CN115778881A - Soothing, moisturizing and refreshing skin care composition, preparation method and application - Google Patents

Abstract

The invention discloses a soothing, moisturizing and refreshing skin care composition, a preparation method and application thereof. When the hydrolyzed Adansonia dubia extract, the algae oligosaccharide and the phloretin are compounded, various skin damage factors can be considered, the skin barrier can be repaired and the microecology of the skin can be balanced at the same time, and the problem that the skin is damaged and difficult to repair is effectively solved. In addition, in more than one embodiment of the invention, through the compound use of the three components, the oil control effect on the skin can be intuitively realized, the skin moisture maintenance is promoted, and the moisture loss is prevented. By applying the three components to the damaged skin simultaneously, the skin problems of skin redness, itching, dryness and desquamation can be remarkably improved.

Description

Soothing, moisturizing and refreshing skin care composition, preparation method and application

Technical Field

The invention relates to the technical field of skin care products, in particular to a soothing, moisturizing and refreshing skin care composition, a preparation method and application thereof.

Background

The skin of a human body has multiple barrier protection mechanisms which are cooperated to protect the skin health of the human body. Firstly, the hair barrier, which is the first protective barrier on the skin, is resistant to external stimuli, in particular to pollutants and ultraviolet radiation; secondly, a microbial barrier formed by skin ecological flora is a second layer of natural protective barrier on the skin, and needs to be maintained, strengthened and restored to avoid the skin from being invaded by harmful bacteria; and a third layer of barrier is formed by taking the horny layer as a physical barrier of a main composition structure, and the third layer of barrier has the function similar to that of a brick wall concrete structure, corresponds to the cells and lipid of the horny layer, protects the inner layer and the outer layer of the skin and prevents the invasion of harmful molecules. Finally, the biological barrier formed by the epidermis and the dermis is the fourth barrier, which is composed of the epidermis layer and the dermis layer, between which cells are in constant communication, and the barrier is an area for restoring the homeostasis of the skin, and promotes the comfortable and balanced state of the skin by reconstructing or reinforcing weak or damaged tissues.

Wherein, for the third barrier skin barrier, the stratum corneum is composed of 20 layers of flat, interwoven keratinocytes; the corneocytes are as tough as "brick", and have lipid as "mortar" to connect them tightly to form "brick wall structure", and the surface of the horny layer has a protective film composed of sweat and sebum, which together with the horny layer forms a barrier to the skin. The protective barrier can lock skin moisture and grease, resist the invasion of various skin surface germs and play an important role in protecting human health. For the second layer of protective barrier, the microecology has competition and restriction relation, and the skin microecology exists on the skin of the body, limbs, face, scalp and the like, and the microecology system of the skin keeps the stability of the skin environment in balance; healthy skin surfaces, the micro-ecology, is generally maintained relatively stable and balanced. At the same time, the micro-ecological changes of the skin interact with various inflammatory reactions on the skin. For example, beneficial flora in the micro-ecology can exert antibiotic action, and through closely interacting with immune cells of human body, immune response can be promoted, and harmful microbial infection can be prevented.

When the skin protective barrier is damaged, particularly when the skin barrier is damaged, the skin is easily corroded by bacteria, viruses and fungi, and a large amount of moisture in the skin is evaporated, so that various problems occur to the skin. It is noteworthy that, in regard to the micro-ecology in the second protective barrier, the other protective barriers including the skin barrier are also damaged, which directly results in the alteration of the microbial composition, causing micro-ecological imbalance. Impaired skin barrier and immune response disorders are associated with increased susceptibility to microbial colonization of the skin, e.g., lipid-rich hair follicle invaginations provide aerobic and anaerobic niches for various microbial communities, making the skin a large ecosystem supporting the symbiotic relationship between hosts and microbes, and when the skin is impaired, this results in significant changes in microbial composition, reduction of beneficial microbes, associated reduction in immune responses, and increased proliferation of harmful microbes. Therefore, the health status of the skin can be maintained based on multiple mechanisms such as skin barrier, skin micro-ecology and immune cell immune response mediated by each.

However, most of the prior art only has one-sided repair of the cuticle, and lacks protection on immune cells, so that the damaged symptoms (redness, pruritus and the like) cannot be radically improved; or barrier repair is not comprehensive, only the stratum corneum is repaired, the influence of the microecological and immune barriers on the skin is neglected, and the recovery of the skin is difficult to improve.

Therefore, there is a need in the art for a substance or related skin care product that can address many aspects of skin damage to effectively solve the problem of skin damage.

Disclosure of Invention

The invention aims to overcome at least one defect of the prior art and provides a soothing, moisturizing and refreshing skin care composition, a preparation method and application thereof.

The invention aims to provide application of a compound of a hydrolyzed Adansonia dubia extract, algae oligosaccharides and phloretin in preparation of products for balancing skin micro-ecology, repairing skin barriers, regulating skin oil secretion, inhibiting skin water loss and/or relieving skin redness, pruritus and desquamation. Skin care products on the market rarely combine and apply skin barrier repair and skin microecology balance care, and skin problems such as skin redness, itching, dryness, desquamation and the like are often difficult or cannot be effectively solved compared with a single care scheme. The technical scheme of complex use of the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin is creatively provided, and the discovery shows that when the three components are used in a complex way, various skin damage factors can be considered, the skin barrier can be repaired and the skin microecology can be balanced, and the problem that the skin is damaged and difficult to repair can be effectively solved. In addition, in more than one embodiment of the invention, through the compound use of the three components, the oil control effect on the skin can be intuitively realized, the skin moisture maintenance is promoted, and the moisture loss is prevented. By applying the three components to the damaged skin simultaneously, the skin problems of skin redness, itching, dryness and desquamation can be remarkably improved.

Further, the hydrolyzed Adansonia digitata extract, the algae oligosaccharide and the phloretin are compounded to be used for preparing products for balancing skin micro-ecology, repairing skin barriers, regulating skin grease secretion, inhibiting skin water loss and relieving skin redness, pruritus and desquamation.

Further, the skin comprises tissue covering a surface of a human or animal body.

Further, the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin are compounded to be used for preparing a product which can balance the skin micro-ecology and repair the skin barrier.

Further, the products include pharmaceutical preparations and daily chemical products.

Further, the pharmaceutical preparation is an external preparation, and the preparation dosage form is selected from cream, patch, ointment, cream preparation, gel and spray.

Further, the pharmaceutical formulation comprises a physiologically acceptable carrier.

Further, the product includes a cream, a lotion, a shampoo and/or a serum. In more than one embodiment of the invention, the face cream, the skin lotion, the shampoo and the essence water are prepared on the basis of the three components of the hydrolyzed mazopus commune extract, the algae oligosaccharide and the phloretin, so that the synergistic effect of the components of the hydrolyzed mazopus commune extract, the algae oligosaccharide and the phloretin is maintained, the characteristics of the corresponding application part are conveniently adapted, the safety is high, and the irritation is small.

Further, balancing skin micro-ecology includes regulating the relative abundance of propionibacteria, acinetobacter, corynebacterium, staphylococcus, bacteroides, prevotella, weissella, bifidobacterium, lactobacillus, and/or waterborne bacteria populations on the skin. In one or more embodiments of the present invention, at least the Propionibacterium, acinetobacter, corynebacterium, staphylococcus, bacteroides, prevotella, weissella, bifidobacterium, lactobacillus, and Aquifex flora are modulated by the modulation of the three aforementioned compositions to promote the restoration of such primary microorganisms to abundance levels similar to healthy skin.

Further, the skin includes facial skin and scalp. In more than one embodiment of the invention, the damage of the facial skin and the scalp can be obviously improved by combining the three components or the skin care product containing the three compositions.

The invention also aims to provide a composition which comprises the hydrolyzed Adansonia simplicifolia extract, the algae oligosaccharide and the phloretin, wherein the weight percentage of the hydrolyzed Adansonia simplicifolia extract, the algae oligosaccharide and the phloretin in the composition is 0.3 to 1.5 percent; further, the paint also comprises a solvent. In more than one embodiment of the invention, when the weight percentage of the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin in the composition is 0.3 to 1.5%, the safety can be guaranteed, the synergistic effect among the components can be provided, and the skin barrier and the microecology can be repaired.

Further, the composition comprises the following components in percentage by weight:

0.1 to 0.5 percent of hydrolyzed macaque extract;

algal oligosaccharides 0.1 to 0.5%;

phloretin 0.1 to 0.5 percent;

supplementing water to 100%.

Further, the composition comprises the following components in percentage by weight:

0.2% of hydrolyzed Adansonia dubia extract;

0.2% of algal oligosaccharides;

0.2% of phloretin;

supplementing water to 100%.

Further, in the above and the following, the water is deionized water.

Further, a method for preparing the composition is provided, which comprises the steps of:

s1, heating water to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 40-45 ℃, and respectively adding the hydrolyzed Paeonia suffruticosa extract, the algal oligosaccharides and the phloretin;

and S3, reducing the temperature to 37-39 ℃, and discharging after the inspection is qualified.

Further, the temperature is decreased to 38 ℃ in step S3.

The invention also aims to provide a face cream which comprises the following components in percentage by weight:

phase A:

supplementing water to 100%

3 to 5 percent of glycerin

EDTA-2Na 0.01~0.03%

0.05 to 0.12 percent of hydroxyethyl cellulose

Carbomer 0.10 to 0.4 percent

Sodium hyaluronate 0.01 to 0.03%

Panthenol 0.4 to 0.6%

Phase B:

sucrose stearate, cetearyl glucoside, cetyl alcohol 1 to 3%

Glyceryl stearate and PEG-100 stearate 1-2%

Cetostearyl alcohol 3 to 4%

1 to 3 percent of polydimethylsiloxane

1 to 3 percent of hydrogenated polyisobutene

0.08 to 0.12 percent of squalane

Tocopherol acetate 0.4 to 0.6%

Caprylic/capric triglyceride 5 to 7%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

Phase D:

arginine 0.5 to 0.6 percent

Phase E

1 to 3 percent of butanediol

0.4 to 0.6 percent of p-hydroxyacetophenone

0.4 to 0.6 percent of 1, 2-hexanediol

Phase F

0.5 to 0.7% of the above composition.

Further, the sucrose stearate, the cetearyl glucoside and the cetyl alcohol are emulsifying agents compounded by mixing the three components, wherein the ratio of the sucrose stearate to the cetearyl glucoside to the cetyl alcohol is 12.5: 35: 52.5. The glyceryl stearate and the PEG-100 stearate are mixed and compounded, and the ratio of the glyceryl stearate to the PEG-100 stearate is 62.5: 37.5. The skin-feel modifier is compounded by mixing four components of polyacrylamide, C13-14 isoparaffin, laureth-7 and water, and at least has the function of a skin-feel modifier, wherein the ratio of the polyacrylamide to the C13-14 isoparaffin to the laureth-7 to the water is 40: 24: 6: 30.

Further, the paint comprises the following components in percentage by weight:

phase A:

supplementing water to 100%

4 percent of glycerin

EDTA-2Na 0.02%

0.1 percent of hydroxyethyl cellulose

0.2 percent of carbomer

Sodium hyaluronate 0.02%

Panthenol 0.5%

Phase B:

sucrose stearate, cetearyl glucoside, cetyl alcohol 2%

Glyceryl stearate, PEG-100 stearate 1.5%

Cetostearyl alcohol 3.5%

2% of polydimethylsiloxane

Hydrogenated polyisobutene 2%

0.1 percent of squalane

Tocopherol acetate 0.5%

Caprylic/capric triglyceride 6.5%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.8%

Phase D:

arginine 0.54%

Phase E

2 percent of butanediol

0.5 percent of p-hydroxyacetophenone

1, 2-hexanediol 0.5%

Phase F

0.6% of the above composition.

Further, the preparation method of the face cream comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, preserving heat for 15-20 minutes, and homogenizing until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A into the phase B, emulsifying and homogenizing for 5-8 minutes, and stirring and defoaming in vacuum;

s3, adding the phase C, homogenizing for 3-5 minutes, and stirring and cooling;

s4, cooling to 69-71 ℃, adding the dissolved phase D, and uniformly stirring;

s5, cooling to 59-61 ℃, adding the dissolved E phase, and uniformly stirring;

s6, cooling to 40-45 ℃, sequentially adding the F-phase materials, and uniformly stirring;

s7, reducing the temperature to 37-39 ℃, and discharging after the inspection is qualified.

Further, the rotation speed for homogenization in step S1 is 3000 rpm.

Further, the temperature is reduced to 70 ℃ in the step S4; s5, reducing the temperature to 60 ℃; step S7 the temperature is reduced to 38 ℃.

The invention also aims to provide the skin lotion which comprises the following components in percentage by weight:

phase A

Water is added to 100 percent

9 to 11 percent of glycerin

EDTA-2Na 0.01~0.03%

0.05 to 0.12 percent of hydroxyethyl cellulose

Carbomer 0.05 to 0.15 percent

Sodium hyaluronate 0.01 to 0.03%

Panthenol 0.4 to 0.6%

Phase B

Cetearyl alcohol, coco glucoside, water, glucose 0.5 to 1.5%

0.8 to 1.3 percent of glycerol stearate and PEG-100 stearate

Cetostearyl alcohol 2 to 3%

1 to 2 percent of polydimethylsiloxane

Hydrogenated polyisobutene 0.5 to 1.5%

0.2 to 0.4 percent of squalane

Tocopherol acetate 0.3 to 0.6 percent

Caprylic/capric triglycerides 5 to 7%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

Phase D

Arginine 0.03 to 0.06 percent

Phase E

1 to 3 percent of butanediol

0.4 to 0.6 percent of p-hydroxyacetophenone

0.4 to 0.6 percent of 1, 2-hexanediol

Phase F

0.5 to 0.7% of the above composition.

The composition is prepared by mixing and compounding four components of cetearyl alcohol, coco-glucoside, water and glucose, wherein the ratio of the cetearyl alcohol to the coco-glucoside to the water to the glucose is 64.5: 35: 0.3: 0.2. The glyceryl stearate and the PEG-100 stearate are mixed and compounded, wherein the ratio of the glyceryl stearate to the PEG-100 stearate is 62.5: 37.5. The skin-feel conditioning agent is prepared by mixing and compounding four components, namely polyacrylamide, C13-14 isoparaffin, laureth-7 and water, and at least has the function of a skin-feel conditioning agent, wherein the ratio of the polyacrylamide to the C13-14 isoparaffin to the laureth-7 to the water is 40: 24: 6: 30.

Further, the skin lotion comprises the following components in percentage by weight:

phase A

Water is added to 100 percent

Glycerol 10%

EDTA-2Na 0.02%

Hydroxyethyl cellulose 0.1%

Carbomer 0.1%

0.02 percent of sodium hyaluronate

Panthenol 0.5%

Phase B

Cetearyl alcohol, coco glucoside, water, glucose 1%

Glyceryl stearate, PEG-100 stearate 1%

Cetostearyl alcohol 2.5%

1.5 percent of polydimethylsiloxane

Hydrogenated polyisobutene 1%

0.3 percent of squalane

Tocopherol acetate 0.5%

Caprylic/capric triglyceride 6.5%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.8%

Phase D

Arginine 0.04%

Phase E

2 percent of butanediol

0.5 percent of p-hydroxyacetophenone

0.5 percent of 1, 2-hexanediol

Phase F

0.6% of the above composition.

Further, the preparation method of the skin lotion comprises the following steps:

s1, adding the phase A into a pot, heating to 80-85 ℃, stirring, keeping the temperature for 15-20 minutes, and homogenizing until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A into the mixture, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum for defoaming;

s3, adding the phase C, homogenizing for 3-5 minutes, and stirring and cooling;

s4, cooling to 69-71 ℃, adding the dissolved phase D, and uniformly stirring;

s5, cooling to 59-61 ℃, adding the dissolved E phase, and uniformly stirring;

s6, cooling to 40-45 ℃, sequentially adding the F-phase materials, and uniformly stirring;

s7, reducing the temperature to 37-39 ℃, and discharging after the inspection is qualified.

Further, the rotation speed for homogenization in step S1 is 3000 rpm.

Further, the temperature is reduced to 70 ℃ in the step S4; s5, reducing the temperature to 60 ℃; step S7 the temperature is reduced to 38 ℃.

The invention also aims to provide a shampoo, which comprises the following components in percentage by weight:

phase A

Supplementing water to 100%

Acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.2 to 0.4%

Ammonium laureth sulfate 6 to 8%

Ethylene glycol distearate 1 to 1.2%

PEG-150 distearate 0.3 to 0.6 percent

Cetostearyl alcohol 0.2 to 0.4%

0.05 to 0.15 percent of EDTA disodium

Trehalose 0.008 to 0.012%

Phase B

1 to 2 percent of cocoyl amphodiacetate

1 to 1.8 percent of cocamidopropyl betaine

PEG-80 sorbitan laurate 1 to 2 percent

Dimethiconol, dodecyl benzene sulfonic acid TEA salt and water 1-3%

Decyl glucoside 0.4 to 0.5%

Panthenol 0.05 to 0.12 percent

Phase C

0.5 to 0.7 percent of phenoxyethanol

Sodium benzoate 0.2 to 0.4%

Phase D

0.5 to 0.7 percent of the composition

Phase E

0.05 to 0.15 percent of citric acid

0.35 to 0.45 percent of sodium chloride.

The composite material is prepared by mixing and compounding dimethiconol, dodecyl benzene sulfonate TEA salt and water, wherein the ratio of dimethiconol to dodecyl benzene sulfonate TEA salt to water is 60: 2: 38.

Further, the shampoo comprises the following components in percentage by weight:

phase A

Water is added to 100 percent

Acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.30%

Ammonium laureth sulfate 7%

Ethylene glycol distearate 1.1%

PEG-150 distearate 0.5%

Cetostearyl alcohol 0.3%

EDTA disodium 0.1%

Trehalose 0.01%

Phase B

Cocoitoyl amphodiacetate disodium 1.5%

1.5% of cocamidopropyl betaine

PEG-80 sorbitan laurate 1.5%

Dimethiconol, dodecyl benzene sulfonic acid TEA salt and water 2%

Decyl glucoside 0.45%

Panthenol 0.1%

Phase C

0.6 percent of phenoxyethanol

Sodium benzoate 0.3%

Phase D

0.6% of the above composition

Phase E

0.1 percent of citric acid

0.4 percent of sodium chloride.

Further, there is provided a method for preparing the shampoo, comprising the steps of:

s1, prefabricating a phase: dispersing sodium benzoate, citric acid and sodium chloride with partial water;

s2, dispersing acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer in a water phase pot, adding the residual raw material of the phase A, heating to 85-88 ℃, stirring for dissolving, and keeping the temperature for 20-30min;

s3, cooling to 69-71 ℃, adding the phase B, stirring until the phase B is dissolved, keeping the temperature for 10-15min, and continuously cooling;

s4, adding C-phase phenoxyethanol and sodium benzoate dispersed by part of water at 44-46 ℃, and uniformly stirring;

s5, adding the phase D, adjusting the pH value and the viscosity by adding the phase E, and performing inspection;

and S6, after the product is qualified, cooling to 37-39 ℃, and discharging through a 200-mesh filter cloth.

Further, in the step S3, the temperature is reduced to 70 ℃; in the step S4, adding C-phase phenoxyethanol and sodium benzoate dispersed by part of water at 45 ℃; and S6, cooling to 38 ℃.

The invention further aims to provide essence water which comprises the following components in percentage by weight:

phase A

Water is added to 100 percent

2 to 4 percent of glycerin

PEG-40 hydrogenated Castor oil 0.05 to 0.15%

Phase B

0.7 to 1 percent of phenoxyethanol

0.05 to 0.12 percent of ethylhexyl glycerin

Phase C

Allantoin 0.3 to 0.55 percent

Sodium hyaluronate 0.8 to 1.1%

Honeysuckle (Lonicera JAPONICA) flower extract 0.008 to 0.011%

0.1 to 0.3 percent of hydrolyzed Adansonia dubia extract

Algal oligosaccharides 0.1 to 0.3%

0.1 to 0.3 percent of phloretin.

Further, the essence water comprises the following components in percentage by weight:

phase A

Water is added to 100 percent

3 percent of glycerin

PEG-40 hydrogenated Castor oil 0.1%

Phase B

0.9 percent of phenoxyethanol

Ethyl hexyl glycerol 0.1%

Phase C

Allantoin 0.5%

1 percent of sodium hyaluronate

Lonicera JAPONICA (Lonicera JAPONICA) flower extract 0.01%

0.2% of hydrolyzed Paeonia Maculosa extract

Algal oligosaccharides 0.2%

Phloretin 0.2%.

Further, the preparation method of the essence water comprises the following steps:

s1, adding phase A deionized water, glycerol and PEG-40 hydrogenated castor oil into a pot, heating to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 70-75 ℃, and adding the B-phase phenoxyethanol and ethylhexyl glycerol;

s3, cooling to 40-45 ℃, and adding the phase C;

s4, reducing the temperature to 37-39 ℃, and discharging after the inspection is qualified.

Further, the temperature in step S4 was decreased to 38 ℃.

Compared with the prior art, the invention has the beneficial effects that: the technical scheme of compounding the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin is creatively provided, and the discovery shows that when the three components are compounded and used, various skin damage factors can be considered, the skin barrier can be repaired and the microecology of the skin can be balanced at the same time, and the problem that the skin is damaged and difficult to repair is effectively solved. In addition, in more than one embodiment of the invention, through the compound use of the three components, the oil control effect on the skin can be intuitively realized, the skin moisture maintenance is promoted, and the moisture loss is prevented. By applying the three components to the damaged skin at the same time, the skin problems of skin redness, itching, dryness and desquamation can be remarkably improved.

Drawings

FIG. 1 shows the formulation of composition 1 to composition 8 in the examples of the present invention.

Figure 2 shows the relative abundance of species of the genus flora structure in healthy facial skin.

FIG. 3 shows the results of the test for balancing the skin's microecological effects of the test compositions of the present invention.

FIG. 4 shows the results of the oil control effect test of the compositions in the examples of the present invention.

Fig. 5 shows the results of scalp transdermal water loss measurement (TEWL) in an embodiment of the present invention.

FIG. 6 shows the results of the relaxing dispel-redness, relieving itching and removing dandruff tests in this example.

FIG. 7 shows monosaccharide information contained in algal oligosaccharides according to the present invention.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The present invention will now be further described with reference to specific examples, which are provided for the purpose of illustration only and are not to be construed as limiting the invention. The test samples and test procedures used in the following examples include the following (generally, according to the conventional conditions or according to the conditions recommended by a reagent company if the specific conditions of the experiment not specified in the examples; reagents, consumables and the like used in the following examples are commercially available without specific description).

Example 1

In this example, first, compositions 1 to 8 were prepared according to FIG. 1.

In this example, the algal oligosaccharides mainly contain sugar monomers as shown in FIG. 7.

The preparation method of the composition 1-8 comprises the following steps:

s1, heating deionized water to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 40-45 ℃, and respectively adding the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin;

and S3, reducing the temperature to about 38 ℃, and discharging after the inspection is qualified.

Then, the following tests were performed for compositions 1 to 8;

1. detecting the effect of the composition on balancing the skin micro-ecology, specifically comprising detecting the effect on balancing the skin micro-flora

This example tested 24 subjects between 18-45 years of age, all subjects having a skin with a predisposition to inflammation; subjects were divided equally into 8 groups of 3 subjects, each group participating in a double-blind randomized clinical study in accordance with ethical principles of medical research. The subjects in each group used 1-8 of the composition, 1ml each time, daily in the morning and evening on the face. Before starting the test on the same day D ₀ And day 28 after testing D ₂₈ The skin microflora was tested separately (skin patches were collected non-invasively through the skin, 16S rRNA gene sequencing was performed on skin sample microbes, and the flora structure, diversity, and gene function were analyzed).

Specifically, facial sampling was performed for skin microbiota analysis (16S rDNA sequence, metagenomic analysis) to obtain diversity index and bacterial makeup.

The 16S rRNA gene sequencing is a technology for performing PCR amplification and high-throughput sequencing on a gene (namely 16S rDNA) hypervariable region of the 16S ribosomal RNA of an environmental sample, and can be used for effectively identifying the types and abundances of bacteria and archaea in a specific environment. The 16S sequence consists of 9 hypervariable regions (V1-V9) interspersed with conserved regions, and is the most commonly used bacterial classification standard. Extracting DNA of an environmental sample, and amplifying a 16S rDNA sequence in the environmental sample; the classification and abundance of bacteria in environmental samples are reflected by detecting the 16S rRNA gene sequence variation and abundance. The 16S sequence can be used to identify most bacteria. Based on an Illumina Miseq sequencing platform, parallel sequencing of a plurality of samples can be completed at one time, and a plurality of information such as environmental sample species classification, species abundance, population structure, system evolution, community comparison and the like can be provided. The 16S third region (V3) and the 16S fourth region (V4) are used for sequencing, the total length is about 459bp, and most of human microorganism species can be identified (the accuracy reaches the first class).

This example was performed with reference to 16S rRNA detection standards, specifically, the 16S rRNA detection standard protocol:

(1) Extracting by using a QIAamp DNA extraction kit, and detecting the extracted DNA;

(2) Detecting the concentration of the DNA by adopting a fluorescence spectrophotometer, and detecting the quality of the DNA by using 1% agarose gel electrophoresis;

(3) Adjusting the concentration of the DNA solution, storing the DNA working solution at 4 ℃ and storing the storage solution at-20 ℃;

(4) Carrying out PCR amplification on the V3-V4 region of the 16S rRNA gene of the sample;

(5) And (3) glue recovery and purification: performing tapping recovery on the target strip to obtain a purified sample;

(6) Quantification of each sample: quantifying each sample by using a Qubit fluorescence quantifier;

(7) Constructing an on-machine library by adopting a standard IlluminaTruSeq DNA library Preparation experimental process (IlluminaTruSeq DNA Sample Preparation Guide); in-silico sequencing was performed using illumina miseq PE 300.

Species composition analysis: in order to obtain species classification information corresponding to each OTU, an RDP classificator Bayesian algorithm is adopted to perform taxonomic analysis on OTU representative sequences with 97% similarity level, and the content of the OTU representative sequences is determined according to the taxonomic levels: domain, kingdom, phylum, class, order, family, genus, and species.

OUT (Operational Taxonomic Units) partitioning and bioinformatic analysis were performed on all sequences according to 97% similarity. According to the result of the taxonomic analysis, the taxonomic comparison condition of one or more samples at each classification level can be known. The data are now presented by relative abundance changes of the species of the flora structure.

The relative abundance of the species of the genus flora structure in healthy facial skin is shown in figure 2.

For this example, the test results are shown in FIG. 3.

Test results of a test of a subject using the composition 8 in the morning and evening for 28 days show that the composition can effectively restore the disordered microbial flora of the damaged skin to a more stable and balanced skin microbial flora state close to that of healthy skin by containing the essence of hydrolyzed cynomolgus monkey tree extract, algal oligosaccharides and phloretin.

2. The composition has oil control effect

This example also performed a control of oil test on 24 subjects, all aged 18-45 years, with a tendency for scalp oil secretion to be vigorous, and the subjects were divided into 8 groups of 3 subjects on average. The subjects in each group used compositions 1-8, respectively, on the scalp in the morning and evening, 2ml each time (during the test period, each subject only performed a simple hair cleansing and did not use a head oil control product other than the test composition). Scalp sebum levels were measured before the start of the test on the same day (day 0) and on days 7, 14, and 28 after use.

In this example, the sebum test is based on quartz crystal sensor technology, and the amount of sebum skin is collected from the scalp by the sensor. The larger the sebum quantity value is, the higher the sebum content is; the smaller the value, the lower the sebum content, and the better the oil control effect of the product. The test results are shown in fig. 4.

At the return visit test of the 14 th day and the 28 th day, the result data show that the composition containing only hydrolyzed cynomolgus monkey tree extract, algae oligosaccharide or phloretin with the single content of 0.5 percent has no obvious oil control effect on the scalp oil; for the composition 8 containing the hydrolyzed macaque extract, the algal oligosaccharides and the phloretin, after the composition 8 is continuously used by a subject, the composition can obviously and more effectively realize the oil control effect, and the oil content is respectively reduced by 31.78% and 51.16% compared with the state of the oil content in the return visit detection on the 14 th day and the 28 th day when the composition 8 contains the essential water of the hydrolyzed macaque extract, the algal oligosaccharides and the phloretin.

3. The composition has effects in relieving redness, relieving itching, and removing dandruff

The study was conducted on 24 subjects aged between 18 and 45 years, all subjects had a tendency to scalp dermatitis reactions (including redness, itching, more dandruff) and the subjects were evenly divided into 8 groups of 3 subjects each. The subjects in each group used compositions 1-8, respectively, daily on the scalp 2ml each time. After 28 consecutive days of use, this example tested the TEWL values of the scalp on days 0, 14, 28, respectively, and the scalp was evaluated for soothing red-dispelling, itching-relieving, and dandruff-removing effects by consumer self-scoring and dermatologist.

1. Scalp percutaneous water loss (TEWL)

Testing an instrument: skin water loss tester Tewameter TM 300; the lower the detection value, the less the percutaneous water loss; the unit is g/(h.m) ² )。

The test principle is as follows: the Tewameter probe measures the density gradient of skin moisture evaporation using two pairs of sensors (temperature and relative humidity) inside the hollow cylinder. The physical basis for the measurement is the diffusion law found by Adolf Fick in 1855: dm/dt = -D8729, A8729dp/dx. Wherein: a = area (m) ² ) M = water loss (g), t = time (h), D = diffusion constant (0.0877 g/m (h (mmHg)), p = atmospheric pressure (mmHg), x = distance from skin surface to vertex (m). The detection results are shown in FIG. 5

At the return visit test of day 14 and day 28, the result data show that the composition containing only hydrolyzed cynomolgus monkey tree extract, algal oligosaccharides or phloretin at a single content of 0.5% has no significant improvement effect on the value of the percutaneous water loss TEWL of the scalp; for the composition 8 simultaneously containing the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin, after a subject continuously uses the composition 8 containing the essential water of the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin, the composition 8 can obviously reduce the water loss rate of the skin, effectively improve the water balance and enhance the barrier function of the scalp.

2. Test for relieving, removing redness, relieving itching and removing dandruff

For convenience of representation, the following evaluation criteria and symbols are used for display, specifically:

degree of scalp redness: +++: indicating severe redness; ++: indicating general redness; +: indicating a very weak degree of redness; 0: indicating no redness.

Degree of scalp itching: +++: indicating severe degree of itching; ++: indicating that the degree of pruritus is general; +: indicating a weak degree of itching; 0: indicating no itching condition.

Degree of dandruff: +++: indicating severe dandruff; ++: indicating general degree of dandruff; +: indicating a weak degree of dandruff; 0: indicating almost no dandruff.

The evaluation results of redness, itching and dandruff degree of scalp are shown in fig. 6.

After 28 days of use, test results of a test subject show that the composition only containing 0.5 percent of hydrolyzed Adiantum ceolatum extract, algae oligosaccharides or phloretin has no obvious improvement effect on the conditions of skin redness, pruritus and dandruff; and the composition 8 containing the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin can effectively relieve the redness, the pruritus and the dandruff of the scalp.

From the above tests and test results, it can be seen that the skin care composition containing hydrolyzed Adansonia henryi extract, algal oligosaccharides and phloretin can effectively improve the moisture balance of the skin, enhance the barrier function of the skin, and balance the micro-ecological environment of the skin, thereby effectively solving the skin problems of redness, itching, dryness, desquamation and the like of the skin.

Meanwhile, the present embodiment also provides compositions 9, 10, and 11, wherein composition 9 comprises: 0.1% of hydrolyzed Adansonia digitata extract; 0.1% of algal oligosaccharides; phloretin 0.1%; water is added to 100 percent. The composition 10 comprises: 0.5% of hydrolyzed Adansonia dubia extract; 0.5% of algal oligosaccharides; phloretin 0.5%; supplementing water to 100%. Composition 11 comprises: 1% of hydrolyzed Adansonia dubia extract; 1% of algal oligosaccharides; phloretin 0%; supplementing water to 100%. The same test as above was carried out again, and the results showed that composition 9 also functions similarly to composition 8, but the effect was slightly weaker than composition 8; composition 10 also functions similarly to composition 8 and performs similarly to composition 8; composition 11 was similar to compositions 1 to 7, and the improvement effect was not significant.

Example 2

The embodiment discloses a facial cream which comprises the following components in percentage by weight:

phase A:

supplementing water to 100%

4 percent of glycerin

EDTA-2Na 0.02%

0.1 percent of hydroxyethyl cellulose

0.2 percent of carbomer

0.02 percent of sodium hyaluronate

Panthenol 0.5%

Phase B:

sucrose stearate, cetearyl glucoside, cetyl alcohol 2%

Glyceryl stearate, PEG-100 stearate 1.5%

Cetostearyl alcohol 3.5%

2% of polydimethylsiloxane

Hydrogenated polyisobutene 2%

0.1 percent of squalane

Tocopherol acetate 0.5%

Caprylic/capric triglyceride 6.5%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.8%

Phase D:

arginine 0.54%

Phase E

2 percent of butanediol

0.5 percent of p-hydroxyacetophenone

0.5 percent of 1, 2-hexanediol

Phase F

The composition is 8.6 percent.

The face cream is prepared by the following preparation method, and comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, keeping the temperature for 15-20 minutes, and homogenizing (3000 r/min) until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A into the mixture, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum for defoaming;

s3, adding the phase C, homogenizing for 3-5 minutes, and stirring and cooling;

s4, cooling to about 70 ℃, adding the dissolved phase D, and uniformly stirring;

s5, cooling to about 60 ℃, adding the dissolved E phase, and uniformly stirring;

s6, cooling to 40-45 ℃, sequentially adding the F-phase materials, and uniformly stirring;

and S7, cooling to about 38 ℃, and discharging after the temperature is qualified.

The cream perfectly maintains the synergistic effect of the hydrolyzed Adansonia dubia extract, the algae oligosaccharides and the phloretin, is convenient for moistening the skin and promotes the recovery of the damaged area.

Meanwhile, the cream is a cream 1, and the embodiment also provides creams 2, 3 and 4, specifically, the formula of the cream 2 is as follows: phase A: supplementing water to 100%; 3% of glycerol; 0.01 percent of EDTA-2Na; 0.05 percent of hydroxyethyl cellulose; 0.10% of carbomer; 0.01 percent of sodium hyaluronate; 0.4 percent of panthenol; phase B: sucrose stearate, cetearyl glucoside, cetyl alcohol 1%; 1% of glyceryl stearate and PEG-100 stearate; cetostearyl alcohol 3%; 1% of polydimethylsiloxane; 1% of hydrogenated polyisobutene; 0.08 percent of squalane; 0.4% of tocopherol acetate; caprylic/capric triglyceride 5%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7%; phase D: 0.5 percent of arginine; phase E: 1% of butanediol; 0.4 percent of p-hydroxyacetophenone; 0.4% of 1, 2-hexanediol; and (3) phase F: composition 8.5%.

The formula of the face cream 3 is as follows: phase A: supplementing water to 100%; 5% of glycerol; 0.03 percent of EDTA-2Na; 0.12 percent of hydroxyethyl cellulose; 0.4% of carbomer; 0.03 percent of sodium hyaluronate; 0.6 percent of panthenol; phase B: sucrose stearate, cetearyl glucoside, cetyl alcohol 3%; 2% of glyceryl stearate and PEG-100 stearate; cetostearyl alcohol 4%; 3% of polydimethylsiloxane; 3% of hydrogenated polyisobutene; 0.12% of squalane; 0.6% of tocopherol acetate; caprylic/capric triglyceride 7%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.9%; phase D: 0.6 percent of arginine; e phase: 3% of butanediol; 0.6 percent of p-hydroxyacetophenone; 0.6 percent of 1, 2-hexanediol; and (3) phase F: composition 8.7%;

the formula of the face cream 4 is as follows: phase A: supplementing water to 100%; 6% of glycerol; 0.05 percent of EDTA-2Na; 0.05 percent of hydroxyethyl cellulose; 0.10% of carbomer; 0.01 to 0.03 percent of sodium hyaluronate; 0.6 percent of panthenol; phase B: sucrose stearate, cetearyl glucoside, cetyl alcohol 3%; 2% of glyceryl stearate and PEG-100 stearate; cetostearyl alcohol 3%; 2% of polydimethylsiloxane; hydrogenated polyisobutene 2%; 0.10% of squalane; 0.5% of tocopherol acetate; caprylic/capric triglyceride 6%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.8%; phase D: 0.5 percent of arginine; e phase: 1% of butanediol; 0.5 percent of p-hydroxyacetophenone; 0.5 percent of 1, 2-hexanediol; and (3) phase F: composition 6.6%.

The application effect of the formulas of the face creams 2 and 3 is consistent with that of the face cream, and the face cream can effectively moisten, repair and maintain the health state of skin, but the time required for achieving the same effect is slightly longer than that of the face cream 1. The formula of the face cream 4 can not achieve the effect of the formula of the face cream 1 and the face creams 2 and 3, and the skin improvement is not obvious.

Example 3

The embodiment discloses a skin lotion, which comprises the following components in percentage by weight:

phase A

Supplementing water to 100%

Glycerol 10%

EDTA-2Na 0.02%

0.1 percent of hydroxyethyl cellulose

Carbomer 0.1%

0.02 percent of sodium hyaluronate

Panthenol 0.5%

Phase B

Cetearyl alcohol, coco glucoside, water, glucose 1%

Glyceryl stearate, PEG-100 stearate 1%

Cetearyl alcohol 2.5%

1.5 percent of polydimethylsiloxane

Hydrogenated polyisobutene 1%

0.3 percent of squalane

Tocopherol acetate 0.5%

Caprylic/capric triglyceride 6.5%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.8%

Phase D

Arginine 0.04%

Phase E

2 percent of butanediol

0.5 percent of p-hydroxyacetophenone

1, 2-hexanediol 0.5%

Phase F

The composition is 8.6 percent.

The skin-moistening lotion is prepared by the following preparation method, and comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, keeping the temperature for 15-20 minutes, and homogenizing (3000 r/min) until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A into the mixture, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum for defoaming;

s3, adding the phase C, homogenizing for 3-5 minutes, and stirring and cooling;

s4, cooling to about 70 ℃, adding the dissolved phase D, and uniformly stirring;

s5, cooling to about 60 ℃, adding the dissolved E phase, and uniformly stirring;

s6, cooling to 40-45 ℃, sequentially adding the F-phase materials, and uniformly stirring;

s7, cooling the temperature to about 38 ℃, and discharging the qualified product after inspection.

Meanwhile, the skin lotion is skin lotion 1, and skin lotions 2, 3 and 4 are also provided in the embodiment, specifically, the formula of the skin lotion 2 is as follows: phase A: supplementing water to 100%; 9% of glycerol; EDTA-2Na 0.01%; 0.05 percent of hydroxyethyl cellulose; 0.05% of carbomer; 0.01 percent of sodium hyaluronate; 0.4 percent of panthenol; phase B: cetearyl alcohol, coco glucoside, water, glucose 0.5%; 0.8% of glycerol stearate and PEG-100 stearate; 2% of cetostearyl alcohol; 1% of polydimethylsiloxane; hydrogenated polyisobutene 0.5%; 0.2% of squalane; 0.3% of tocopherol acetate; caprylic/capric triglyceride 5%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7%; phase D: 0.03 percent of arginine; e phase: 1% of butanediol; 0.4 percent of p-hydroxyacetophenone; 0.4% of 1, 2-hexanediol; and (3) phase F: composition 8.5%.

The formula of the skin lotion 3 is as follows: phase A: supplementing water to 100%; 11% of glycerol; 0.03 percent of EDTA-2Na; 0.12 percent of hydroxyethyl cellulose; 0.15% of carbomer; 0.03 percent of sodium hyaluronate; 0.6 percent of panthenol; phase B: cetearyl alcohol, coco glucoside, water, glucose 1.5%; 1.3% of glyceryl stearate and PEG-100 stearate; cetostearyl alcohol 3%; 2% of polydimethylsiloxane; 1.5% of hydrogenated polyisobutene; 0.4 percent of squalane; 0.6% of tocopherol acetate; caprylic/capric triglyceride 7%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.9%; phase D: 0.6 percent of arginine; phase E: 3% of butanediol; 0.6 percent of p-hydroxyacetophenone; 0.6 percent of 1, 2-hexanediol; and (3) phase F: composition 8.7%;

the formula of the skin lotion 4 is as follows: phase A: supplementing water to 100%; 6% of glycerol; 0.05 percent of EDTA-2Na; 0.05 percent of hydroxyethyl cellulose; 0.10% of carbomer; 0% of sodium hyaluronate; 1% of panthenol; phase B: cetostearyl alcohol, coco glucoside, water, glucose 2%; 2% of glyceryl stearate and PEG-100 stearate; cetostearyl alcohol 3%; 2% of polydimethylsiloxane; hydrogenated polyisobutene 2%; 0.10% of squalane; 0.5% of tocopherol acetate; caprylic/capric triglyceride 6%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0 percent; phase D: 0.5 percent of arginine; e phase: 1% of butanediol; 0.5 percent of p-hydroxyacetophenone; 0.5 percent of 1, 2-hexanediol; and (3) phase F: composition 6.6%.

The applying effect of the formulas of the skin moistening creams 2 and 3 is consistent with that of the skin moistening cream 1, and the skin moistening cream can effectively moisten, repair and maintain the health state of the skin, but the time required for achieving the same effect is slightly longer than that of the skin moistening cream 1. The formula of the emollient lotion 4 can not achieve the effect of the formula of the emollient lotion 1 and the emollient lotions 2 and 3, and the improvement of the skin is not obvious.

Example 4

The embodiment discloses a shampoo, which comprises the following components in percentage by weight:

phase A

Supplementing water to 100%

Acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.30%

Ammonium laureth sulfate 7%

Ethylene glycol distearate 1.1%

PEG-150 distearate 0.5%

Cetostearyl alcohol 0.3%

EDTA disodium 0.1%

Trehalose 0.01%

Phase B

Cocoitoyl amphodiacetate disodium 1.5%

1.5% of cocamidopropyl betaine

PEG-80 sorbitan laurate 1.5%

Dimethiconol, dodecyl benzene sulfonate TEA salt and water 2%

Decyl glucoside 0.45%

Panthenol 0.1%

Phase C

0.6 percent of phenoxyethanol

Sodium benzoate 0.3%

Phase D

The composition is 8.6 percent

Phase E

0.1 percent of citric acid

0.4 percent of sodium chloride.

The shampoo is prepared by the following preparation method, and comprises the following steps:

s1, prefabricating phase: dispersing sodium benzoate, citric acid and sodium chloride with partial water;

s2, dispersing acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer in a water phase pot, then adding the residual raw material of the phase A, heating to 85-88 ℃, stirring for dissolving, and preserving heat for 20-30min;

s3, cooling to about 70 ℃, adding the phase B, stirring until the phase B is dissolved, keeping the temperature for 10-15min, and continuously cooling;

s4, adding C-phase phenoxyethanol and sodium benzoate dispersed by part of water at about 45 ℃, and uniformly stirring;

s5, adding the phase D, adjusting the pH value and the viscosity by adding the phase E, and performing inspection;

and S6, after the product is qualified, cooling to about 38 ℃, and discharging through 200-mesh filter cloth.

Meanwhile, the shampoo is the shampoo 1, and the present embodiment further provides the shampoos 2, 3, and 4, and specifically, the shampoo 2 has the following formula: phase A: supplementing water to 100%; 0.2% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer; 6% of ammonium laureth sulfate; ethylene glycol distearate 1%; 0.3 percent of PEG-150 distearate; cetostearyl alcohol 0.2%; 0.05% of EDTA disodium; trehalose 0.008%; phase B: 1% of cocoyl amphodiacetate disodium salt; 1% of cocamidopropyl betaine; 1% of PEG-80 sorbitan laurate; dimethiconol, dodecyl benzene sulfonic acid TEA salt and water 1%; decyl glucoside 0.4%; 0.05 percent of panthenol; and C phase: 0.5 percent of phenoxyethanol; 0.2 percent of sodium benzoate; phase D: 8.5% of the aforementioned composition; phase E: 0.05% of citric acid; 0.35 percent of sodium chloride.

The shampoo 3 has the following formula: phase A: supplementing water to 100%; acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.4%; 8% of ammonium laureth sulfate; ethylene glycol distearate 1.2%; 0.6 percent of PEG-150 distearate; cetostearyl alcohol 0.4%; 0.15% of EDTA disodium; trehalose 0.012%; phase B: 2% of cocoyl amphodiacetate disodium; 1.8% of cocamidopropyl betaine; 2% of PEG-80 sorbitan laurate; polydimethylsiloxanol, dodecyl benzene sulfonate TEA salt and water 3 percent; decyl glucoside 0.5%; 0.12 percent of panthenol; and C phase: 0.7 percent of phenoxyethanol; 0.4 percent of sodium benzoate; phase D: 8.7% of the aforementioned composition; e phase: 0.15 percent of citric acid; 0.45 percent of sodium chloride.

The shampoo 4 has the following formula: phase A: supplementing water to 100%; acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0%; 6% of ammonium laureth sulfate; ethylene glycol distearate 0%; 0.3 percent of PEG-150 distearate; cetostearyl alcohol 0.2%; 0.05% of EDTA disodium; trehalose 0.008%; phase B: 1% of cocoyl amphodiacetate disodium salt; cocamidopropyl betaine 0%; 1% of PEG-80 sorbitan laurate; dimethiconol, dodecyl benzene sulfonic acid TEA salt and water 1%; decyl glucoside 0.4%; 0.05 percent of panthenol; and C phase: 0.5 percent of phenoxyethanol; 0.2 percent of sodium benzoate; phase D: 7.5% of the composition; phase E: 0.05% of citric acid; 0.35 percent of sodium chloride.

The shampoo 2, 3 has similar effect to the shampoo 1, can effectively control oil and promote scalp repair, but has weaker effect than the shampoo 1. The shampoo 4 formulation does not provide the same effect as the above-described shampoo 1 and shampoo 2, 3 formulations, and the improvement is not significant.

Example 5

The embodiment discloses essence water which comprises the following components in percentage by weight:

phase A

Supplementing water to 100%

Glycerol 3%

PEG-40 hydrogenated Castor oil 0.1%

Phase B

0.9 percent of phenoxyethanol

Ethylhexyl glycerin 0.1%

Phase C

Allantoin 0.5%

1 percent of sodium hyaluronate

Lonicera JAPONICA (Lonicera JAPONICA) flower extract 0.01%

0.2% of hydrolyzed Paeonia Maculosa extract

Algal oligosaccharides 0.2%

Phloretin 0.2%.

The essence water is prepared by the following preparation method, and comprises the following steps:

s1, adding phase A deionized water, glycerol and PEG-40 hydrogenated castor oil into a pot, heating to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 70-75 ℃, and adding the B-phase phenoxyethanol and ethylhexyl glycerol;

s3, cooling to 40-45 ℃, and adding the phase C;

and S4, cooling to about 38 ℃, and discharging after the temperature is qualified.

Meanwhile, the embodiment also provides essence liquids 2, 3 and 4, and specifically, the formula of the essence liquid 2 is as follows: phase A: supplementing water to 100%; 2% of glycerol; 0.05% of PEG-40 hydrogenated castor oil; phase B: 0.7 percent of phenoxyethanol; 0.05% of ethylhexyl glycerol; and C phase: 0.3 percent of allantoin; 0.8 percent of sodium hyaluronate; flos Lonicerae (Lonicera Japonica) extract 0.008%; 0.1% of hydrolyzed Adansonia dubia extract; 0.1% of algal oligosaccharides; phloretin 0.1%;

the formula of the essence liquid 3 is as follows: phase A: supplementing water to 100%; 4% of glycerol; 0.15% of PEG-40 hydrogenated castor oil; phase B: 1% of phenoxyethanol; 0.12% of ethylhexyl glycerol; and C phase: allantoin 0.55%; 1.1 percent of sodium hyaluronate; flos Lonicerae (Lonicera Japonica) extract 0.011%; 0.3% of hydrolyzed Adansonia dubia extract; 0.3% of algal oligosaccharides; phloretin 0.3%;

the formula of the essence liquid 4 is as follows: phase A: supplementing water to 100%; 2% of glycerol; 0.1 percent of PEG-40 hydrogenated castor oil; phase B: 0.9 percent of phenoxyethanol; 0.1% of ethylhexyl glycerol; and C phase: 0% of allantoin; 1% of sodium hyaluronate; flos Lonicerae (Lonicera Japonica) extract 0%; 0.2% of hydrolyzed Adansonia dubia extract; 0% of algal oligosaccharides; phloretin 0.2%.

The application effect of the formula of the essence water 2 and the formula of the essence water 3 is similar to that of the essence water 1, the skin barrier can be effectively repaired and the microecology can be balanced, and meanwhile, the essence water is basically nonirritating, but the effect is weaker than that of the essence water 1. The formula of the essence liquid 4 cannot achieve the effect of the formula of the essence liquid 1 and the formula of the essence liquids 2 and 3, and the improvement is not obvious.

It should be understood that the above-mentioned embodiments of the present invention are only examples for clearly illustrating the technical solutions of the present invention, and are not intended to limit the specific embodiments of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention claims should be included in the protection scope of the present invention claims.

Claims (10)

1. The application of the compound of the hydrolyzed Adansonia dubia extract, the algae oligosaccharide and the phloretin in preparing products for balancing skin micro-ecology, repairing skin barriers, regulating skin grease secretion, inhibiting skin water loss and/or relieving skin redness, pruritus and desquamation.

2. The use of claim 1, wherein the hydrolyzed Adansonia dubia extract, the algal oligosaccharides and the phloretin are compounded for preparing a product for balancing skin microecology and repairing skin barrier.

3. Use according to claim 1, characterized in that balancing the skin micro-ecology comprises modulating the relative abundance of propionibacteria, acinetobacter, corynebacterium, staphylococcus, bacteroides, prevotella, weissella, bifidobacterium, lactobacillus and/or aquaticus flora on the skin.

4. Use according to claim 1, characterized in that the skin comprises the facial skin and the scalp.

5. A composition is characterized by comprising a hydrolyzed Adansonia simplicifolia extract, algae oligosaccharide and phloretin, wherein the weight percentage of the hydrolyzed Adansonia simplicifolia extract, the algae oligosaccharide and the phloretin in the composition is 0.3-1.5%.

6. The composition according to claim 5, characterized by comprising the following components in percentage by weight:

0.1 to 0.5 percent of hydrolyzed Adansonia dubia extract;

0.1 to 0.5 percent of algal oligosaccharides;

phloretin 0.1-0.5%;

water is added to 100 percent.

7. The face cream is characterized by comprising the following components in percentage by weight:

phase A:

water is added to 100 percent

3 to 5 percent of glycerin

EDTA-2Na 0.01~0.03%

0.05 to 0.12 percent of hydroxyethyl cellulose

Carbomer 0.10 to 0.4 percent

Sodium hyaluronate 0.01 to 0.03%

Panthenol 0.4 to 0.6%

Phase B:

sucrose stearate, cetearyl glucoside, cetyl alcohol 1 to 3%

Glyceryl stearate and PEG-100 stearate 1-2%

Cetostearyl alcohol 3 to 4%

1 to 3 percent of polydimethylsiloxane

1 to 3 percent of hydrogenated polyisobutene

Squalane 0.08 to 0.12 percent

Tocopherol acetate 0.4 to 0.6 percent

Caprylic/capric triglyceride 5 to 7%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7 to 0.9%

Phase D:

arginine 0.5 to 0.6 percent

Phase E

1 to 3 percent of butanediol

0.4 to 0.6 percent of p-hydroxyacetophenone

0.4 to 0.6 percent of 1, 2-hexanediol

Phase F

0.5 to 0.7% of the composition according to any one of claims 5 to 6.

8. The skin lotion is characterized by comprising the following components in percentage by weight:

phase A

Supplementing water to 100%

9 to 11 percent of glycerin

EDTA-2Na 0.01~0.03%

0.05 to 0.12 percent of hydroxyethyl cellulose

Carbomer 0.05 to 0.15 percent

Sodium hyaluronate 0.01 to 0.03%

Panthenol 0.4 to 0.6%

Phase B

Cetostearyl alcohol, coco glucoside, water, glucose 0.5 to 1.5%

0.8 to 1.3 percent of glycerol stearate and PEG-100 stearate

Cetostearyl alcohol 2 to 3%

1 to 2 percent of polydimethylsiloxane

Hydrogenated polyisobutene 0.5 to 1.5%

Squalane 0.2 to 0.4 percent

Tocopherol acetate 0.3 to 0.6 percent

Caprylic/capric triglycerides 5 to 7%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

Phase D

Arginine 0.03 to 0.06%

Phase E

1 to 3 percent of butanediol

0.4 to 0.6 percent of p-hydroxyacetophenone

0.4 to 0.6 percent of 1, 2-hexanediol

Phase F

0.5 to 0.7% of the composition according to any one of claims 5 to 6.

9. The shampoo is characterized by comprising the following components in percentage by weight:

phase A

Supplementing water to 100%

Acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.2-0.4%

Ammonium laureth sulfate 6 to 8%

Ethylene glycol distearate 1 to 1.2%

PEG-150 distearate 0.3 to 0.6 percent

Cetostearyl alcohol 0.2 to 0.4%

0.05 to 0.15 percent of EDTA disodium

Trehalose 0.008 to 0.012%

Phase B

1 to 2 percent of cocoyl amphodiacetate

Cocoamidopropyl betaine 1 to 1.8%

1 to 2 percent of PEG-80 sorbitan laurate

Dimethiconol, dodecyl benzene sulfonic acid TEA salt and water 1-3%

Decyl glucoside 0.4 to 0.5%

Panthenol 0.05 to 0.12 percent

Phase C

0.5 to 0.7 percent of phenoxyethanol

Sodium benzoate 0.2 to 0.4 percent

Phase D

The composition according to any one of claims 5 to 6, which is 0.5 to 0.7%

Phase E

0.05 to 0.15 percent of citric acid

0.35 to 0.45 percent of sodium chloride.

10. The essence lotion is characterized by comprising the following components in percentage by weight:

phase A

Water is added to 100 percent

2 to 4 percent of glycerin

PEG-40 hydrogenated Castor oil 0.05 to 0.15%

Phase B

0.7 to 1 percent of phenoxyethanol

0.05 to 0.12 percent of ethylhexyl glycerol

Phase C

Allantoin 0.3 to 0.55 percent

Sodium hyaluronate 0.8 to 1.1%

Honeysuckle flower extract 0.008 to 0.011%

0.1 to 0.3 percent of hydrolyzed Adansonia dubia extract

Algal oligosaccharides 0.1 to 0.3%

0.1 to 0.3 percent of phloretin.

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