CN117338671A - Composition containing clove and cnidium fruit and application - Google Patents
Composition containing clove and cnidium fruit and application Download PDFInfo
- Publication number
- CN117338671A CN117338671A CN202311566018.3A CN202311566018A CN117338671A CN 117338671 A CN117338671 A CN 117338671A CN 202311566018 A CN202311566018 A CN 202311566018A CN 117338671 A CN117338671 A CN 117338671A
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- composition
- clove
- cnidium fruit
- skin
- rosewood
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- 239000000203 mixture Substances 0.000 title claims abstract description 129
- 235000016639 Syzygium aromaticum Nutrition 0.000 title claims abstract description 56
- 244000223014 Syzygium aromaticum Species 0.000 title claims abstract description 56
- 241000212948 Cnidium Species 0.000 title claims abstract description 38
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 38
- 244000086363 Pterocarpus indicus Species 0.000 claims abstract description 36
- 235000009984 Pterocarpus indicus Nutrition 0.000 claims abstract description 36
- 239000000419 plant extract Substances 0.000 claims abstract description 33
- 239000002904 solvent Substances 0.000 claims abstract description 29
- 239000002537 cosmetic Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920001213 Polysorbate 20 Polymers 0.000 claims abstract description 17
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims abstract description 17
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims abstract description 17
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 6
- 239000004359 castor oil Substances 0.000 claims abstract description 4
- 235000019438 castor oil Nutrition 0.000 claims abstract description 4
- 150000002148 esters Chemical class 0.000 claims abstract description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 4
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000284 extract Substances 0.000 claims abstract description 3
- 239000003921 oil Substances 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 19
- 230000028327 secretion Effects 0.000 claims description 9
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 6
- 239000000499 gel Substances 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 10
- 230000001276 controlling effect Effects 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 44
- 239000000843 powder Substances 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- 241000238876 Acari Species 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 16
- 229920005862 polyol Polymers 0.000 description 14
- 150000003077 polyols Chemical class 0.000 description 14
- 238000002156 mixing Methods 0.000 description 13
- 230000001815 facial effect Effects 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 239000011259 mixed solution Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 241000628997 Flos Species 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 239000004519 grease Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 229960004063 propylene glycol Drugs 0.000 description 5
- 238000010298 pulverizing process Methods 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 238000007873 sieving Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 206010064503 Excessive skin Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of cosmetics, in particular to a composition containing clove and cnidium fruit and application thereof. The composition of the invention comprises the following components in percentage by mass: 1-15% of plant extract, 2.5-25% of polyalcohol, 1-20% of solubilizer and the balance of water; the plant extract is an extract obtained by extracting a mixture of clove, cnidium fruit and rosewood seeds with an ethanol solution; the polyalcohol comprises at least one of glycerol, propylene glycol and butanediol; the solubilizer comprises at least one of Tween-20, PEG-40 hydrogenated castor oil and polyglycerol ester. The composition has excellent mite-removing, oil-controlling and moisturizing effects and also has a good antibacterial effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition containing clove and cnidium fruit and application thereof.
Background
Mites are parasites on the skin and cannot be seen by naked eyes, but after the mites are propagated on the skin and grow too much, allergic reaction can be caused on the skin, and especially at the nose part, uncomfortable symptoms such as skin itch, red swelling and the like can be caused. Mites can continuously irritate skin after contacting the skin, and can gather at the wet and dark parts of the skin, and at the moment, the mites can possibly have symptoms such as redness and dryness of the skin. If mites stay on the skin for too long, the mites possibly enter the skin to suck secretions of the skin, and if mites block the pores, the pores are blocked, and the secretion of sebaceous glands is increased.
Excessive skin grease can accumulate in pores, is easy to be infected by propionibacterium acnes, and has acne; it may also cause clogging of pores, and after bacterial infection, folliculitis may be induced, and symptoms such as redness and itching of skin may occur. Excessive skin grease can also cause unbalance of skin water and oil, elastic fibers of the skin can be damaged, so that the skin is loose, and the damage of fat particles, blackheads and the like can be caused.
The existing cosmetic products often have the effects of moisturizing, whitening, sun protection and the like, and have various functions; however, the effect intensity of a single function is relatively low; research into cosmetic products having excellent mite-killing, oil-controlling and moisturizing effects has presented challenges to research and development personnel. The present invention is based on the above-described technical problems, and the present invention has been made.
Disclosure of Invention
Based on the solution of the technical problems, the invention provides the composition containing the clove and the fructus cnidii and the application thereof.
The raw materials of clove, rosewood seed and cnidium fruit used in the invention are matched with the components of a polyol humectant and a solubilizer, so that excellent mite removal, oil control, moisture preservation and bacteriostasis effects are provided. The invention optimizes the extraction process of the clove, the cnidium fruit and the rosewood seed, improves the extraction efficiency of the active components for removing mites, controlling oil, preserving moisture and inhibiting bacteria in the clove, the cnidium fruit and the rosewood seed, and endows the combination with excellent mite removing, oil controlling, preserving moisture and inhibiting bacteria effects. Meanwhile, the dosage proportion of the clove, the cnidium fruit and the rosewood seed is optimized, and higher efficiency performance is provided. The invention also uses the solubilizer component which can effectively deliver the active components of the clove, the cnidium fruit and the rosewood seed to the skin and promote the active components to be efficiently absorbed by the skin, thereby further improving the effects of removing mites, controlling oil, preserving moisture, inhibiting bacteria and the like of the composition on the skin of a human body.
In one aspect, the present invention provides a composition comprising clove and cnidium fruit, the composition comprising a plant extract, a polyol, a solubilising agent and water.
Further, the plant extract is an extract obtained by extracting a mixture of clove, cnidium fruit and rosewood seeds with an ethanol solution.
Further, the polyol comprises at least one of glycerol, propylene glycol and butylene glycol.
Further, the solubilizer comprises at least one of tween-20, PEG-40 hydrogenated castor oil and polyglycerol ester.
Further, the composition containing clove and cnidium fruit provided by the invention comprises the following components in percentage by mass: 1-15% of plant extract, 2.5-25% of polyalcohol, 1-20% of solubilizer and the balance of water; the plant extract is obtained by extracting a mixture of clove, fructus cnidii and rosewood seeds with an ethanol solution; the polyalcohol comprises at least one of glycerol, propylene glycol and butanediol; the solubilizer comprises at least one of Tween-20, PEG-40 hydrogenated castor oil and polyglycerol ester.
Further, the plant extract is used in the composition of the present invention in an amount of 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% by mass, or in an amount ranging between any of the foregoing values.
Further, in the preparation of the plant extract, the mass ratio of the clove to the cnidium fruit is 1 (0.8-1.5). The mass ratio is further selected to be a ratio of 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, or a ratio range between any of the above.
Further, in the preparation of the plant extract, the mass ratio of the clove to the rosewood seeds is 1 (0.4-1). The mass ratio is further selected to be a ratio of 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, or a ratio range between any of the above.
Further, in the preparation of the plant extract, the ethanol solution is an ethanol water solution with the mass percentage concentration of 40-55%. The mass percentage concentration is further selected to be 40%, 42%, 44%, 45%, 47%, 50%, 52%, 55%, or a mass ratio in a range of values between any of the above.
Further, the preparation method of the plant extract comprises the following steps:
(1) Respectively pulverizing flos Caryophylli, fructus Cnidii, and rosewood seed, and sieving; mixing according to the dosage to obtain a plant powder mixture;
(2) Mixing the plant powder mixture with an ethanol solution, heating and stirring to obtain a mixed solution;
(3) Filtering the mixed solution, concentrating the filtrate into paste, and drying to obtain the plant extract.
Further, the screening particle sizes of the clove, the cnidium fruit and the rosewood seeds in the step (1) are all 0.01-10mm, or the particle sizes of the values of 0.01mm, 0.05mm, 0.1mm, 0.5mm, 1mm, 5mm and 10mm or the particle sizes in the range between any two values.
Further, in the step (1), when mixing is carried out, the mass ratio of the clove to the fructus cnidii is 1 (0.8-1.5). The mass ratio is further selected to be a ratio of 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, or a ratio range between any of the above.
Further, in the step (1), when mixing is performed, the mass ratio of the clove to the rosewood seeds is 1 (0.4-1). The mass ratio is further selected to be 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, or a ratio range between any of the above.
Further, the mass ratio of the plant powder mixture to the ethanol solution in the step (2) is 1: (3-100), or a ratio of 1:5, 1:10, 1:15, 1:20, 1:30, 1:40, 1:50, 160, 1:80, 1:90, or a range between any two of the above.
Further, the ethanol solution in the step (2) is ethanol water solution with the mass percentage concentration of 40-55%. The mass percentage concentration is further selected to be 40%, 42%, 44%, 45%, 47%, 50%, 52%, 55%, or a mass ratio in a range of values between any of the above.
Further, the heating temperature in the step (2) is 50 to 75 ℃, or a temperature of 52 ℃, 55 ℃, 58 ℃, 60 ℃, 62 ℃, 65 ℃, 68 ℃, 70 ℃, 72 ℃, 75 ℃, or a temperature in a numerical range between any of the above values.
Further, the stirring speed in the step (2) is 100-5000 rpm, or 200 rpm, 500 rpm, 800 rpm, 1000 rpm, 2000 rpm, 4000 rpm, or a value range between any of the above values.
Further, the stirring time in the step (2) is 1-48 hours, or a numerical time of 2 hours, 5 hours, 8 hours, 10 hours, 12 hours, 15 hours, 20 hours, 25 hours, 30 hours, 35 hours, 40 hours, 45 hours, or a time of a numerical range between any of the above values.
Further, the mass of the paste concentrated in the step (3) is 2-10 times of the mass of the plant powder mixture, or 3 times, 4 times, 5 times, 6 times, 7 times, 8 times, 9 times, or a multiple of a numerical range between any of the above values.
Further, the drying in step (3) is performed until the water content of the plant extract is less than 12%, or less than 10%, less than 8%, less than 6%, less than 5%.
Further, the preparation method of the plant extract comprises the following steps:
(1) Respectively pulverizing flos Caryophylli, fructus Cnidii, and rosewood seed, sieving, and selecting powder with particle diameter of 0.01-10 mm; mixing flos Caryophylli and fructus Cnidii at a mass ratio of (0.8-1.5) and flos Caryophylli and rosewood seed at a mass ratio of (0.4-0.1) to obtain plant powder mixture;
(2) Mixing the plant powder mixture with 40-55% ethanol water solution according to the mass ratio of 1: (3-100), heating to 50-75 ℃, and stirring for 1-48 hours at the rotating speed of 100-5000 rpm to obtain a mixed solution;
(3) Filtering the mixed solution, concentrating the filtrate into paste which is 2-10 times of the mass of the plant powder mixture, and drying until the water content is lower than 12% to obtain the plant extract.
Further, the polyol is used in the composition of the present invention in an amount of 3%, 5%, 10%, 12%, 15%, 18%, 20%, 22%, 24% by mass, or in an amount ranging between any of the foregoing values.
Further, the amount of the solubilizer in the composition of the present invention is 2%, 5%, 10%, 12%, 14%, 15%, 17%, 18%, 20% by mass, or a range between any of the above values.
Further, the use of a solubilizing agent system comprising a combination of tween-20 and polyglycerol-6-dicaprate is more suitable for the compositions of the present invention for the purpose of increasing the delivery of the active ingredient to the skin and promoting efficient absorption of the active ingredient by the skin. The mass ratio of tween-20 to polyglycerol-6-dicaprate is preferably selected to be 1: (1.5-2.5), or 1:1.5, 1:1.6, 1:1.7, 1: ratios of 1.8, 1:1.9, 1:2, 1:2.2, 1:2.4, 1:2.5, or ratio ranges between any of the above.
Further, the water used in the composition of the present invention may be at least one of deionized water, purified water, distilled water, ionized water, and the like.
In another aspect, the present invention provides the preparation of the composition comprising clove and cnidium fruit, which can be obtained by a conventional method. Such as by stirring and mixing.
In another aspect, the invention provides the use of the composition comprising clove and cnidium fruit, including the use for the preparation of cosmetics for combating mites or controlling oil secretion. The cosmetic comprises water, oil or gel.
In another aspect, the present invention provides a cosmetic comprising the composition comprising clove and cnidium fruit and a cosmetic base. The mass percentage of the composition containing the clove and the cnidium fruit in the cosmetic is 1-30%, or the numerical value of 2%, 5%, 8%, 10%, 12%, 15%, 18%, 20%, 25% and 30% or the range between any two numerical values.
The beneficial effects are that:
the clove, rosewood seed and cnidium fruit used in the invention are matched with the components of the polyol humectant and the solubilizer, so that excellent mite removal, oil control, moisture preservation and bacteriostasis effects are provided. The invention optimizes the extraction process of the clove, the cnidium fruit and the rosewood seed, improves the extraction efficiency of the active components for removing mites, controlling oil, preserving moisture and inhibiting bacteria in the clove, the cnidium fruit and the rosewood seed, and endows the combination with excellent mite removing, oil controlling, preserving moisture and inhibiting bacteria effects. The invention also optimizes the dosage proportion of the clove, the cnidium fruit and the rosewood seed, and provides higher efficiency performance. The invention also uses the solubilizer component which can effectively deliver the active components of the clove, the cnidium fruit and the rosewood seed to the skin and promote the active components to be efficiently absorbed by the skin, thereby further improving the effects of removing mites, controlling oil, preserving moisture, inhibiting bacteria and the like of the composition on the skin of a human body.
The composition has excellent mite removing effect, can remove about 89.25% of mites in 35 hours and about 99.47% of mites in 60 hours, has good prospect in the application of preparing mite removing cosmetic products, can endow cosmetics with mite removing effect and increase the using feel of the cosmetics.
The matching of the clove and the rosewood seeds used in the invention can endow the composition with excellent mite-killing function, and when the mass ratio of the clove to the rosewood seeds is 1: in the range of (0.4-1), the obtained plant extract can endow the composition of the invention with high-efficiency mite-killing function, so that the composition of the invention has better application prospect in mite-killing products.
The composition has remarkable oil control effect, can eliminate the generation of excessive oil of the skin with the proportion of about 39.52% in 6 weeks, can remove sebum secretion of the skin with the proportion of about 58.13% in 10 weeks, has good application in the preparation of cosmetic products for inhibiting the secretion of the skin oil, can endow cosmetics with the effect of removing the excessive oil and can increase the skin lightness.
The combination of the tween-20 and the polyglycerol-6 dicaprate used in the invention can mutually promote and synergistically increase the effective delivery of the active ingredients to the skin and the efficient absorption of the active ingredients by the skin, thereby further improving the oil control effect of the composition on the skin of a human body. When the dosage ratio of the two reaches 1: (1.5-2.5), the mite-killing effect of the obtained composition is more remarkable.
Compared with other solubilizer components, the combination of the tween-20 and the polyglycerol-6 dicaprate has better effect of effectively delivering the active components to the skin and promoting the active components to be absorbed by the skin.
The increase rate of the moisture content of the facial skin of the composition reaches 35.78% at 5 hours after the composition is used, and the increase rate of the moisture content of the facial skin reaches 22.67% at 10 hours; the composition has excellent moisturizing and moisturizing effects, can obviously enhance the moisture content of facial skin and enhance the skin elasticity effect of a user.
The composition has the advantages of simple preparation method, excellent mite removal, oil control and moisture preservation effects and wide application prospect.
Detailed Description
The invention will be described in connection with specific embodiments which will better illustrate the effects of the invention. The materials such as various raw materials, reagents and equipment used in the invention can be purchased in the market or can be prepared by the existing method.
1. Preparation of the composition
1. Composition 1:
the composition 1 comprises the following raw materials in percentage by mass: 10% of plant extract, 18% of polyol, 8.4% of solubilizer and the balance of water; the polyol is 10% of glycerol and 8% of 1, 2-propylene glycol, and the solubilizer consists of the following components in percentage by mass: 2 and polyglycerol-6 dicaprate;
the preparation method of the plant extract comprises the following steps:
(1) Respectively pulverizing flos Caryophylli, fructus Cnidii, and rosewood seed, sieving, and selecting powder with particle diameter of 0.01-10 mm; mixing according to the mass ratio of the clove to the cnidium fruit of 1:1 and the mass ratio of the clove to the rosewood seed of 1:0.8 to obtain a plant powder mixture;
(2) Mixing the plant powder mixture with 50% ethanol water solution according to the mass ratio of 1:10, heating to 68 ℃, and stirring for 10 hours at the rotating speed of 200 revolutions per minute to obtain a mixed solution;
(3) Filtering the mixed solution, and concentrating the filtrate under reduced pressure at 65deg.C and pressure of 2.5kPa to obtain a paste which is 6 times the mass of the plant powder mixture; then freeze-drying under vacuum of 12Pa at-25deg.C until the water content is 5.4%, to obtain the plant extract;
the preparation of the composition 1 is as follows: the plant extract, polyol, solubilizing agent and water were mixed and stirred at a rotation speed of 200 rpm and a temperature of 40 c for 0.5 hours to obtain the composition 1.
2. Composition 2:
the composition 2 comprises the following raw materials in percentage by mass: 10.5% of a plant extract, 17.6% of a polyol, 7.5% of a solubilizing agent and the balance water; the polyol is 7.6% of glycerol and 10% of 1, 2-propylene glycol, and the solubilizer consists of the following components in percentage by mass: 1.5 tween-20 and polyglycerol-6-dicaprate;
the preparation method of the plant extract comprises the following steps:
(1) Respectively pulverizing flos Caryophylli, fructus Cnidii, and rosewood seed, sieving, and selecting powder with particle diameter of 0.01-10 mm; mixing according to the mass ratio of the clove to the cnidium fruit of 1:0.9 and the mass ratio of the clove to the rosewood seed of 1:1 to obtain a plant powder mixture;
(2) Mixing the plant powder mixture with 55 mass percent ethanol aqueous solution according to the mass ratio of 1:12, heating to 68 ℃, stirring for 9 hours at the rotating speed of 200 revolutions per minute to obtain a mixed solution;
(3) Filtering the mixed solution, and concentrating the filtrate under reduced pressure at 60 ℃ and a pressure of 2.3kPa to obtain a paste, wherein the mass of the paste is 7 times of that of the plant powder mixture; then freeze-drying under vacuum of 12Pa at-28deg.C until the water content is 5.8% to obtain the plant extract;
the preparation of the composition 2 is as follows: the plant extract, polyol, solubilizing agent and water were mixed and stirred at a rotation speed of 200 rpm and a temperature of 45 c for 0.8 hours to obtain the composition 2.
3. Composition 3:
the composition 3 comprises the following raw materials in percentage by mass: 9.5% of plant extract, 17% of polyol, 10.5% of solubilizer and the balance of water; the polyol is 12% of glycerol and 5% of 1, 2-propylene glycol, and the solubilizer consists of the following components in percentage by mass: 2.5 tween-20 and polyglycerol-6-dicaprate;
the preparation method of the plant extract comprises the following steps:
(1) Respectively pulverizing flos Caryophylli, fructus Cnidii, and rosewood seed, sieving, and selecting powder with particle diameter of 0.01-10 mm; mixing according to the mass ratio of the clove to the cnidium fruit of 1:1.2 and the mass ratio of the clove to the rosewood seed of 1:0.4 to obtain a plant powder mixture;
(2) Mixing the plant powder mixture with 50% ethanol water solution according to the mass ratio of 1:15, heating to 70 ℃, and stirring for 8.5 hours at the rotating speed of 300 revolutions per minute to obtain a mixed solution;
(3) Filtering the mixed solution, and concentrating the filtrate under reduced pressure at 62 ℃ and a pressure of 2.7kPa to obtain a paste, wherein the mass of the paste is 4.5 times of that of the plant powder mixture; then freeze-drying under vacuum of 11Pa at-27deg.C until the water content is 6.2% to obtain the plant extract;
the preparation of the composition 3 is as follows: the plant extract, polyol, solubilizing agent and water were mixed and stirred at a speed of 300 rpm and a temperature of 40 c for 0.6 hours to obtain the composition 3.
4. Composition 4: the only difference from the composition 1 is that the mass ratio of the clove to the rosewood seeds is 1:0.05, the other is the same as in composition 1.
5. Composition 5: the only difference from the composition 1 is that the mass ratio of the clove to the rosewood seeds is 1:0.2, the others being identical to those of composition 1.
6. Composition 6: the only difference from the composition 1 is that the mass ratio of the clove to the rosewood seeds is 1:1.2, the others being identical to those of composition 1.
7. Composition 7: the only difference from the composition 1 is that the mass ratio of the clove to the rosewood seeds is 1:2, the others are the same as those of composition 1.
8. Composition 8: the only difference from composition 1 is that the solubilizing agent is tween-20, otherwise identical to composition 1.
9. Composition 9: the only difference from composition 1 is that the solubilizer is polyglycerol-6 dicaprate, otherwise identical to composition 1.
10. Composition 10: the only difference from composition 1 is that fatty alcohol polyoxyethylene ether AEO-9 was used instead of the solubilizing agent, otherwise the same as composition 1.
11. Composition 11: the only difference from composition 1 is the use of polyethylene glycol-2000 instead of the solubilizing agent, otherwise identical to composition 1.
12. Composition 12: the only difference from composition 1 is that the mass ratio of tween-20 and polyglycerol-6-dicaprate is 1:1, otherwise identical to composition 1.
2. Effect testing
The above compositions 1 to 12 were subjected to the effect test described below.
I. Mite removal effect test
The above compositions 1 to 7 were used as test subjects for mite-killing effect, and were sequentially registered as groups I-1 to I-7, and mite-killing effect test was performed. The method for mite removal effect test is carried out by referring to the method described in the standard NY/T1151.2-2006; the treatment amount and treatment time are as follows: 4.0mL of samples from groups I-1 to I-7 were taken and mixed with mites for 35 hours and 60 hours, respectively, and tested for mite death rate for 35 hours and 60 hours, respectively. The results are shown in Table 1.
Table 1: mite removal effect test
As can be seen from the results of the mite-killing effect test in Table 1, the composition of the present invention has excellent mite-killing effect, can remove about 89.25% of mites at 35 hours, and about 99.47% of mites at 60 hours, and has good prospects in the application of the cosmetic product for killing mites, and can give cosmetics with mite-killing effect and increase the feel of use.
As shown by the comparison results of I1-I7, the combination of the clove and the rosewood seeds used in the invention can endow the composition with excellent mite-killing function, and when the mass ratio of the clove to the rosewood seeds in the plant extract is lower than 1:0.4 and higher than 1:1, the obtained plant extract endows the composition with relatively lower mite-killing effect; when the mass ratio of the clove to the rosewood seeds is 1: in the range of (0.4-1), the obtained plant extract can endow the composition of the invention with high-efficiency mite-killing function, so that the composition of the invention has better application prospect in mite-killing products.
2. Skin control oil effect test
The above compositions 1 to 3 and 8 to 12 were used as test subjects for mite-killing effect. The specific test method comprises the following steps: people with vigorous grease secretion (age 25-45 years) were selected as volunteers and randomly divided into 8 groups of 4 male and female volunteers each. Testing of volunteer cheeks using a grease tester sebumersm 815The oil content of the product is denoted as A 0 week . Compositions 1-3, 8-12 were applied to volunteers in the respective groups at about 7 pm daily, uniformly applied to the cheek at about 0.15g, and used for 10 weeks. The compositions were tested for lipid content at the cheeks of the same part of the user, respectively at 6 weeks and 10 weeks of use, and are labeled A, respectively For 6 weeks And A For 10 weeks . Then, the grease reduction ratio T was calculated for 6 weeks and 10 weeks For 6 weeks And T For 10 weeks The method comprises the steps of carrying out a first treatment on the surface of the The calculation formula is as follows: grease reduction ratio T at 6 weeks For 6 weeks ＝100％×(A 0 week -A For 6 weeks )/A 0 week Fat reduction ratio T of 10 weeks For 10 weeks ＝100％×(A 0 week -A For 10 weeks )/A 0 week . The specific results of the skin control oil effect test are shown in table 2.
Table 2: skin control oil effect test
According to the test results of the skin oil control effect in Table 2, the oil control effect of the composition is remarkable, the generation of excessive oil on the skin with the proportion of about 39.52% can be eliminated in 6 weeks, the sebum secretion of the skin with the proportion of about 58.13% can be removed in 10 weeks, the composition has good application in the preparation of cosmetic products for inhibiting the secretion of the skin oil, the effect of eliminating the excessive oil can be endowed to cosmetics, and the skin lightening effect can be improved.
As can be seen from the comparison results of the compositions 1 and 8-9, the combination of tween-20 and polyglycerol-6 dicaprate used in the invention has better effect than that of only one of the two compositions, and the combination of the tween-20 and the polyglycerol-6 dicaprate can mutually promote and synergistically increase the effective delivery of the active ingredients to the skin and the efficient absorption of the active ingredients by the skin, thereby further improving the oil control effect of the composition on the skin of a human body. When the dosage ratio of the two reaches 1: (1.5-2.5), the mite-killing effect of the obtained composition is more remarkable.
From a comparison of compositions 1, 10, 11, the combination of tween-20 and polyglycerol-6-dicaprate of the invention has better effect of effectively delivering active ingredients to the skin and promoting the efficient absorption of active ingredients by the skin than other solubilizer ingredients.
3. Moisture effect test
The moisturizing effect test was performed using the above compositions 1 to 3. The specific test is as follows: selecting several volunteers of age (between 40-60 years of age) and dividing them into 3 groups of 8 persons each, 4 men and women each; three groups of volunteers tested the moisturizing effect of compositions 1-3, respectively. After the volunteers of the subject had used the same cleansing such as cleansing the face, the face was rubbed off, and then the volunteers of each group had used 1.2g of the compositions 1 to 3, respectively, on the face, and the skin moisture content of the face after cleansing and before using the composition, 5 hours and 10 hours of using the composition was measured using a CM825 tester model number provided by CK corporation in germany, and then the skin moisture content increase ratio was calculated; wherein, the 5-hour facial skin moisture content increase ratio a5=100% × (5-hour facial skin moisture content-facial skin moisture content before use of the composition)/facial skin moisture content before use of the composition, and the 10-hour facial skin moisture content increase ratio a10=100% × (10-hour facial skin moisture content-facial skin moisture content before use of the composition)/facial skin moisture content before use of the composition. The moisturizing effect test is shown in Table 3.
Table 3: moisture effect test
As can be seen from the test results in Table 3, the composition of the present invention had a moisture content increase of 35.78% in the facial skin at 5 hours after use and 22.67% in the facial skin at 10 hours; the composition has excellent moisturizing and moisturizing effects, can obviously enhance the moisture content of facial skin and enhance the skin elasticity effect of a user.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. A composition comprising clove and cnidium fruit, characterized in that: the preparation method comprises the following steps of: 1-15% of plant extract, 2.5-25% of polyalcohol, 1-20% of solubilizer and the balance of water;
the plant extract is an extract obtained by extracting a mixture of clove, cnidium fruit and rosewood seeds with an ethanol solution;
the polyalcohol comprises at least one of glycerol, propylene glycol and butanediol;
the solubilizer comprises at least one of Tween-20, PEG-40 hydrogenated castor oil and polyglycerol ester.
2. The composition comprising clove and cnidium fruit according to claim 1, wherein: the mass ratio of the clove to the cnidium fruit is 1 (0.8-1.5).
3. The composition comprising clove and cnidium fruit according to claim 1, wherein: the mass ratio of the clove to the rosewood seeds is (0.7-1.3).
4. The composition comprising clove and cnidium fruit according to claim 1, wherein: the solubilizer comprises tween-20 and polyglycerol-6-dicaprate.
5. The composition comprising clove and cnidium fruit according to claim 4, wherein: the mass ratio of the tween-20 to the polyglycerol-6 dicaprate is 1: (1.5-2.5).
6. The composition comprising clove and cnidium fruit according to claim 1, wherein: the ethanol solution is ethanol water solution with the mass percentage concentration of 40-55%.
7. Use of a composition comprising clove and cnidium fruit according to any one of claims 1 to 6, characterised in that: including use in the preparation of cosmetics for acarid control or for controlling oil secretion.
8. The use according to claim 7, wherein: the cosmetic comprises water, oil or gel.
9. A cosmetic product characterized by: a composition and cosmetic base comprising the clove and cnidium fruit as claimed in any one of claims 1 to 6.
10. The cosmetic product of claim 9, wherein: the mass percentage of the composition containing the clove and the cnidium fruit in the cosmetic is 1-30%.
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