CN117045533A - Fibroin supermolecule hair care composition and application thereof - Google Patents
Fibroin supermolecule hair care composition and application thereof Download PDFInfo
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- CN117045533A CN117045533A CN202311286067.1A CN202311286067A CN117045533A CN 117045533 A CN117045533 A CN 117045533A CN 202311286067 A CN202311286067 A CN 202311286067A CN 117045533 A CN117045533 A CN 117045533A
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- 108010022355 Fibroins Proteins 0.000 title claims abstract description 121
- 239000000203 mixture Substances 0.000 title claims abstract description 83
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 84
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 82
- 210000004761 scalp Anatomy 0.000 claims abstract description 50
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 9
- 239000011575 calcium Substances 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 96
- 239000002453 shampoo Substances 0.000 claims description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 239000003755 preservative agent Substances 0.000 claims description 36
- 230000002335 preservative effect Effects 0.000 claims description 34
- 238000002156 mixing Methods 0.000 claims description 25
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 15
- 239000001110 calcium chloride Substances 0.000 claims description 15
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 15
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 19
- 208000001840 Dandruff Diseases 0.000 abstract description 16
- 230000003020 moisturizing effect Effects 0.000 abstract description 11
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
- 108090000623 proteins and genes Proteins 0.000 abstract description 6
- 108010076876 Keratins Proteins 0.000 abstract description 4
- 102000011782 Keratins Human genes 0.000 abstract description 4
- 210000002510 keratinocyte Anatomy 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000002209 hydrophobic effect Effects 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 208000017520 skin disease Diseases 0.000 abstract description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 46
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 45
- 210000003491 skin Anatomy 0.000 description 43
- 229910052751 metal Inorganic materials 0.000 description 38
- 239000002184 metal Substances 0.000 description 38
- 229920000289 Polyquaternium Polymers 0.000 description 22
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 22
- 229940083037 simethicone Drugs 0.000 description 22
- 238000002360 preparation method Methods 0.000 description 18
- 239000000047 product Substances 0.000 description 16
- 239000002994 raw material Substances 0.000 description 16
- 239000003921 oil Substances 0.000 description 12
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 11
- 229960002798 cetrimide Drugs 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 11
- 230000002421 anti-septic effect Effects 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 210000003128 head Anatomy 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 210000002374 sebum Anatomy 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 230000003301 hydrolyzing effect Effects 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 239000000376 reactant Substances 0.000 description 5
- 230000008439 repair process Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 239000004519 grease Substances 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 210000001061 forehead Anatomy 0.000 description 3
- 102000007236 involucrin Human genes 0.000 description 3
- 108010033564 involucrin Proteins 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 102000000905 Cadherin Human genes 0.000 description 2
- 108050007957 Cadherin Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 210000001047 desmosome Anatomy 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000000413 hydrolysate Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108700041153 Filaggrin Proteins Proteins 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102100034934 Papilin Human genes 0.000 description 1
- 101710142044 Papilin Proteins 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 108060008539 Transglutaminase Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 102000014823 calbindin Human genes 0.000 description 1
- 108060001061 calbindin Proteins 0.000 description 1
- 229960002713 calcium chloride Drugs 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000008876 conformational transition Effects 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229940038580 oat bran Drugs 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 229940095673 shampoo product Drugs 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application relates to the technical field of hair and scalp care products, in particular to a fibroin supermolecule hair care composition and application thereof. The technical proposal comprises: the hair care composition combines scalp active ingredients with fibroin molecules to form a fibroin-calcium salt-fibroin supramolecular structure. The supermolecular structure of the supermolecular hair care composition can be better combined with hair keratin, a hydrophobic film is formed on the surface of the hair, moisture and protein in the hair can be effectively protected and locked, loss of nutrient components is avoided, the repairing function is improved, and meanwhile, the absorption of calcium ions is better promoted, the repairing and the function metabolism of scalp keratinocytes are better regulated through the calcium ion salt-fibroin supermolecular structure; the hair care composition has good anti-dandruff effect and moisturizing effect, can effectively control oil on scalp, improve scalp microecology, regulate scalp metabolism and effectively solve scalp disorder.
Description
Technical Field
The application relates to the technical field of hair and scalp care products, in particular to a fibroin supermolecule hair care composition and application thereof.
Background
The shampoo, also called shampoo and shampoo, is the most widely used shampoo product, and is also one of the most commonly used shampoos for hair. Is used for cleaning the grease, sweat scale, cell falling off the scalp, foreign dust, microorganism, residue of shaping product and bad smell, etc. adhered on the scalp and hair, keeping the scalp and hair clean and the hair beautiful.
Sebum is produced by sebaceous gland cells in the scalp and then secreted to the scalp surface, and a sebum film formed by sebum and sweat on the surface of a human body is one of important components of the first barrier of the human body, and the normal sebum secretion amount is very important for maintaining the healthy state of the scalp. Excessive secretion of scalp grease can cause bad appearance and uncomfortable touch feeling of the scalp, excessive sebum is distributed on the surface of the scalp, and a large amount of lipophilic bacteria can be propagated, so that the microecological balance of the scalp is destroyed; dust is easy to pollute, the normal functions are affected to a certain extent, and certain trouble is brought to daily activities. Thus, oil control is an important solution to the problem of treating such scalp, and at the same time, conditioning of oily skin is one of the problems many consumers seek to improve.
Calcium ions and calbindins play an important role in scalp differentiation and injury repair. Calcium ions act as regulators of keratinocyte proliferation and differentiation in normal renewal of the mammalian scalp. Mouse keratinocytes cultured in vitro maintain proliferation activity at low calcium ion concentration (0.05 mm); proliferation was stopped, differentiation was initiated and transglutaminase (IVN), involucrin (IVN), papilin (lopercrin) and profilaggrin expression were induced at high calcium ion concentration of 0.1 mm. In vivo experiments also showed that the epidermis of neonatal and adult hairless mice had a calcium ion gradient. It is suggested that changes in intracellular calcium ion concentration may regulate epidermal differentiation. Disruption of epidermal permeability can alter scalp calcium ion gradients. Calcium ions also play a role in the different phases of scalp injury repair.
The scalp requires "calcium", the biological function of calcium ions: in the scalp epidermis, calcium ion concentration calcium is distributed in a trapezoid shape, and the concentration of calcium in the superficial layer of the epidermis is high and the concentration of calcium in the deep layer of the epidermis is low. The functions are as follows: (1) effectively regulate division and keratinization of scalp cells; (2) affecting the synthesis and secretion of sebum and natural moisturizing factors; (3) maintenance of self-regulation and regeneration of scalp barrier function; (4) affecting the formation of scalp melanin. The alpha-hydroxy acid may act as a chelating agent to reduce the concentration of local calcium ions of the cation-dependent cell adhesion molecule. Loss of calcium ions in cadherins such as desmosomes results in a reduction of cell desmosome linkages. This makes it easy for the normally protected endogenous stratum corneum trypsin on cadherins to proteolytically occur. When calcium ions are reduced, adherent cells are destroyed and exfoliation occurs. Thus, calcium ion loss or reduction leads to scalp keratinous metabolic abnormalities.
Inorganic calcium ions or free calcium ions are not easily absorbed by skin under the action of skin barrier, and too high concentration of calcium ions is easy to cause skin allergy, so that in order to promote better affinity of calcium ions and skin keratinocytes, the best method is to combine calcium ions and proteins to form supermolecules.
In SILK gland of silkworm, SILK protein has conformation of SILK-I, and is mainly composed of random coil. In the case of the discharged fibrous SILK, the SILK protein has a conformation of SILK-II, which is mainly a folded structure. We have found in solid CCP-MASSMR spectroscopy of the conformational transition of silk fibroin caused by metal ions that the presence of a certain degree of metal ions favors the transition of SILKI to SILKII conformation.
Therefore, the design of the metal calcium ion fibroin supermolecule not only solves the problems of affinity, permeation, absorption and utilization of calcium ions and skin cutin, but also changes the spatial structure of the fibroin molecule through the existence of the metal calcium ions, so that the novel metal calcium ion fibroin supermolecule has novel skin and hair care functions.
Although a large amount of shampoo with oil control, relieving and anti-dandruff effects is publicized on the market at present, basically, all anti-dandruff agents such as ganbazole, ZPT and OCT are added, and the shampoo is generally poor in oil control, relieving and anti-dandruff effects, and has general conditions such as moisture retention and repair capability on scalp, so that scalp microecological imbalance and scalp barrier function damage can be caused after long-term use, and scalp problems such as vigorous grease secretion, increased dandruff and alopecia can be caused. Therefore, we propose a metallic calcium ion fibroin supermolecule hair care composition and its use.
Disclosure of Invention
The application aims at solving the problems in the background technology and provides a fibroin supermolecule hair care composition and application thereof.
The technical scheme of the application is as follows: a metallic calcium ion fibroin supermolecule skin and hair care composition combines scalp active ingredients with fibroin molecules to form a fibroin-calcium ion salt-fibroin supermolecule structure.
Optionally, the source of calcium ion salt is preferably calcium chloride.
Optionally, the content of the metal calcium ion fibroin supermolecule composition is as follows:
1-20% of fibroin;
10-30% of calcium ion salt;
based on the total mass of the metallic calcium ion fibroin supermolecule composition.
Optionally, a combination of water, fibroin, calcium salt and preservative is added to the metallic calcium fibroin supermolecule composition.
Optionally, in the metal calcium ion fibroin supermolecule composition, the content of each component is as follows:
73.5% of water, 5% of fibroin, 1.5% of preservative and 20% of calcium ion salt, based on the total mass of the metallic calcium ion fibroin supermolecule composition.
Optionally, the fibroin adopted by the metal calcium ion fibroin supermolecule composition is medium-high molecular fibroin obtained based on high-quality fresh cut cocoons.
Wherein the molecular weight of the medium and high molecular fibroin ranges from 7000 to 10 ten thousand daltons.
Optionally, the metallic calcium ion fibroin supramolecular composition may further include citric acid;
wherein the content of the citric acid is 0-2.0%, based on the total mass of the metal calcium ion fibroin supermolecule composition.
Optionally, the fibroin-calcium ion salt-fibroin supermolecular structure is prepared by adding fibroin and calcium ions into a constant-temperature airtight ultrasonic reactor and mixing.
In another aspect, the application discloses the use of a fibroin-containing supramolecular skin and hair care composition in shampoos, hair shampoos, body washes, hand washes, scalp care products, and skin care products.
Compared with the prior art, the application has the following beneficial technical effects:
according to the application, calcium ions participate in swelling and dissociation of silk fibroin when the medium-polymer fibroin is dissolved, and simultaneously active ingredients and fibroin molecules can be combined to form a fibroin-calcium ion-fibroin supermolecular structure. The supermolecular structure is similar to that of the hair flake, can selectively repair the F-layer on the surface of the hair and the internal cavity, and can be adsorbed to the damaged part without accumulating at the healthy part. Meanwhile, the supermolecular structure can form a hydrophobic film on the surface of the hair, can effectively protect and lock moisture and protein in the hair, avoid loss of nutrient components, improve the repairing function, and solve the problems that free calcium ions are poor in skin permeability and absorptivity, and high concentration of free calcium ions can cause skin dehydration, allergy and the like. The calcium ions formed into supermolecule with fibroin have better affinity and penetrability with skin keratin, and can better play a functional role.
According to the application, the spatial structure of the hydrolyzed high molecular fibroin is changed through the existence of the metal calcium ions, so that the hydrolyzed high molecular fibroin is differentiated from the functional effect of silk hydrolysate obtained in other modes, and is blended into the metal calcium ion fibroin supermolecule composition, so that the prepared metal calcium ion fibroin supermolecule composition has good anti-dandruff effect, moisturizing effect and skin repairing effect, and meanwhile, the oil control can be effectively carried out on scalp, scalp microecology is improved, scalp metabolism is regulated, and scalp disorder is effectively solved.
Detailed Description
The technical solutions in the embodiments will be clearly and completely described below in connection with the embodiments of the present application. It will be apparent that the embodiments described below are only some, but not all, embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
In the following examples, the preservative is prepared by mixing 80% of water, 10% of 1, 2-pentanediol, 6.2% of oat bran extract, 3.2% of radix sophorae flavescentis extract and 0.6% of soybean seed extract, and other preservatives with preservative efficacy can be added.
Preparation of a metal calcium ion fibroin supermolecule skin and hair care composition:
example 1
The raw materials of the metal calcium ion fibroin supermolecule skin and hair care composition comprise: 5% of fibroin, 1.5% of preservative, 10% of calcium chloride and the balance of water.
The preparation process of the supermolecule composition comprises the following steps:
and (3) cleaning the selected fresh cut cocoons, degumming to obtain silk fibroin, and hydrolyzing the silk fibroin into silk fibroin with molecular weight of 7000-10 ten thousand by using a biological enzyme method. Adding calcium chloride and deionized water into a constant-temperature airtight ultrasonic reactor for dissolution, then adding silk fibroin with the activity content of 5%, sealing the ultrasonic reactor, setting the reaction temperature to 80 ℃ for 30 minutes, observing the state of the reactants, adding a preservative, adjusting the pH to about 6.0 by using citric acid, filtering to remove impurities, and adding the preservative to prepare the metal calcium ion silk fibroin supermolecule skin and hair care composition, namely the silk supermolecule composition 1 in the following table 1.
Example 2
The raw materials of the metal calcium ion fibroin supermolecule skin and hair care composition comprise: 5% of fibroin, 1.5% of preservative, 15% of calcium chloride and the balance of water.
The preparation process of the supermolecule composition comprises the following steps:
and (3) cleaning the selected fresh cut cocoons, degumming to obtain silk fibroin, and hydrolyzing the silk fibroin into silk fibroin with molecular weight of 7000-10 ten thousand by using a biological enzyme method. Adding calcium chloride and deionized water into a constant-temperature airtight ultrasonic reactor for dissolution, then adding silk fibroin with the activity content of 5%, sealing the ultrasonic reactor, setting the reaction temperature to 80 ℃ for 30 minutes, observing the state of the reactants, adding a preservative, adjusting the pH to about 6.0 by using citric acid, filtering to remove impurities, and adding the preservative to prepare the metal calcium ion silk fibroin supermolecule skin and hair care composition, namely the silk supermolecule composition 2 in the following table 1.
Example 3
The raw materials of the metal calcium ion fibroin supermolecule skin and hair care composition comprise: 5% of fibroin, 1.5% of preservative, 20% of calcium chloride and the balance of water.
The preparation process of the supermolecule composition comprises the following steps:
and (3) cleaning the selected fresh cut cocoons, degumming to obtain silk fibroin, and hydrolyzing the silk fibroin into silk fibroin with molecular weight of 7000-10 ten thousand by using a biological enzyme method. Adding calcium chloride and deionized water into a constant-temperature airtight ultrasonic reactor for dissolution, then adding silk fibroin with the activity content of 5%, sealing the ultrasonic reactor, setting the reaction temperature to 80 ℃ for 30 minutes, observing the state of the reactants, adding a preservative, adjusting the pH to about 6.0 by using citric acid, filtering to remove impurities, and adding the preservative to prepare the metal calcium ion silk fibroin supermolecule skin and hair care composition, namely the silk supermolecule composition 3 in the following table 1.
Example 4
The raw materials of the metal calcium ion fibroin supermolecule skin and hair care composition comprise: 5% of fibroin, 1.5% of preservative, 25% of calcium chloride and the balance of water.
The preparation process of the supermolecule composition comprises the following steps:
and (3) cleaning the selected fresh cut cocoons, degumming to obtain silk fibroin, and hydrolyzing the silk fibroin into silk fibroin with molecular weight of 7000-10 ten thousand by using a biological enzyme method. Adding calcium chloride and deionized water into a constant-temperature airtight ultrasonic reactor for dissolution, then adding silk fibroin with the activity content of 5%, sealing the ultrasonic reactor, setting the reaction temperature to 80 ℃ for 30 minutes, observing the state of the reactants, adding a preservative, adjusting the pH to about 6.0 by using citric acid, filtering to remove impurities, and adding the preservative to prepare the metal calcium ion silk fibroin supermolecule skin and hair care composition, namely the silk supermolecule composition 4 in the following table 1.
Example 5
The raw materials of the metal calcium ion fibroin supermolecule skin and hair care composition comprise: 5% of fibroin, 1.5% of preservative, 30% of calcium chloride and the balance of water.
The preparation process of the supermolecule composition comprises the following steps:
and (3) cleaning the selected fresh cut cocoons, degumming to obtain silk fibroin, and hydrolyzing the silk fibroin into silk fibroin with molecular weight of 7000-10 ten thousand by using a biological enzyme method. Adding calcium chloride and deionized water into a constant-temperature airtight ultrasonic reactor for dissolution, then adding silk fibroin with the activity content of 5%, sealing the ultrasonic reactor, setting the reaction temperature to 80 ℃ for 30 minutes, observing the state of the reactants, adding a preservative, adjusting the pH to about 6.0 by using citric acid, filtering to remove impurities, and adding the preservative to prepare the metal calcium ion silk fibroin supermolecule skin and hair care composition, namely the silk supermolecule composition 5 in the following table 1.
Application example 1
Shampoo raw material: the metal calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 1 comprises 3% of sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 2
Shampoo raw material: the metal calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 2 comprises 3% of sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 3
Shampoo raw material: the metal calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 3 comprises 3% of sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 4
Shampoo raw material: the metal calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 4 comprises 3% of sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 5
Shampoo raw material: the metal calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 5 comprises 3% of sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 6
Shampoo raw material: the metallic calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 1 comprises 4% of sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 7
Shampoo raw material: corresponding to the example 1 obtained, the metal calcium ion fibroin supermolecule skin and hair care composition 3.5%, sodium laurylsulfate 2.0%, sodium laurylsulfate 13%, simethicone 1.2%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, citric acid 1.0%, preservative 0.5% and water balance.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 8
Shampoo raw material: the metallic calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 1 comprises 4.5% of a metallic calcium ion fibroin supermolecule skin and hair care composition, 2.0% of sodium lauryl sulfate, 13% of sodium dodecyl sulfate, 1.2% of simethicone, 0.5% of western Qu Lvan, 0.1% of polyquaternium, 1.0% of citric acid, 0.5% of a preservative and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Application example 9
Shampoo raw material: 5% of the metal calcium ion fibroin supermolecule skin and hair care composition obtained in the corresponding example 1, 2.0% of sodium lauryl sulfate, 13% of sodium dodecyl sulfate, 1.2% of simethicone, 0.5% of western Qu Lvan, 0.1% of polyquaternium, 1.0% of citric acid, 0.5% of preservative and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, metal calcium ion fibroin supermolecule skin and hair care composition, simethicone, cetrimide, polyquaternium, etc. into the reactor, mixing, adding antiseptic, and adjusting pH with citric acid to obtain shampoo.
Comparative example 1
Shampoo raw material: sodium lauryl sulfate 2.0%, sodium dodecyl sulfate 13%, western Qu Lvan 0.5.5%, polyquaternium 0.1%, calcium chloride 0.5%, simethicone 1.2%, citric acid 1.0%, preservative 0.5% and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, calcium chloride, simethicone, cetrimide, polyquaternium and the like into the reactor, mixing uniformly, adding preservative, and regulating the PH with citric acid to obtain the shampoo.
Comparative example 2
Shampoo raw material: 5% of fibroin, 2.0% of sodium lauryl sulfate, 13% of sodium dodecyl sulfate, 0.5% of western Qu Lvan, 0.1% of polyquaternium, 1.2% of simethicone, 1.0% of citric acid, 0.5% of preservative and the balance of water.
The preparation process of the shampoo comprises the following steps:
adding water and sodium dodecyl sulfate into a reactor, mixing, sequentially adding sodium laurylsulfate, fibroin, simethicone, cetrimide, polyquaternium and the like into the reactor, mixing uniformly, adding a preservative, and adjusting the PH with citric acid to obtain the shampoo.
Table 1: examples 1-9 and comparative examples 1-2 components and proportions
| Component (A) | Application example 1 | Application example 2 | Application example 3 | Application example 4 | Application example 5 | Application example 6 | Application example 7 | Application example 8 | Application example 9 | Comparative example 1 | Comparative example 2 |
| Silk supermolecule composition 1 | 3% | - | - | - | - | 4% | 3.5% | 4.5% | 5% | - | - |
| Silk supermolecule composition 2 | - | 3% | - | - | - | - | - | - | - | - | - |
| Silk supermolecule composition 3 | - | - | 3% | - | - | - | - | - | - | - | - |
| Silk supermolecule composition 4 | - | - | - | 3% | - | - | - | - | - | - | - |
| Silk supermolecule composition 5 | - | - | - | - | 3% | - | - | - | - | - | - |
| Fibroin protein | - | - | - | - | - | - | - | - | - | - | 5% |
| Calcium chloride | - | - | - | - | - | - | - | - | - | 0.5% | - |
| Sodium lauryl sulfate | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% | 2.0% |
| Sodium dodecyl sulfate | 13% | 13% | 13% | 13% | 13% | 13% | 13% | 13% | 13% | 13% | 13% |
| Dimethicone | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% | 1.2% |
| Western Qu Lvan | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% |
| Polyquaternary ammonium salt | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% | 0.1% |
| Citric acid | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% | 1.0% |
| Preservative agent | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% | 0.5% |
| Water and its preparation method | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of | Allowance of |
Performance test: the shampoos obtained according to application examples 1-9 and comparative examples 1-2 were subjected to the following performance tests:
1. oil control performance test, test basis: according to the laboratory self-simulation test method for the moisturizing efficacy of the shampoo and the test scheme for the moisturizing efficacy of the shampoo, which are drawn up by the specific requirements of the consignor. Healthy female/male volunteers aged 18-50 years were selected and tested as follows:
a. under the management of testers, 11 subjects clean the forehead part by using an alkaline soap-based cleaning product, clean water is washed clean, and then the forehead part is sucked dry by using a chipless water-absorbing dry paper towel;
b. taking a region with the area of 3cm multiplied by 3cm from the forehead of a subject as a sample application region, measuring the amount of oil on the scalp surface of the sample application region, measuring 3 times at different positions in each region, and taking the measurement result as an initial value, wherein the measurement result is expressed by a measurement average value of 3 times;
c. the shampoos obtained in application examples 1 to 9 and comparative examples 1 to 2 were used for 11 volunteers, respectively, a certain amount of the sample was taken and uniformly applied to a prescribed area, and then after 1h,2h,3h, and 4h, the amounts of the scalp surface oils on the areas to which the sample was applied were measured, respectively, with a Sebumeter oil test probe, and the measurement results were expressed as average values of 3 measurements, as measurement values.
Table 2: oil content for different time periods
| Project | 1h | 2h | 3h | 4h |
| Example 1 | 48.7 | 69.3 | 73.0 | 74.5 |
| Example 2 | 48.6 | 69.2 | 72.9 | 74.3 |
| Example 3 | 48.7 | 69.5 | 72.9 | 74.1 |
| Example 4 | 48.5 | 69.8 | 73.1 | 75.0 |
| Example 5 | 48.3 | 69.7 | 72.6 | 74.5 |
| Example 6 | 48.5 | 69.6 | 72.5 | 74.6 |
| Example 7 | 48.4 | 69.8 | 72.8 | 74.2 |
| Example 8 | 49.9 | 70.4 | 73.5 | 85.8 |
| Example 9 | 49.7 | 70.7 | 73.7 | 85.6 |
| Comparative example 1 | 68.2 | 83.7 | 103.7 | 105.5 |
| Comparative example 2 | 69.4 | 86.5 | 104.6 | 105.8 |
The table shows that the shampoo prepared by the application can effectively control the secretion of grease within 4 hours after being used, and has good oil control effect.
2. Moisture retention performance test, test basis: according to the laboratory self-simulation test method for the moisturizing efficacy of the shampoo and the test scheme for the moisturizing efficacy of the shampoo, which are drawn up by the specific requirements of the consignor.
Healthy female/male volunteers aged 18-50 years were selected and tested as follows:
the shampoo obtained in application examples 1-9 and comparative examples 1-2 were used for 11 volunteers, respectively, and subjects used the product continuously for 28 days, the method of using the product: once every three days, after the hair is moistened, a proper amount of the product is evenly smeared, and the scalp and the hair are gently massaged for 3-5 minutes and then flushed; subjects were subjected to a full head test using a self-front-back control at D0 (day 0 before shampoo) and D28 (day 28); after the subject is adapted for at least 20 minutes in an environment with a temperature of 21+ -1deg.C and a humidity of 50+ -5% RH, the moisture content of the scalp and the horny layer of the head of the subject is collected.
Table 3: moisture content of scalp stratum corneum of subject's head
From the above table, it can be seen that the shampoo prepared by the application has a significantly reduced moisture content of scalp cuticle compared with that before use after the shampoo is continuously used for 28 days. Therefore, under the conditions of the study, it is considered that the moisture content at the application site is maintained and the moisturizing effect is exhibited.
3. And (3) testing anti-dandruff performance according to the following steps: according to the laboratory self-simulation test method for the moisturizing efficacy of the shampoo and the test scheme for the moisturizing efficacy of the shampoo, which are drawn up by the specific requirements of the consignor.
Healthy female/male volunteers aged 18-50 years were selected and tested as follows:
the shampoo obtained in application examples 1-9 and comparative examples 1-2 were used for 11 volunteers, respectively, and subjects used the product continuously for 28 days, the method of using the product: is used once every three days, after the hair is moistened, a proper amount of the product is evenly smeared, and the scalp and the hair are gently massaged for 3-5 minutes and then flushed. Subjects were subjected to a full head test using a self-front and back control at time points D0 (day 0 before shampoo) and D28 (day 28). After the subjects were acclimated to an environment with a temperature of 21±1 ℃ and a humidity of 50±5% rh for at least 20 minutes, dandruff index collection was performed on the heads of the subjects.
Table 4: dandruff index of subject's head
From the above table, it can be seen that the shampoo prepared by the present application has significantly reduced dandruff score and dandruff index after 28 days of continuous use of the product. It is therefore believed that under the conditions of the study, the product helps to slow down the production of dandruff; is helpful for reducing dandruff adhered to scalp and hair, and has anti-dandruff effect.
According to the comparison of application examples 1, 8 and 9, the product prepared by combining calcium ions and fibroin to form a supermolecular structure has better effect in the aspects of oil control, moisture preservation and anti-dandruff effects than the product prepared by combining zinc ions and fibroin and the product prepared by combining copper ions and fibroin, and the preference of the technical scheme protected by the application is proved.
According to the application, calcium ions participate in the swelling and dissociation of fibroin molecules when the fibroin is dissolved, and meanwhile, active ingredients and the fibroin molecules can be combined to form a fibroin-calcium ion-fibroin supermolecular structure. The supermolecular structure is the same as that of the hair flake, can selectively repair the F-layer on the surface of the hair and the internal cavity, and can be adsorbed to the damaged part without being accumulated at the healthy part. Meanwhile, the supermolecular structure can form a hydrophobic film on the surface of the hair, so that the moisture and protein in the hair can be effectively protected and locked, the loss of nutrient components is avoided, and the repairing function is improved. In addition, the spatial structure of the hydrolyzed high molecular fibroin is changed by the existence of metal calcium ions, so that the hydrolyzed high molecular fibroin is different from the silk hydrolysate obtained in other modes in function, and is integrated into the shampoo, so that the prepared shampoo has good anti-dandruff effect and moisturizing effect, and meanwhile, the shampoo can effectively control oil on scalp, improve scalp microecology and regulate scalp metabolism. The free calcium ions have poor skin permeation and absorption properties, and the high concentration of the free calcium ions can lead to skin dehydration and allergy, and the calcium ions which form supermolecules with fibroin have better affinity and permeability with skin keratin, so that the skin keratin can play a better role.
The above-described embodiments are merely a few alternative embodiments of the present application, and many alternative modifications and combinations of the above-described embodiments will be apparent to those skilled in the art based on the technical solutions of the present application and the related teachings of the above-described embodiments.
Claims (9)
1. A fibroin supramolecular hair care composition according to claim 1, wherein the hair care composition combines scalp active ingredients with fibroin molecules to form a fibroin-calcium salt-fibroin supramolecular structure.
2. A fibroin supramolecular hair care composition according to claim 1, wherein the source of calcium ion salt is preferably calcium chloride.
3. The fibroin supramolecular hair care composition of claim 1, wherein the hair care composition comprises:
1-20% of fibroin;
10-30% of calcium ion salt;
based on the total mass of the hair care composition.
4. The fibroin supermolecule hair care composition of claim 1, wherein a combination of water, fibroin, preservative and calcium salt is added to the hair care composition.
5. The fibroin supermolecule hair care composition according to claim 4, wherein the hair care composition comprises the following components:
73.5% water, 5% fibroin, 1.5% preservative, 20% calcium salt, based on the total mass of the hair care composition.
6. The fibroin supermolecule hair care composition according to claim 1, wherein the fibroin used in the hair care composition is medium-high molecular silk fibroin obtained based on high-quality fresh cut cocoons;
wherein the molecular weight of the medium and high molecular fibroin is in the range of 1 ten thousand to 10 ten thousand daltons.
7. The fibroin supramolecular hair care composition of claim 1, further comprising citric acid;
wherein the citric acid is present in an amount of 2.0% based on the total mass of the hair care composition.
8. The fibroin supermolecule hair care composition according to claim 1, wherein the fibroin-calcium ion salt-fibroin supermolecule structure is prepared by adding fibroin and calcium ions into a constant temperature closed ultrasonic reactor and mixing.
9. Use of a fibroin-containing supramolecular hair care composition according to claim 1 in shampoos, hair shampoos, body washes, hand washes, scalp care products, skin care products.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003002898A (en) * | 2001-04-17 | 2003-01-08 | Kowa Co | Method for producing undecomposed silk fibroin solution and skin care agent containing the same |
| KR20190130714A (en) * | 2018-05-15 | 2019-11-25 | 농업회사법인 에스에스바이오팜 주식회사 | Extraction method of silk peptide by enzymatic hydrolysis under ultra high pressure |
| US20200360266A1 (en) * | 2017-11-10 | 2020-11-19 | Conopco, Inc., D/B/A Unilever | A hair care composition comprising silk fibroin |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003002898A (en) * | 2001-04-17 | 2003-01-08 | Kowa Co | Method for producing undecomposed silk fibroin solution and skin care agent containing the same |
| US20200360266A1 (en) * | 2017-11-10 | 2020-11-19 | Conopco, Inc., D/B/A Unilever | A hair care composition comprising silk fibroin |
| KR20190130714A (en) * | 2018-05-15 | 2019-11-25 | 농업회사법인 에스에스바이오팜 주식회사 | Extraction method of silk peptide by enzymatic hydrolysis under ultra high pressure |
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