CN117778226A - L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 - Google Patents
L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 Download PDFInfo
- Publication number
- CN117778226A CN117778226A CN202311326274.5A CN202311326274A CN117778226A CN 117778226 A CN117778226 A CN 117778226A CN 202311326274 A CN202311326274 A CN 202311326274A CN 117778226 A CN117778226 A CN 117778226A
- Authority
- CN
- China
- Prior art keywords
- lysine
- strain
- mutant strain
- corynebacterium glutamicum
- corynebacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/15—Corynebacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/0102—Diaminopimelate decarboxylase (4.1.1.20)
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20210030960 | 2021-03-09 | ||
| KR10-2021-0030960 | 2021-03-09 | ||
| KR1020210054313A KR20220126610A (ko) | 2021-03-09 | 2021-04-27 | L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법 |
| KR10-2021-0054313 | 2021-04-27 | ||
| CN202110660129.5A CN115044490B (zh) | 2021-03-09 | 2021-06-15 | L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110660129.5A Division CN115044490B (zh) | 2021-03-09 | 2021-06-15 | L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117778226A true CN117778226A (zh) | 2024-03-29 |
Family
ID=83156207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311326274.5A Pending CN117778226A (zh) | 2021-03-09 | 2021-06-15 | L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 |
| CN202110660129.5A Active CN115044490B (zh) | 2021-03-09 | 2021-06-15 | L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110660129.5A Active CN115044490B (zh) | 2021-03-09 | 2021-06-15 | L-赖氨酸生产能力得到提高的谷氨酸棒状杆菌突变株及利用其的l-赖氨酸的生产方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250283126A1 (https=) |
| EP (1) | EP4306644A4 (https=) |
| JP (1) | JP7766704B2 (https=) |
| KR (1) | KR20230165734A (https=) |
| CN (2) | CN117778226A (https=) |
| AU (1) | AU2021432764B2 (https=) |
| BR (1) | BR112023018219A2 (https=) |
| CA (1) | CA3211636A1 (https=) |
| MX (1) | MX2023010588A (https=) |
| WO (1) | WO2022191358A1 (https=) |
| ZA (1) | ZA202308733B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115927432A (zh) * | 2022-10-17 | 2023-04-07 | 齐鲁工业大学 | 一种产l-氨基酸的谷氨酸棒状杆菌工程菌的构建方法及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0775579A (ja) * | 1993-09-08 | 1995-03-20 | Mitsubishi Chem Corp | ジアミノピメリン酸デカルボキシラーゼをコードする遺伝子を含むｄｎａ断片およびその利用 |
| JP4035855B2 (ja) * | 1996-06-05 | 2008-01-23 | 味の素株式会社 | Ｌ−リジンの製造法 |
| US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| WO2008033001A1 (en) * | 2006-09-15 | 2008-03-20 | Cj Cheiljedang Corporation | A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same |
| KR100838038B1 (ko) | 2006-12-29 | 2008-06-12 | 씨제이제일제당 (주) | Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법 |
| KR100858913B1 (ko) * | 2007-03-09 | 2008-09-17 | 한국과학기술원 | 부위특이적 변이에 의해 제조된 고수율의 ｌ－쓰레오닌생산균주 및 이를 이용한 ｌ－쓰레오닌의 제조방법 |
| US9169502B2 (en) * | 2010-06-15 | 2015-10-27 | Paik Kwang Industrial Co., Ltd. | Method of producing L-lysine using a Corynebacterium glutamicum microorganism |
| KR101492134B1 (ko) * | 2012-05-22 | 2015-02-12 | 백광산업 주식회사 | 코리네형 세균 유래 ｓｏｄ 유전자의 프로모터 변이체 및 상기 프로모터 변이체를 이용한 Ｌ-라이신의 생산 방법 |
| EP3387135B1 (en) * | 2015-12-07 | 2021-02-17 | Zymergen Inc. | Promoters from corynebacterium glutamicum |
| BR112018011503A2 (pt) * | 2015-12-07 | 2018-12-04 | Zymergen Inc | promotores da corynebacterium glutamicum |
| KR20200026881A (ko) | 2017-06-07 | 2020-03-11 | 지머젠 인코포레이티드 | 코리네박테리움 글루타미컴으로부터의 프로모터 및 보조 유전자 발현을 조절하는 데 이의 용도 |
| CN109750069B (zh) * | 2017-11-01 | 2025-08-01 | 宁夏伊品生物科技股份有限公司 | 生产l-赖氨酸的重组菌、其构建方法以及l-赖氨酸的生产方法 |
| CN110951662B (zh) * | 2019-12-26 | 2024-03-12 | 新疆梅花氨基酸有限责任公司 | 一种高产赖氨酸的棒状细菌及其构建方法与应用 |
| KR102269639B1 (ko) * | 2020-02-12 | 2021-06-25 | 대상 주식회사 | L-글루탐산 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-글루탐산의 생산 방법 |
| KR102139806B1 (ko) | 2020-02-13 | 2020-07-30 | 씨제이제일제당 (주) | 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법 |
| CN112980867B (zh) * | 2021-03-09 | 2023-04-11 | 中国科学院深圳先进技术研究院 | 一种改造谷氨酸棒杆菌启动子的重组菌株及其构建方法与产l-氨基酸的应用 |
-
2021
- 2021-04-30 BR BR112023018219A patent/BR112023018219A2/pt unknown
- 2021-04-30 WO PCT/KR2021/005509 patent/WO2022191358A1/ko not_active Ceased
- 2021-04-30 MX MX2023010588A patent/MX2023010588A/es unknown
- 2021-04-30 CA CA3211636A patent/CA3211636A1/en active Pending
- 2021-04-30 EP EP21930458.1A patent/EP4306644A4/en active Pending
- 2021-04-30 AU AU2021432764A patent/AU2021432764B2/en active Active
- 2021-04-30 US US18/280,986 patent/US20250283126A1/en active Pending
- 2021-04-30 JP JP2023555483A patent/JP7766704B2/ja active Active
- 2021-06-15 CN CN202311326274.5A patent/CN117778226A/zh active Pending
- 2021-06-15 CN CN202110660129.5A patent/CN115044490B/zh active Active
-
2023
- 2023-09-13 ZA ZA2023/08733A patent/ZA202308733B/en unknown
- 2023-11-23 KR KR1020230164308A patent/KR20230165734A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP4306644A4 (en) | 2025-04-16 |
| KR20230165734A (ko) | 2023-12-05 |
| CA3211636A1 (en) | 2022-09-15 |
| AU2021432764B2 (en) | 2025-08-14 |
| JP2024511329A (ja) | 2024-03-13 |
| US20250283126A1 (en) | 2025-09-11 |
| CN115044490B (zh) | 2024-03-29 |
| AU2021432764A1 (en) | 2023-09-28 |
| MX2023010588A (es) | 2023-12-08 |
| JP7766704B2 (ja) | 2025-11-10 |
| BR112023018219A2 (pt) | 2023-11-28 |
| CN115044490A (zh) | 2022-09-13 |
| ZA202308733B (en) | 2025-06-25 |
| EP4306644A1 (en) | 2024-01-17 |
| WO2022191358A1 (ko) | 2022-09-15 |
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