CN115778881B - Skin care composition capable of relieving, moisturizing and refreshing, preparation method and application - Google Patents

Abstract

The invention discloses a skin care composition capable of relieving, moisturizing and refreshing, a preparation method and application thereof. When the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin are compounded, various skin damage factors can be considered, the skin barrier can be restored and the microecology of the skin can be balanced at the same time, and the problem that the damaged skin is difficult to restore can be effectively solved. In addition, in more than one embodiment of the invention, through the compound use of three components, the oil control effect on the skin can be intuitively achieved, the maintenance of skin moisture is promoted, and the moisture loss is prevented. By applying three components simultaneously to damaged skin, the skin problems of redness, itching, dryness and desquamation of the skin can be significantly improved.

Description

Skin care composition capable of relieving, moisturizing and refreshing, preparation method and application

Technical Field

The invention relates to the technical field of skin care products, in particular to a skin care composition capable of relieving, moisturizing and refreshing, a preparation method and application.

Background

The skin of a human body has a plurality of barrier protection mechanisms, and the plurality of barrier protection mechanisms cooperatively protect the skin health of the human body. Firstly, the hair barrier, which is the first protective barrier on the skin, can resist external stimuli, especially to contaminants and ultraviolet radiation; secondly, a microbial barrier formed by ecological flora of the skin is a second natural protective barrier on the skin, and needs to be maintained, reinforced and recovered to avoid invasion of bad bacteria on the skin; and a third barrier layer is formed for protecting the barrier layer, which has the function similar to a brick wall concrete structure, corresponds to the cells and lipid of the horny layer, protects the inner layer and the outer layer of the skin and prevents invasion of harmful molecules. Finally, the biological barrier formed by epidermis and dermis is the fourth barrier, which is composed of epidermis and dermis, between which cells are constantly in communication, and the barrier is the area for restoring the skin homeostasis, and promotes the comfortable and balanced state of the skin by reconstructing or strengthening weak or damaged tissues.

Wherein, for the third barrier skin barrier, the stratum corneum is composed of 20 layers of flat, intertwined keratinocytes; the keratinocytes are as tough as "bricks" with lipids like "mortar" between them to tightly connect the keratinocytes together to form a "brick wall structure", and the surface of the stratum corneum is also provided with a protective film composed of sweat and sebum, which together with the stratum corneum forms a barrier for the skin. The protective barrier can lock skin moisture and grease, resist invasion of various skin surface bacteria, and plays an important role in protecting human health. For the second layer of protective barrier, the microecology has competition and restriction relation, and the body, limbs, face, scalp skin and the like have skin microecology, and the balance of the skin microecology system maintains the stability of the skin environment; healthy skin surfaces, the micro-ecology generally remains relatively stable and balanced. At the same time, the micro-ecological changes of the skin interact with various inflammatory reactions on the skin. For example, beneficial bacteria in the microecology exert antibiotic action, promote immune response by closely interacting with human immune cells, and prevent harmful microorganism infection.

When the skin protection barrier is damaged, particularly when the skin barrier is damaged, the skin is easily eroded by bacteria, viruses and fungi, and a large amount of moisture in the skin is evaporated, so that various problems occur to the skin. Notably, damage to other protective barriers, including skin barriers, in the second protective barrier can also directly result in changes in microbial composition, causing a microecological imbalance. Impaired skin barrier, immune response imbalance is closely related to increased susceptibility to microbial colonization of the skin, e.g., lipid-rich hair follicle invagination provides an aerobic and anaerobic niche for various microflora, making the skin a large ecosystem supporting symbiotic relationships between host and microorganisms, and when the skin is damaged, it results in significant changes in microbial composition, reduced beneficial microorganisms, reduced immune responses associated therewith, and increased proliferation of harmful microorganisms. Therefore, the health state of the skin can be maintained under multiple mechanisms such as skin barrier, skin microecology and immune cell immune response mediated by each.

However, most of the prior art skin care only repairs the horny layer on one side, lacks protection to immune cells, and causes damaged symptoms (redness, itching and the like) to be unable to be radically improved; or, the barrier repair is incomplete, only the stratum corneum is repaired, the influence of the microecology and the immune barrier on the skin is ignored, and the recovery of the skin is difficult to improve.

Therefore, there is a need in the art for a substance or related skin care product that addresses multiple factors of skin damage to effectively address the problem of skin damage.

Disclosure of Invention

The invention aims to overcome at least one defect of the prior art, and provides a skin care composition with the advantages of relieving, moisturizing and refreshing, a preparation method and application, and hydrolyzed monkey bread extract, algae oligosaccharides and phloretin cooperate to achieve the effects of restoring skin barrier and balancing skin microecology, and has an effective restoration effect on damaged skin.

The invention aims to provide an application of a hydrolyzed monkey bread tree extract, an algae oligosaccharide and phloretin in preparation of a product for balancing skin microecology, repairing skin barrier, regulating skin grease secretion, inhibiting skin water diversion and/or relieving skin redness, itching and desquamation. Skin care products on the market rarely integrate the care of repairing skin barriers and balancing skin micro-ecology and apply the skin care products, and the skin care products are more difficult or impossible to effectively solve skin problems such as redness, itching, dryness, desquamation and the like compared with a single care scheme. The application creatively provides a technical scheme for the compound use of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin, and discovers that when the three components are used in a compound way, various skin damage factors can be considered, skin barriers can be repaired simultaneously, the microecology of the skin can be balanced, and the problem that the damaged skin is difficult to repair can be effectively solved. In addition, in more than one embodiment of the invention, through the compound use of three components, the oil control effect on the skin can be intuitively achieved, the maintenance of skin moisture is promoted, and the moisture loss is prevented. By applying three components simultaneously to damaged skin, the skin problems of redness, itching, dryness and desquamation of the skin can be significantly improved.

Further, the application of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin in preparing products for balancing skin microecology, repairing skin barrier, regulating skin grease secretion, inhibiting skin moisture loss and relieving skin redness, itching and desquamation.

Further, the skin comprises tissue covering a surface of a human or animal body.

Further, the application of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin in the preparation of the product for balancing the skin microecology and repairing the skin barrier.

Further, the products include pharmaceutical preparations and daily chemicals.

Further, the pharmaceutical preparation is an external preparation, and the preparation dosage form is selected from the group consisting of cream, patch, ointment, cream preparation, gel and spray.

Further, the pharmaceutical formulation includes a physiologically acceptable carrier.

Further, the product includes a cream, a lotion, a shampoo and/or a serum. In one or more embodiments of the present invention, the face cream, the skin lotion, the shampoo and the essence water are prepared based on the above three components of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin, so that the synergistic effect of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin components is maintained, and the present invention is convenient for adapting to the characteristics of the corresponding application part, and has high safety and small irritation.

Further, balancing skin micro-ecology includes modulating the relative abundance of propionibacterium, acinetobacter, corynebacterium, staphylococcus, bacteroides, prasuvorexant, weissella, bifidobacterium, lactobacillus and/or aqua bacteria populations on the skin. In one or more embodiments of the invention, at least the Propionibacterium, acinetobacter, corynebacterium, staphylococcus, bacteroides, prevotella, weissella, bifidobacterium, lactobacillus and Sargassum populations can be modulated by modulation of the three aforementioned compositions to promote recovery of such major microorganisms to levels similar to those of healthy skin.

Further, the skin includes facial skin and scalp. In one or more embodiments of the present invention, the damage to the facial skin and scalp can be significantly ameliorated by the combination of the three aforementioned components or skin care products comprising the three aforementioned compositions.

Still another object of the present invention is to provide a composition comprising hydrolyzed monkey tree extract, algae oligosaccharides and phloretin, wherein the weight percentage of hydrolyzed monkey tree extract, algae oligosaccharides and phloretin in the composition is 0.3-1.5%; further, a solvent is also included. In one or more embodiments of the present invention, when the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin are 0.3 to 1.5% by weight of the composition, safety can be ensured and a synergistic effect between the components can be provided, while repairing skin barrier and microecology.

Further, the composition comprises the following components in percentage by weight:

hydrolyzing 0.1-0.5% of a monkey bread tree extract;

0.1-0.5% of algae oligosaccharides;

0.1-0.5% of phloretin;

the water is added to 100 percent.

Further, the composition comprises the following components in percentage by weight:

hydrolyzing the extract of the monkey bread tree by 0.2%;

0.2% of algae oligosaccharides;

phloretin 0.2%;

the water is added to 100 percent.

Further, in the foregoing and in the following, the water is deionized water.

Further, there is provided a method for preparing the above composition, comprising the steps of:

s1, heating water to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 40-45 ℃, and respectively adding hydrolyzed monkey tree extract, algae oligosaccharide and phloretin;

and S3, reducing the temperature to 37-39 ℃, and inspecting qualified discharge.

Further, the temperature in step S3 is reduced to 38 ℃.

The invention also aims to provide a facial cream which comprises the following components in percentage by weight:

phase A:

the water is supplemented to 100%

3-5% of glycerol

EDTA-2Na 0.01~0.03%

0.05-0.12% of hydroxyethyl cellulose

Carbomer 0.10-0.4%

0.01 to 0.03 percent of sodium hyaluronate

0.4-0.6% of panthenol

And B phase:

sucrose stearate, cetostearyl glucoside and cetyl alcohol 1-3%

Glycerol stearate and PEG-100 stearate 1-2%

Cetostearyl alcohol 3-4%

1-3% of polydimethylsiloxane

Hydrogenated polyisobutene 1-3%

0.08-0.12% of squalane

0.4-0.6% of tocopheryl acetate

Caprylic/capric triglyceride 5-7%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

And D phase:

arginine 0.5-0.6%

E phase

1-3% of butanediol

0.4-0.6% of p-hydroxyacetophenone

0.4-0.6% of 1, 2-hexanediol

F phase

0.5-0.7% of the composition.

Further, the sucrose stearate, the cetostearyl glucoside and the cetyl alcohol are mixed and compounded emulsifying agents, wherein the proportion of the sucrose stearate, the cetostearyl glucoside and the cetyl alcohol is 12.5:35:52.5. The glycerol stearate and the PEG-100 stearate are mixed and compounded, and the proportion of the glycerol stearate to the PEG-100 stearate is 62.5:37.5. The skin-feel modifier is compounded by mixing four components, namely polyacrylamide, C13-14 isoparaffin, laureth-7 and water, wherein the proportion of the polyacrylamide, the C13-14 isoparaffin, the laureth-7 and the water is 40:24:6:30.

Further, the composition comprises the following components in percentage by weight:

phase A:

the water is supplemented to 100%

Glycerol 4%

EDTA-2Na 0.02%

Hydroxyethyl cellulose 0.1%

Carbomer 0.2%

Sodium hyaluronate 0.02%

Panthenol 0.5%

And B phase:

sucrose stearate, cetostearyl glucoside, cetyl alcohol 2%

Glycerol stearate, PEG-100 stearate 1.5%

Cetostearyl alcohol 3.5%

Polydimethylsiloxane 2%

Hydrogenated polyisobutene 2%

Squalane 0.1%

Tocopheryl acetate 0.5%

Caprylic/capric triglyceride 6.5%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7, water 0.8%

And D phase:

arginine 0.54%

E phase

Butanediol 2%

P-hydroxyacetophenone 0.5%

1, 2-hexanediol 0.5%

F phase

0.6% of the composition.

Further, the preparation method of the face cream comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, preserving heat for 15-20 minutes, and homogenizing until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum to remove foam;

S3, adding the phase C, homogenizing for 3-5 minutes, stirring and cooling;

s4, cooling to 69-71 ℃, adding the dissolved D phase, and uniformly stirring;

s5, cooling to 59-61 ℃, adding the dissolved E phase, and uniformly stirring;

s6, reducing the temperature to 40-45 ℃, sequentially adding the materials of the phase F, and uniformly stirring;

s7, cooling to 37-39 ℃, and checking qualified discharge.

Further, the homogenizing speed in step S1 is 3000 rpm.

Further, the temperature in the step S4 is reduced to 70 ℃; step S5, the temperature is reduced to 60 ℃; step S7, the temperature is reduced to 38 ℃.

It is still another object of the present invention to provide a skin lotion comprising the following components in weight percent:

phase A

The water is supplemented to 100%

Glycerol 9-11%

EDTA-2Na 0.01~0.03%

0.05-0.12% of hydroxyethyl cellulose

Carbomer 0.05-0.15%

0.01 to 0.03 percent of sodium hyaluronate

0.4-0.6% of panthenol

Phase B

Cetostearyl alcohol, cocoyl glucoside, water and glucose 0.5-1.5%

Glycerol stearate and PEG-100 stearate 0.8-1.3%

Cetostearyl alcohol 2-3%

1-2% of polydimethylsiloxane

Hydrogenated polyisobutene 0.5-1.5%

0.2 to 0.4 percent of squalane

0.3-0.6% of tocopheryl acetate

Caprylic/capric triglyceride 5-7%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

D phase

Arginine 0.03-0.06%

E phase

1-3% of butanediol

0.4-0.6% of p-hydroxyacetophenone

0.4-0.6% of 1, 2-hexanediol

F phase

0.5-0.7% of the composition.

The cetostearyl alcohol, the coco glucoside, the water and the glucose are mixed and compounded, wherein the mixture ratio of the cetostearyl alcohol, the coco glucoside, the water and the glucose is 64.5:35:0.3:0.2. The glycerol stearate and the PEG-100 stearate are mixed and compounded, wherein the proportion of the glycerol stearate to the PEG-100 stearate is 62.5:37.5. The skin-feel modifier is compounded by mixing four components, namely polyacrylamide, C13-14 isoparaffin, laureth-7 and water, wherein the proportion of the polyacrylamide, the C13-14 isoparaffin, the laureth-7 and the water is 40:24:6:30.

Further, the skin cream comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Glycerol 10%

EDTA-2Na 0.02%

Hydroxyethyl cellulose 0.1%

Carbomer 0.1%

Sodium hyaluronate 0.02%

Panthenol 0.5%

Phase B

Cetostearyl alcohol, coco glucoside, water, glucose 1%

Glycerol stearate, PEG-100 stearate 1%

Cetostearyl alcohol 2.5%

Polydimethylsiloxane 1.5%

Hydrogenated polyisobutene 1%

Squalane 0.3%

Tocopheryl acetate 0.5%

Caprylic/capric triglyceride 6.5%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7, water 0.8%

D phase

Arginine 0.04%

E phase

Butanediol 2%

P-hydroxyacetophenone 0.5%

1, 2-hexanediol 0.5%

F phase

0.6% of the composition.

Further, the preparation method of the skin cream comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, preserving heat for 15-20 minutes, and homogenizing until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum to remove foam;

s3, adding the phase C, homogenizing for 3-5 minutes, stirring and cooling;

S4, cooling to 69-71 ℃, adding the dissolved D phase, and uniformly stirring;

s5, cooling to 59-61 ℃, adding the dissolved E phase, and uniformly stirring;

s6, reducing the temperature to 40-45 ℃, sequentially adding the materials of the phase F, and uniformly stirring;

s7, cooling to 37-39 ℃, and checking qualified discharge.

Further, the homogenizing speed in step S1 is 3000 rpm.

Further, the temperature in the step S4 is reduced to 70 ℃; step S5, the temperature is reduced to 60 ℃; step S7, the temperature is reduced to 38 ℃.

The invention also aims to provide a shampoo which comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.2-0.4%

6-8% of laureth ammonium sulfate

1-1.2% of glycol distearate

PEG-150 distearate 0.3-0.6%

Cetostearyl alcohol 0.2-0.4%

EDTA disodium 0.05-0.15%

Trehalose 0.008-0.012%

Phase B

1-2% of cocoyl amphoteric diacetic acid disodium

1-1.8% of cocoamidopropyl betaine

PEG-80 sorbitan laurate 1-2%

Polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 1-3%

Decyl glucoside 0.4-0.5%

0.05-0.12% of panthenol

Phase C

0.5 to 0.7% of phenoxyethanol

Sodium benzoate 0.2-0.4%

D phase

0.5-0.7% of the composition

E phase

Citric acid 0.05-0.15%

0.35-0.45% of sodium chloride.

The mixture ratio of the polydimethyl siloxane alcohol, the dodecyl benzene sulfonic acid TEA salt and the water is 60:2:38.

Further, the shampoo comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.30%

Ammonium laureth sulfate 7%

Glycol distearate 1.1%

PEG-150 distearate 0.5%

Cetostearyl alcohol 0.3%

EDTA disodium 0.1%

Trehalose 0.01%

Phase B

Cocoyl amphodiacetate disodium 1.5%

Cocoamidopropyl betaine 1.5%

PEG-80 sorbitan laurate 1.5%

Polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 2%

Decyl glucoside 0.45%

Panthenol 0.1%

Phase C

Phenoxyethanol 0.6%

Sodium benzoate 0.3%

D phase

0.6% of the aforementioned composition

E phase

Citric acid 0.1%

Sodium chloride 0.4%.

Further, the preparation method of the shampoo comprises the following steps:

s1, prefabricating phases: dispersing sodium benzoate, citric acid and sodium chloride in part of water in advance;

s2, dispersing acrylic acid (ester)/C10-30 alkanol acrylic ester crosslinked polymer in a water phase pot, then adding the rest raw materials of the phase A, heating to 85-88 ℃, stirring and dissolving, and preserving heat for 20-30min;

s3, cooling to 69-71 ℃, adding the phase B, stirring until the phase B is dissolved, preserving heat for 10-15min, and continuously cooling;

s4, adding phase C phenoxyethanol and sodium benzoate which is partially dispersed, and uniformly stirring at the temperature of 44-46 ℃;

S5, adding the phase D, and finally, adjusting the pH value and the viscosity by adding the phase E, and carrying out inspection;

and S6, cooling to 37-39 ℃ after the materials are qualified, and discharging through 200-mesh filter cloth.

Further, in the step S3, the temperature is reduced to 70 ℃; in the step S4, adding phase C phenoxyethanol and sodium benzoate which is partially dispersed at 45 ℃; step S6, cooling to 38 ℃.

The invention further aims at providing essence water which comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

2-4% of glycerol

PEG-40 hydrogenated castor oil 0.05-0.15%

Phase B

0.7-1% of phenoxyethanol

0.05-0.12% of ethylhexyl glycerol

Phase C

Allantoin 0.3-0.55%

0.8 to 1.1% of sodium hyaluronate

Honeysuckle (LONICERA JAPONICA) flower extract 0.008-0.011%

0.1-0.3% of hydrolyzed monkey bread tree extract

0.1 to 0.3% of algae oligosaccharide

0.1-0.3% of phloretin.

Further, the essence water comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Glycerol 3%

PEG-40 hydrogenated castor oil 0.1%

Phase B

Phenoxyethanol 0.9%

Ethylhexyl glycerol 0.1%

Phase C

Allantoin 0.5%

Sodium hyaluronate 1%

Honeysuckle (LONICERA JAPONICA) flower extract 0.01%

Hydrolyzed monkey bread tree extract 0.2%

Algae oligosaccharide 0.2%

Phloretin 0.2%.

Further, the preparation method of the essence water comprises the following steps:

s1, putting phase A deionized water, glycerol and PEG-40 hydrogenated castor oil into a pot, heating to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 70-75 ℃, and adding phase B phenoxyethanol and ethylhexyl glycerol;

s3, reducing the temperature to 40-45 ℃, and adding a phase C;

s4, cooling to 37-39 ℃, and checking qualified discharge.

Further, the temperature is reduced to 38 ℃ in step S4.

Compared with the prior art, the invention has the beneficial effects that: the technical scheme of the compound use of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin is creatively provided, and the three components are found to be capable of taking into consideration various skin damage factors when being used in a compound way, and the problems of skin damage and difficult restoration can be effectively solved by simultaneously restoring skin barriers and balancing the microecology of the skin. In addition, in more than one embodiment of the invention, through the compound use of three components, the oil control effect on the skin can be intuitively achieved, the maintenance of skin moisture is promoted, and the moisture loss is prevented. By applying three components simultaneously to damaged skin, the skin problems of redness, itching, dryness and desquamation of the skin can be significantly improved.

Drawings

FIG. 1 shows the formulation of compositions 1 to 8 according to the embodiment of the present invention.

Figure 2 shows the relative abundance of flora and fauna species in healthy facial skin.

FIG. 3 shows the results of the test for the balance of skin micro-ecology effect of the test compositions in the examples of the present invention.

FIG. 4 shows the results of the oil control effect test of the compositions of the examples of the present invention.

FIG. 5 shows the results of scalp percutaneous moisture loss (TEWL) test in the examples of the present invention.

FIG. 6 shows the results of the test for soothing redness, itching and scurf removal in the examples of the present invention.

FIG. 7 shows monosaccharide information contained in the algal oligosaccharides in the examples of the present invention.

Detailed Description

It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The invention will now be further illustrated with reference to specific examples, which are given solely for the purpose of illustration and are not to be construed as limiting the invention. The test specimens and test procedures used in the following examples include those (if the specific conditions of the experiment are not specified in the examples, generally according to conventional conditions or according to the recommended conditions of the reagent company; the reagents, consumables, etc. used in the examples described below are commercially available unless otherwise specified).

Example 1

In this example, first, composition 1 to composition 8 were prepared according to fig. 1.

In this example, the algal oligosaccharides mainly contain sugar monomers as shown in FIG. 7.

The preparation method of the composition 1-composition 8 comprises the following steps:

s1, heating deionized water to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 40-45 ℃, and respectively adding hydrolyzed monkey tree extract, algae oligosaccharide and phloretin;

s3, cooling to about 38 ℃, and checking to be qualified and discharging.

Then, the following test was performed for composition 1 to composition 8;

1. detecting the effect of the composition on balancing skin micro-ecology, including in particular the effect of balancing skin microbiota

This example tested 24 subjects between 18-45 years of age, all subjects having a predisposition to inflammatory response to their skin; subjects were equally divided into 8 groups of 3 each and enrolled in a double blind randomized clinical study that was in compliance with the ethical guidelines of medical research. The subjects of each group used compositions 1-8, respectively, daily, in the morning and evening, each time with 1ml. D before the test is started on the same day ₀ And day 28D after testing ₂₈ The skin microflora was tested separately (skin patches were collected non-invasively through the skin, 16S rRNA gene sequencing was performed on skin sample microorganisms, and flora structure, diversity and gene function were analyzed).

Specifically, facial sampling was performed for skin microbiota analysis (16S rDNA sequence, metagenomic analysis) to obtain diversity index and bacterial composition.

The 16S rRNA gene sequencing refers to a technology for carrying out PCR amplification and high-throughput sequencing on a gene (namely 16S rDNA) hypervariable region of the 16S ribosomal RNA of an environmental sample, and can effectively identify the microorganism types and abundance of bacteria and archaea under specific environments. The 16S sequence consists of 9 hypervariable regions (V1-V9), interspersed with conserved regions, are the most common bacterial classification standard. Extracting the DNA of the environmental sample and amplifying the 16S rDNA sequence; the classification and abundance of bacteria in the environmental sample are reflected by detecting the sequence variation and abundance of the 16S rRNA gene. The 16S sequence can be used to identify most bacteria. Based on an Illumina Miseq sequencing platform, parallel sequencing of a plurality of samples can be completed at one time, and a plurality of information such as environmental sample species classification, species abundance, population structure, system evolution, community comparison and the like are provided. Sequencing through the 16S third region (V3) and the fourth region (V4) is about 459bp in total length, and most human microorganism types can be identified (the accuracy reaches a class).

The present embodiment operates with reference to the 16S rRNA detection standard, specifically, the 16S rRNA detection standard operation flow:

(1) Extracting by using a QIAamp DNA extraction kit, and detecting the extracted DNA;

(2) Detecting the concentration of the DNA by adopting a fluorescence spectrophotometer, and detecting the quality of the DNA by using 1% agarose gel electrophoresis;

(3) Adjusting the concentration of the DNA solution, storing the DNA working solution at 4 ℃ and storing the storage solution at-20 ℃;

(4) PCR amplification was performed on the V3-V4 region of the sample 16S rRNA gene;

(5) And (3) glue recovery and purification: performing tapping recovery on the target strip to obtain a purified sample;

(6) Quantification of each sample: quantifying each sample by using a Qubit fluorescent quantifying instrument;

(7) Construction of the on-press library using standard IlluminaTruSeq DNA library preparation protocol (IlluminaTruSeq DNA Sample Preparation Guide); on-machine sequencing was performed using IlluminaMiSeq PE 300.

Species composition analysis: in order to obtain species classification information corresponding to each OTU, an RDP classification bayesian algorithm is used to perform a taxonomic analysis on OTU representative sequences with 97% similarity level, and at each taxonomic level: domain, kingdom, phylum, class, order, family, genus, species, and species.

All sequences were partitioned OUT (Operational Taxonomic Units) according to 97% similarity and analyzed for bioinformatics. Based on the results of the taxonomic analysis, the taxonomic alignment of one or more samples at each taxonomic level can be known. Data are now presented by changes in the relative abundance of flora structural genus species.

The relative abundance of flora structural species in healthy facial skin is shown in figure 2.

For this embodiment, the test results are shown in FIG. 3.

The test results of the test carried out by the subjects in the morning and evening show that the composition 8 contains essence water of hydrolyzed monkey bread tree extract, algae oligosaccharides and phloretin, and can more effectively restore the damaged skin disorder microbial flora to a relatively stable and balanced skin microbial flora state close to healthy skin.

2. Oil control effect of the composition

This example also conducted an oil control test on 24 subjects, aged between 18-45 years, all subjects had a tendency to have vigorous scalp oil secretion, and the subjects were equally divided into 8 groups of 3 subjects each. The subjects of each group used compositions 1-8, each on the scalp, each 2ml each in the morning and evening (each subject was only briefly hair cleaned during the test and did not use head oil control products other than the test composition). Scalp sebum content was measured before the test was started on the day (day 0), and on days 7, 14, and 28 after use.

In this example, sebum testing is based on quartz crystal sensor technology, whereby the amount of sebum is collected from the scalp by a sensor. The larger the sebum skin quantity value is, the higher the sebum content is; the smaller the number, the lower the sebum content, the better the oil control effect of the product. The test results are shown in fig. 4.

The results data at the return visit test at day 14 and day 28 show that compositions containing only a single 0.5% content of hydrolyzed monkey bread tree extract, algae oligosaccharides or phloretin have no significant oil control effect on scalp oil; and for the composition 8 containing the hydrolyzed monkey tree extract, the algae oligosaccharides and the phloretin, after the subject continuously uses the essence water containing the hydrolyzed monkey tree extract, the algae oligosaccharides and the phloretin in the composition 8, the composition can obviously and effectively realize the oil control effect, and the oil content is respectively reduced by 31.78 percent and 51.16 percent on the 14 th and 28 th return visit detection compared with the 0 th state.

3. The composition has effects of relieving and eliminating red, relieving itching, and removing dandruff

The study tested 24 subjects, between 18 and 45 years of age, all subjects had a tendency to respond to scalp dermatitis (including redness, itching, more dandruff) and the subjects were equally divided into 8 groups of 3 subjects. The subjects of each group used compositions 1-8, respectively, on the scalp in the morning and evening, each time 2ml. For 28 days of continuous use, the present example tested TEWL values of the scalp on day 0, day 14, and day 28, respectively, and evaluated the scalp soothing, redness-removing, itching-relieving, and dandruff-removing effects with the dermatologist by consumer self-evaluation.

1. Scalp percutaneous moisture loss (TEWL)

Test instrument: skin moisture loss tester Tewameter TM 300; the lower the detection value, the less the percutaneous moisture loss; the unit is g/(h.m) ² )。

The test principle is as follows: the tewatemeter probe measures the density gradient of skin moisture evaporation using two pairs of sensors (temperature and relative humidity) within the hollow cylinder. The physical basis of the measurement is the law of diffusion found by Adolf Fick in 1855: dm/dt= -D ∙ a ∙ dp/dx. Wherein: a=area (m ² ) M=water loss (g), t=time (h), d=diffusion constant (0.0877 g/m (h (mmHg)), p=atmospheric pressure (mmHg), x=distance of skin surface to zenith (m). Detection results such asFIG. 5 shows

The results data at the return visit test at day 14 and day 28 show that compositions containing only a single 0.5% content of hydrolyzed monkey bread tree extract, algae oligosaccharides or phloretin have no significant improvement effect on the percutaneous moisture loss TEWL value of the scalp; for the composition 8 containing the hydrolyzed monkey tree extract, the algae oligosaccharides and the phloretin, after the subject continuously uses the essence water containing the hydrolyzed monkey tree extract, the algae oligosaccharides and the phloretin in the composition 8, the composition 8 can remarkably reduce the skin water loss rate, effectively improve the water balance and enhance the barrier function of the scalp.

2. Test for relieving and removing redness, relieving itching and removing dandruff

For convenience of representation, the following evaluation standards and symbols are used for display, and specifically:

scalp redness degree: +++: indicating that redness is severe; ++: indicating that the redness level is general; +: indicating a very weak redness; 0: indicating no redness.

Scalp itching degree: +++: indicating that the itching degree was severe; ++: indicating that the degree of itching is general; +: indicating a weak degree of itching; 0: indicating no itching.

Degree of dandruff: +++: indicating severe dandruff; ++: indicating that the degree of dandruff is general; +: indicating a very weak level of dandruff; 0: indicating little dandruff.

The evaluation results of redness, itching and dandruff degree of the scalp are shown in fig. 6.

After 28 days of use, the test results of the subjects show that the composition containing only a single hydrolyzed monkey bread tree extract, algae oligosaccharides or phloretin with the content of 0.5% has no obvious improvement effect on the conditions of redness, itching and dandruff of the skin; and the composition 8 essence water containing the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin can effectively relieve the redness, itching and dandruff of the scalp.

From the above test results, it is known that the skin care composition containing hydrolyzed monkey bread tree extract, algae oligosaccharides and phloretin can effectively improve skin moisture balance, enhance skin barrier function, and balance skin microecological environment, thereby effectively solving skin problems such as redness, itching, dryness, desquamation and the like.

Meanwhile, the present embodiment also provides compositions 9, 10, 11, wherein the composition 9 comprises: hydrolyzing the extract of the monkey bread tree by 0.1%; 0.1% of algae oligosaccharides; phloretin 0.1%; the water is added to 100 percent. Composition 10 comprises: hydrolyzing the extract of the monkey bread tree by 0.5%; 0.5% of algae oligosaccharides; phloretin 0.5%; the water is added to 100 percent. Composition 11 comprises: hydrolyzing the extract of the monkey bread tree by 1%; 1% of algae oligosaccharides; phloretin 0%; the water is added to 100 percent. The same test as above was performed, and the result showed that composition 9 also functions similarly to composition 8, but the effect was slightly weaker than that of composition 8; composition 10 also functions similarly to composition 8 and has a similar effect to composition 8; composition 11 was similar to compositions 1-7, with no significant improvement.

Example 2

The embodiment discloses a face cream which comprises the following components in percentage by weight:

Phase A:

the water is supplemented to 100%

Glycerol 4%

EDTA-2Na 0.02%

Hydroxyethyl cellulose 0.1%

Carbomer 0.2%

Sodium hyaluronate 0.02%

Panthenol 0.5%

And B phase:

sucrose stearate, cetostearyl glucoside, cetyl alcohol 2%

Glycerol stearate, PEG-100 stearate 1.5%

Cetostearyl alcohol 3.5%

Polydimethylsiloxane 2%

Hydrogenated polyisobutene 2%

Squalane 0.1%

Tocopheryl acetate 0.5%

Caprylic/capric triglyceride 6.5%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7, water 0.8%

And D phase:

arginine 0.54%

E phase

Butanediol 2%

P-hydroxyacetophenone 0.5%

1, 2-hexanediol 0.5%

F phase

The composition was 8.6%.

The face cream is prepared by the following preparation method, which comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, preserving heat for 15-20 minutes, and homogenizing (3000 rpm) until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum to remove foam;

S3, adding the phase C, homogenizing for 3-5 minutes, stirring and cooling;

s4, the temperature is reduced to about 70 ℃, and the dissolved D phase is added and stirred uniformly;

s5, the temperature is reduced to about 60 ℃, dissolved E phase is added, and the mixture is stirred uniformly;

s6, reducing the temperature to 40-45 ℃, sequentially adding the materials of the phase F, and uniformly stirring;

s7, cooling to about 38 ℃, and checking to be qualified and discharging.

The facial cream perfectly maintains the synergistic effect of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin, is convenient for moisturizing the skin and promoting the recovery of damaged areas.

Meanwhile, the aforementioned face cream is face cream 1, and the present embodiment further provides face creams 2, 3, 4, specifically, face cream 2 has the formula: phase A: supplementing water to 100%; glycerol 3%; EDTA-2Na 0.01%; hydroxyethyl cellulose 0.05%; carbomer 0.10%; sodium hyaluronate 0.01%; panthenol 0.4%; and B phase: sucrose stearate, cetostearyl glucoside, cetyl alcohol 1%; glycerol stearate, PEG-100 stearate 1%; cetostearyl alcohol 3%; 1% of polydimethylsiloxane; hydrogenated polyisobutene 1%; squalane 0.08%; tocopherol acetate 0.4%; caprylic/capric triglyceride 5%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7%; and D phase: arginine 0.5%; e phase: 1% of butanediol; 0.4% of p-hydroxyacetophenone; 0.4% of 1, 2-hexanediol; and F phase: composition 8.5%.

The formula of the face cream 3 is as follows: phase A: supplementing water to 100%; 5% of glycerol; EDTA-2Na 0.03%; 0.12% of hydroxyethyl cellulose; carbomer 0.4%; sodium hyaluronate 0.03%; panthenol 0.6%; and B phase: sucrose stearate, cetostearyl glucoside, cetyl alcohol 3%; glycerol stearate, PEG-100 stearate 2%; cetostearyl alcohol 4%; 3% of polydimethylsiloxane; hydrogenated polyisobutene 3%; 0.12% of squalane; 0.6% of tocopheryl acetate; caprylic/capric triglyceride 7%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.9%; and D phase: arginine 0.6%; e phase: 3% of butanediol; 0.6% of p-hydroxyacetophenone; 0.6% of 1, 2-hexanediol; and F phase: composition 8.7%;

the formula of the face cream 4 is as follows: phase A: supplementing water to 100%; 6% of glycerol; EDTA-2Na 0.05%; hydroxyethyl cellulose 0.05%; carbomer 0.10%; 0.01-0.03% of sodium hyaluronate; panthenol 0.6%; and B phase: sucrose stearate, cetostearyl glucoside, cetyl alcohol 3%; glycerol stearate, PEG-100 stearate 2%; cetostearyl alcohol 3%; 2% of polydimethylsiloxane; hydrogenated polyisobutene 2%; 0.10% of squalane; 0.5% of tocopheryl acetate; caprylic/capric triglyceride 6%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.8%; and D phase: arginine 0.5%; e phase: 1% of butanediol; 0.5% of p-hydroxyacetophenone; 0.5% of 1, 2-hexanediol; and F phase: composition 6.6%.

The formula applying effect of the face cream 2 and 3 is consistent with the face cream effect, and the face cream can effectively moisten, repair and maintain the skin health state, but the time required for achieving the same effect is longer than that of the face cream 1. The formula of the face cream 4 cannot achieve the effect of the formula of the face cream 1 and the face creams 2 and 3, and the improvement of the skin is not obvious.

Example 3

The embodiment discloses a skin lotion which comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Glycerol 10%

EDTA-2Na 0.02%

Hydroxyethyl cellulose 0.1%

Carbomer 0.1%

Sodium hyaluronate 0.02%

Panthenol 0.5%

Phase B

Cetostearyl alcohol, coco glucoside, water, glucose 1%

Glycerol stearate, PEG-100 stearate 1%

Cetostearyl alcohol 2.5%

Polydimethylsiloxane 1.5%

Hydrogenated polyisobutene 1%

Squalane 0.3%

Tocopheryl acetate 0.5%

Caprylic/capric triglyceride 6.5%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7, water 0.8%

D phase

Arginine 0.04%

E phase

Butanediol 2%

P-hydroxyacetophenone 0.5%

1, 2-hexanediol 0.5%

F phase

The composition was 8.6%.

The skin lotion is prepared by the following preparation method, and comprises the following steps:

s1, putting the phase A into a pot, heating to 80-85 ℃, stirring, preserving heat for 15-20 minutes, and homogenizing (3000 rpm) until the phase A is completely dissolved;

s2, heating the phase B to 80-85 ℃, stirring until the phase B is completely dissolved, adding the phase A, emulsifying and homogenizing for 5-8 minutes, and stirring in vacuum to remove foam;

s3, adding the phase C, homogenizing for 3-5 minutes, stirring and cooling;

s4, the temperature is reduced to about 70 ℃, and the dissolved D phase is added and stirred uniformly;

s5, the temperature is reduced to about 60 ℃, dissolved E phase is added, and the mixture is stirred uniformly;

s6, reducing the temperature to 40-45 ℃, sequentially adding the materials of the phase F, and uniformly stirring;

s7, cooling to about 38 ℃, and checking to be qualified and discharging.

Meanwhile, the skin lotion is skin lotion 1, and the embodiment also provides skin lotions 2, 3 and 4, specifically, the formula of skin lotion 2 is as follows: phase A: supplementing water to 100%; glycerol 9%; EDTA-2Na 0.01%; hydroxyethyl cellulose 0.05%; carbomer 0.05%; sodium hyaluronate 0.01%; panthenol 0.4%; and B phase: cetostearyl alcohol, coco glucoside, water, glucose 0.5%; glycerol stearate, PEG-100 stearate 0.8%; cetostearyl alcohol 2%; 1% of polydimethylsiloxane; hydrogenated polyisobutene 0.5%; 0.2% of squalane; 0.3% of tocopheryl acetate; caprylic/capric triglyceride 5%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7%; and D phase: arginine 0.03%; e phase: 1% of butanediol; 0.4% of p-hydroxyacetophenone; 0.4% of 1, 2-hexanediol; and F phase: composition 8.5%.

The formula of the skin lotion 3 is as follows: phase A: supplementing water to 100%; 11% of glycerol; EDTA-2Na 0.03%; 0.12% of hydroxyethyl cellulose; carbomer 0.15%; sodium hyaluronate 0.03%; panthenol 0.6%; and B phase: cetostearyl alcohol, coco glucoside, water, 1.5% glucose; glycerol stearate, PEG-100 stearate 1.3%; cetostearyl alcohol 3%; 2% of polydimethylsiloxane; hydrogenated polyisobutene 1.5%; 0.4% of squalane; 0.6% of tocopheryl acetate; caprylic/capric triglyceride 7%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.9%; and D phase: arginine 0.6%; e phase: 3% of butanediol; 0.6% of p-hydroxyacetophenone; 0.6% of 1, 2-hexanediol; and F phase: composition 8.7%;

the formula of the skin lotion 4 is as follows: phase A: supplementing water to 100%; 6% of glycerol; EDTA-2Na 0.05%; hydroxyethyl cellulose 0.05%; carbomer 0.10%; sodium hyaluronate 0%; panthenol 1%; and B phase: cetostearyl alcohol, coco glucoside, water, glucose 2%; glycerol stearate, PEG-100 stearate 2%; cetostearyl alcohol 3%; 2% of polydimethylsiloxane; hydrogenated polyisobutene 2%; 0.10% of squalane; 0.5% of tocopheryl acetate; caprylic/capric triglyceride 6%; and C phase: polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0%; and D phase: arginine 0.5%; e phase: 1% of butanediol; 0.5% of p-hydroxyacetophenone; 0.5% of 1, 2-hexanediol; and F phase: composition 6.6%.

The formula applying effect of the skin cream 2 and 3 is consistent with that of the skin cream 1, and the skin cream can effectively moisten, repair and maintain the skin health state, but the time required for achieving the same effect is slightly longer than that of the skin cream 1. The formula of the skin lotion 4 cannot achieve the effects of the formula of the skin lotion 1 and the formulas of the skin lotions 2 and 3, and the improvement of the skin is not obvious.

Example 4

The embodiment discloses a shampoo, which comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.30%

Ammonium laureth sulfate 7%

Glycol distearate 1.1%

PEG-150 distearate 0.5%

Cetostearyl alcohol 0.3%

EDTA disodium 0.1%

Trehalose 0.01%

Phase B

Cocoyl amphodiacetate disodium 1.5%

Cocoamidopropyl betaine 1.5%

PEG-80 sorbitan laurate 1.5%

Polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 2%

Decyl glucoside 0.45%

Panthenol 0.1%

Phase C

Phenoxyethanol 0.6%

Sodium benzoate 0.3%

D phase

Composition 8.6%

E phase

Citric acid 0.1%

Sodium chloride 0.4%.

The shampoo is prepared by the following preparation method, which comprises the following steps:

s1, prefabricating phases: dispersing sodium benzoate, citric acid and sodium chloride in part of water in advance;

s2, dispersing acrylic acid (ester)/C10-30 alkanol acrylic ester crosslinked polymer in a water phase pot, then adding the rest raw materials of the phase A, heating to 85-88 ℃, stirring and dissolving, and preserving heat for 20-30min;

s3, cooling to about 70 ℃, adding the phase B, stirring until the phase B is dissolved, preserving heat for 10-15min, and continuing cooling;

s4, adding phase C phenoxyethanol and sodium benzoate which is partially dispersed, and uniformly stirring;

s5, adding the phase D, and finally, adjusting the pH value and the viscosity by adding the phase E, and carrying out inspection;

s6, cooling to about 38 ℃ after being qualified, and discharging through 200-mesh filter cloth.

Meanwhile, the shampoo is shampoo 1, and the embodiment further provides shampoos 2, 3 and 4, specifically, the shampoo 2 comprises the following formula: phase A: supplementing water to 100%; acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.2%; 6% of ammonium laureth sulfate; ethylene glycol distearate 1%; PEG-150 distearate 0.3%; cetostearyl alcohol 0.2%; EDTA disodium 0.05%; trehalose 0.008%; and B phase: 1% of disodium cocoyl amphodiacetate; cocoamidopropyl betaine 1%; PEG-80 sorbitan laurate 1%; polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 1%; decyl glucoside 0.4%; panthenol 0.05%; and C phase: 0.5% of phenoxyethanol; sodium benzoate 0.2%; and D phase: 0.5% of the aforementioned composition; e phase: citric acid 0.05%; sodium chloride 0.35%.

The formula of the shampoo 3 is as follows: phase A: supplementing water to 100%; acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.4%; 8% of ammonium laureth sulfate; ethylene glycol distearate 1.2%; PEG-150 distearate 0.6%; cetostearyl alcohol 0.4%; EDTA disodium 0.15%; trehalose 0.012%; and B phase: 2% of disodium cocoyl amphodiacetate; cocoamidopropyl betaine 1.8%; PEG-80 sorbitan laurate 2%; polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 3%; decyl glucoside 0.5%; panthenol 0.12%; and C phase: 0.7% of phenoxyethanol; sodium benzoate 0.4%; and D phase: 0.7% of the aforementioned composition; e phase: citric acid 0.15%; sodium chloride 0.45%.

The formula of the shampoo 4 is as follows: phase A: supplementing water to 100%; acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0%; 6% of ammonium laureth sulfate; ethylene glycol distearate 0%; PEG-150 distearate 0.3%; cetostearyl alcohol 0.2%; EDTA disodium 0.05%; trehalose 0.008%; and B phase: 1% of disodium cocoyl amphodiacetate; cocoamidopropyl betaine 0%; PEG-80 sorbitan laurate 1%; polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 1%; decyl glucoside 0.4%; panthenol 0.05%; and C phase: 0.5% of phenoxyethanol; sodium benzoate 0.2%; and D phase: 0.5% of the aforementioned composition 7; e phase: citric acid 0.05%; sodium chloride 0.35%.

The shampoo 2 and 3 has similar formula application effect to the shampoo 1, can effectively control oil and promote scalp repair, but has weaker effect than the shampoo 1. The shampoo 4 formulation failed to achieve the same effect as the shampoo 1 and shampoo 2 and 3 formulations, and the improvement was not obvious.

Example 5

The embodiment discloses essence water which comprises the following components in percentage by weight:

phase A

The water is supplemented to 100%

Glycerol 3%

PEG-40 hydrogenated castor oil 0.1%

Phase B

Phenoxyethanol 0.9%

Ethylhexyl glycerol 0.1%

Phase C

Allantoin 0.5%

Sodium hyaluronate 1%

Honeysuckle (LONICERA JAPONICA) flower extract 0.01%

Hydrolyzed monkey bread tree extract 0.2%

Algae oligosaccharide 0.2%

Phloretin 0.2%.

The essence water is prepared by the following preparation method, and comprises the following steps:

s1, putting phase A deionized water, glycerol and PEG-40 hydrogenated castor oil into a pot, heating to 90 ℃, stirring and preserving heat for 15-20 minutes;

s2, cooling to 70-75 ℃, and adding phase B phenoxyethanol and ethylhexyl glycerol;

s3, reducing the temperature to 40-45 ℃, and adding a phase C;

S4, cooling to about 38 ℃, and checking to be qualified and discharging.

Meanwhile, the embodiment also provides essence water 2, 3 and 4, specifically, the formula of the essence water 2 is as follows: phase A: supplementing water to 100%; glycerol 2%; 0.05% of PEG-40 hydrogenated castor oil; and B phase: 0.7% of phenoxyethanol; 0.05% of ethylhexyl glycerol; and C phase: allantoin 0.3%; sodium hyaluronate 0.8%; honeysuckle (LONICERA JAPONICA) flower extract 0.008%; hydrolyzing the extract of the monkey bread tree by 0.1%; 0.1% of algae oligosaccharides; phloretin 0.1%;

the formula of the essence liquid 3 is as follows: phase A: supplementing water to 100%; glycerol 4%; 0.15% of PEG-40 hydrogenated castor oil; and B phase: phenoxyethanol 1%; 0.12% of ethylhexyl glycerol; and C phase: allantoin 0.55%; 1.1% of sodium hyaluronate; honeysuckle (LONICERA JAPONICA) flower extract 0.011%; hydrolyzing the extract of the monkey bread tree by 0.3%; 0.3% of algae oligosaccharides; phloretin 0.3%;

the formula of essence water 4 is as follows: phase A: supplementing water to 100%; glycerol 2%; 0.1% of PEG-40 hydrogenated castor oil; and B phase: 0.9% of phenoxyethanol; 0.1% of ethylhexyl glycerol; and C phase: allantoin 0%; sodium hyaluronate 1%; honeysuckle (LONICERA JAPONICA) flower extract 0%; hydrolyzing the extract of the monkey bread tree by 0.2%; algae oligosaccharide 0%; phloretin 0.2%.

The formula application effects of the essence water 2 and 3 are similar to those of the essence water 1, so that the skin barrier can be effectively repaired, the microecology can be balanced, and meanwhile, the essence water is basically non-irritating, but the effect is weaker than that of the essence water 1. The formula of the essence water 4 cannot achieve the effects similar to those of the formula of the essence water 1 and the formulas of the essence water 2 and the essence water 3, and the improvement is not obvious.

It should be understood that the foregoing examples of the present invention are merely illustrative of the present invention and are not intended to limit the present invention to the specific embodiments thereof. Any modification, equivalent replacement, improvement, etc. that comes within the spirit and principle of the claims of the present invention should be included in the protection scope of the claims of the present invention.

Claims (10)

1. The application of the compound composition of the hydrolyzed monkey bread tree extract, the algae oligosaccharides and the phloretin in preparing products for balancing skin microecology, repairing skin barriers, regulating and controlling skin grease secretion, inhibiting skin water diversion and/or relieving skin redness, itching and desquamation is provided, wherein in the compound composition, the hydrolyzed monkey bread tree extract accounts for 0.1-0.5% by weight, the algae oligosaccharides accounts for 0.1-0.5% by weight, and the phlores Pi Suzhan accounts for 0.1-0.5% by weight.

2. The use according to claim 1, characterized in that the use of a composition of hydrolyzed monkey bread tree extract, algae oligosaccharides and phloretin for the preparation of a product with the functions of balancing skin micro-ecology and repairing skin barrier.

3. The use according to claim 1, wherein balancing skin micro-ecology comprises modulating the relative abundance of propionibacterium, acinetobacter, corynebacterium, staphylococcus, bacteroides, prasugrel, weissella, bifidobacterium, lactobacillus and/or aqua bacteria flora on the skin.

4. The use according to claim 1, wherein the skin comprises facial skin and scalp.

5. A composition is characterized by comprising a hydrolyzed monkey bread tree extract, an algae oligosaccharide and phloretin, wherein the weight percentage of the hydrolyzed monkey bread tree extract, the algae oligosaccharide and the phloretin in the composition is 0.3-1.5%; and the hydrolyzed monkey bread tree extract accounts for 0.1-0.5 wt%, the algae oligosaccharides accounts for 0.1-0.5 wt% and the roots Pi Suzhan account for 0.1-0.5 wt%.

6. The composition of claim 5, comprising the following components in weight percent:

hydrolyzing 0.1-0.5% of a monkey bread tree extract;

0.1-0.5% of algae oligosaccharides;

0.1-0.5% of phloretin;

the water is added to 100 percent.

7. A facial cream, characterized by comprising the following components in percentage by weight:

phase A:

the water is supplemented to 100%

3-5% of glycerol

EDTA-2Na 0.01~0.03%

0.05-0.12% of hydroxyethyl cellulose

Carbomer 0.10-0.4%

0.01 to 0.03 percent of sodium hyaluronate

0.4-0.6% of panthenol

And B phase:

sucrose stearate, cetostearyl glucoside and cetyl alcohol 1-3%

Glycerol stearate and PEG-100 stearate 1-2%

Cetostearyl alcohol 3-4%

1-3% of polydimethylsiloxane

Hydrogenated polyisobutene 1-3%

0.08-0.12% of squalane

0.4-0.6% of tocopheryl acetate

Caprylic/capric triglyceride 5-7%

And C phase:

polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

And D phase:

arginine 0.5-0.6%

E phase

1-3% of butanediol

0.4-0.6% of p-hydroxyacetophenone

0.4-0.6% of 1, 2-hexanediol

F phase

The composition of any one of claims 5 to 6, 0.5 to 0.7%.

8. The skin lotion is characterized by comprising the following components in percentage by weight:

phase A

The water is supplemented to 100%

Glycerol 9-11%

EDTA-2Na 0.01~0.03%

0.05-0.12% of hydroxyethyl cellulose

Carbomer 0.05-0.15%

0.01 to 0.03 percent of sodium hyaluronate

0.4-0.6% of panthenol

Phase B

Cetostearyl alcohol, cocoyl glucoside, water and glucose 0.5-1.5%

Glycerol stearate and PEG-100 stearate 0.8-1.3%

Cetostearyl alcohol 2-3%

1-2% of polydimethylsiloxane

Hydrogenated polyisobutene 0.5-1.5%

0.2 to 0.4 percent of squalane

0.3-0.6% of tocopheryl acetate

Caprylic/capric triglyceride 5-7%

Phase C

Polyacrylamide, C13-14 isoparaffin, laureth-7 and water 0.7-0.9%

D phase

Arginine 0.03-0.06%

E phase

1-3% of butanediol

0.4-0.6% of p-hydroxyacetophenone

0.4-0.6% of 1, 2-hexanediol

F phase

The composition of any one of claims 5 to 6, 0.5 to 0.7%.

9. The shampoo is characterized by comprising the following components in percentage by weight:

phase A

The water is supplemented to 100%

Acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.2-0.4%

6-8% of laureth ammonium sulfate

1-1.2% of glycol distearate

PEG-150 distearate 0.3-0.6%

Cetostearyl alcohol 0.2-0.4%

EDTA disodium 0.05-0.15%

Trehalose 0.008-0.012%

Phase B

1-2% of cocoyl amphoteric diacetic acid disodium

1-1.8% of cocoamidopropyl betaine

PEG-80 sorbitan laurate 1-2%

Polydimethyl siloxane alcohol, dodecyl benzene sulfonic acid TEA salt and water 1-3%

Decyl glucoside 0.4-0.5%

0.05-0.12% of panthenol

Phase C

0.5 to 0.7% of phenoxyethanol

Sodium benzoate 0.2-0.4%

D phase

A composition according to any one of claims 5 to 6, 0.5 to 0.7%

E phase

Citric acid 0.05-0.15%

0.35-0.45% of sodium chloride.

10. The essence water is characterized by comprising the following components in percentage by weight:

Phase A

The water is supplemented to 100%

2-4% of glycerol

PEG-40 hydrogenated castor oil 0.05-0.15%

Phase B

0.7-1% of phenoxyethanol

0.05-0.12% of ethylhexyl glycerol

Phase C

Allantoin 0.3-0.55%

0.8 to 1.1% of sodium hyaluronate

0.008-0.011% of honeysuckle extract

0.1-0.3% of hydrolyzed monkey bread tree extract

0.1 to 0.3% of algae oligosaccharide

0.1-0.3% of phloretin.

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