CN117137977A - Preparation method of lactation-promoting traditional Chinese medicine composition for sows - Google Patents

Preparation method of lactation-promoting traditional Chinese medicine composition for sows Download PDF

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CN117137977A
CN117137977A CN202311356669.XA CN202311356669A CN117137977A CN 117137977 A CN117137977 A CN 117137977A CN 202311356669 A CN202311356669 A CN 202311356669A CN 117137977 A CN117137977 A CN 117137977A
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parts
brown sugar
promoting
sows
lactation
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张世新
刘加梅
贾付从
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Beijing Zhongnong Jinteng Biopharmaceutical Co ltd
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Beijing Zhongnong Jinteng Biopharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

Abstract

The invention discloses a preparation method of a lactation promoting traditional Chinese medicine composition for sows, which belongs to the technical field of traditional Chinese veterinary medicines and comprises the following steps: weighing the raw materials; steaming brown sugar in basin, dissolving in warm water to obtain brown sugar water; mixing brown sugar water and yellow wine, soaking, air drying, and pulverizing into superfine powder; or mixing and dissolving the fermented glutinous rice juice and brown sugar, soaking the raw materials, adding water until all the materials are submerged, boiling in a sealed stainless steel pot, and taking the liquid medicine and the residues. The traditional Chinese medicine composition for promoting lactation of sows, which is prepared by the method, is prepared by reasonable formula of traditional Chinese medicines, and has no medicine residue and no toxic or side effect; the preparation method is simple and is suitable for the requirement of large-scale industrial production. The feed has the main effects of improving lactation yield and immunity of sows, promoting postpartum recovery, stress resistance and the like of sows, accelerating piglet growth, improving disease resistance of piglets, promoting early weaning of young animals, improving uniformity of young animals and finally improving economic benefits of breeding industry.

Description

Preparation method of lactation-promoting traditional Chinese medicine composition for sows
Technical Field
The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a preparation method of a lactation-promoting traditional Chinese medicine composition for sows.
Background
In livestock production, some sows are frequently in postpartum hypogalactia or weaning, the growth speed, the immunity, the weaning nest weight and the like of piglets are seriously influenced, the piglets are sick, grow slowly and grow stagnantly, and serious economic losses are brought to pig farmers. There are many reasons for the lack or lack of lactation in sows after delivery: 1. sow malnutrition, emaciation, weakness, body weakness and physiological hypofunction; the sow is overfertilized, and the breasts are filled with fat; the sow is premature in hybridization and the mammary gland is hypoplastic; the pregnant women are inappropriately fed, the expansion degree of breasts is poor before and after delivery, partial primary milk is available, but the lactation is not carried out soon; 2. the sow suffers from complications such as mastitis and endometritis after delivery, and has symptoms of anorexia, listlessness, breast red swelling, oliguria and agalactia. The sow is required to find out the reason and adopt proper measures to solve the problem of postpartum hypogalactia or agalactia.
Therefore, how to develop a method for preparing the lactation promoting traditional Chinese medicine composition for the sow, which can improve the lactation yield and the immunity of the sow, promote the postpartum recovery, the stress resistance and the like of the sow, accelerate the growth of piglets, improve the disease resistance of the piglets, promote the early weaning of young animals, improve the uniformity of the young animals and finally improve the economic benefit of the breeding industry, by reasonably screening and composing the traditional Chinese medicine, is a technical problem which needs to be solved by the technicians in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a preparation method of a lactation-promoting traditional Chinese medicine composition for sows, which solves the problem that the sows lack or have no lactation after delivery.
In order to achieve the above purpose, the invention is realized by the following technical scheme:
a preparation method of a lactation-promoting traditional Chinese medicine composition for sows comprises the following steps:
(1) Weighing the following raw material medicaments in part by weight: 3-6 parts of astragalus membranaceus, 3-6 parts of uniflower swisscentaury root, 3-6 parts of ligusticum wallichii, 3-6 parts of angelica sinensis, 3-6 parts of medulla tetrapanacis, 3-6 parts of semen vaccariae and 3-6 parts of prepared rehmannia root;
(2) Steaming brown sugar in basin, dissolving in 40-50deg.C warm water to obtain brown sugar water with brown sugar content of 5-20wt%;
(3) Mixing and soaking the crude drugs with brown sugar water and yellow wine according to the volume ratio of 10:3 for 24 hours, taking out the crude drugs, airing and crushing the crude drugs into superfine powder;
or mixing and dissolving the fermented glutinous rice juice and the brown sugar, soaking the raw material medicines for 48 hours, adding water until all the medicinal materials are submerged, adding 10L of the fermented glutinous rice juice into 1kg of brown sugar, boiling for 40 minutes by using a closed stainless steel pot, and taking the medicinal liquid and the medicinal residues.
Further, the weight portions of the raw materials are as follows: 3.5-6 parts of astragalus membranaceus, 3.5-6 parts of uniflower swisscentaury root, 3.5-6 parts of ligusticum wallichii, 3.5-6 parts of angelica sinensis, 3.5-6 parts of medulla tetrapanacis, 3.5-6 parts of semen vaccariae and 3.5-6 parts of prepared rehmannia root.
Further, the particle size of the ultrafine powder is 300 mesh or more.
Further, the dosage of the superfine powder is 200g of each pig, 1000g of the traditional Chinese medicine composition is diluted with 2-3 distilled water to be filled into each bag of the traditional Chinese medicine composition when the traditional Chinese medicine composition is used, and the traditional Chinese medicine composition is used for 3-5 days as a treatment course once a day;
or the dosage of the liquid medicine is 100mL of the liquid medicine per 100kg of the liquid medicine fed by the pig by weight, 2 times a day, 3-5 days for continuous feeding, and the corresponding medicine dreg mixed material is fed.
Modern pharmaceutical research shows that each medicine has the following effects:
1. astragalus root, radix astragali, sweet in taste and slightly warm in nature; the Chinese medicinal composition enters lung, spleen, liver and kidney meridians; has effects in invigorating qi, consolidating superficial resistance, inducing diuresis, relieving edema, removing toxic substances, promoting pus discharge, healing sore, promoting granulation, enhancing immunity, protecting liver, promoting urination, resisting aging and stress, lowering blood pressure, and inhibiting bacteria. The chemical components of radix astragali mainly comprise flavonoids, saponins and polysaccharides, wherein the flavonoids comprise four kinds of flavonoids, isoflavone and pterocarpan, and the saponins comprise radix astragali saponin and its soyasaponin. In addition, the composition also contains monosaccharide, amino acid, protein, riboflavin, folic acid, nicotinic acid, vitamin D, linoleic acid, linolenic acid, microelements, vanillic acid, ferulic acid, isoferulic acid, p-hydroxyphenyl acrylic acid, caffeic acid, chlorogenic acid, palmitic acid and the like. Modern pharmaceutical research shows that astragalus has various pharmacological actions: (1) enhancing the immunity of the organism: astragalus root can strengthen the phagocytic function of reticuloendothelial system, so that the number of blood leucocytes and polynuclear leucocytes is obviously increased, the phagocytic percentage and phagocytic index of macrophages are obviously increased, and the astragalus root has the effect of promoting humoral immunity and cellular immunity. Astragalus mongholicus also increases the activity of lymphokine (interleukin-2) activated natural killer cells (LAK). (2) enhancing the stress capability of the organism: the astragalus polysaccharide has obvious anti-fatigue effect, can obviously prolong the swimming time of hydrocortisone-depleted mice and increase the epinephrine weight, has obvious tolerance to various hypoxia models of the mice, and can obviously reduce systemic oxygen consumption and increase the hypoxia tolerance of tissues. The astragalus polysaccharide has obvious low temperature resistance, and can obviously prolong the antibiotic life of normal and deficiency mice. (3) promote metabolism and improve cardiac function. (4) liver protection and blood pressure reduction: astragalus root can prevent liver glycogen from decreasing and has a protective effect on carbon tetrachloride hepatitis of mice. (5) antibacterial and antiviral effects: radix astragali has inhibiting effects on Bacillus dysenteriae, pneumococcus, hemolytic streptococcus, golden yellow, lemon color, and white staphylococcus. Astragalus mongholicus has the capability of enhancing virus induced interferon and has a certain inhibition effect on pathogenic effects of oral viruses and influenza Sendai BB1 viruses, but has no direct inactivation effect.
2. Radix Rhapontici, bitter and salty in taste, and cold in nature; enter stomach and large intestine meridians. Has effects of clearing heat and detoxicating, dredging channels and promoting lactation, and can be used for treating acute mastitis, swelling and pain, galactostasis, carbuncle, skin sore, spasm of wet arthralgia and tendons, bone joint pain, and toxic heat and bloody dysentery. Modern researches have shown that the main components of uniflower swisscentaury root are: rhizoma Phragmitis, qizhou, contains volatile oil; the fruit of Echinops ritro L of Xinjiang contains Echinopsine, and the seed contains Echinopsine (Echinopsine) and Echinopsine (Echinine). Modern pharmaceutical research shows that the pharmacological actions of uniflower swisscentaury root are as follows: (1) effects on the central nervous system: the effect of the privet head alkali is similar to that of strychnine, the small dose has exciting effect on animals, the large dose causes spasm, and the systemic inhibition appears later; has effects in waking up mice sleep caused by barbital, exciting neuromuscular device, and promoting peripheral nerve recovery. (2) effects on the cardiovascular system: the prinsepia utilis can cause blood pressure drop and heart contractility increase for anesthetized cat, and heart contractility tension increase for isolated frog heart, contraction amplitude decrease, and high concentration can stop heart in systole. Exhibiting vasodilation to isolated rabbit ears. (3) effect on intestinal smooth muscle: the prinsepia utilis royle alkali can increase the tension of the cat in vitro intestinal canal and inhibit the rabbit in vitro intestinal canal. It is weaker in spasmolytic action than Shining. (4) antifungal action: the radix Rhapontici (unknown variety) water infusion (1:3) has various degrees of inhibition effects on dermatophytes such as Trichophyton schoenlafricanum and Nocardia astrotrichlica in vitro. Clinically, the uniflower swisscentaury root and a plurality of traditional Chinese medicines are used together, and can be used for treating initial sores and carbuncles, galactostasis, breast swelling and pain and other symptoms; can also be used for treating tumor, obesity, cystic hyperplasia of breast, etc.
3. Ligusticum wallichii, pungent in flavor and warm in nature; enter liver, gallbladder and pericardium meridians. Has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain, and can be used for treating traumatic injury, qi and blood stasis, retention of placenta, puerperal blood stasis, and rheumatalgia. The active ingredients of rhizoma Ligustici Chuanxiong mainly include alkaloids such as ligustrazine (chuanxiongzine), loline (pelolyrine), and L-isoleucine-L-valine anhydride, organic acids and phenols such as ferulic acid (ferulic acid), siraitia acid, and chrysophanol, volatile oils such as ligustilide (ligustilide), cnidilide (cnidilide), neocnidilide (neocnidilide), and senkyunolide, and other ingredients. Modern pharmaceutical researches have shown that Ligusticum wallichii has the following pharmacological actions: (1) cardiovascular effects: the rhizoma Ligustici Chuanxiong water extract and alkaloid have effects of dilating coronary artery, increasing coronary artery flow, improving myocardial anoxia, and reducing myocardial oxygen consumption, and can be used for relieving coronary heart disease and angina pectoris. Is beneficial to playing the role of dilating blood vessels in brain, improving microcirculation, inhibiting platelet aggregation and the like. (2) antithrombotic action: ligustrazine can increase cAMP content in platelets, has inhibitory effect on thromboxane A2 (TXA 2) and alkaloids, can reduce platelet surface activity, inhibit platelet aggregation, and depolymerize aggregated platelets. Can shorten the length of thrombus, reduce the dry weight and wet weight of thrombus, and has certain curative effect on Diffuse Intravascular Coagulation (DIC). (3) spasmolytic and analgesic effects: chuan Xiong is water-extracted or alcohol-extracted extractum, which can inhibit the contraction of small intestine and uterus in vitro. Chuan (Chinese character)The volatile oil and decoction of rhizoma Ligustici Chuanxiong have tranquilizing effect, and the decoction can resist caffeine excitation. (4) antibacterial action: has obvious inhibiting effect on various gram-negative intestinal bacteria and inhibiting effect on various dermatophytes. In addition, researches show that the active ingredients of the ligusticum wallichii, such as ligustrazine, ferulic acid and the like, have the functions of scavenging oxygen free radicals and relieving Ca 2+ Overload, vascular endothelial cell protection, vascular dilation, apoptosis and hypertrophy inhibition, immune state regulation, platelet aggregation and thrombosis resistance, and multiple cytokine expression influence, thereby being capable of playing roles for multiple systems, multiple organs and multiple diseases.
4. Dang Gui is sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians. Has effects in replenishing blood, nourishing blood, promoting blood circulation, relieving pain, moistening dryness, and relieving constipation, and can be used for treating blood deficiency, fatigue, pain due to blood stasis, traumatic injury, carbuncle, swelling, sore, constipation, and fetal production. Modern pharmacological researches have further proved that Chinese angelica has the effects of promoting blood circulation, removing blood stasis, enriching blood, relieving pain and the like, and meanwhile, chinese angelica has the effects of resisting inflammation, scavenging oxygen free radicals, protecting liver, promoting bile flow, protecting kidney, enhancing immune function and the like. The medicinal chemistry research shows that the angelica mainly contains volatile oil, saccharides, amino acids, organic acids, flavonoids, coumarin, vitamins and other chemical components. (1) The volatile oil of Angelica sinensis is the main active part of the volatile oil for relieving spasm of vascular smooth muscle, wherein the activity of artemethide is strongest, and the mechanism of the volatile oil is probably to interfere with the metabolism of calcium ions in cells. (2) Ferulic acid has strong antioxidant and free radical scavenging effects, and has effects of inhibiting platelet aggregation, resisting thrombosis, inhibiting liver synthesis cholesterol, reducing blood lipid, improving atherosclerosis, resisting bacteria and viruses, regulating immunity, resisting myocardial ischemia, and resisting liver injury. (3) The saccharides contained in Angelica sinensis are mainly fructose, sucrose (40%) and acidic polysaccharide with complement activity. The radix Angelicae sinensis polysaccharide has effects of replenishing blood, regulating immunity and regulating metabolism. The Angelica sinensis polysaccharide can promote differentiation of pluripotent hematopoietic stem cells and CFU-GM layer, stimulate marrow granule single-line hematopoietic, and increase peripheral blood leukocyte. The angelica polysaccharide can regulate the complement receptor activity of lymphocyte membrane phase, strengthen lymphocyte immune response and have certain enhancement effect on organism immune function. When the recombinant strain returns to have strong capability of inducing gamma-interferon, the recombinant strain has an anti-tumor effect. (4) It also has antiinflammatory, analgesic, liver protecting, gallbladder function promoting, kidney and lung protecting effects.
5. Medulla Tetrapanacis has sweet and light taste and cold property; enter lung and stomach meridians. Has effects of clearing heat, promoting urination, and promoting lactation, and can be used for treating damp-heat in bladder, dysuria, and galactorrhea. Modern pharmaceutical researches show that the medulla of the medulla Junci contains 5.95% ash, 1.07% fat, 1.11% protein, 48.73% crude fiber, 5% pentosan and 28.04% uronic acid. Pharmacological experiments show that the medulla Tetrapanacis has better diuretic, anti-inflammatory and antipyretic effects. Especially, the medulla Tetrapanacis has rich polysaccharide content, and has certain effects of regulating immunity and resisting oxidation.
6. Semen Vaccariae, bitter in taste and mild in nature; enter liver and stomach meridians. Has the functions of dredging collaterals, promoting lactation, promoting blood circulation and removing blood stasis; is mainly used for treating galactostasis, acute mastitis and furuncle. The chemical components of the semen vaccariae mainly comprise triterpenoid saponins, flavonoid glycosides, coumarin and alkaloids. Has antioxidant, vascular smooth muscle dilating and angiogenesis inhibiting pharmacological activities; has pharmacological effects of resisting early pregnancy, resisting tumor, exciting uterus, promoting lactation, etc. Researches show that the Huang Tongzao glycoside component of the semen vaccariae is one of the effective components of the semen vaccariae, has the effect of promoting lactation, promotes proliferation of mammary epithelial cells of mice by inducing expression of cyclin D1, and induces expression of beta-casein genes by activating Jak-stat5 signaling pathway.
7. The prepared rehmannia root is a processed product of the dried rehmannia root, and after being processed, the medicine property is changed from slight cold to slight warm, so that the tonifying property is enhanced. Sweet taste and warm nature; it enters liver and kidney meridians. Has the effects of replenishing blood, nourishing essence, replenishing marrow, and is used for treating deficiency of liver-yin and kidney-yin, deficiency of blood, essence deficiency, flaccidity of waist and crotch, dyspnea due to deficiency, chronic cough, deficiency heat and night sweat. The chemical components in the prepared rehmannia root mainly comprise polysaccharide, 5-hydroxymethylfurfural, amino acid, iridoids, rehmannia root, mannitol, vitamin A substances, trihydroxy ionone and the like, and the chemical components are the material basis of pharmacological actions of the prepared rehmannia root. The prepared rehmannia root polysaccharide has the main functions of enhancing the hematopoiesis of organisms, enhancing the immunity of the organisms, resisting oxidation, resisting mutation and inhibiting the central nervous system. The prepared rehmannia root 5-hydroxymethyl furfural has the functions of resisting oxidation, improving hemorheology and the like. The prepared rehmannia root water extract can obviously stimulate Balb/C mice to secrete cytokine TNF-alpha, and the TNF-alpha has the killing activity and the anti-tumor activity on tumor cells, so that the prepared rehmannia root has the anti-tumor activity. The aqueous extract of radix rehmanniae Preparata not only can promote endothelial cell proliferation, but also can enhance memory and resist anxiety. In addition, researches show that the prepared rehmannia root ethanol extract has the functions of resisting aging and obviously promoting the regeneration of red blood cells, and improving the organism function deficiency caused by blood deficiency.
The traditional Chinese medicine composition has the following formula principle: the semen vaccariae in the prescription has the effects of promoting blood circulation, dredging channels, promoting lactation and relieving swelling, is a monarch drug and is mainly used for treating galactostasis, acute mastitis and furuncle; the Chinese angelica and the szechuan lovage rhizome have the effects of replenishing blood and activating blood, the astragalus and the prepared rehmannia root have the effects of tonifying qi and strengthening spleen, expelling toxin and expelling pus, and replenishing essence and marrow, and are ministerial drugs; radix Rhapontici has effects of removing toxic substances, resolving carbuncle, dredging channels and promoting lactation, and medulla Tetrapanacis has effects of activating collaterals, inducing diuresis and relieving swelling, and is used as adjuvant drug. The medicines are combined together to play the roles of tonifying qi, nourishing blood, dredging channels and promoting lactation. The compound feed has remarkable effects of preventing and treating hypogalactia of sows, has extremely remarkable lactation promoting effect by adopting the proportion described in the embodiment 3, and is particularly suitable for promoting lactation of sows.
The beneficial effects of the invention are as follows:
1. the traditional Chinese medicine composition soaked by brown sugar has obvious prevention and treatment effects on lack of lactation of sows and lack of lactation, and improves lactation yield by 5-15%.
2. Can effectively improve the immunity of the organism, promote the postpartum recovery of the sow, resist stress and the like.
3. Improving disease resistance of piglets, promoting early weaning of young animals, improving uniformity of young animals, accelerating growth of piglets, and finally improving economic benefit of breeding industry.
4. The traditional Chinese medicine composition is diluted with white spirit and boiled water until the liquid medicine can be filled, and the traditional Chinese medicine oral liquid has low or no residue in the pig body, is not easy to generate drug resistance and has good biological safety.
5. The invention has simple and reasonable formula, no medicine residue, no toxic or side effect, abundant traditional Chinese medicine resources, simple preparation method and low cost, and is suitable for the requirement of large-scale industrial production.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The preparation method of the lactation-promoting traditional Chinese medicine composition for the sows comprises the following steps:
(1) Weighing the following raw material medicaments in part by weight: 3kg of astragalus membranaceus, 3kg of uniflower swisscentaury root, 3kg of szechuan lovage rhizome, 6kg of Chinese angelica, 6kg of medulla tetrapanacis, 6kg of semen vaccariae and 6kg of prepared rehmannia root;
(2) Steaming and dissolving brown sugar in basin, and dissolving in 40 deg.C warm water to obtain brown sugar water with brown sugar content of 5wt%;
(3) Mixing and soaking the crude drugs with brown sugar water and yellow wine according to the volume ratio of 10:3 for 24 hours, taking out the crude drugs, airing and crushing the crude drugs into superfine powder.
Example 2
The preparation method of the lactation-promoting traditional Chinese medicine composition for the sows comprises the following steps:
(1) Weighing the following raw material medicaments in part by weight: 3.5kg of astragalus membranaceus, 3.5kg of uniflower swisscentaury root, 3.5kg of ligusticum wallichii, 6kg of angelica sinensis, 6kg of medulla tetrapanacis, 6kg of semen vaccariae and 6kg of prepared rehmannia root;
(2) Steaming and dissolving brown sugar in a basin, and dissolving in warm water at 45 ℃ to obtain brown sugar water, wherein the content of brown sugar in the brown sugar water is 15wt%;
(3) Mixing and soaking the crude drugs with brown sugar water and yellow wine according to the volume ratio of 10:3 for 24 hours, taking out the crude drugs, airing and crushing the crude drugs into superfine powder.
Example 3
The preparation method of the lactation-promoting traditional Chinese medicine composition for the sows comprises the following steps:
(1) Weighing the following raw material medicaments in part by weight: astragalus root 4.5kg, uniflower swisscentaury root 4.5kg, ligusticum wallichii 4.5kg, chinese angelica root 4.5kg, medulla tetrapanacis 4.5kg, seed of cowherb 4.5kg, prepared rehmannia root 4.5kg;
(2) Steaming and dissolving brown sugar in basin, and dissolving in 50deg.C warm water to obtain brown sugar water with brown sugar content of 20wt%;
(3) Mixing and dissolving the fermented glutinous rice juice and the brown sugar, soaking the raw materials for 48 hours, adding water until all the materials are submerged, adding 10L of the fermented glutinous rice juice into 1kg of brown sugar, boiling for 40 minutes by using a closed stainless steel pot, and taking the liquid medicine and the medicinal residues.
The Chinese medicinal materials used in examples 1-3 all meet the standards of the second edition of the Chinese animal pharmacopoeia 2020.
The dosage of the superfine powder is 200g each pig, when the medicated bag is used, 1000g of the medicated composition is diluted with 2-3 distilled water to obtain medicinal liquid, and the medicinal liquid can be taken once a day for 3-5 days as a treatment course;
the dosage of the liquid medicine is 100mL of the liquid medicine is fed per 100kg of pigs by weight, 2 times per day, 3-5 days for continuous feeding, and the corresponding medicine dreg is mixed for feeding.
Clinical test example:
dosage of experimental and control groups:
the experimental group adopts the traditional Chinese medicine composition of the example 2, the dosage is 200g each pig, 1000g of the traditional Chinese medicine composition is diluted with 2-3 distilled spirit and warm boiled water for each bag when the traditional Chinese medicine composition is used, the traditional Chinese medicine composition can be taken after being filled with the liquid medicine, and the treatment course is 4 days after once a day.
The control group adopts the lactation promoting powder, the dosage is 40-60g for each pig, once a day, and 4 days are taken as a treatment course.
1. Test site: hebei Chengde Pingquan county;
2. test time: 2022, 11-12 months;
3. test animals: pig;
4. test results: see table 1 below.
TABLE 1 clinical trial results
Test index Experimental group Control group
Total number of sows tested 8 8
Total number of parity 93 92
Number of head of live baby 89 87
Yield of live offspring (%) 95.69 94.56
Weight of primary nest (Kg) 21.575 21.65
Average birth weight (Kg/head) 1.93 1.93
Number of death in lactation period 2 5
Number of deaths at weaning 1 3
Number of weaning heads 86 79
Weaning nest weight (Kg) 87.6 78.7
Average weaning weight (Kg/head) 8.15 7.97
Sow weaning 10 days estrus mating number 8 7
Sow weaning 10 days oestrus mating rate (%) 100 87.5
The description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (4)

1. The preparation method of the lactation-promoting traditional Chinese medicine composition for the sows is characterized by comprising the following steps of:
(1) Weighing the following raw material medicaments in part by weight: 3-6 parts of astragalus membranaceus, 3-6 parts of uniflower swisscentaury root, 3-6 parts of ligusticum wallichii, 3-6 parts of angelica sinensis, 3-6 parts of medulla tetrapanacis, 3-6 parts of semen vaccariae and 3-6 parts of prepared rehmannia root;
(2) Steaming brown sugar in basin, dissolving in 40-50deg.C warm water to obtain brown sugar water with brown sugar content of 5-20wt%;
(3) Mixing and soaking the crude drugs with brown sugar water and yellow wine according to the volume ratio of 10:3 for 24 hours, taking out the crude drugs, airing and crushing the crude drugs into superfine powder;
or mixing and dissolving the fermented glutinous rice juice and the brown sugar, soaking the raw material medicines for 48 hours, adding water until all the medicinal materials are submerged, adding 10L of the fermented glutinous rice juice into 1kg of brown sugar, boiling for 40 minutes by using a closed stainless steel pot, and taking the medicinal liquid and the medicinal residues.
2. The preparation method of the lactation-promoting Chinese medicinal composition for sows as claimed in claim 1, wherein the raw materials comprise the following components in parts by weight: 3.5-6 parts of astragalus membranaceus, 3.5-6 parts of uniflower swisscentaury root, 3.5-6 parts of ligusticum wallichii, 3.5-6 parts of angelica sinensis, 3.5-6 parts of medulla tetrapanacis, 3.5-6 parts of semen vaccariae and 3.5-6 parts of prepared rehmannia root.
3. The method for preparing a lactating pharmaceutical composition for sow as claimed in claim 1, wherein the particle size of the superfine powder is more than 300 meshes.
4. The method for preparing the lactation-promoting Chinese medicinal composition for the sows, which is characterized in that the dosage of the superfine powder is 200g each time for each pig, and 1000g of the Chinese medicinal composition is diluted to liquid medicine with 2-3 white spirit and warm boiled water for each bag when the composition is used, and the liquid medicine can be taken once a day for 3-5 days as a treatment course;
or the dosage of the liquid medicine is 100mL of the liquid medicine per 100kg of the liquid medicine fed by the pig by weight, 2 times a day, 3-5 days for continuous feeding, and the corresponding medicine dreg mixed material is fed.
CN202311356669.XA 2023-10-19 2023-10-19 Preparation method of lactation-promoting traditional Chinese medicine composition for sows Pending CN117137977A (en)

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