CN117243834A - Oil-control acne-removing composition with high octanoyl glycine content, and preparation method and application thereof - Google Patents
Oil-control acne-removing composition with high octanoyl glycine content, and preparation method and application thereof Download PDFInfo
- Publication number
- CN117243834A CN117243834A CN202311297904.0A CN202311297904A CN117243834A CN 117243834 A CN117243834 A CN 117243834A CN 202311297904 A CN202311297904 A CN 202311297904A CN 117243834 A CN117243834 A CN 117243834A
- Authority
- CN
- China
- Prior art keywords
- parts
- content
- oil
- isohexadecane
- acne
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
The invention relates to the technical field of cosmetics, and particularly discloses a high-content octanoyl glycine oil-control acne-removal composition, and a preparation method and application thereof. The high-content octanoylglycine oil control acne removal composition comprises the following components in parts by mass: 45-58 parts of octanoylglycine, 8-11 parts of acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 2.25-6 parts of sodium polyacryl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerol cocoate. A preparation method of the high-content octanoyl glycine oil control acne removal composition comprises the step of uniformly mixing all the components to obtain the high-content octanoyl glycine oil control acne removal composition. An application of the oil-controlling acne-removing composition with high content of octanoylglycine is that the composition is added into cosmetics. The oil-control acne-removal composition with high octanoyl glycine content has the effects of mildness, safety, freshness, ventilation, oil control and acne removal.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a high-content octanoyl glycine oil-control acne-removal composition, and a preparation method and application thereof.
Background
Acne, also known as whelk or comedo, is a chronic inflammatory skin condition caused by inflammation of the sebaceous gland of the hair follicle, and has been one of the major skin problems afflicting many consumers. The acne is complicated in cause and is caused by various factors such as environment, living habit, hormone, sebum secretion, barrier damage, skin microecology and the like, for example, hormone disorder, bad living habit, complete removal of makeup, pore blockage and the like, wherein excessive secretion of skin grease and mass multiplication of propionibacterium acnes are important causes for the occurrence of the acne.
The majority of acne-removing products on the market at present use high-dose oil-controlling acne-removing components such as azelaic acid, salicylic acid, metronidazole, polyquaternium-73 and the like, and the oil-controlling acne-removing components have extremely strong antibacterial activity, can rapidly reduce the number of propionibacterium acnes, have good oil-controlling effect and have obvious blackhead and acne-removing effects. However, these oil-controlling acne-removing components have the problem of high skin irritation, and not only are consumers sensitive to skin not friendly, but even consumers insensitive to skin can be stimulated to generate allergic reaction on skin after long-term use of the acne-removing product containing the components, so that the skin can be inflamed again and acne recurs.
Therefore, a product which is mild, safe and low in irritation and is used for controlling oil and removing acnes is needed.
Disclosure of Invention
In order to achieve the purpose of mildly and safely controlling oil and removing acnes, the application provides a high-content octanoylglycine oil-controlling and acne-removing composition, and a preparation method and application thereof. According to the application, the high-content octanoylglycine oil control acne removal composition which is mild and safe, fresh and breathable in skin feel, and capable of controlling oil and removing acnes can be obtained through synergistic compounding of octanoylglycine, acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerol cocoate.
In a first aspect, the present application provides a high content octanoylglycine oil control acne removal composition, which adopts the following technical scheme:
the high-content octanoyl glycine oil control acne removal composition comprises the following components in parts by mass: 45-58 parts of octanoylglycine, 8-11 parts of acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 2.25-6 parts of poly (acryl dimethyl taurine) sodium (and) isohexadecane (and) PEG-7 glycerin cocoate.
In the technical scheme, the octanoylglycine is a very excellent cosmetic efficacy ingredient, and can be used as a skin conditioner, a surfactant, a cleanser and the like in cosmetics. Firstly, the octanoyl glycine has a good antibacterial effect, has a strong inhibition effect on staphylococcus aureus, acne shortbar bacterin and the like, and can inhibit excessive secretion of sebum, so that the octanoyl glycine has a remarkable effect on preventing and improving acne, can play a role in preventing and enhancing the preservative effect in a formula, can reduce the use amount of the preservative in a formula system, and reduces the irritation caused by the preservative; secondly, the octanoyl glycine has good affinity for skin, and can efficiently convey active ingredients in cosmetics, so that the use effect of other functional ingredients can be improved; finally, octanoylglycine can effectively inhibit the activation of elastase, prevent the decomposition of elastin, and can be used for reducing the generation of wrinkles in anti-wrinkle products.
Sodium polyacryl dimethyl taurate (and isohexadecane (and) PEG-7 glycerol cocoate) is a thickening agent which is formed into a hollow spherical structure by the applicant through a specific preparation process, has remarkable air permeability, and has a certain accommodating capacity for grease, so that the thickening agent has an adsorption oil control effect in skin care products; the acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer (and isohexadecane) polysorbate-80 are the acidic thickening agents prepared by the applicant through a specific preparation process, have strong thickening capacity in an acidic formula, can well thicken acidic nonionic raw materials such as glycolic acid, lactic acid, salicylic acid, azelaic acid and the like, and can remarkably improve the storage stability of the acidic formula system; the acidic high molecular thickener also has certain emulsifying capacity, and can obtain a more stable emulsifying system when being used by being compounded with a nonionic small molecular emulsifier. According to the preparation method, through the compounding of the sodium polyacryl dimethyl taurate (and) and the PEG-7 glycerol cocoate, the acrylic acid TEA salt/acrylic acid dimethyl taurate TEA salt copolymer (and) and the isohexadecane (and) polysorbate-80, the defect that the stability of an acid system of a high-acid system product, such as a high-content azelaic acid product, a high-content octanoyl glycine product and other products is poor, the phenomena that the acid system product is easy to crystallize, water out, delaminate and the like are obviously relieved, and the acid system of the high-content octanoyl glycine oil control acne removal composition is further stabilized.
The application can keep good stability through the interaction of octanoylglycine, TEA (acrylic acid) salt/TEA (acrylic acid) salt copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate, can be placed in a hollow structure through the combination of TEA (acrylic acid) salt/TEA (acrylic acid) salt copolymer (and) isohexadecane (and) polysorbate-80 and sodium polyacryl dimethyltaurate (and) PEG-7 glycerol cocoate, can achieve long-term refreshing and breathable effects, solve the problem of bad effect of similar oil control acne products, greatly improve the good experience of consumers, and can achieve the effect of synergistically reducing the alpha-glucosidase, the alpha-glucosidase (5-alpha-glucosidase, and the isohexadecane (5-co) sodium palmitoyl glycinate and the isopalmitoyl dimethyltaurate (and) sodium polyacryl dimethyltaurate (and) isohexadecane (PEG-7 glycerol cocoate) through the interaction of the octanoylglycine and the TEA salt/TEA (and) and the PEG-7 glycerol cocoate (and the PEG-7 glycerol cocoate) which are coordinated, whereas 5α -reductase is a membrane protease dependent on reduced coenzyme ii (NADPH), an important androgen metabolizing enzyme in the skin, capable of irreversibly converting Testosterone (Testosterone, T) into Dihydrotestosterone (DHT), DHT being the most active androgen, capable of inducing excessive secretion of lipids from the skin glands. DHT levels can be reduced by inhibiting 5α -reductase activity, thereby effectively alleviating excessive secretion of grease from sebaceous glands.
Preferably, the high-content octanoylglycine oil control acne removal composition comprises the following components in parts by mass: 48 to 52 parts of octanoylglycine, 10 to 11 parts of acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 5 to 6 parts of poly (acryl dimethyl taurine) sodium (and) isohexadecane (and) PEG-7 glycerin cocoate.
The technical scheme is summarized, and the technical effects of better promoting the inhibition of 5 alpha-reductase by the octanoyl glycine are achieved by further limiting the dosage of the octanoyl glycine, the acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, the sodium polyacryl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerol cocoate, so that the oil control and acne removal effects of the high-content octanoyl glycine oil control and acne removal composition are further enhanced, and the fresh and mild use experience of the high-content octanoyl glycine oil control and acne removal composition is better improved.
Preferably, the high-content octanoylglycine oil control acne removal composition comprises the following components in parts by mass: 50 parts of octanoylglycine, 10 parts of acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 5 parts of sodium polyacryloyl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate.
In the technical scheme, better oil control and acne removal effects are achieved by further limiting the dosages of octanoylglycine, acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerol cocoate.
Preferably, the high-content octanoylglycine oil control acne removal composition further comprises the following components in parts by mass: 8-11 parts of fructo-oligosaccharide, 2-6 parts of purslane extract and 17-22 parts of hydroxyethyl urea.
In the technical scheme, the fructo-oligosaccharide is a typical prebiotic, has good effects in regulating skin microecology and promoting the growth of probiotics, and has the effects of relieving allergy, resisting inflammation and reducing irritation.
The purslane extract is a very effective plant extract, and contains rich flavone and alkaloid, so that the purslane extract has good effect of inhibiting inflammatory factors such as IL-6, NO, PGE2 and the like, has the effects of resisting oxidation and bacteria, and can improve the skin hydration capability.
The hydroxyethyl urea can permeate into the stratum corneum to increase the water content of the skin, solve the problem of skin dryness, improve the skin feel of the product, is a humectant with extremely high cost performance, has remarkable moisturizing effect, smooth coating feel, no stickiness and no greasiness compared with the traditional humectant, and gives the skin a moist comfortable feel, and has extremely wide applicability due to the nonionic nature of the hydroxyethyl urea, and has the effects of remarkably softening the stratum corneum of the skin and increasing the skin elasticity.
According to the preparation method, based on octanoylglycine, TEA (and) isohexadecane (and) polysorbate-80 and sodium polyacyl dimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate, fructo-oligosaccharide, purslane extract and hydroxyethyl urea are further added, and the six substances are matched with each other to realize synergistic effect, so that the unexpected technical effect of promoting the generation of beta-endorphin and the further technical effect of promoting the inhibition of 5 alpha-reductase by octanoylglycine are achieved, wherein the beta-endorphin can reduce the pain caused by skin inflammation through being combined with opioid receptors in the brain, and can reduce the release of inflammatory factors, inhibit inflammatory reaction, promote the immune tolerance of organisms, and promote the secretion of the beta-endorphin, so that the effects of relieving the pain, burning and the like of the skin can be effectively achieved, and the development of skin inflammation can be further inhibited. Meanwhile, the addition of the hydroxyethyl urea further adjusts the use skin feel of the high-content octanoyl glycine oil-control acne-removal composition, and further optimizes the fresh and breathable use skin feel of the high-content octanoyl glycine oil-control acne-removal composition, so that the high-content octanoyl glycine oil-control acne-removal composition with the advantages of being mild, safe, fresh and breathable, controlling oil and removing acnes and relieving skin is obtained.
Preferably, the high-content octanoylglycine oil control acne removal composition further comprises the following components in parts by mass: 10-11 parts of fructo-oligosaccharide, 2-3 parts of purslane extract and 19-21 parts of hydroxyethyl urea.
According to the technical scheme, the technical effects of promoting the generation of beta-endorphin and inhibiting 5 alpha-reductase are achieved by further limiting the dosage of fructo-oligosaccharide, purslane extract and hydroxyethyl urea, better oil control and acne removal effects are achieved, meanwhile, bad feelings such as burning and pain caused by acne can be relieved better, and the effects of oil control and acne removal of the oil control and acne removal composition with high content of octanoylglycine are further optimized.
Preferably, the high-content octanoylglycine oil control acne removal composition comprises the following components in parts by mass: 50 parts of octanoylglycine, 10 parts of acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 5 parts of sodium polyacryloyl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate, 10 parts of fructo-oligosaccharide, 2.95 parts of purslane extract and 20 parts of hydroxyethyl urea.
According to the technical scheme, the technical effects of promoting the generation of beta-endorphin and inhibiting 5 alpha-reductase are better achieved by further limiting the dosage of octanoylglycine, TEA acrylate/TEA acrylate copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate, fructo-oligosaccharide, purslane extract and hydroxyethyl urea, so that better effects of mildly controlling oil and acne and relieving skin are achieved, and better skin care experience is brought.
In a second aspect, the present application provides a preparation method of a high-content octanoylglycine oil control acne removal composition, which adopts the following technical scheme:
a preparation method of a high-content octanoyl glycine oil control acne removal composition comprises the steps of accurately weighing octanoyl glycine, acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer (and isohexadecane (and) polysorbate-80, poly (sodium acryloyldimethyl taurate) (and isohexadecane (and) PEG-7 glycerol cocoate), heating to 80-85 ℃, stirring until the mixture is completely dissolved, and cooling to normal temperature to obtain the high-content octanoyl glycine oil control acne removal composition.
Preferably, the octanoylglycine, the TEA acrylate/TEA acrylate copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate are accurately weighed, then heated to 80-85 ℃ and stirred until the mixture is completely dissolved, cooled to 40-45 ℃ and added with fructo-oligosaccharide, purslane extract and hydroxyethyl urea, and stirred for 3-5 min at 200-220 r/min, thus obtaining the oil-control acne-removing composition with high octanoylglycine content.
According to the technical scheme, the high-content octanoylglycine oil control acne removal composition prepared by the scheme has good stability and better storage performance.
In a third aspect, the application of the high-content octanoylglycine oil control acne removal composition in cosmetics adopts the following technical scheme:
the application of the high-content octanoyl glycine oil control acne removal composition in cosmetics is that the high-content octanoyl glycine oil control acne removal composition in the first aspect is added into cosmetics.
According to the technical scheme, the high-content octanoylglycine oil control acne removal composition is added into the cosmetics, so that a good mild oil control acne removal effect is achieved, and a good fresh and breathable skin feel experience can be provided for the cosmetics.
In summary, the present application includes at least one of the following beneficial technical effects:
1. according to the preparation method, the octanoylglycine, the TEA acrylate/TEA acrylate copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate are compounded, so that the unexpected technical effect of improving the inhibition of 5 alpha-reductase by octanoylglycine is achieved, and the excessive secretion of grease from sebaceous glands is effectively relieved. Furthermore, the interaction of the TEA acrylate/TEA acrylate copolymer (and) isohexadecane (and) polysorbate-80 and sodium polyacryl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate keeps good stability, and the interaction of the octanoyl glycine and sodium polyacryl dimethyl taurate (and) PEG-7 glycerol cocoate reduces skin grease secretion and redundant grease can be placed in a hollow structure, so that fresh and breathable skin feel experience and good mild oil control acne removal effect are achieved, the problem that most similar oil control acne removal products are poor in skin feel is solved, and good experience of consumers is greatly improved.
2. According to the application, based on octanoylglycine, TEA acrylate/acryloyldimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80 and sodium polyacryloyl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerin cocoate, fructo-oligosaccharide, purslane extract and hydroxyethyl urea are further added, and the six substances are mutually matched to realize synergistic effect, so that the unexpected technical effect of promoting the generation of beta-endorphin and the technical effect of further promoting the inhibition of 5 alpha-reductase by octanoylglycine are achieved, the addition of hydroxyethyl urea further adjusts the use skin feel of the oil-control acne-removing composition with high octanoylglycine content, and the fresh and breathable use skin feel of the oil-control acne-removing composition with high octanoylglycine content is further optimized.
Drawings
Fig. 1 is a graph showing the effects of D0, D3, and D7 of the oil-control acne-removing emulsion of application example 5 on one subject in experiment 5.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Examples 1 to 5
A composition with high content of octanoylglycine for controlling oil and removing acne comprises octanoylglycine, TEA acrylate/TEA acrylate copolymer of acryloyldimethyl taurate, isohexadecane polysorbate-80, sodium polyacryl dimethyl taurate, and PEG-7 glycerol cocoate, and fructo-oligosaccharide, herba Portulacae extract, and hydroxyethyl urea.
Wherein the amounts of the components of examples 1-5 are shown in Table 1.
Table 1:
table of the amounts of the components of the oil-controlling and acne-removing compositions with high octanoylglycine content of examples 1 to 5
Wherein, partial material sources are shown in Table 2.
Table 2:
source of material
The preparation method of the oil-control acne-removing composition with high content of octanoylglycine in examples 1-5 comprises the following steps: accurately weighing octanoylglycine, TEA acrylate/TEA acrylate copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryl dimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate, heating to 85 ℃, stirring until the mixture is completely dissolved, cooling to 45 ℃, adding fructo-oligosaccharide, purslane extract and hydroxyethyl urea, and stirring for 3min at 220r/min to obtain the high-content octanoylglycine oil-control acne-removing composition.
Example 6
A high-content octanoylglycine oil control acne-removing composition is different from example 5 in that fructo-oligosaccharide, purslane extract and hydroxyethyl urea are not added.
Example 7
Unlike example 5, the high-content octanoylglycine oil control acne removal composition was free of fructooligosaccharides.
Example 8
Unlike example 5, the high content octanoylglycine oil control acne treatment composition was free of purslane extract.
Example 9
Unlike example 5, there was no hydroxyethylurea added to the oil-control anti-acne composition having a high octanoylglycine content.
Comparative example 1
An oil-controlling acne-removing composition is different from example 6 in that octanoylglycine is replaced with azelaic acid in an equal amount.
Wherein azelaic acid is commercially available.
Comparative example 2
An oil-controlling acne-removing composition, unlike example 6, does not contain caprylylglycine.
Comparative example 3
A high content octanoylglycine oil control anti-acne composition, unlike example 6, does not contain TEA acrylate/TEA acrylate copolymer (and) isohexadecane (and) polysorbate-80.
Comparative example 4
Unlike example 6, the high content octanoylglycine oil control anti-acne composition does not contain sodium polyacryl dimethyltaurate (and isohexadecane (and) PEG-7 glycerol cocoate.
Comparative example 5
An oil-controlling acne-removing composition, unlike example 6, contains only caprylyl glycine.
Application example 1
An oil-control acne-removing emulsion comprises 52.05kg of water, 22.5kg of oil-control acne-removing composition, 12kg of thickener, 6kg of softener, 0.05kg of disodium ethylenediamine tetraacetate, 2.7kg of sodium hydroxide and 1kg of zinc sulfate.
Wherein the thickener is composed of 4kg of sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80, 1kg of polyacrylate cross-linked polymer-6, 2kg of cetostearyl alcohol, 5kg of cetylstearyl alcohol (and) cetylstearyl glucoside.
Wherein the emollient is composed of 1kg of glyceryl stearate, 3kg of caprylic/capric triglyceride and 2kg of polydimethylsiloxane.
Among them, sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 are purchased from the Guangzhou Baifu wetting chemical company, trade name:SAE G10 fresh-type emulsion thickener.
The oil control and acne removal composition is the high-content octanoylglycine oil control and acne removal composition prepared in example 1.
The preparation method of the oil-control acne-removing emulsion comprises the following steps of:
step 1: weighing thickener and emollient, heating to 85deg.C for dissolving; homogenizing at 2200r/min, and pouring disodium edetate, sodium hydroxide and zinc sulfate while homogenizing, and homogenizing for 3min.
Step 2: and (3) cooling the product obtained in the step (1) to 50 ℃, adding the oil-control acne-removing composition, and homogenizing for 3min at 2200r/min until the material is uniform, thus obtaining the oil-control acne-removing emulsion.
Application example 2
An oil-control acne-removing emulsion, which is different from application example 1, comprises 37.55kg of water, 37kg of oil-control acne-removing composition, 12kg of thickener, 6kg of softener, 0.05kg of disodium ethylenediamine tetraacetate, 2.7kg of sodium hydroxide and 1kg of zinc sulfate.
Application example 3
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 2.
Application example 4
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 3.
Application example 5
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 4.
Application example 6
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 5.
Application example 7
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 6.
Application example 8
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 7.
Application example 9
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 8.
Application example 10
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in example 9.
Comparative application example 1
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the oil-control acne-removing composition prepared in comparative example 1.
Comparative application example 2
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the oil-control acne-removing composition prepared in comparative example 2.
Comparative application example 3
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in comparative example 3.
Comparative application example 4
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in comparative example 4.
Comparative application example 5
The oil-control acne-removing emulsion is different from application example 1 in that the oil-control acne-removing composition is the high-content octanoylglycine oil-control acne-removing composition prepared in comparative example 5.
Experiment
Experiment 1
5 alpha-reductase inhibition assay
Experimental group sample fluid: the oil control acne removal composition and PBS buffer solution of each example and comparative example are shown in the specification with the weight ratio of 1:100 volume ratio.
The experimental method comprises the following steps:
the experiments are divided into a blank control group and a positive control combined experiment group, wherein the blank control group is formed by adding 1mL of a buffer solution of LPBS, 1mL of an enzyme solution, 1mL of an ADPH solution of Testosterone solution into a sample tube, the positive control group is formed by adding 1mL of a finasteride solution (the concentration of the finasteride solution is 2.5 mmol/L), 1mL of the enzyme solution, 1mL of the ADPH solution of Testosterone solution, and the experiment group is formed by adding 1mL of the sample solution, 1mL of the enzyme solution, 1mL of the ADPH solution of Testosterone solution into the sample tube. After the experimental samples are prepared in the sample tube, the sample tube is gently shaken to mix the experimental samples, 200 mu L of the sample tube is taken by a liquid-transfering gun and is placed in a 96-hole ELISA plate, 3 parallel experimental samples are made, the sample tube is placed in an ELISA instrument for detection, and the absorbance at 340nm is measured to obtain a measured value A 1 Blank control is additionally designated as A 1 enzyme . The experimental sample is put into a 37 ℃ for incubation for 20 minutes, then is put into an enzyme-labeled instrument for detection, and the absorbance at 340nm is measured to be the measured value A 2 Blank control is additionally designated as A 2 enzyme . The 5 a-reductase inhibition ratio was calculated according to the following formula, inhibition ratio (%) = [1- (a) 1 -A 2 )/(A 1 enzyme -A 2 enzyme )]*100%, the experimental results are recorded in Table 3.
Table 3:
results of 5 alpha-reductase inhibition experiments
It is apparent from the combination of examples 1 to 9, comparative examples 1 to 5 and Table 3 that examples 1 to 9 have excellent effects of inhibiting 5α -reductase.
In combination with example 6 and comparative examples 2-5 and Table 3, it is apparent that the synergistic interaction of caprylylglycine, TEA acrylate/TEA acryloyldimethyltaurate copolymer (and) isohexadecane (and) polysorbate-80, sodium polyacryloyldimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate can significantly improve the technical effect of caprylylglycine in inhibiting 5 alpha-reductase activity, thereby achieving better oil control effect.
Experiment 2
Test for the detection of the effect of promoting the production of beta-endorphin in keratinocytes
Experimental group samples: the oil control and acne removal compositions of the above examples and comparative examples.
The experimental method comprises the following steps:
at 37℃with 5% CO 2 Under the cell culture conditions of (2) normal human epidermal cells, keratinocytes (Gibco) were cultured to the point of fusion on 6-well cell culture plates, and then experimental treatments were performed, respectively. Wherein the experimental group is keratinocyte culture medium containing 0.01% of mass concentration of the experimental group sample; the blank is untreated keratinocyte medium; 3 replicates were run for each group. The treated keratinocyte medium was incubated at 37℃with 5% CO 2 After 6h of culture under the cell culture conditions of (2) and centrifuging at 4000rpm for 10min, collecting supernatant, detecting the content of beta-endorphin by using a human beta-endorphin (beta-EP) detection kit (Shanghai Yu Biotechnology Co., ltd.), and recording the content of B as the experimental group 1 Blank control is also designated B 2 The relative rate of increase (%) in the amount of beta-endorphin produced was calculated according to the following formula, and the relative rate of increase (%) = [ (B) 1 -B 2 )/B 2 ]*100%, record experiment knotThe results are shown in Table 4.
Table 4:
experimental results for promoting the production of beta-endorphin in keratinocytes
| Group of | Relative increase in beta-endorphin production (%) |
| Example 1 | 31.65 |
| Example 2 | 31.57 |
| Example 3 | 31.72 |
| Example 4 | 31.43 |
| Example 5 | 31.86 |
| Example 6 | 7.27 |
| Example 7 | 8.38 |
| Example 8 | 9.26 |
| Example 9 | 9.14 |
| Comparative example 1 | 10.12 |
| Comparative example 2 | 0.23 |
| Comparative example 3 | 7.18 |
| Comparative example 4 | 7.23 |
| Comparative example 5 | 7.06 |
In combination with examples 1 to 9, comparative examples 1 to 5 and Table 4, it is apparent that examples 1 to 5 have a good technical effect of promoting the production of beta-endorphin in keratinocytes.
In combination with examples 5 and examples 6-9 and Table 4, it is readily apparent that the unexpected technical effect of promoting the production of beta-endorphin in keratinocytes by the high content of caprylylglycine oil control acne removing composition can be achieved by further adding fructo-oligosaccharide, purslane extract, and hydroxyethyl urea on the basis of caprylylglycine, TEA acrylate/TEA acrylate copolymer (and isocetyl (and) polysorbate-80, sodium polyacryloyldimethyltaurate (and) isohexadecane (and) PEG-7 glycerol cocoate.
Experiment 3
Patch test
Test sample: the oil control and acne removal compositions of the above examples and comparative examples.
The subject: the skin-sensitive population between 18 and 60 years of age is not limited to men and women, and is randomly divided into 14 groups of 10 people each.
The test method comprises the following steps: the test pieces were placed in a closed patch test method by selecting an appropriate patch device, 0.025g of the test piece was placed in the patch test device, the test piece was removed after 24 hours by using a hypoallergenic tape for external use on the inner side of the forearm of various subjects, and skin reactions were observed within 0.5/24/48 hours after the removal, and the results were recorded in Table 6 according to the skin classification criteria (Table 5) in the cosmetic safety Specification (2015).
Table 5:
skin grading standard
Table 6:
patch test results
In combination with examples 1-9, comparative examples 1-5 and Table 6, it is readily apparent that examples 1-9, comparative examples 2-5 have good mildness and that comparative example 1 may have some irritation to the skin.
Experiment 4
Stability test
Test sample: the oil-control acne-removing emulsion of each application example and the comparative application example.
The test method comprises the following steps:
(1) Test samples were tested as per water 1:10 in volume ratio, and respectively measuring the pH at normal temperature after mixing and diluting.
(2) And (3) carrying out heat resistance, cold resistance and cold and heat cycle tests on the test sample, wherein the test conditions are as follows: a heat resistance test: and respectively preserving the heat for 3 months at 48+/-2 ℃, and performing physical and chemical tests after recovering the room temperature.
b cold resistance test: and respectively preserving the heat for 3 months at the temperature of minus 18 plus or minus 2 ℃, and carrying out physicochemical test after the room temperature is restored.
c cold and hot cycle test: respectively and sequentially preserving heat at 48 ℃ and normal temperature and-18 ℃ for 24 hours, circulating for three times according to the sequence, and performing physicochemical test after the room temperature is restored, wherein the test method is QB/T2660.
The results of the above test are shown in Table 7.
Table 7:
stability test results
In combination with application examples 1 to 10, comparative application examples 1 to 5 and Table 7, it is not easy to see that application examples 1 to 10, comparative application examples 1/2/5 have good stability, whereas comparative application example 3/4 has poor stability, and specific analysis considers that comparative application example 3 lacks the stability of the high-content octanoylglycine oil control acne composition due to the absence of the composition of acrylic acid TEA salt/acrylic acid dimethyltaurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, and comparative application example 4 lacks the stability of the high-content octanoylglycine oil control acne composition due to the absence of the sodium polyacryloyldimethyltaurate (and) isohexadecane (and) PEG-7 glycerol oleate, and thus applicant believes that the present application solves the problems of the high-content octanoylglycine oil control acne composition by the combination of the sodium polyacryldimethyltaurate (and) isohexadecane (and) and the TEA-7 glycerol oleate, the TEA salt/acrylic acid dimethyltaurate copolymer (and) isohexadecane (and) polysorbate-80, the high-content azelaine acid system is well relieved, and the defect of the system of the high-content octanoylglycine acid (and) is further overcome by the composition of the acid system of the acid which has good stability of the product of the acid system of the acid which has no more stable water control, the sodium polyacryl dimethyl taurate and the isohexadecane and PEG-7 glycerol cocoate are synergistic, so that the stability of the oil-control acne-removing composition with high content of octanoyl glycine can be well maintained.
Experiment 5
Efficacy evaluation
The detection basis is as follows: T/TDCA004-2021 cosmetic acne-removing efficacy test method.
Detecting a sample: the oil-control acne-removing emulsion of each application example and the comparative application example.
The subject: the detection method has the advantages that the detection method is used for detecting the acne and comprises the steps of (1) between the ages of 18 and 60 years, oiliness acne muscles, no other skin diseases which can influence the detection result, no other products with acne removing effects are taken or used during detection, no allergic phenomenon exists on the product for evaluating the efficacy, 150 people are randomly divided into 15 groups, and 10 people in each group.
The detection method comprises the following steps: the test sample is continuously used for 7 days by the subject, the test sample is used for 2 times a day, a proper amount of test sample is taken to cover the acne part after cleaning, and the test sample is massaged until the test sample is absorbed; the subjects were tested for the red area ratio, the number of porphyrins, of the faces (left/middle/right) before using the test product (D0), after using the test product for 3 days (D3), after using the test product for 7 days (D7), and the number of acne lesions (individual) were evaluated by the dermatologist, and the red area ratio improvement rate (%), the number of porphyrins reduction rate (%), and the number of acne lesions reduction rate (%) after using the product for 3 days (D3), after using the test product for 7 days (D7) were calculated as follows: the red area ratio improvement rate (%) = [ (red area ratio-D0 red area ratio after X days)/D0 red area ratio ]. Times.100%, porphyrin number reduction rate (%) = [ (porphyrin number-D0 porphyrin number after X days)/D0 porphyrin number ]. Times.100%, acne skin loss number reduction rate (%) = [ (acne skin loss number after X days-D0 acne skin loss number)/D0 acne skin loss number ]. Times.100%, and the detection results are shown in table 8, wherein the smaller the values of red area ratio, porphyrin number and acne skin loss number prove better skin effect.
Meanwhile, adverse reaction evaluation was performed by dermatologists 3 days after using the test product (D3) and 7 days after using the test product (D7), and the self-evaluation roll was filled in by the subject, and the detection results are shown in table 9.
Table 8:
testing the statistics of the number of red areas, purple matters and acne lesions of the face
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Table 9:
adverse reaction evaluation and questionnaire
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In Table 9, "none" means no adverse reaction.
In combination with the oil-control acne-removing emulsion of application examples 1-10 and comparative application examples 1-5 and tables 8 and 9, it is easy to see that application examples 1-10 have good effects of mildness, safety, oil control, acne removal and skin relief, and application examples 7-10 have good effects of mildness, safety and oil control, acne removal.
It is apparent from the analysis of the combination of application example 7 and comparative application examples 1 to 5 that application example 7 has good effects of mildly safe, oil-controlling and acne-removing and skin soothing, whereas comparative application example 1 is added with azelaic acid, and thus the skin improving effect of comparative application example 1 is slower than that of application example 7, and comparative application example 2 is not added with caprylylglycine, and the oil-controlling and acne-removing effect of comparative application example 2 is hardly felt, comparative application example 5 is added with caprylylglycine only than application example 7, comparative application example 3 is not added with TEA salt of acrylic acid/TEA salt of acryloyldimethyl taurate copolymer (and) isocetyl (and) polysorbate-80, comparative application example 4 is not added with sodium (and) isohexadecyl dimethyl taurate (and) PEG-7 glycerol cocoate, and the oil-controlling effect of comparative application examples 3 to 5 is not as good as that of application example 7, the applicant has the specific analysis of that the oil-controlling and acne-removing effects of caprylylglycine (and isopropyl taurate) can be achieved only by the co-controlling effect of caprylylglycine (and isopropyl taurate) and isopropyl taurate (and isopropyl taurate) sodium (and isopropyl taurate) are not expected to achieve the synergistic effect of the effects of the poly (and isopropyl taurate) sodium (and isopropyl taurate) sulfonate), meanwhile, the high-content octanoylglycine oil control and acne removal composition breaks through the situation that part of products on the market are conceptually added with oil control and acne removal components, the octanoylglycine is used as a main component, and acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer (and isohexadecane (and) polysorbate-80 and sodium polyacryl dimethyl taurine (and isohexadecane (and) PEG-7 glycerol cocoate are used as auxiliary materials, so that the oil control and acne removal composition has a practical and effective oil control and acne removal effect.
It is apparent from the analysis of application example 6 and application examples 7 to 10 that application example 6 has better skin soothing effect by adding fructo-oligosaccharide, purslane extract and hydroxyethyl urea, and the applicant specifically analyzes that the application example 6 further adds fructo-oligosaccharide, purslane extract and hydroxyethyl urea on the basis of caprylylglycine, acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer (and isohexadecane (and) polysorbate-80, sodium polyacyl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate, thereby having better technical effect of promoting the generation of beta-endorphin and further promoting the inhibition of 5 alpha-reductase by caprylylglycine, and further achieving better effects of mildness, safety, fresh air permeability, oil control, acne removal and skin soothing.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (9)
1. The high-content octanoyl glycine oil control acne removal composition is characterized by comprising the following components in parts by mass:
45-58 parts of octanoylglycine, 8-11 parts of acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 2.25-6 parts of sodium polyacryl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerol cocoate.
2. The high-content octanoyl glycine oil control acne removal composition according to claim 1, wherein the high-content octanoyl glycine oil control acne removal composition comprises the following components in parts by mass:
48-52 parts of octanoylglycine, 10-11 parts of acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 5-6 parts of poly (acryl dimethyl taurine) sodium (and) isohexadecane (and) PEG-7 glycerol cocoate.
3. The high-content octanoyl glycine oil control acne removal composition according to claim 1, wherein the high-content octanoyl glycine oil control acne removal composition comprises the following components in parts by mass:
50 parts of octanoylglycine, 10 parts of acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 5 parts of sodium polyacryloyl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate.
4. The high-content octanoylglycine oil control acne removal composition according to claim 1, further comprising the following components in parts by mass:
8-11 parts of fructo-oligosaccharide, 2-6 parts of purslane extract and 17-22 parts of hydroxyethyl urea.
5. The high-content octanoylglycine oil control acne removal composition according to claim 4, further comprising the following components in parts by mass:
10-11 parts of fructo-oligosaccharide, 2-3 parts of purslane extract and 19-21 parts of hydroxyethyl urea.
6. The high-content octanoylglycine oil control acne removal composition according to claim 5, wherein the high-content octanoylglycine oil control acne removal composition comprises the following components in parts by mass:
50 parts of octanoylglycine, 10 parts of acrylic acid TEA salt/acryloyldimethyl taurate TEA salt copolymer (and) isohexadecane (and) polysorbate-80, 5 parts of sodium polyacryloyl dimethyl taurate (and) isohexadecane (and) PEG-7 glycerol cocoate, 10 parts of fructo-oligosaccharide, 2.95 parts of purslane extract and 20 parts of hydroxyethyl urea.
7. A preparation method of the high-content octanoyl glycine oil control acne removal composition according to claim 1-3, which is characterized in that the octanoyl glycine, the acrylic acid TEA salt/acrylic acid dimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, poly (sodium acryl dimethyl taurine) (and) isohexadecane (and) PEG-7 glycerol cocoate are accurately weighed, heated to 80-85 ℃, stirred until the mixture is completely dissolved, and cooled to normal temperature, so that the high-content octanoyl glycine oil control acne removal composition is obtained.
8. The method for preparing the high-content octanoyl glycine oil control acne removal composition according to claim 4-6, wherein the octanoyl glycine, the acrylic acid TEA salt/acryloyldimethyl taurine TEA salt copolymer (and) isohexadecane (and) polysorbate-80, the sodium polyacryl dimethyl taurine (and) isohexadecane (and) PEG-7 glycerol cocoate are accurately weighed, then heated to 80-85 ℃, stirred until the mixture is completely dissolved, cooled to 40-45 ℃, added with fructo-oligosaccharide, purslane extract and hydroxyethyl urea, and stirred for 3-5 min at 200-220 r/min, so that the high-content octanoyl glycine oil control acne removal composition is obtained.
9. Use of the high-content octanoyl glycine oil control and acne removal composition according to any one of claims 1 to 6 in cosmetics, wherein the high-content octanoyl glycine oil control and acne removal composition is added into cosmetics.
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012119860A1 (en) * | 2011-03-09 | 2012-09-13 | L'oreal | Cosmetic composition containing a dibenzoylmethane derivative and a monoester-monoamide compound of methylsuccinic acid; process for photostabilizing a dibenzoylmethane derivative |
| WO2013102248A2 (en) * | 2012-01-06 | 2013-07-11 | . Johnson & Johnson Do Brasil Industria E Comercio De Produtos Para Saude Ltda. | "aqueous cosmetic sunscreen composition and use thereof, cosmetic method for application of said composition, cosmetic method to prevent and control skin oiliness, cosmetic method to protect the skin from the damages caused by ultraviolet radiation, and cosmetic product." |
| CN105012479A (en) * | 2015-07-22 | 2015-11-04 | 广州科玛生物科技有限公司 | Acne treatment composition and application thereof and acne treatment cream containing acne treatment composition |
| US20170096418A1 (en) * | 2015-10-01 | 2017-04-06 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
| CN107982167A (en) * | 2017-12-06 | 2018-05-04 | 绿馨颜（惠州）生物科技有限公司 | Clearly not de- adornment element face is white for a kind of low oil content |
| CN115089499A (en) * | 2022-05-20 | 2022-09-23 | 广州耀悦生物科技有限公司 | Mud film with space cage type structure and preparation method |
| CN115300447A (en) * | 2022-08-01 | 2022-11-08 | 广州市妆妍生物技术有限公司 | A skin care composition for late use facial skin and its preparation method |
| CN115381736A (en) * | 2022-09-28 | 2022-11-25 | 广州百孚润化工有限公司 | Eye cream composition and preparation method thereof |
| CN115887289A (en) * | 2022-10-27 | 2023-04-04 | 广州百孚润化工有限公司 | Moisturizing composition, cosmetic containing moisturizing composition and preparation method of cosmetic |
| CN117323258A (en) * | 2023-12-01 | 2024-01-02 | 广州百孚润化工有限公司 | Bubble mask and preparation method thereof |
-
2023
- 2023-10-09 CN CN202311297904.0A patent/CN117243834B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012119860A1 (en) * | 2011-03-09 | 2012-09-13 | L'oreal | Cosmetic composition containing a dibenzoylmethane derivative and a monoester-monoamide compound of methylsuccinic acid; process for photostabilizing a dibenzoylmethane derivative |
| WO2013102248A2 (en) * | 2012-01-06 | 2013-07-11 | . Johnson & Johnson Do Brasil Industria E Comercio De Produtos Para Saude Ltda. | "aqueous cosmetic sunscreen composition and use thereof, cosmetic method for application of said composition, cosmetic method to prevent and control skin oiliness, cosmetic method to protect the skin from the damages caused by ultraviolet radiation, and cosmetic product." |
| CN105012479A (en) * | 2015-07-22 | 2015-11-04 | 广州科玛生物科技有限公司 | Acne treatment composition and application thereof and acne treatment cream containing acne treatment composition |
| US20170096418A1 (en) * | 2015-10-01 | 2017-04-06 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
| CN107982167A (en) * | 2017-12-06 | 2018-05-04 | 绿馨颜（惠州）生物科技有限公司 | Clearly not de- adornment element face is white for a kind of low oil content |
| CN115089499A (en) * | 2022-05-20 | 2022-09-23 | 广州耀悦生物科技有限公司 | Mud film with space cage type structure and preparation method |
| CN115300447A (en) * | 2022-08-01 | 2022-11-08 | 广州市妆妍生物技术有限公司 | A skin care composition for late use facial skin and its preparation method |
| CN115381736A (en) * | 2022-09-28 | 2022-11-25 | 广州百孚润化工有限公司 | Eye cream composition and preparation method thereof |
| CN115887289A (en) * | 2022-10-27 | 2023-04-04 | 广州百孚润化工有限公司 | Moisturizing composition, cosmetic containing moisturizing composition and preparation method of cosmetic |
| CN117323258A (en) * | 2023-12-01 | 2024-01-02 | 广州百孚润化工有限公司 | Bubble mask and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 毛倩敏;何如霞;陈爱珍;吴迪;何聪芬;: "大学生面部痤疮问题的解决与效果评价", 日用化学品科学, no. 02, 25 February 2016 (2016-02-25) * |
| 马振友等: "皮肤美容化妆品制剂手册 第2版", 31 January 2015, 中医古籍出版社, pages: 698 - 699 * |
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