CN117099790A - Sterilization composition for preventing and treating wheat stem-based rot - Google Patents
Sterilization composition for preventing and treating wheat stem-based rot Download PDFInfo
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- CN117099790A CN117099790A CN202311079154.XA CN202311079154A CN117099790A CN 117099790 A CN117099790 A CN 117099790A CN 202311079154 A CN202311079154 A CN 202311079154A CN 117099790 A CN117099790 A CN 117099790A
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- Prior art keywords
- flutriafol
- wheat stem
- carvacrol
- aloe
- emodin
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- 241000209140 Triticum Species 0.000 title claims abstract description 32
- 235000021307 Triticum Nutrition 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 230000001954 sterilising effect Effects 0.000 title description 2
- 238000004659 sterilization and disinfection Methods 0.000 title description 2
- 239000005787 Flutriafol Substances 0.000 claims abstract description 42
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 claims abstract description 40
- YDQWDHRMZQUTBA-UHFFFAOYSA-N Aloe emodin Chemical compound C1=CC=C2C(=O)C3=CC(CO)=CC(O)=C3C(=O)C2=C1O YDQWDHRMZQUTBA-UHFFFAOYSA-N 0.000 claims abstract description 37
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 26
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 22
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 22
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 15
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000005770 Eugenol Substances 0.000 claims abstract description 13
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960002217 eugenol Drugs 0.000 claims abstract description 13
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 241001451172 Fusarium pseudograminearum Species 0.000 abstract description 15
- 239000003814 drug Substances 0.000 abstract description 11
- 230000002195 synergetic effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 7
- 238000011282 treatment Methods 0.000 abstract description 7
- 239000000575 pesticide Substances 0.000 abstract description 6
- 230000002265 prevention Effects 0.000 abstract description 6
- 244000052616 bacterial pathogen Species 0.000 description 8
- 206010059866 Drug resistance Diseases 0.000 description 7
- 239000013043 chemical agent Substances 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000004071 biological effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 3
- 241000223218 Fusarium Species 0.000 description 3
- 235000011399 aloe vera Nutrition 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000009036 growth inhibition Effects 0.000 description 3
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 description 2
- 241001116389 Aloe Species 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 241000223195 Fusarium graminearum Species 0.000 description 2
- 239000005839 Tebuconazole Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000010413 mother solution Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 description 1
- MNHVNIJQQRJYDH-UHFFFAOYSA-N 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione Chemical compound N1=CNC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl MNHVNIJQQRJYDH-UHFFFAOYSA-N 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000186892 Aloe vera Species 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 1
- 206010010264 Condition aggravated Diseases 0.000 description 1
- 239000005502 Cyhalofop-butyl Substances 0.000 description 1
- TYIYMOAHACZAMQ-CQSZACIVSA-N Cyhalofop-butyl Chemical group C1=CC(O[C@H](C)C(=O)OCCCC)=CC=C1OC1=CC=C(C#N)C=C1F TYIYMOAHACZAMQ-CQSZACIVSA-N 0.000 description 1
- 239000005767 Epoxiconazole Substances 0.000 description 1
- 241000223194 Fusarium culmorum Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- HPUXDMUGCAWDFW-UHFFFAOYSA-N Osthole Natural products COc1ccc2CCC(=O)Oc2c1C=CC(=O)C HPUXDMUGCAWDFW-UHFFFAOYSA-N 0.000 description 1
- 239000005825 Prothioconazole Substances 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 239000005842 Thiophanate-methyl Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000006013 carbendazim Substances 0.000 description 1
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- MBRLOUHOWLUMFF-UHFFFAOYSA-N osthole Chemical compound C1=CC(=O)OC2=C(CC=C(C)C)C(OC)=CC=C21 MBRLOUHOWLUMFF-UHFFFAOYSA-N 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- -1 triazole sterol Chemical class 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and particularly relates to a bactericidal composition for preventing and treating wheat stem basal rot. The active ingredient of the bactericidal composition is compounded by flutriafol and carvacrol, eugenol or aloe-emodin. When the flutriafol and carvacrol, eugenol or aloe-emodin are compounded in the composition, the co-toxicity coefficient of the fusarium pseudograminearum for causing the wheat stem basal rot is greater than 120, the composition shows a synergistic effect, the prevention and treatment effect on the wheat stem basal rot can be improved, and the composition can provide support for developing a novel medicament for preventing and treating the wheat stem basal rot.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a bactericidal composition for preventing and treating wheat stem basal rot.
Background
Wheat stem rot is a typical soil-borne disease, and the pathogen is complex: various fusarium and other pathogenic bacteria such as yellow fusarium (Fusarium culmorum), fusarium graminearum (Fusarium graminearum), fusarium pseudograminearum (Fusarium pesudogramineaqum) and the like are included, wherein the fusarium pseudograminearum (F.pesudogeraminearum) is the dominant pathogenic bacteria of wheat stem-based rot in Huang-Huai wheat regions in China.
The wheat stem rot can occur from the tillering stage to the mature stage of wheat, and is distributed in each wheat producing area, so that the yield of wheat is seriously affected. In recent years, due to the transformation of planting modes and the large-area popularization of straw returning technology, pathogenic bacteria are continuously accumulated in fields, so that the wheat stem-based rot of the main wheat producing area in China frequently occurs and the trend of disease aggravation is presented.
At present, no disease-resistant wheat variety capable of effectively resisting the wheat stem basal rot is bred, and the disease-resistant wheat variety is mainly controlled by chemical agents in agricultural production, and the common chemical agents are as follows: thiophanate-methyl, carbendazim, prothioconazole, tebuconazole, epoxiconazole, and cyhalofop-butyl, etc. The chemical agent has the advantages of quick effect, good control effect and the like, but the long-term application of a single chemical agent easily causes the generation and development of the drug resistance of pathogenic bacteria, and the pathogenic bacteria of the wheat stem base rot are reported to show the drug resistance of different degrees to the existing various bactericides, so that the control effect on the wheat stem base rot is gradually reduced. However, the blind method of increasing the dosage of the pesticide increases the efficacy in a short time, but this aggravates the development of drug resistance. Therefore, development of novel chemical agents is necessary.
The combination of synergistic effect of the compound screening of different pesticide varieties can reduce the influence on the environment, and can delay the development of drug resistance of pathogenic bacteria, thereby being an economic and effective means for preventing and treating diseases and developing novel medicaments. The flutriafol is triazole sterol demethylation inhibitor bactericide developed by Zhengda group Co., ltd. The flutriafol can effectively inhibit the biosynthesis of ergosterol, cause rupture of fungal cell walls, has broad-spectrum antibacterial activity and stronger systemic property, and has good protection and treatment effects on a plurality of fungal diseases caused by basidiomycetes and ascomycetes.
The inventor finds that when the flutriafol and carvacrol, eugenol or aloe-emodin are subjected to binary compounding, the flutriafol has a synergistic effect on Fusarium pseudograminearum causing wheat stem basal rot, and at present, no relevant report on the compounding is yet found.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a bactericidal composition for preventing and treating wheat stem basal rot, which aims to solve the problem of long-term application of a single chemical agent.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the active ingredients of the bactericidal composition are compounded by flutriafol and carvacrol, eugenol or aloe-emodin in a binary mode.
More specifically, the mass ratio of the flutriafol to the carvacrol is 1-10:19-1.
More specifically, the mass ratio of the flutriafol to the eugenol is 1-5:25-1.
More specifically, the mass ratio of the flutriafol to the aloe-emodin is 1-36:6-1.
The invention also provides application of the bactericidal composition in prevention and control of wheat stem basal rot.
Compared with the prior art, the invention has the following beneficial effects:
(1) When the flutriafol and carvacrol, eugenol or aloe-emodin are compounded in the composition, the co-toxicity coefficient of the fusarium pseudograminearum for causing the wheat stem basal rot is greater than 120, the composition shows a synergistic effect, the prevention and treatment effect on the wheat stem basal rot can be improved, and the composition can provide support for developing a novel medicament for preventing and treating the wheat stem basal rot.
(2) When the flutriafol and carvacrol, eugenol or aloe-emodin are compounded in the composition, the development of drug resistance of pathogenic bacteria can be effectively delayed, and the pesticide application dosage can be reduced based on the drug resistance, so that the prevention and control cost and the environmental pollution are reduced.
Detailed Description
The following description of the embodiments of the present invention will be apparent from, and is intended to provide a thorough description of, the embodiments of the present invention, and not a complete description of, the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
Examples: indoor biological Activity assay
1. Test strain
Fusarium pseudograminearum (F.pesudogeraqum). And collecting the infected wheat plants, separating in a laboratory to obtain fusarium pseudograminearum, and storing the fusarium pseudograminearum on a PDA culture medium.
2. Test agent
95% of flutriafol technical, 92.5% of carvacrol technical, 98.5% of eugenol technical and 97% of aloe-emodin technical are all commercially available.
Dissolving the test agent with dimethyl sulfoxide, diluting with 0.1% Tween-80 aqueous solution to obtain single-agent mother solution, and setting multiple groups of ratios, wherein each single-agent mother solution and the ratio mixture have 5 mass concentration gradients according to an equal ratio method.
3. Test methods (cf. NY/T1156.2-2006, section 2. Test Petri dish method for growth inhibition of mycelium of pathogenic fungi for agricultural chemical laboratory biological assay guidelines).
Adding 45mL of pre-melted PDA culture medium into a sterile conical flask, cooling to about 50 ℃, quantitatively sucking 5mL of liquid medicine into the conical flask, fully shaking uniformly, pouring into a plurality of culture dishes with the diameter of 9cm, and cooling to form a medicine-containing flat plate with the corresponding concentration, wherein each culture dish has 10 mL; and simultaneously, setting treatment without medicament as blank control, and setting 5 repeats for each mass concentration liquid medicine.
Cutting bacterial cakes with the diameter of 5mm from the colony edge of the tested bacterial strain by using a puncher, inoculating the bacterial cakes to the centers of a medicine-containing flat plate and a blank control flat plate, covering a dish cover, placing the dish cover in a 30 ℃ incubator for culturing for 72 hours, measuring the colony diameter by using a crisscross method, and calculating the growth inhibition rate of different treatments on hyphae.
4. Data analysis: performing data statistical analysis by DPS software, and linearly regressing with the value of the disinfectant concentration logarithmic value x and the value of the corresponding hypha growth inhibition rate logarithmic value y to obtain a virulence regression equation and the virulence EC of the medicament on the target pathogen 50 Values and co-toxicity coefficients (CTCs) were calculated according to the grand cloud Pei method.
5. Measurement results
The synergy of the agents was evaluated based on the calculated co-toxicity coefficient (CTC), CTC.ltoreq.80 being antagonism, CTC.ltoreq.120 being additive, CTC.ltoreq.120 being synergy, the results being shown in tables 1-3.
TABLE 1 indoor biological Activity of Fusarium pseudograminearum by combination of flutriafol and carvacrol
| Medicament name and ratio | EC50(mg/L) | ATI | TTI | CTC |
| Flutriafol | 1.6069 | 100.0000 | -- | -- |
| Carvacrol | 17.5518 | 9.1552 | -- | -- |
| Flutriafol 1: carvacrol 19 | 5.1558 | 31.1668 | 13.6974 | 227.5379 |
| Flutriafol 1: carvacrol 9 | 6.7431 | 23.8303 | 18.2397 | 130.6509 |
| Flutriafol 1: carvacrol 7 | 4.6276 | 34.7243 | 20.5108 | 169.2976 |
| Flutriafol 1: carvacrol 3 | 2.8466 | 56.4498 | 31.8664 | 177.1453 |
| Flutriafol 1: carvacrol 1 | 2.4178 | 66.4612 | 54.5776 | 121.7739 |
| Flutriafol 3: carvacrol 1 | 1.5117 | 106.2975 | 77.2888 | 137.5329 |
| Flutriafol 7: carvacrol 1 | 0.9907 | 162.1984 | 88.6444 | 182.9765 |
| Flutriafol 10: carvacrol 1 | 0.8493 | 189.2029 | 91.7414 | 206.2350 |
As can be seen from Table 1, after the flutriafol and the carvacrol are compounded, the mass ratio is 1-10: the co-toxicity coefficient of the Fusarium pseudograminearum in the 19-1 is more than 120, and the synergistic effect is shown.
TABLE 2 indoor biological Activity of Fusarium pseudograminearum by combination of tebuconazole and eugenol
As can be seen from table 2, after the flutriafol and the eugenol are compounded, the mass ratio is 1-5: the co-toxicity coefficient of the fusarium pseudograminearum in the 25-1 is more than 120, and the synergistic effect is shown.
TABLE 3 indoor biological Activity of flutriafol and aloe vera Huang Sufu against Fusarium pseudograminearum
| Medicament name and ratio | EC50(mg/L) | ATI | TTI | CTC |
| Flutriafol | 1.6069 | 100.0000 | -- | -- |
| Aloe-emodin | 202.7342 | 0.7926 | -- | -- |
| Flutriafol 1: aloe-emodin 6 | 5.4348 | 29.5669 | 14.9651 | 197.5721 |
| Flutriafol 1:aloe-emodin 3 | 3.6667 | 43.8241 | 25.5945 | 171.2251 |
| Flutriafol 1: aloe-emodin 1 | 1.8903 | 85.0077 | 50.3963 | 168.6784 |
| Flutriafol 3: aloe-emodin 1 | 0.6546 | 245.4782 | 75.1982 | 326.4417 |
| Flutriafol 6: aloe-emodin 1 | 0.4277 | 375.7073 | 85.8275 | 437.7469 |
| Flutriafol 16: aloe-emodin 1 | 0.9217 | 174.3409 | 94.1643 | 185.1455 |
| Flutriafol 26: aloe-emodin 1 | 1.3361 | 120.2679 | 96.3257 | 124.8556 |
| Flutriafol 36: aloe-emodin 1 | 0.6759 | 237.7423 | 97.3187 | 244.2924 |
As can be seen from Table 3, after the flutriafol and aloe are compounded with Huang Sufu, the mass ratio is 1-36: the co-toxicity coefficient of the 6-1 to the fusarium pseudograminearum is greater than 120, and the synergistic effect is shown.
In conclusion, when the flutriafol and magnolol, osthole, carvacrol, eugenol or aloe are Huang Sufu, the flutriafol has a synergistic effect on fusarium pseudograminearum causing wheat stem basal rot, can improve the prevention and treatment effect of the wheat stem basal rot, delay the development of drug resistance of pathogenic bacteria, reduce the pesticide application dosage based on the synergistic effect, and reduce the prevention and treatment cost and environmental pollution.
The foregoing descriptions of specific exemplary embodiments of the present invention are presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application to thereby enable one skilled in the art to make and utilize the invention in various exemplary embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (5)
1. The bactericidal composition for preventing and treating wheat stem-based rot is characterized in that the active ingredients of the bactericidal composition are compounded by flutriafol and carvacrol, eugenol or aloe-emodin.
2. The bactericidal composition of claim 1, wherein the mass ratio of flutriafol to carvacrol is 1-10:19-1.
3. The bactericidal composition of claim 1, wherein the mass ratio of flutriafol to eugenol is 1-5:25-1.
4. The bactericidal composition of claim 1, wherein the mass ratio of flutriafol to aloe-emodin is 1-36:6-1.
5. Use of the bactericidal composition according to any of claims 1-4 for controlling stalk rot in wheat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311079154.XA CN117099790A (en) | 2023-08-25 | 2023-08-25 | Sterilization composition for preventing and treating wheat stem-based rot |
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| CN202311079154.XA CN117099790A (en) | 2023-08-25 | 2023-08-25 | Sterilization composition for preventing and treating wheat stem-based rot |
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