CN1173972C - 氮杂环醚衍生物及其作为烟碱乙酰胆碱受体调节剂的应用 - Google Patents
氮杂环醚衍生物及其作为烟碱乙酰胆碱受体调节剂的应用 Download PDFInfo
- Publication number
- CN1173972C CN1173972C CNB988106507A CN98810650A CN1173972C CN 1173972 C CN1173972 C CN 1173972C CN B988106507 A CNB988106507 A CN B988106507A CN 98810650 A CN98810650 A CN 98810650A CN 1173972 C CN1173972 C CN 1173972C
- Authority
- CN
- China
- Prior art keywords
- pyridyl
- oxygen
- alkyl
- disease
- piperidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (9)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK1259/97 | 1997-11-05 | ||
DK1259/1997 | 1997-11-05 | ||
DK125997 | 1997-11-05 | ||
DKPA19980085 | 1998-06-26 | ||
DKPA199800850 | 1998-06-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1278258A CN1278258A (zh) | 2000-12-27 |
CN1173972C true CN1173972C (zh) | 2004-11-03 |
Family
ID=26064766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB988106507A Expired - Fee Related CN1173972C (zh) | 1997-11-05 | 1998-11-05 | 氮杂环醚衍生物及其作为烟碱乙酰胆碱受体调节剂的应用 |
Country Status (12)
Country | Link |
---|---|
US (3) | US6756386B1 (zh) |
EP (2) | EP1357121A1 (zh) |
JP (1) | JP2001522846A (zh) |
CN (1) | CN1173972C (zh) |
AT (1) | ATE247104T1 (zh) |
AU (1) | AU747419B2 (zh) |
CA (1) | CA2306477A1 (zh) |
DE (1) | DE69817214T2 (zh) |
DK (1) | DK1034174T3 (zh) |
HK (1) | HK1032234A1 (zh) |
NZ (1) | NZ503626A (zh) |
WO (1) | WO1999024422A1 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562847B1 (en) | 1998-08-25 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
US6303638B1 (en) | 1999-08-06 | 2001-10-16 | The Regents Of The University Of California | Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor |
MXPA02002115A (es) * | 1999-09-14 | 2002-10-31 | Abbott Lab | Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. . |
DE10117686A1 (de) * | 2001-04-09 | 2002-10-24 | Celanese Ventures Gmbh | Protonenleitende Membran und deren Verwendung |
AU2002360403A1 (en) * | 2001-11-19 | 2003-06-10 | Elan Pharmaceuticals, Inc. | (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of Alzheimer's disease |
WO2004113297A2 (en) * | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1642898B1 (en) * | 2003-06-27 | 2013-03-27 | Msd K.K. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
CN1960985A (zh) * | 2004-06-18 | 2007-05-09 | 神经研究公司 | 作为单胺神经递质再摄取抑制剂的新颖烷基取代的哌啶衍生物 |
US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
CN103977003A (zh) | 2007-04-02 | 2014-08-13 | 帕金森氏病研究院 | 用于降低治疗的副作用的方法和组合物 |
AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
JP6654960B2 (ja) * | 2016-01-15 | 2020-02-26 | 日本曹達株式会社 | ルテニウム錯体の製造方法 |
JP2020503950A (ja) | 2017-01-06 | 2020-02-06 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 経皮薬剤送達の装置及び方法 |
JP7420797B2 (ja) | 2018-05-29 | 2024-01-23 | モーニングサイド ベンチャー インベストメンツ リミテッド | 薬剤送達の方法及びシステム |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR829845A (fr) | 1936-12-04 | 1938-07-07 | Delle Atel Const Electr | Coupe-circuit à basse tension à élément fusible rechargeable |
FR2306697A1 (fr) * | 1975-04-10 | 1976-11-05 | Sogeras | Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants |
US4379161A (en) * | 1979-06-07 | 1983-04-05 | Michel Thominet | Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics |
DE3227741A1 (de) * | 1982-07-24 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung |
US4592866A (en) * | 1982-09-30 | 1986-06-03 | A. H. Robins Company, Inc. | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof |
ZA848275B (en) | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4667031A (en) * | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
DE3835291A1 (de) | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
DE4208254A1 (de) * | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
US5965582A (en) * | 1994-08-03 | 1999-10-12 | Asta Medica Aktiengesellschaft | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
GB2295387A (en) * | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
IL118279A (en) * | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
AU1608397A (en) * | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
ES2208812T3 (es) | 1997-02-25 | 2004-06-16 | Akzo Nobel N.V. | Derivados de azetidina y de pirrolidina. |
US6562847B1 (en) * | 1998-08-25 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
DE19904261A1 (de) | 1999-02-03 | 2000-08-10 | Basf Ag | Verfahren zur Herstellung von Dimethylsulfit |
RU2145680C1 (ru) | 1999-06-28 | 2000-02-20 | Открытое акционерное общество "Магистральные нефтепроводы Центральной Сибири" | Пеногенератор (варианты) |
GB0203968D0 (en) | 2002-02-19 | 2002-04-03 | Gavon Res & Dev Ltd | Mixer |
JP2003297848A (ja) | 2002-04-01 | 2003-10-17 | Matsushita Electric Ind Co Ltd | 半導体装置の製造方法 |
-
1998
- 1998-11-05 AT AT98952578T patent/ATE247104T1/de not_active IP Right Cessation
- 1998-11-05 CN CNB988106507A patent/CN1173972C/zh not_active Expired - Fee Related
- 1998-11-05 AU AU10224/99A patent/AU747419B2/en not_active Ceased
- 1998-11-05 NZ NZ503626A patent/NZ503626A/en unknown
- 1998-11-05 WO PCT/DK1998/000478 patent/WO1999024422A1/en active IP Right Grant
- 1998-11-05 EP EP03011485A patent/EP1357121A1/en not_active Withdrawn
- 1998-11-05 JP JP2000520436A patent/JP2001522846A/ja not_active Withdrawn
- 1998-11-05 DE DE69817214T patent/DE69817214T2/de not_active Expired - Lifetime
- 1998-11-05 DK DK98952578T patent/DK1034174T3/da active
- 1998-11-05 CA CA002306477A patent/CA2306477A1/en not_active Abandoned
- 1998-11-05 EP EP98952578A patent/EP1034174B1/en not_active Expired - Lifetime
-
2000
- 2000-04-14 US US09/550,379 patent/US6756386B1/en not_active Expired - Fee Related
-
2001
- 2001-04-23 HK HK01102859A patent/HK1032234A1/xx not_active IP Right Cessation
-
2004
- 2004-05-19 US US10/848,132 patent/US7202237B2/en not_active Expired - Fee Related
-
2007
- 2007-03-09 US US11/715,872 patent/US20070161614A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040242558A1 (en) | 2004-12-02 |
EP1034174A1 (en) | 2000-09-13 |
DK1034174T3 (da) | 2003-09-22 |
HK1032234A1 (en) | 2001-07-13 |
JP2001522846A (ja) | 2001-11-20 |
CN1278258A (zh) | 2000-12-27 |
AU747419B2 (en) | 2002-05-16 |
US6756386B1 (en) | 2004-06-29 |
NZ503626A (en) | 2002-05-31 |
AU1022499A (en) | 1999-05-31 |
ATE247104T1 (de) | 2003-08-15 |
DE69817214D1 (de) | 2003-09-18 |
WO1999024422A1 (en) | 1999-05-20 |
EP1357121A1 (en) | 2003-10-29 |
US20070161614A1 (en) | 2007-07-12 |
EP1034174B1 (en) | 2003-08-13 |
DE69817214T2 (de) | 2004-06-09 |
US7202237B2 (en) | 2007-04-10 |
CA2306477A1 (en) | 1999-05-20 |
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CI01 | Publication of corrected invention patent application |
Correction item: Priority number Correct: PA199800850 False: PA199800085 Number: 52 Page: 91 Volume: 16 |
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CI02 | Correction of invention patent application |
Correction item: Priority number Correct: PA199800850 False: PA199800085 Number: 52 Page: The title page Volume: 16 |
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Free format text: CORRECT: NUMBER OF PRIORITY; FROM: PA199800085 TO: PA199800850 |
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