillation or vacuum extraction.
In a preferred embodiment of the present invention, the raw materials are pretreated, and the pretreatment comprises washing the Chinese herbal medicines and naturally drying the Chinese herbal medicines.
In a preferred embodiment of the present invention, the vacuum extraction conditions include: extracting under the conditions of pressure of 30-50kPa and temperature of 65-85 deg.C for 2-8 h. The pressure is typically, but not limited to, 30kPa, 35kPa, 40kPa, 45kPa, or 50 kPa; temperatures are typically, but not limited to, 65 ℃, 70 ℃, 75 ℃, 80 ℃ or 85 ℃; the extraction time is typically, but not limited to, 2h, 3h, 4h, 5h, 6h, 7h or 8 h. The method adopts vacuum extraction method to obtain Chinese medicinal volatile oil as effective component of each Chinese medicinal material, and has the advantages of simple equipment, easy operation, low cost and high yield.
In a preferred embodiment of the invention, the extraction is carried out at a pressure of 30kPa and at a temperature of 68 ℃ for 8 h; extracting under 50kPa at 82 deg.C for 2 h.
A Chinese medicinal volatile oil sustained-release sachet containing the above Chinese medicinal composition for tranquilizing mind.
The traditional Chinese medicine slow-release sachet has the advantages of convenience in carrying, convenience in use, wide application places and remarkable slow-release effect besides the beneficial effects of the traditional Chinese medicine composition, so that the traditional Chinese medicine slow-release sachet is long in service life and low in cost.
In a preferred embodiment of the present invention, a sustained release carrier is further included. When the traditional Chinese medicine composition is volatile oil of various traditional Chinese medicines, due to the characteristics of volatile oil, such as easy volatilization, easy oxidation and easy decomposition, the problems of serious loss of effective components and the like exist in the preparation process and the storage process. The prior traditional process mainly uses a beta-cyclodextrin inclusion technology to improve the stability and the solubility of the volatile oil, but the process is more complex and is suitable for special requirements of pharmaceutical preparations and the like. The beta-cyclodextrin carrier has large dosage, and the performances of thermal stability, inclusion rate and the like are not the best choice as the slow release carrier in the traditional Chinese medicine slow release sachet.
In a preferred embodiment of the present invention, the slow release carrier comprises one or more of graphene oxide, activated carbon or zeolite molecular sieve, and the slow release carrier is further preferably graphene oxide. The graphene oxide is a derivative of graphene after oxidation treatment, has a single atomic layer structure, is a two-dimensional plane structure, has a large specific surface area, and is randomly distributed with groups such as hydroxyl, epoxy, carboxyl and the like. The activated carbon material is amorphous carbon obtained by processing treatment, has huge specific surface area and complex void structure, and is a good hydrophobic adsorbent. Zeolite molecular sieves are a class of inorganic crystalline materials having uniform microporous, regular pore structure. The graphene oxide, the active carbon or the zeolite molecular sieve can effectively improve the solidification rate and the thermal stability of the volatile oil, and the like, thereby achieving the effect of slowly releasing the volatile oil.
A preparation method of the traditional Chinese medicine volatile oil slow-release sachet comprises the following steps: mixing the raw materials uniformly, and bagging to obtain the traditional Chinese medicine slow-release sachet. The method has simple preparation process, and can be used for large-scale mass production, and the prepared sachet can effectively improve sleep, and has long release time and uniform product quality.
In a preferred embodiment of the invention, the traditional Chinese medicine composition is mixed with a slow release carrier to obtain solidified powder, and the solidified powder is subpackaged into bags to obtain the traditional Chinese medicine slow release sachet.
In a preferred embodiment of the present invention, the slow release carrier comprises one or more of graphene oxide, activated carbon or zeolite molecular sieve, and the slow release carrier is further preferably graphene oxide. The graphene oxide is a derivative of graphene after oxidation treatment, has a single atomic layer structure, is a two-dimensional plane structure, has a large specific surface area, and is randomly distributed with groups such as hydroxyl, epoxy, carboxyl and the like. The activated carbon material is amorphous carbon obtained by processing treatment, has huge specific surface area and complex void structure, and is a good hydrophobic adsorbent. Zeolite molecular sieves are a class of inorganic crystalline materials having uniform microporous, regular pore structure. The graphene oxide, the active carbon or the zeolite molecular sieve can effectively improve the solidification rate and the thermal stability of the volatile oil, and the like, thereby achieving the effect of slowly releasing the volatile oil.
In a preferred embodiment of the present invention, the mass ratio of the traditional Chinese medicine composition to the sustained-release carrier is 1:0.5-1.2, preferably 1:0.7-1.2, and more preferably 1: 0.8-1.1. The mass ratio of the traditional Chinese medicine composition to the sustained-release carrier is typically but not limited to 1:0.5, 1:0.7, 1:0.9, 1:1 or 1: 1.2.
In a preferred embodiment of the present invention, the mixing conditions include: mixing for 3-8min under the conditions of 150-300 r/min. The mixing speed is typically, but not limited to, 150r/min, 170r/min, 190r/min, 200r/min, 220r/min, 240r/min, 260r/min, 280r/min or 300 r/min; the mixing time is typically, but not limited to, 3min, 4min, 5min, 6min, 7min or 8 min.
In a preferred embodiment of the present invention, the preparation method of the volatile oil of each raw material in the Chinese medicinal composition independently comprises steam distillation or vacuum extraction.
In a preferred embodiment of the present invention, the raw materials are pretreated, and the pretreatment comprises washing the Chinese herbal medicines and naturally drying the Chinese herbal medicines.
In a preferred embodiment of the present invention, the vacuum extraction conditions include: extracting under the conditions of pressure of 30-50kPa and temperature of 65-85 deg.C for 2-8 h. The pressure is typically, but not limited to, 30kPa, 35kPa, 40kPa, 45kPa, or 50 kPa; temperatures are typically, but not limited to, 65 ℃, 70 ℃, 75 ℃, 80 ℃ or 85 ℃; the extraction time is typically, but not limited to, 2h, 3h, 4h, 5h, 6h, 7h or 8 h.
To facilitate a clearer understanding of the contents of the present invention, reference will now be made in detail to the following specific embodiments. These examples are illustrative only and do not limit the scope of the present invention in any way.
Example 1
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 15 parts of wild jujube seed volatile oil, 10 parts of gardenia volatile oil, 1 part of sandalwood volatile oil, 15 parts of horse-lily volatile oil, 3 parts of melissa volatile oil, 20 parts of lavender volatile oil, 3 parts of chamomile volatile oil, 15 parts of orange flower volatile oil, 3 parts of sweet orange volatile oil and 8 parts of grapefruit volatile oil.
Example 2
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 25 parts of wild jujube seed volatile oil, 3 parts of gardenia volatile oil, 6 parts of sandalwood volatile oil, 6 parts of horse-lily volatile oil, 10 parts of melissa volatile oil, 10 parts of lavender volatile oil, 10 parts of chamomile volatile oil, 5 parts of orange flower volatile oil, 10 parts of sweet orange volatile oil and 1 part of grapefruit volatile oil.
Example 3
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 17 parts of wild jujube seed volatile oil, 8 parts of gardenia volatile oil, 1 part of sandalwood volatile oil, 13 parts of horse-lily volatile oil, 3 parts of melissa volatile oil, 17 parts of lavender volatile oil, 3 parts of chamomile volatile oil, 13 parts of orange flower volatile oil, 5 parts of sweet orange volatile oil and 8 parts of grapefruit volatile oil.
Example 4
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 24 parts of wild jujube seed volatile oil, 3 parts of gardenia volatile oil, 5 parts of sandalwood volatile oil, 6 parts of horse-lily volatile oil, 8 parts of melissa volatile oil, 10 parts of lavender volatile oil, 8 parts of chamomile volatile oil, 7 parts of orange flower volatile oil, 10 parts of sweet orange volatile oil and 3 parts of grapefruit volatile oil.
Example 5
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 18 parts of wild jujube seed volatile oil, 6 parts of gardenia volatile oil, 2 parts of sandalwood volatile oil, 10 parts of horse-tree-lotus volatile oil, 3 parts of melissa volatile oil, 15 parts of lavender volatile oil, 3 parts of chamomile volatile oil, 12 parts of orange flower volatile oil, 6 parts of sweet orange volatile oil and 7 parts of grapefruit volatile oil.
Example 6
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 22 parts of wild jujube seed volatile oil, 3 parts of gardenia volatile oil, 5 parts of sandalwood volatile oil, 6 parts of horse-lily volatile oil, 6 parts of melissa volatile oil, 10 parts of lavender volatile oil, 6 parts of chamomile volatile oil, 8 parts of orange flower volatile oil, 9 parts of sweet orange volatile oil and 3 parts of grapefruit volatile oil.
Example 7
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 20 parts of wild jujube seed volatile oil, 5 parts of gardenia volatile oil, 3 parts of sandalwood volatile oil, 8 parts of horse-lily volatile oil, 5 parts of melissa volatile oil, 13 parts of lavender volatile oil, 5 parts of chamomile volatile oil, 10 parts of orange flower volatile oil, 8 parts of sweet orange volatile oil and 5 parts of grapefruit volatile oil.
Example 8
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 1.
Example 9
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 2.
Example 10
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 3.
Example 11
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 4.
Example 12
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 5.
Example 13
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 6.
Example 14
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises graphene oxide and the traditional Chinese medicine composition in the embodiment 7.
Example 15
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises activated carbon and the traditional Chinese medicine composition in the embodiment 7.
Example 16
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises a zeolite molecular sieve and the traditional Chinese medicine composition in the embodiment 7.
Example 17
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises beta-cyclodextrin and the traditional Chinese medicine composition in the embodiment 7.
Example 18
The embodiment provides a preparation method of a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises the following steps: mixing the Chinese medicinal composition and the sustained-release carrier at a mass ratio of 1:0.5, stirring at 300r/min for 3min to obtain a sustained-release carrier containing the Chinese medicinal composition, packaging in non-woven fabric, and packaging in sachet.
Example 19
The embodiment provides a preparation method of a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises the following steps: mixing the Chinese medicinal composition and the sustained-release carrier at a mass ratio of 1:1.2, stirring at 150r/min for 8min to obtain a sustained-release carrier containing the Chinese medicinal composition, packaging in non-woven fabric, and packaging in sachet.
Example 20
The embodiment provides a preparation method of a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises the following steps: mixing the Chinese medicinal composition and the sustained-release carrier at a mass ratio of 1:1, stirring at 200r/min for 5min to obtain a sustained-release carrier containing the Chinese medicinal composition, and packaging in a non-woven fabric and packaging in a sachet.
Example 21
The embodiment provides a preparation method of a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises the following steps: mixing the Chinese medicinal composition and the sustained-release carrier at a mass ratio of 1:2, stirring at 100r/min for 10min to obtain a sustained-release carrier containing the Chinese medicinal composition, and packaging in a non-woven fabric and packaging in a sachet.
Example 22
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 15 parts of spina date seed, 10 parts of gardenia, 1 part of sandalwood, 15 parts of horse-tree lotus, 3 parts of balm, 20 parts of lavender, 3 parts of chamomile, 15 parts of orange flower, 3 parts of sweet orange and 8 parts of grapefruit.
Example 23
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 25 parts of spina date seed, 3 parts of gardenia, 6 parts of sandalwood, 6 parts of horse buckwheat, 10 parts of balm, 10 parts of lavender, 10 parts of chamomile, 5 parts of orange flower, 10 parts of sweet orange and 1 part of grapefruit.
Example 24
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 17 parts of spina date seed, 8 parts of gardenia, 1 part of sandalwood, 13 parts of horse-tree lotus, 3 parts of balm, 17 parts of lavender, 3 parts of chamomile, 13 parts of orange flower, 5 parts of sweet orange and 8 parts of grapefruit.
Example 25
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 24 parts of spina date seed, 3 parts of gardenia, 5 parts of sandalwood, 6 parts of horse buckwheat, 8 parts of balm, 10 parts of lavender, 8 parts of chamomile, 7 parts of orange flower, 10 parts of sweet orange and 3 parts of grapefruit.
Example 26
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 18 parts of spina date seed, 6 parts of gardenia, 2 parts of sandalwood, 10 parts of horse buckwheat, 3 parts of balm, 15 parts of lavender, 3 parts of chamomile, 12 parts of orange flower, 6 parts of sweet orange and 7 parts of grapefruit.
Example 27
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 22 parts of spina date seed, 3 parts of gardenia, 5 parts of sandalwood, 6 parts of horse buckwheat, 6 parts of balm, 10 parts of lavender, 6 parts of chamomile, 8 parts of orange flower, 9 parts of sweet orange and 3 parts of grapefruit.
Example 28
The embodiment provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 20 parts of spina date seed, 5 parts of gardenia, 3 parts of sandalwood, 8 parts of horse buckwheat, 5 parts of balm, 13 parts of lavender, 5 parts of chamomile, 10 parts of orange flower, 8 parts of sweet orange and 5 parts of grapefruit.
Example 29
The embodiment provides a traditional Chinese medicine slow-release sachet for tranquilizing and allaying excitement, which comprises the traditional Chinese medicine composition in the embodiment 28.
Comparative example 1
The comparative example provides a traditional Chinese medicine volatile oil composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 10 parts of wild jujube seed volatile oil, 14 parts of gardenia volatile oil, 0.5 part of sandalwood volatile oil, 20 parts of horse-tree-lotus volatile oil, 1 part of balm volatile oil, 23 parts of lavender volatile oil, 1 part of chamomile volatile oil, 15 parts of orange flower volatile oil, 1 part of sweet orange volatile oil and 10 parts of grapefruit volatile oil.
Comparative example 2
The comparative example provides a traditional Chinese medicine volatile oil composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 20 parts of wild jujube seed volatile oil, 3 parts of sandalwood volatile oil, 8 parts of horse buckwheat volatile oil, 13 parts of lavender volatile oil, 5 parts of chamomile volatile oil, 8 parts of sweet orange volatile oil and 5 parts of grapefruit volatile oil.
Comparative example 3
The comparative example provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 10 parts of spina date seed, 14 parts of gardenia, 0.5 part of sandalwood, 20 parts of horse-buckwheat, 1 part of balm, 23 parts of lavender, 1 part of chamomile, 15 parts of orange flower, 1 part of sweet orange and 10 parts of grapefruit.
Comparative example 4
The comparative example provides a traditional Chinese medicine composition for tranquilizing and allaying excitement, which comprises the following components in parts by weight: 20 parts of spina date seed, 3 parts of sandalwood, 8 parts of horse buckwheat, 13 parts of lavender, 5 parts of chamomile, 8 parts of sweet orange and 5 parts of grapefruit.
Test example 1 Inclusion Effect
The sachet components of examples 8-17 were prepared according to the preparation method of example 20, and the inclusion rate and yield were counted, and the results are as follows:
Figure BDA0001761005120000141
Figure BDA0001761005120000151
as can be seen from the results in the above table, the inclusion rate and yield of the sachet traditional Chinese medicine volatile oil compositions in examples 8-17 are both high. Specifically, the traditional Chinese medicine volatile oil composition of the sachet in examples 8-14 uses graphene oxide as an inclusion carrier, and the inclusion rate and the yield are both significantly better than the activated carbon in example 15, the zeolite molecular sieve in example 16 and the beta-cyclodextrin in example 17. Graphene oxide, activated carbon, zeolite molecular sieve and beta-cyclodextrin are preferably used as the inclusion carrier in sequence.
The sachet components of example 14 were prepared according to the preparation method of examples 18-21, and the inclusion rate and yield were counted, and the results are as follows:
inclusion Rate (%) Yield (%)
Example 18 85.2 77.85
Example 19 84.9 78.35
Example 20 85.8 79.58
Example 21 79.2 75.02
From the above results, it can be seen that the inclusion rate and the yield of the preparation methods of examples 18-20 are higher than those of the preparation method of example 21, which indicates that the product prepared by the preparation method of the sachet provided by the invention has good performance.
Test example 2 stability and sustained Release
Taking out the same mass of clathrate from the sachet in examples 8-17, storing at constant temperature of 60 deg.C for seven days with the same mass of Chinese medicinal volatile oil composition in example 7 as comparative example, extracting volatile oil in 1, 3, 5, 7 days respectively, measuring content, and comparing stability and sustained release of the volatile oil composition. The statistical results are as follows:
Figure BDA0001761005120000152
Figure BDA0001761005120000161
as can be seen from the results in the table, the stability of the composition in the sachets in examples 8-17 is higher, and compared with the traditional Chinese medicine volatile oil composition, the stability after volatile oil inclusion is remarkably improved, which indicates that the slow release carrier in the invention can remarkably improve the slow release time of the traditional Chinese medicine volatile oil composition and prolong the service life of the sachets. Specifically, the graphene oxide is used as an inclusion carrier in the inclusion compounds in examples 8 to 14, and the stability of the inclusion compounds is remarkably superior to that of the activated carbon in example 15, the zeolite molecular sieve in example 16 and the beta-cyclodextrin in example 17. Graphene oxide, activated carbon, zeolite molecular sieve and beta-cyclodextrin are preferably used as the inclusion carrier in sequence.
Test example 3 Effect
According to the traditional Chinese medicine volatile oil compositions in the examples 1-7 and the comparative examples 1-2, the sachet is prepared by taking graphene oxide as a slow release carrier according to the method for preparing the sachet in the example 20, a diazepam injection is taken as a positive control group, meanwhile, a blank control group is set, and statistics is carried out on the autonomic activity of mice. Each group had 12 mice, 6 of which were male and female.
Wherein, the specific operation of the autonomous activity condition is as follows: in the experimental groups of examples 1-7 and comparative examples 1-2, sachets of the same mass were used, the slow release carrier in the sachets containing 0.6g of the Chinese medicinal volatile oil composition, and the number of activities of the incense within 20min was recorded by a recorder; the positive control group is administered with 0.1mL/10g by intragastric administration, and the activity times within 20min of administration are recorded by a recorder; the blank control group was placed in a cotton ball soaked with 0.6g of physiological saline and the number of activities within 20min of administration was recorded by a recorder. The statistical results are given in the following table, wherein: comparing with blank group, P is less than 0.05, P is less than 0.01:
number of autonomic activities before administration After the administration of the times of autonomic activity
Example 1 654±152＊ 152±31＊＊
Example 2 658±121＊ 146±32＊＊
Example 3 665±123＊ 143±27＊＊
Example 4 653±114＊ 147±31＊＊
Example 5 662±119＊ 158±22＊＊
Example 6 671±108＊ 153±15＊＊
Example 7 676±132 143±12＊＊
Comparative example 1 672±102＊ 375±23＊＊
Comparative example 2 669±103＊ 381±17＊＊
Positive control group 640±105 64±13
Blank group 652±112 516±76
It can be seen from the data in the above table that the number of autonomic activity of the mice in examples 1 to 7, comparative examples 1 to 2 and the positive control group was significantly reduced. Specifically, the mice of examples 1 to 7 had a lower number of autonomous activities than those of comparative examples 1 to 2, and a little higher number than that of the positive control group. The traditional Chinese medicine volatile oil composition provided by the invention has reasonable components and proportion, can effectively play a role in tranquilizing and allaying excitement and is beneficial to improving sleep.
Test example 4 Effect
According to the traditional Chinese medicine volatile oil compositions in the examples 1-7 and the comparative examples 1-2, the sachet is prepared by taking graphene oxide as a slow release carrier according to the method for preparing the sachet in the example 20, the heart-benefiting mind-tranquilizing tablet is taken as a positive control group, a blank control group is arranged at the same time, and the sleep latency and the sleep duration of the mouse are counted. Each group had 12 mice, 6 of which were male and female.
The method comprises the following specific operations: in examples 1 to 7 and comparative examples 1 to 2, the test group was injected with pentobarbital sodium 50mg/kg in the abdominal cavity of each mouse 24 hours later using a sachet of the same mass of 1.2g, and the sleep latency (disappearance time of righting reflex) and the sleep duration (time from disappearance of righting reflex to recovery) were observed and recorded; the positive control group is administrated with 17mg/10g of Yixinningshen tablets by stomach irrigation, the administration is carried out once every 12h, 50mg/kg of pentobarbital sodium is injected into the abdominal cavity of each mouse after 24h, and the sleep onset latency (disappearance time of righting reflex) and the sleep duration (disappearance time of righting reflex to recovery) are observed and recorded; the blank control group was placed with a cotton ball soaked with 1.2g of physiological saline, the cotton ball was changed 2 times a day, and 24 hours later, pentobarbital sodium 50mg/kg was injected into the abdominal cavity of each mouse, and the sleep latency (disappearance of righting reflex) and the sleep duration (time from disappearance of righting reflex to recovery) were observed and recorded. The statistical results are given in the following table, wherein: comparing with blank group, P is less than 0.05, P is less than 0.01:
when falling asleep and hidingInterval (min) Duration of sleep (min)
Example 1 4.09±0.53＊ 18.56±8.45＊＊
Example 2 4.76±0.97＊ 17.34±7.68＊＊
Example 3 4.12±1.23＊ 18.98±6.52＊＊
Example 4 3.56±0.58＊ 18.20±6.23＊＊
Example 5 3.65±0.86＊ 17.12±7.23＊＊
Example 6 3.78±0.78＊ 18.23±8.45＊＊
Example 7 3.42±1.54 19.02±8.12＊＊
Comparative example 1 4.89±1.26＊ 15.87±8.56＊＊
Comparative example 2 5.45±0.98＊ 13.85±6.75＊＊
Positive control group 4.64±1.43＊ 20.52±6.12＊＊
Blank group 5.64±0.53 12.38±1.81
It can be seen from the data in the above table that the mice in examples 1 to 7, comparative examples 1 to 2 and the positive control group had significantly reduced sleep latency and prolonged sleep duration. Specifically, the mice of examples 1-7 had sleep onset latencies less than those of comparative examples 1-2, while being substantially the same as or less than that of the positive control group; the duration of sleep was significantly longer in the mice of examples 1-7 than in comparative examples 1-2, while being slightly less in the positive control group. The traditional Chinese medicine volatile oil composition provided by the invention has reasonable components and proportion, can effectively play a role in tranquilizing and allaying excitement and is beneficial to improving sleep.
While particular embodiments of the present invention have been illustrated and described, it would be obvious that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (19)

1. The traditional Chinese medicine composition for tranquilizing and allaying excitement is characterized by comprising the following components in parts by weight: 15-25 parts of wild jujube seed volatile oil, 3-10 parts of gardenia volatile oil, 1-6 parts of sandalwood volatile oil, 6-15 parts of horse-tree lotus volatile oil, 3-10 parts of melissa volatile oil, 10-20 parts of lavender volatile oil, 3-10 parts of chamomile volatile oil, 5-15 parts of orange flower volatile oil, 3-10 parts of sweet orange volatile oil and 1-8 parts of grapefruit volatile oil.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 17-24 parts of wild jujube seed volatile oil, 3-8 parts of gardenia volatile oil, 1-5 parts of sandalwood volatile oil, 6-13 parts of horse-tree lotus volatile oil, 3-8 parts of melissa volatile oil, 10-17 parts of lavender volatile oil, 3-8 parts of chamomile volatile oil, 7-13 parts of orange flower volatile oil, 5-10 parts of sweet orange volatile oil and 3-8 parts of grapefruit volatile oil.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 18-22 parts of wild jujube seed volatile oil, 3-6 parts of gardenia volatile oil, 2-5 parts of sandalwood volatile oil, 6-10 parts of horse-tree lotus volatile oil, 3-6 parts of melissa volatile oil, 10-15 parts of lavender volatile oil, 3-6 parts of chamomile volatile oil, 8-12 parts of orange flower volatile oil, 6-9 parts of sweet orange volatile oil and 3-7 parts of grapefruit volatile oil.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the preparation method of each volatile oil in the Chinese medicinal composition independently comprises steam distillation or vacuum extraction.
5. The traditional Chinese medicine composition of claim 4, wherein the vacuum extraction conditions comprise: extracting under the conditions of pressure of 30-50kPa and temperature of 65-85 deg.C for 2-8 h.
6. A slow release sachet comprising the Chinese medicinal composition of any one of claims 1 to 5.
7. The traditional Chinese medicine slow-release sachet of claim 6, further comprising a slow-release carrier.
8. The traditional Chinese medicine slow-release sachet of claim 7, wherein the slow-release carrier comprises one or more of graphene oxide, activated carbon or zeolite molecular sieve.
9. The traditional Chinese medicine slow-release sachet of claim 7, wherein the slow-release carrier is graphene oxide.
10. The preparation method of the traditional Chinese medicine slow-release sachet of claim 6, which comprises the following steps: mixing the raw materials uniformly, and bagging to obtain the traditional Chinese medicine slow-release sachet.
11. The preparation method according to claim 10, wherein the Chinese medicinal composition is mixed with a sustained-release carrier to obtain a solidified powder, and the solidified powder is separately packaged into a bag to obtain the Chinese medicinal sustained-release sachet.
12. The preparation method of claim 11, wherein the slow release carrier comprises one or more of graphene oxide, activated carbon or zeolite molecular sieves.
13. The preparation method according to claim 11, wherein the slow release carrier is graphene oxide.
14. The preparation method of claim 11, wherein the mass ratio of the traditional Chinese medicine composition to the sustained-release carrier is 1: 0.5-1.2.
15. The preparation method of claim 14, wherein the mass ratio of the traditional Chinese medicine composition to the sustained-release carrier is 1: 0.7-1.2.
16. The preparation method of claim 15, wherein the mass ratio of the traditional Chinese medicine composition to the sustained-release carrier is 1: 0.8-1.1.
17. The method of claim 11, wherein the mixing conditions comprise: mixing for 3-8min under the conditions of 150-300 r/min.
18. The method of any one of claims 10-17, wherein the volatile oils are extracted from the composition by steam distillation or vacuum extraction.
19. The preparation method according to claim 18, wherein the conditions of the vacuum extraction method comprise: extracting under the conditions of pressure of 30-50kPa and temperature of 65-85 deg.C for 2-8 h.
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