CN117417939A - 抗TGF-β抗体及其用途 - Google Patents

抗TGF-β抗体及其用途 Download PDF

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Publication number
CN117417939A
CN117417939A CN202311230922.7A CN202311230922A CN117417939A CN 117417939 A CN117417939 A CN 117417939A CN 202311230922 A CN202311230922 A CN 202311230922A CN 117417939 A CN117417939 A CN 117417939A
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CN
China
Prior art keywords
antibody
tgf
seq
cells
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202311230922.7A
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English (en)
Chinese (zh)
Other versions
CN117417939A8 (zh
Inventor
G·夏皮罗
K·布劳恩
P·费恩
R·C·格雷戈里
R·科杜里
刘锋
N·马尔科娃
P·曼库
J·R·波拉德
邱华伟
J·泰拉伯
C·温特
俞翠琤
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Sanofi Aventis France
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Sanofi Aventis France
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Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority claimed from PCT/IB2018/000088 external-priority patent/WO2018134681A1/en
Publication of CN117417939A publication Critical patent/CN117417939A/zh
Publication of CN117417939A8 publication Critical patent/CN117417939A8/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202311230922.7A 2017-01-20 2018-01-19 抗TGF-β抗体及其用途 Pending CN117417939A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762448800P 2017-01-20 2017-01-20
EP17305061.8 2017-01-20
EP1730561.8 2017-01-20
US62/448,800 2017-01-20
EP17305061 2017-01-20
CN201880007975.3A CN110520441B8 (zh) 2017-01-20 2018-01-19 抗TGF-β抗体及其用途
PCT/IB2018/000088 WO2018134681A1 (en) 2017-01-20 2018-01-19 Anti-tgf-beta antibodies and their use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880007975.3A Division CN110520441B8 (zh) 2017-01-20 2018-01-19 抗TGF-β抗体及其用途

Publications (2)

Publication Number Publication Date
CN117417939A true CN117417939A (zh) 2024-01-19
CN117417939A8 CN117417939A8 (zh) 2024-07-12

Family

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CN202311230922.7A Pending CN117417939A (zh) 2017-01-20 2018-01-19 抗TGF-β抗体及其用途
CN201880007975.3A Active CN110520441B8 (zh) 2017-01-20 2018-01-19 抗TGF-β抗体及其用途

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US (4) US10766955B2 (https=)
JP (4) JP7213186B2 (https=)
CN (2) CN117417939A (https=)
AU (2) AU2018209391B2 (https=)
BR (1) BR112019014787A2 (https=)
CA (1) CA3050845A1 (https=)
CL (1) CL2019002011A1 (https=)
CO (1) CO2019008946A2 (https=)
CR (1) CR20190375A (https=)
DO (1) DOP2019000191A (https=)
EC (1) ECSP19059553A (https=)
IL (3) IL268112B2 (https=)
MA (1) MA47311A (https=)
MX (2) MX2019008551A (https=)
MY (1) MY200751A (https=)
NZ (1) NZ796440A (https=)
PE (1) PE20200734A1 (https=)
PH (1) PH12019501635A1 (https=)
SG (1) SG11201906660TA (https=)
TW (3) TWI787230B (https=)
UY (1) UY37575A (https=)
ZA (1) ZA201904494B (https=)

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TWI856437B (zh) 2024-09-21
CO2019008946A2 (es) 2019-09-30
AU2018209391B2 (en) 2024-08-15
US20220195026A1 (en) 2022-06-23
AU2024264593A1 (en) 2024-12-05
IL311866B2 (en) 2026-03-01
US12049496B2 (en) 2024-07-30
JP7411832B2 (ja) 2024-01-11
SG11201906660TA (en) 2019-08-27
US20200399358A1 (en) 2020-12-24
DOP2019000191A (es) 2019-10-15
CN117417939A8 (zh) 2024-07-12
US20180244763A1 (en) 2018-08-30
US20250026821A1 (en) 2025-01-23
CL2019002011A1 (es) 2019-11-22
IL311866A (en) 2024-06-01
CN110520441B8 (zh) 2024-07-09
ZA201904494B (en) 2020-12-23
CN110520441A (zh) 2019-11-29
UY37575A (es) 2018-10-31
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