CN116725037A - Bactericide composition for preventing and treating dragon fruit canker - Google Patents
Bactericide composition for preventing and treating dragon fruit canker Download PDFInfo
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- CN116725037A CN116725037A CN202310725092.9A CN202310725092A CN116725037A CN 116725037 A CN116725037 A CN 116725037A CN 202310725092 A CN202310725092 A CN 202310725092A CN 116725037 A CN116725037 A CN 116725037A
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- dragon fruit
- nikkomycin
- preventing
- bactericide composition
- canker
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- 235000018481 Hylocereus undatus Nutrition 0.000 title claims abstract description 29
- 244000157072 Hylocereus undatus Species 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 239000003899 bactericide agent Substances 0.000 title claims abstract description 14
- 229930184499 Nikkomycin Natural products 0.000 claims abstract description 34
- WWJFFVUVFNBJTN-UHFFFAOYSA-N neopolyoxin C Natural products C=1C=C(O)C=NC=1C(O)C(C)C(N)C(=O)NC(C(O)=O)C(C(C1O)O)OC1N1C=CC(=O)NC1=O WWJFFVUVFNBJTN-UHFFFAOYSA-N 0.000 claims abstract description 33
- WWJFFVUVFNBJTN-VHDFTHOZSA-N nikkomycin Z Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)[C@H](NC(=O)[C@@H](N)[C@H](C)[C@H](O)C=2N=CC(O)=CC=2)C(O)=O)C=CC(=O)NC1=O WWJFFVUVFNBJTN-VHDFTHOZSA-N 0.000 claims abstract description 31
- 239000005842 Thiophanate-methyl Substances 0.000 claims abstract description 19
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000005783 Fluopyram Substances 0.000 claims abstract description 10
- KVDJTXBXMWJJEF-UHFFFAOYSA-N fluopyram Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CCNC(=O)C1=CC=CC=C1C(F)(F)F KVDJTXBXMWJJEF-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000005807 Metalaxyl Substances 0.000 claims description 15
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 claims description 15
- 241001443610 Aschersonia Species 0.000 claims description 6
- 241001547451 Neoscytalidium dimidiatum Species 0.000 claims description 4
- 244000052616 bacterial pathogen Species 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims 2
- 239000003139 biocide Substances 0.000 claims 2
- 239000000575 pesticide Substances 0.000 abstract description 7
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
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- 239000003814 drug Substances 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 7
- 230000002265 prevention Effects 0.000 description 6
- 238000013329 compounding Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 239000005839 Tebuconazole Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 238000003912 environmental pollution Methods 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000000447 pesticide residue Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000010413 mother solution Substances 0.000 description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Chemical compound CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- WWJFFVUVFNBJTN-UIBIZFFUSA-N (2S)-2-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino]-2-[(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid Chemical class C[C@@H]([C@H](N)C(=O)N[C@@H]([C@H]1O[C@H]([C@@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)C(O)=O)[C@H](O)c1ccc(O)cn1 WWJFFVUVFNBJTN-UIBIZFFUSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000186063 Arthrobacter Species 0.000 description 1
- 241000238421 Arthropoda Species 0.000 description 1
- TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 102000005469 Chitin Synthase Human genes 0.000 description 1
- 108700040089 Chitin synthases Proteins 0.000 description 1
- 239000005760 Difenoconazole Substances 0.000 description 1
- 241001661277 Moelleriella libera Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006013 carbendazim Substances 0.000 description 1
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002420 orchard Substances 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
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- 238000012216 screening Methods 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/28—Streptomyces
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and particularly relates to a bactericide composition for preventing and treating dragon fruit canker. The bactericide composition for preventing and treating dragon fruit canker comprises the effective components of nikkomycin and thiophanate-methyl or fluopyram according to the proportion of 1-150:150-1 by mass ratio. The bactericidal composition is compounded by two active ingredients with different action mechanisms, has obvious synergistic effect and can improve the control effect on the dragon fruit canker.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a bactericide composition for preventing and treating dragon fruit canker.
Background
The dragon fruit is a perennial tropical and subtropical fruit, has rich nutrition and unique functions, contains plant albumin and anthocyanin which are rare in common plants, and is rich in vitamins and water-soluble dietary fibers. In recent years, along with the gradual expansion of the large-scale artificial planting area of the dragon fruits, the diseases of the dragon fruits are increased, and the dragon fruit canker caused by the new and dark aschersonia aleyrodis Neoscytalidium dimidiatum is a common disease in the domestic dragon fruit planting. The disease of the dragon fruit canker starts from tender stems, the initial circular concave chlorosis spots gradually become orange, the stems and fruits are completely rotted when serious, the yield of an orchard is reduced by 20-30%, the yield can be reduced by 50% when serious, even the dragon fruit canker is in absolute harvest, and the dragon fruit canker gradually becomes a main disease in the production of the dragon fruit.
The carbendazim, flusilazole, difenoconazole, thiophanate-methyl and other medicaments can be used for preventing and controlling dragon fruit canker, but the long-term unreasonable use causes the serious drug resistance of pathogenic bacteria, so that the prevention effect is reduced. In addition, the chemical pesticide is unreasonably used for a long time to prevent and treat the dragon fruit canker, the prevention and treatment cost is increased, and the risks of environmental pollution, pesticide residues and the like are caused. Therefore, research and development of novel chemical pesticides with high efficiency, low toxicity and low residue are important directions for the development of future pesticides.
Nikkomycins are nucleoside peptide antibiotics that block the synthesis of chitin, a key element necessary for the fungal cell wall, by inhibiting chitin synthase specific to the fungus, causing the expansion and rupture of the fungal cells, a mechanism of action unique to the fungus. The patent of application number CN201310358167.0 discloses a pesticide composition containing tebuconazole and nikkomycin, and particularly discloses that when tebuconazole and nikkomycin are compounded according to a certain mass ratio, obvious synergism is shown, and the dosage can be reduced, so that the prevention and control cost is reduced, and the pollution to the environment is reduced. Although the related compounding formula of tebuconazole and nikkomycin has been reported, no related report of compounding of nikkomycin and thiophanate-methyl, fluopyram or metalaxyl is seen at present.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a bactericide composition for preventing and treating dragon fruit canker, which can improve the prevention and treatment effect on the dragon fruit canker, reduce the prevention and treatment cost and reduce the risks of environmental pollution and pesticide residues.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the bactericide composition for preventing and treating dragon fruit canker comprises the effective components of nikkomycin and thiophanate-methyl or fluopyram according to the proportion of 1-150:150-1 by mass ratio.
Preferably, the mass ratio of the nikkomycin to the thiophanate-methyl is 1-6:16-1.
Preferably, the mass ratio of the nikkomycin to the fluopyram is 1-20:4-1.
Preferably, the mass ratio of the nikkomycin to the metalaxyl is 1-30:15-1.
The invention also provides a bactericide, which comprises the bactericidal composition.
The invention also provides application of the bactericidal composition in controlling dragon fruit canker.
Preferably, the pathogenic bacteria of the dragon fruit canker is Arthrobacter neodarkii Neoscytalidium dimidiatum.
Compared with the prior art, the invention has the following beneficial effects:
(1) The bactericidal composition is compounded by two active ingredients with different action mechanisms, has obvious synergistic effect, can improve the control effect on the dragon fruit canker, and is also beneficial to overcoming and delaying the generation of drug resistance.
(2) The bactericidal composition disclosed by the invention can reduce the dosage of active ingredients, reduce the prevention and treatment cost, reduce the environmental pollution and pesticide residues, has good safety and meets the safety requirement of pesticide preparations.
Detailed Description
The following description of the embodiments of the present invention will be apparent from, and is intended to provide a thorough description of, the embodiments of the present invention, and not a complete description of, the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
Examples: screening of control agents
1. Test strain
And collecting a dragon fruit canker sample, performing pathogen separation, purification, identification and pathogenicity determination in a laboratory, determining that the obtained pathogen is new darkness aschersonia (Neoscytalidium dimidiatum), and storing the new darkness aschersonia on a PDA culture medium.
2. Test agent
98% of nikkomycin raw medicine, 98% of thiophanate-methyl raw medicine, 96% of fluopyram raw medicine and 98% of metalaxyl raw medicine are all sold in the market.
After the test agent is dissolved, the test agent is diluted by 0.1 percent Tween-80 water solution to prepare single-agent mother solution, a plurality of groups of proportions are arranged, and each single-agent mother solution and the proportion mixture are provided with 5 mass concentration gradients according to an equal proportion method.
3. Test method
The hypha growth rate method is adopted. Adding 9mL of pre-melted PDA culture medium into a sterile conical flask, sequentially quantitatively sucking 1mL of liquid medicine from low concentration to high concentration, respectively adding into the conical flask, shaking uniformly, pouring into a culture dish with the diameter of 9cm, and preparing a medicine-containing flat plate with corresponding concentration; treatments without agent were also included as blank, and 5 replicates were set for each treatment.
Cutting bacterial cake at the edge of bacterial colony of tested strain with a puncher with diameter of 5mm, inoculating to the centers of the drug-containing plate and the blank control plate, covering the dish cover, culturing in a constant temperature oven at 28deg.C for 2d, measuring bacterial colony diameter with crisscross method, and calculating the inhibition rate of different treatments to hypha growth.
4. Data analysis: performing data statistical analysis by DPS software, and linearly regressing with the value of the disinfectant concentration logarithmic value x and the value of the corresponding hypha growth inhibition rate logarithmic value y to obtain a virulence regression equation and the virulence EC of the medicament on the target pathogen 50 Values and co-toxicity coefficients (CTCs) were calculated according to the grand cloud Pei method.
5. Measurement results
The synergy of the agents was evaluated based on the calculated co-toxicity coefficient (CTC), CTC.ltoreq.80 being antagonism, CTC.ltoreq.120 being additive, CTC.ltoreq.120 being synergy, the results being shown in tables 1-3.
TABLE 1 indoor biological Activity of Nicotin and thiophanate-methyl in combination with New Endocarpium channel
| Medicament name and ratio | EC50(mg/L) | ATI | TTI | CTC |
| Nicotycin | 9.6086 | 100.0000 | -- | -- |
| Thiophanate-methyl | 6.0773 | 158.1064 | -- | -- |
| Nikkomycin 1: thiophanate-methyl 16 | 4.0870 | 235.1015 | 154.6884 | 151.9840 |
| Nikkomycin 1: thiophanate-methyl 12 | 3.9005 | 246.3428 | 153.6367 | 160.3411 |
| Nikkomycin 1: thiophanate-methyl 8 | 4.8863 | 196.6437 | 151.6501 | 129.6693 |
| Nikkomycin 1: thiophanate-methyl 4 | 5.4230 | 177.1824 | 146.4851 | 120.9559 |
| Nikkomycin 1: thiophanate-methyl 1 | 6.0136 | 159.7812 | 129.0532 | 123.8103 |
| Nikkomycin 4: thiophanate-methyl 1 | 2.9645 | 324.1221 | 111.6213 | 290.3766 |
| Nikkomycin 6: thiophanate-methyl 1 | 3.5190 | 273.0492 | 108.3009 | 252.1208 |
As shown in Table 1, after the compounding of the nikkomycin and the thiophanate-methyl, the mass ratio is 1-6: the co-toxicity coefficient of the new and dark aschersonia is more than 120 in the range of 16-1, and the synergistic effect is shown.
TABLE 2 indoor biological Activity of Nicotinamide and Fluopyram complexation on New Endocarpium
As shown in table 2, after the nikkomycin and fluopyram are compounded, the mass ratio is 1-20: the co-toxicity coefficient of the new and dark aschersonia is more than 120 in the range of 4-1, and the synergistic effect is shown.
TABLE 3 indoor biological Activity of Nicotin and metalaxyl in combination with New Arthropoda pusilla
| Medicament name and ratio | EC50(mg/L) | ATI | TTI | CTC |
| Nicotycin | 9.6086 | 100.0000 | -- | -- |
| metalaxyl-A medicine | 4.4127 | 217.7488 | -- | -- |
| Nikkomycin 1: metalaxyl 15 | 2.3757 | 404.4534 | 210.3895 | 192.2403 |
| Nikkomycin 1: metalaxyl 10 | 3.7222 | 258.1430 | 207.0443 | 124.6801 |
| Nikkomycin 1: metalaxyl-A medicine5 | 1.9631 | 489.4605 | 198.1240 | 247.0476 |
| Nikkomycin 1: metalaxyl 1 | 4.9467 | 194.2426 | 158.8744 | 122.2618 |
| Nikkomycin 5: metalaxyl 1 | 6.2004 | 154.9674 | 119.6248 | 129.5446 |
| Nikkomycin 10: metalaxyl 1 | 6.7611 | 142.1159 | 110.7044 | 128.3742 |
| Nikkomycin 20: metalaxyl 1 | 7.1892 | 133.6533 | 105.6071 | 126.5571 |
| Nikkomycin 30: metalaxyl 1 | 5.7941 | 165.8342 | 103.7983 | 159.7658 |
As can be seen from table 3, after compounding the nikkomycin and metalaxyl, the mass ratio is 1-30: the co-toxicity coefficient of the new and dark aschersonia is more than 120 in the range of 15-1, and the synergistic effect is shown.
In conclusion, when the nikkomycin, thiophanate-methyl, fluopyram or metalaxyl are compounded in the bactericidal composition disclosed by the invention, the co-toxicity coefficient of the bactericidal composition for the pathogenic bacteria of the dragon fruit canker is greater than 120, the bactericidal composition has an obvious synergistic effect, can improve the control effect on the dragon fruit canker, and is also beneficial to overcoming and delaying the generation of drug resistance.
The foregoing descriptions of specific exemplary embodiments of the present invention are presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application to thereby enable one skilled in the art to make and utilize the invention in various exemplary embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (7)
1. The bactericide composition for preventing and treating the dragon fruit canker is characterized in that the effective components of the bactericide composition are prepared from 1-150 parts of nikkomycin, thiophanate-methyl, fluopyram or metalaxyl: 150-1 by mass ratio.
2. The bactericide composition according to claim 1, characterized in that the mass ratio of the nikkomycin to the thiophanate-methyl is 1-6:16-1.
3. The bactericide composition according to claim 1, characterized in that the mass ratio of the nikkomycin to the fluopyram is 1-20:4-1.
4. The bactericide composition according to claim 1, characterized in that the mass ratio of the nikkomycin to the metalaxyl is 1-30:15-1.
5. A biocide comprising the biocide composition of any one of claims 1-4.
6. Use of the bactericide composition according to any one of claims 1 to 4 for controlling dragon fruit canker.
7. The use according to claim 6, wherein the pathogenic bacteria of the canker of dragon fruit is aschersonia robusta Neoscytalidium dimidiatum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310725092.9A CN116725037A (en) | 2023-06-19 | 2023-06-19 | Bactericide composition for preventing and treating dragon fruit canker |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN117286154A (en) * | 2023-11-23 | 2023-12-26 | 海南大学三亚南繁研究院 | Method for knocking out new Arthrobacter darkness and application thereof |
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| CN117286154A (en) * | 2023-11-23 | 2023-12-26 | 海南大学三亚南繁研究院 | Method for knocking out new Arthrobacter darkness and application thereof |
| CN117286154B (en) * | 2023-11-23 | 2024-01-30 | 海南大学三亚南繁研究院 | Method for knocking out new Arthrobacter darkness and application thereof |
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