CN117082978A - Disinfectant agent - Google Patents

Disinfectant agent Download PDF

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Publication number
CN117082978A
CN117082978A CN202280014070.5A CN202280014070A CN117082978A CN 117082978 A CN117082978 A CN 117082978A CN 202280014070 A CN202280014070 A CN 202280014070A CN 117082978 A CN117082978 A CN 117082978A
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CN
China
Prior art keywords
disinfectant
agent
edta
cysteine
dithiothreitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280014070.5A
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Chinese (zh)
Inventor
熊小波
管涛
常国栋
张平
罗亮
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Protgen Ltd
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Protgen Ltd
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Publication of CN117082978A publication Critical patent/CN117082978A/en
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Provided is a novel disinfectant, comprising: active agents, adjuvants and buffers; wherein the auxiliary agent comprises the following components: chelating agents, reducing agents that provide free mercapto groups, weak reducing agents, and reducing agents. The disinfectant is particularly suitable for killing the novel coronavirus.

Description

Disinfectant agent Technical Field
The present invention relates to the field of disinfectants.
Background
The novel coronavirus pneumonia (abbreviated as "new coronapneumonia" or "Covid-19") is an acute infectious pneumonia, and no specific medicine exists at present. Currently, the virus has spread widely worldwide, resulting in infection in millions of people.
Social demands for anti-viral agents have increased from Covid-19 epidemic situations. Currently, disinfectants on the market are mainly divided into four categories. 1. Phenols, such as drop, have good sterilizing effect, but have the advantages of strong smell, slight water solubility, residue and corrosiveness. 2. Hypochlorous acids, such as 84 disinfectant, have strong irritation and corrosiveness, although they have good sterilizing effect, and are commonly used for disinfecting liquids, such as swimming pools, tap water, and the like. 3. Alcohols, such as 75% alcohol, are currently the most commonly used disinfectants. However, the odor is relatively harsh and flammable, and has extremely high safety hazards during preparation, transportation and storage. 4. Quaternary ammonium salts, such as Jieer's killer and Xinjieer's killer, have strong sterilization capability and can effectively kill bacteria, fungi and viruses. The disinfectant has mild smell and no corrosiveness, can be completely dissolved in water, and can be directly used for disinfecting skin and medical use.
Benzalkonium chloride, an (N-alkyl-phenyl-dimethyl) ammonium chloride mixture, belongs to cationic surfactants of quaternary ammonium salts. The disinfectant is widely used as disinfectant or preservative. The long-chain alkyl group can destroy the cell (wall) membrane of the microorganism, so that the microorganism dies, and the sterilization effect is achieved. Viruses have no cell walls, are weaker than bacteria, and are easier to kill. Therefore, manufacturers develop various disinfectants containing benzalkonium chloride, and patent CN102065696B discloses a universal sterilizing disinfectant which takes benzalkonium chloride, sorbic acid, benzoic acid and the like as active agents and has high-efficiency sterilizing capability. But the active pH value is 2.5-4.0, and the product is acidic, and is obviously not suitable for popularization and application. Patent CN201611024695 discloses a composite disinfectant consisting of benzalkonium chloride and other surfactants, which can kill (log > 6) escherichia coli, staphylococcus aureus, streptococcus white, pseudomonas aeruginosa with high efficiency within 5 minutes. Patent CN201010289039 discloses a compound antibacterial agent and a preparation method thereof. The method takes benzalkonium chloride, didecyl dimethyl ammonium chloride and epsilon-polylysine as main antibacterial components, and can kill (log > 4) Escherichia coli, staphylococcus aureus and Streptococcus albus 100% within 2 minutes. Patent CN202010085304 discloses a formulation of skin disinfection cleaning liquid and a preparation method thereof, the detergent is compounded by benzalkonium chloride and cetylpyridinium chloride, and can kill (log > 5) colibacillus 100% in 1 minute and 99.9% of skin surface bacteria in 10 minutes, the patent mentions that the method can be used for daily prevention of novel coronaviruses, but no specific data is disclosed.
Although the disinfectant has the performance of efficiently killing microorganisms, the time required for killing is still long, the requirement for quick killing in various application scenes is difficult to meet, the disinfectant is complex in component, complex in preparation process, high in production cost and capable of polluting the environment after being used. At present, the phenomenon of 'physical transmission' and 'environmental transmission' of Covid-19 generally exists, and a transient and efficient disinfectant suitable for the surfaces of people and objects is needed to effectively cut off a virus transmission chain.
Summary of The Invention
The invention provides a novel disinfectant, comprising: active agents, adjuvants and buffers; wherein the auxiliary comprises: chelating agents, reducing agents that provide free mercapto groups, weak reducing agents, and reducing agents.
The active agent is preferably a quaternary ammonium salt cationic surfactant, and can be one or more of the following substances: benzalkonium chloride, benzalkonium bromide, benzethonium chloride, cetylpyridinium chloride. The preferred active agent is benzalkonium chloride.
The chelating agent is preferably one or more of the following: ethylenediamine tetraacetic acid (EDTA), ethylenediamine tetraacetic acid sodium salt (EDTA-Na) 2 ) Amino triacetic acid (NTA), ethylene glycol diethyl ether diamine tetraacetic acid (EGTA), diethylene Triamine Pentaacetic Acid (DTPA). Particularly preferred chelating agents are ethylenediamine tetraacetic acid (EDTA) or ethylenediamine tetraacetic acid sodium salt (EDTA-Na) 2 )。
The reducing agent for providing free mercapto is preferably one or more of the following substances: L-Cysteine (L-Cysteine), reduced glutathione, beta mercaptoethanol. L-cysteine is particularly preferred.
The weak reducing agent is preferably one or more of the following substances: sodium sulfite (Na) 2 SO 3 ) Vitamin C, vitamin E. A particularly preferred weak reducing agent is sodium sulfite.
The reducing agent is preferably one or more of the following substances: dithiothreitol (DTT), tris (2-carboxyethyl) phosphine (TCEP). A particularly preferred reducing agent is dithiothreitol.
In a preferred embodiment of the present invention, in a preferred embodiment,the auxiliary agent comprises the following components: EDTA or EDTA-Na 2 L-cysteine, sodium sulfite, dithiothreitol.
The buffering agent is preferably one or more of the following substances: tris (hydroxymethyl) aminomethane (Tris), 4-hydroxyethyl piperazine ethane sulfonic acid (HEPES), 3-morpholinopropane sulfonic acid (MOPS). A particularly preferred buffer is Tris.
In a particularly preferred embodiment, the disinfectant comprises: benzalkonium chloride as an active agent; EDTA-Na as an auxiliary agent 2 L-cysteine, sodium sulfite, dithiothreitol; tris as buffer.
In some embodiments, the concentration of benzalkonium chloride as the active agent is 0.001% to 0.5% (W/V), preferably 0.01% (W/V).
In some embodiments, EDTA-Na as an adjunct 2 L-cysteine, sodium sulfite, dithiothreitol concentrations are each independently in the range of 0.01-100 mM; preferably in the range of 1-10 mM.
The disinfectant of the present invention is particularly suitable for disinfecting or inhibiting new coronaviruses. The disinfectant may be applied to the human body, such as the hands, or to public places (e.g. hospitals, subways, schools, airports), logistic cold chains or physical surfaces, such as containers.
The disinfectant using low concentration active agent as main component has the features of short acting time, high sterilizing effect, mild condition, no irritation, no pollution, etc. The disinfectant can be used as a disinfectant on the surface of a human body (such as hands), and is very suitable for disinfecting the surfaces of large containers in public places, logistics cold chains, ports and the like where people gather.
Detailed Description
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.
"coronavirus" refers to a class of enveloped viruses that can cause disease in vertebrates, particularly mammals or birds, and has a single positive strand RNA genome. They belong to the order of the phylogenetic group of the order of the cage-viruses (Nidovirales), the family of the Coronaviridae (Coronaviridae). 7 coronaviruses have been found to be capable of infecting humans, including HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2. Some of the diseases they cause are milder, like common influenza, while others may be fatal, such as SARS, MERS and covd-19. The coronavirus responsible for the COVID-19 is SARS-CoV-2, also known as "New coronavirus".
The invention provides a novel disinfectant, comprising: active agents, adjuvants and buffers; wherein the auxiliary comprises: chelating agents, reducing agents that provide free mercapto groups, weak reducing agents, and reducing agents.
The "active agent" may be a variety of commonly used active agents suitable for bacterial and viral killing. The preferred active agent is a quaternary ammonium salt type cationic surfactant, which may be, for example, one or more of the following: benzalkonium chloride, benzalkonium bromide, benzethonium chloride, cetylpyridinium chloride. A particularly preferred active agent is benzalkonium chloride.
The active agents of the present invention may also comprise one or several other types of active agents, such as anionic or nonionic surfactants and the like.
The quaternary ammonium salt cationic surfactant has the advantages of low sterilization concentration, no irritation, no toxicity and no corrosiveness, and has the functions of surface adsorption, surface tension reduction and certain washing function.
Buffers are used to provide a relatively stable solution environment. Preferably near neutral pH, e.g. 5-8. Various commonly used buffers, such as Tris, may be used.
The auxiliary agent has an important function of enhancing the disinfection efficacy of the disinfectant. The auxiliary agent comprises four components: chelating agents, reducing agents that provide free mercapto groups, weak reducing agents, and reducing agents.
The chelating agent can chelate with heavy metal ions in water, and reduce the influence of the heavy metal ions on the disinfectant effect. The chelating agent of the present invention may be EDTA or its sodium salt, or the like.
The reducing agent providing free mercapto groups is preferably one or more of the following substances, which act as stabilizing disinfectants: L-Cysteine (L-Cysteine), reduced glutathione, beta mercaptoethanol. L-cysteine is particularly preferred.
The weak reducing agent is preferably one or more of the following substances, which play a role in stabilizing the disinfectant: sodium sulfite (Na) 2 SO 3 ) Vitamin C and its derivatives, vitamin E and its derivatives. A particularly preferred weak reducing agent is sodium sulfite.
The reducing agent is preferably one or more of the following substances, which serve as stabilizing disinfectants: dithiothreitol (DTT), tris (2-carboxyethyl) phosphine (TCEP). A particularly preferred reducing agent is dithiothreitol.
Unless otherwise indicated, the methods and techniques used in this specification are generally performed according to methods well known and conventional in the art and described in the various references set forth or cited in this specification.
Example 1 preparation of disinfectant
1) Disinfectant component:
buffering agent: the preparation of Tris-containing solid-state drug,
active agent: the benzalkonium chloride is used as a catalyst,
auxiliary agent: EDTA-Na 2 、L-Cysteine、Na 2 SO 3 、DTT。
2) Preparing a disinfectant:
tris buffer at a concentration of 10mM is prepared and the raw materials of each component are weighed according to a disinfectant formulation (see example 3 for details), as follows: benzalkonium chloride, L-Cysteine, DTT, na 2 SO 3 、EDTA-Na 2 Add to Tris buffer and stir until completely dissolved. Finally, HCl or NaOH is used for regulating the pH value to 8.0-8.5, and pure water is used for constant volume.
3) Preparation of other reagents
Control reagent: 10mM Tris-HCl, pH 8.0.
Neutralizing agent: 3g of Tween 80 is taken and dissolved in 100mL of water, 0.3g of lecithin is weighed and added into the solution, and after the lecithin is fully dissolved, the mixture is filtered by a 0.45 mu m filter membrane for later use.
Example 2 evaluation of the killing Effect
1) Preparing bacterial liquid: staphylococcus aureus (ATCC 6538) and Escherichia coli (CICC 10899) were inoculated on LB solid plates and cultured at 37 ℃. After single colony grows out, single colony is picked up to liquid LB culture medium and cultured at 37 ℃. When the OD600 of the bacterial liquid reaches 0.6-0.8 (bacterial log value is more than 8), the bacterial cells are collected by centrifugation, the supernatant is discarded, the bacterial cells are resuspended by using an equal volume of buffer solution, and the bacterial cells are placed on ice for standby.
2) Sterilization experiment: 10. Mu.L of the bacterial liquid was taken in a 1.5mL EP tube, then 90. Mu.L of a disinfectant was added to the EP tube, and the mixture was uniformly mixed and reacted at room temperature for 10 seconds, and 900. Mu.L of a neutralizing agent was immediately added. The reaction product in the EP tube was then entirely spread on LB solid plates and incubated at 37℃for 24-28 hours.
Another 10. Mu.L of the bacterial liquid was put into a 1.5mL EP tube, then 90. Mu.L of the buffer was added to the EP tube, and the mixture was mixed and reacted at room temperature for 10 seconds, followed by immediately adding 900. Mu.L of the neutralizing agent. The reaction product in the EP tube was then serially diluted to 10 -10 After doubling, the cells were plated on LB solid plates and incubated at 37℃for 24-28 hours as a control.
The number of single colonies growing on the plates is taken as a quantitative basis, three plates are adopted for parallel test in each group of disinfection experiments, and the average value of the number of single colonies of the three plates is taken.
Example 3 evaluation of sterilizing Effect of disinfectant
The bactericidal potency was evaluated according to the method of example 2 for each component of the disinfectant and for formulations of each component in different combinations.
1) Disinfectant and evaluation of disinfection effect of various components in the disinfectant:
disinfectant: a buffering agent, an active agent and an auxiliary agent,
buffering agent: 10mM Tris-HCl, pH 8.0,
active agent: 0.1 percent of benzalkonium chloride (W/V),
auxiliary agent: 1mM EDTA-Na 2 +10mM L-Cysteine+5mM Na 2 SO 3 +10mM DTT using the above three components and a mixture of the three components (disinfectant) respectively, as described in example 2The sterilization experiment is carried out by the method, and the result is as follows:
the active agent benzalkonium chloride has stronger bactericidal activity when used alone, but can not achieve 100% bactericidal effect within 10 seconds. When the benzalkonium chloride is used together with the buffering agent and the auxiliary agent, the sterilizing effect can reach 100% in 10 seconds. Therefore, the auxiliary agent and the buffering agent can improve the disinfection efficiency of the active agent, and the buffering agent has no disinfection effect when being singly used.
2) The addition of adjuvants and buffering agents can reduce the use concentration of the active agent. With auxiliary agent (1 mM EDTA-Na) 2 、10mM L-Cysteine、5mM Na 2 SO 3 10mM DTT) and buffer (10 mM Tris-HCl, pH 8.0) as fixed components, and the killing rate of benzalkonium chloride with different concentrations on the tested bacteria was tested.
The following table shows:
the results show that the 0.01% concentration of active agent kills all the test bacteria within 10 seconds when the auxiliary agent and the buffer agent are used together. The use concentration of the active agent is 1/10 of the common concentration (0.1%) of the like product, and the killing time is 1/6 of the common time (1 minute) of the like product.
2) 0.01% of active agent benzalkonium chloride and different auxiliary agent formulas are matched to achieve the disinfection effect:
the test sample formulations are shown in the following table:
the bactericidal effect was verified as in example 2, with the following results:
the results show that the components in the auxiliary agent of the disinfectant are mutually independent and do not influence each other, and the killing efficiency of 100% can be achieved only when all the auxiliary agent components are matched at the same time.

Claims (25)

  1. A disinfectant, comprising: active agents, adjuvants and buffers;
    wherein the auxiliary comprises: chelating agents, reducing agents that provide free mercapto groups, weak reducing agents, and reducing agents.
  2. The disinfectant according to claim 1, wherein the active agent is a quaternary ammonium salt type cationic surfactant.
  3. A disinfectant as set forth in claim 1, wherein said active agent includes one or more of the following: benzalkonium chloride, benzalkonium bromide, benzethonium chloride, cetylpyridinium chloride.
  4. The disinfectant of claim 1, wherein the active agent is benzalkonium chloride.
  5. A disinfectant as claimed in any one of claims 1 to 4, wherein the chelating agent comprises one or more of the following: ethylenediamine tetraacetic acid (EDTA), ethylenediamine tetraacetic acid sodium salt (EDTA-Na) 2 ) Amino triacetic acid (NTA), ethylene glycol diethyl ether diamine tetraacetic acid (EGTA), diethylene Triamine Pentaacetic Acid (DTPA).
  6. The disinfectant as set forth in any one of claims 1 to 5, wherein said chelating agent is ethylenediamine tetraacetic acid (EDTA) or ethylenediamine tetraacetic acid sodium salt (EDTA-Na 2 )。
  7. A disinfectant as claimed in any one of claims 1 to 6, wherein the reducing agent providing free mercapto groups comprises one or more of the following: L-Cysteine (L-Cysteine), reduced glutathione, beta mercaptoethanol.
  8. The disinfectant as set forth in any of claims 1 to 7, wherein said reducing agent providing free mercapto groups is L-cysteine.
  9. A disinfectant as claimed in any one of claims 1 to 8, wherein the weak reducing agent comprises one or more of the following: sodium sulfite (Na) 2 SO 3 ) Vitamin C, vitamin E.
  10. A disinfectant as claimed in any one of claims 1 to 9, wherein the weak reducing agent is sodium sulfite.
  11. A disinfectant as claimed in any one of claims 1 to 10, wherein the reducing agent comprises one or more of the following: dithiothreitol (DTT), tris (2-carboxyethyl) phosphine (TCEP).
  12. A disinfectant as claimed in any one of claims 1 to 11, wherein the reducing agent is dithiothreitol.
  13. A disinfectant as claimed in any one of claims 1 to 12, wherein the auxiliary comprises: EDTA or EDTA-Na 2 L-cysteine, sodium sulfite, dithiothreitol.
  14. A disinfectant as claimed in any one of claims 1 to 13, wherein the buffer comprises one or more of the following: tris (hydroxymethyl) aminomethane (Tris), 4-hydroxyethyl piperazine ethane sulfonic acid (HEPES), 3-morpholinopropane sulfonic acid (MOPS).
  15. The disinfectant of any one of claims 1 to 14, wherein the buffer is Tris.
  16. The disinfectant of any one of claims 1 to 15, wherein the disinfectant comprises: benzalkonium chloride as an active agent; EDTA-Na as an auxiliary agent 2 L-cysteine, sodium sulfite, dithiothreitol; tris as buffer.
  17. A disinfectant as claimed in any one of claims 1 to 16 wherein the concentration of benzalkonium chloride as the active agent is from 0.001% to 0.5% (W/V).
  18. A disinfectant as claimed in any one of claims 1 to 16, wherein the concentration of benzalkonium chloride as the active agent is 0.01% (W/V).
  19. A disinfectant as claimed in any one of claims 1 to 18 wherein EDTA-Na is used as an auxiliary agent 2 L-cysteine, sodium sulfite, dithiothreitol concentrations are each independently in the range of 0.01-100 mM.
  20. A disinfectant as claimed in any one of claims 1 to 19 wherein EDTA-Na is used as an auxiliary agent 2 L-cysteine, sodium sulfite, dithiothreitol concentrations are each independently in the range of 1-10 mM.
  21. Use of a disinfectant as claimed in any one of claims 1 to 20 for killing or inhibiting a new coronavirus.
  22. The use of claim 21, wherein the disinfectant is applied to a human surface.
  23. The use of claim 21, wherein the disinfectant is applied to the surface of the object.
  24. Use of a disinfectant as claimed in any of claims 1 to 20 for disinfecting or inhibiting bacteria.
  25. The use according to claim 24, wherein the bacterium is escherichia coli or staphylococcus aureus.
CN202280014070.5A 2021-02-10 2022-02-10 Disinfectant agent Pending CN117082978A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021101855312 2021-02-10
CN202110185531 2021-02-10
PCT/CN2022/075750 WO2022171153A1 (en) 2021-02-10 2022-02-10 Disinfectant

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CN117082978A true CN117082978A (en) 2023-11-17

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WO (1) WO2022171153A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117643311A (en) * 2023-12-01 2024-03-05 北京舜雷科技有限公司 Composition, preparation method and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06279268A (en) * 1993-01-27 1994-10-04 Takeda Chem Ind Ltd Disinfecting and sterilizing agent and aerosol composition containing the same
CN104621104A (en) * 2015-02-02 2015-05-20 山东威高药业股份有限公司 Disinfectant with low corrosiveness
CN109316536A (en) * 2018-10-22 2019-02-12 湖南中威制药有限公司 A kind of skin mucosa disinfecting agent and preparation method thereof
CN112042645A (en) * 2020-08-22 2020-12-08 西北工业大学 Composite quaternary ammonium salt disinfectant
CN112043701A (en) * 2020-09-24 2020-12-08 上海中医药大学 Medical application of long-chain quaternary ammonium salt compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117643311A (en) * 2023-12-01 2024-03-05 北京舜雷科技有限公司 Composition, preparation method and application

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