CA3050845A1 - Anti-tgf-beta antibodies and their use - Google Patents

Anti-tgf-beta antibodies and their use Download PDF

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Publication number
CA3050845A1
CA3050845A1 CA3050845A CA3050845A CA3050845A1 CA 3050845 A1 CA3050845 A1 CA 3050845A1 CA 3050845 A CA3050845 A CA 3050845A CA 3050845 A CA3050845 A CA 3050845A CA 3050845 A1 CA3050845 A1 CA 3050845A1
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CA
Canada
Prior art keywords
antibody
cancer
seq
fragment
tgf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3050845A
Other languages
English (en)
French (fr)
Inventor
Gary Shapiro
Kevin BROWEN
Patrick Finn
Richard C. Gregory
Rao KODURI
Feng Liu
Natalia MALKOVA
Parminder MANKOO
Jack R. Pollard
Huawei Qiu
Joachim Theilhaber
Christopher Winter
Marcella Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority claimed from PCT/IB2018/000088 external-priority patent/WO2018134681A1/en
Publication of CA3050845A1 publication Critical patent/CA3050845A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3050845A 2017-01-20 2018-01-19 Anti-tgf-beta antibodies and their use Pending CA3050845A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762448800P 2017-01-20 2017-01-20
EP1730561.8 2017-01-20
US62/448,800 2017-01-20
EP17305061 2017-01-20
PCT/IB2018/000088 WO2018134681A1 (en) 2017-01-20 2018-01-19 Anti-tgf-beta antibodies and their use

Publications (1)

Publication Number Publication Date
CA3050845A1 true CA3050845A1 (en) 2018-07-26

Family

ID=61656071

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3050845A Pending CA3050845A1 (en) 2017-01-20 2018-01-19 Anti-tgf-beta antibodies and their use

Country Status (22)

Country Link
US (4) US10766955B2 (https=)
JP (4) JP7213186B2 (https=)
CN (2) CN117417939A (https=)
AU (2) AU2018209391B2 (https=)
BR (1) BR112019014787A2 (https=)
CA (1) CA3050845A1 (https=)
CL (1) CL2019002011A1 (https=)
CO (1) CO2019008946A2 (https=)
CR (1) CR20190375A (https=)
DO (1) DOP2019000191A (https=)
EC (1) ECSP19059553A (https=)
IL (3) IL268112B2 (https=)
MA (1) MA47311A (https=)
MX (2) MX2019008551A (https=)
MY (1) MY200751A (https=)
NZ (1) NZ796440A (https=)
PE (1) PE20200734A1 (https=)
PH (1) PH12019501635A1 (https=)
SG (1) SG11201906660TA (https=)
TW (3) TW202506185A (https=)
UY (1) UY37575A (https=)
ZA (1) ZA201904494B (https=)

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Publication number Publication date
AU2018209391B2 (en) 2024-08-15
SG11201906660TA (en) 2019-08-27
MX2019008551A (es) 2020-01-27
US20220195026A1 (en) 2022-06-23
US10766955B2 (en) 2020-09-08
TWI856437B (zh) 2024-09-21
IL323799A (en) 2025-12-01
CN110520441B8 (zh) 2024-07-09
TW201833135A (zh) 2018-09-16
JP7411832B2 (ja) 2024-01-11
CN117417939A8 (zh) 2024-07-12
DOP2019000191A (es) 2019-10-15
MA47311A (fr) 2019-11-27
NZ796440A (en) 2025-12-19
UY37575A (es) 2018-10-31
TW202506185A (zh) 2025-02-16
IL311866A (en) 2024-06-01
JP7844425B2 (ja) 2026-04-13
JP7213186B2 (ja) 2023-01-26
TW202313678A (zh) 2023-04-01
AU2018209391A1 (en) 2019-09-05
NZ756431A (en) 2025-03-28
US11242384B2 (en) 2022-02-08
IL268112B1 (en) 2025-05-01
ZA201904494B (en) 2020-12-23
CR20190375A (es) 2019-12-17
IL311866B2 (en) 2026-03-01
US20200399358A1 (en) 2020-12-24
JP2020514310A (ja) 2020-05-21
CO2019008946A2 (es) 2019-09-30
IL268112A (en) 2019-09-26
JP2026036696A (ja) 2026-03-05
US20180244763A1 (en) 2018-08-30
US12049496B2 (en) 2024-07-30
IL268112B2 (en) 2025-09-01
ECSP19059553A (es) 2019-08-30
TWI787230B (zh) 2022-12-21
JP2024038040A (ja) 2024-03-19
CL2019002011A1 (es) 2019-11-22
US20250026821A1 (en) 2025-01-23
PH12019501635A1 (en) 2019-11-04
BR112019014787A2 (pt) 2020-02-27
CN117417939A (zh) 2024-01-19
CN110520441A (zh) 2019-11-29
PE20200734A1 (es) 2020-07-23
CN110520441B (zh) 2023-11-14
MY200751A (en) 2024-01-13
JP2023052376A (ja) 2023-04-11
AU2024264593A1 (en) 2024-12-05
IL311866B1 (en) 2025-11-01
MX2023002588A (es) 2023-03-22

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