CN1169948C - 生物相容的支架的制备方法及由该方法制备的支架 - Google Patents
生物相容的支架的制备方法及由该方法制备的支架 Download PDFInfo
- Publication number
- CN1169948C CN1169948C CNB001326376A CN00132637A CN1169948C CN 1169948 C CN1169948 C CN 1169948C CN B001326376 A CNB001326376 A CN B001326376A CN 00132637 A CN00132637 A CN 00132637A CN 1169948 C CN1169948 C CN 1169948C
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- Prior art keywords
- salt
- polymer
- polymkeric substance
- organic solvent
- gel
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims description 18
- 229920000642 polymer Polymers 0.000 claims abstract description 100
- 150000003839 salts Chemical class 0.000 claims abstract description 57
- 239000003960 organic solvent Substances 0.000 claims abstract description 33
- 239000000243 solution Substances 0.000 claims abstract description 23
- 239000003929 acidic solution Substances 0.000 claims abstract description 15
- 238000002791 soaking Methods 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 13
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 6
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- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 4
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- 229920002988 biodegradable polymer Polymers 0.000 description 4
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- 239000002002 slurry Substances 0.000 description 2
- YFBKQHDAKFOTLB-UHFFFAOYSA-N 2-(1,3-diphenyl-1h-tetrazol-1-ium-2-yl)-4,5-dimethyl-1,3-thiazole;bromide Chemical compound [Br-].S1C(C)=C(C)N=C1N1[NH+](C=2C=CC=CC=2)N=CN1C1=CC=CC=C1 YFBKQHDAKFOTLB-UHFFFAOYSA-N 0.000 description 1
- JNLCUVJKTXKKSG-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;lead Chemical compound [Pb].OC(=O)CC(O)(C(O)=O)CC(O)=O JNLCUVJKTXKKSG-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
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- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 description 1
- 101710204410 Scaffold protein Proteins 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0014—Use of organic additives
- C08J9/0023—Use of organic additives containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-1999-0050922A KR100372751B1 (ko) | 1999-11-16 | 1999-11-16 | 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법 |
| KR50922/1999 | 1999-11-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1297042A CN1297042A (zh) | 2001-05-30 |
| CN1169948C true CN1169948C (zh) | 2004-10-06 |
Family
ID=19620369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001326376A Expired - Fee Related CN1169948C (zh) | 1999-11-16 | 2000-11-16 | 生物相容的支架的制备方法及由该方法制备的支架 |
Country Status (10)
| Country | Link |
|---|---|
| KR (1) | KR100372751B1 (enExample) |
| CN (1) | CN1169948C (enExample) |
| AR (1) | AR026510A1 (enExample) |
| AU (1) | AU780321B2 (enExample) |
| BR (1) | BR0005413B1 (enExample) |
| CA (1) | CA2326057A1 (enExample) |
| HU (1) | HUP0004498A3 (enExample) |
| IL (1) | IL139715A (enExample) |
| NZ (1) | NZ508148A (enExample) |
| SG (1) | SG92758A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147810B (zh) * | 2007-11-01 | 2010-05-19 | 南昌大学第一附属医院 | 细胞-生物可降解材料复合物及其制备方法和应用 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491703B (zh) * | 2001-12-24 | 2013-02-20 | 财团法人工业技术研究院 | 体外组织的培养方法及其多孔隙载体 |
| KR100629392B1 (ko) * | 2002-05-10 | 2006-09-29 | 주식회사 리젠 바이오텍 | 스케폴드를 이용한 체외에서의 정자 배양방법 |
| KR100499096B1 (ko) * | 2002-09-13 | 2005-07-01 | 이진호 | 조직공학용 다공성 고분자 지지체의 제조방법 |
| CN101115475A (zh) | 2004-12-10 | 2008-01-30 | 塔利马治疗公司 | 用于治疗指甲单位病症的组合物和方法 |
| US20060275230A1 (en) | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
| CN100431622C (zh) * | 2005-12-08 | 2008-11-12 | 东南大学 | 组织工程用聚合物多孔支架材料的方法及其制备装置 |
| WO2007107038A1 (en) * | 2006-03-20 | 2007-09-27 | Hua Liu | Constructing tumor model in vitro and its application |
| KR100760511B1 (ko) * | 2006-11-16 | 2007-10-04 | 한국과학기술연구원 | 과산화수소를 이용한 조직공학용 다공성 생분해 고분자지지체의 제조 방법 |
| KR100963435B1 (ko) | 2008-06-19 | 2010-06-17 | 한국과학기술연구원 | 서방형 약물전달 및 조직재생용 덮인 다공성 생분해성고분자 미립구의 제조 방법 |
| KR101003749B1 (ko) | 2008-09-19 | 2010-12-23 | 문형순 | 폴리락타이드를 이용한 다공성 소재의 제조 방법 |
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| WO2014159060A1 (en) | 2013-03-14 | 2014-10-02 | Hallux, Inc. | Method of treating infections, diseases or disorders of nail unit |
| CN106701570A (zh) * | 2015-08-18 | 2017-05-24 | 重庆润泽医药有限公司 | 一种组织细胞培养装置 |
| WO2017099261A1 (ko) * | 2015-12-07 | 2017-06-15 | 주식회사 글로원 | 염침출 및 침지침강법을 이용한 스캐폴더 제조방법 및 그 스캐폴더 |
| US12102973B2 (en) | 2015-12-18 | 2024-10-01 | Safeguard Biosystems Holdings Ltd. | Three-dimensional polymer networks with channels situated therein |
| EP3418741A1 (en) * | 2017-06-19 | 2018-12-26 | Safeguard Biosystems Holdings Ltd. | Three-dimensional polymer networks and their use |
| CN110947035B (zh) * | 2019-10-30 | 2022-04-05 | 中山大学附属第六医院 | 一种p4hb补片表面多孔化改性的方法及p4hb补片 |
| CN114958709B (zh) * | 2021-12-07 | 2024-04-19 | 中科睿极(海宁)生物科技有限公司 | 可快速崩解的微载体聚集体及其制备方法 |
| CN115645609A (zh) * | 2021-12-30 | 2023-01-31 | 盐城工业职业技术学院 | 一种三维多孔生物可降解聚合物人工食管支架及其制备方法 |
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| US5514378A (en) * | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
| US5502092A (en) * | 1994-02-18 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Biocompatible porous matrix of bioabsorbable material |
| US5723508A (en) * | 1996-01-25 | 1998-03-03 | Northwestern University | Method of fabricating emulsion freeze-dried scaffold bodies and resulting products |
| US5817343A (en) * | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
| US6165486A (en) * | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
| KR100288488B1 (ko) * | 1999-03-18 | 2001-04-16 | 윤덕용 | 발포성 염을 이용한 생체조직공학용 다공성 고분자 지지체의 제조방법 |
| US6586246B1 (en) * | 1999-03-18 | 2003-07-01 | Innotech Medical, Inc. | Preparing porous biodegradable polymeric scaffolds for tissue engineering using effervescent salts |
| US6103255A (en) * | 1999-04-16 | 2000-08-15 | Rutgers, The State University | Porous polymer scaffolds for tissue engineering |
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1999
- 1999-11-16 KR KR10-1999-0050922A patent/KR100372751B1/ko not_active Expired - Fee Related
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2000
- 2000-11-14 AU AU71600/00A patent/AU780321B2/en not_active Ceased
- 2000-11-14 NZ NZ508148A patent/NZ508148A/en not_active IP Right Cessation
- 2000-11-15 SG SG200006625A patent/SG92758A1/en unknown
- 2000-11-15 HU HU0004498A patent/HUP0004498A3/hu unknown
- 2000-11-15 CA CA002326057A patent/CA2326057A1/en not_active Abandoned
- 2000-11-15 IL IL139715A patent/IL139715A/en not_active IP Right Cessation
- 2000-11-16 AR ARP000106064A patent/AR026510A1/es unknown
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147810B (zh) * | 2007-11-01 | 2010-05-19 | 南昌大学第一附属医院 | 细胞-生物可降解材料复合物及其制备方法和应用 |
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|---|---|
| AU7160000A (en) | 2001-05-17 |
| SG92758A1 (en) | 2002-11-19 |
| NZ508148A (en) | 2002-05-31 |
| IL139715A0 (en) | 2002-02-10 |
| AU780321B2 (en) | 2005-03-17 |
| BR0005413A (pt) | 2001-08-07 |
| AR026510A1 (es) | 2003-02-12 |
| CA2326057A1 (en) | 2001-05-16 |
| HU0004498D0 (enExample) | 2001-01-29 |
| KR100372751B1 (ko) | 2003-02-17 |
| HUP0004498A2 (hu) | 2001-10-28 |
| BR0005413B1 (pt) | 2012-08-07 |
| HUP0004498A3 (en) | 2003-10-28 |
| CN1297042A (zh) | 2001-05-30 |
| IL139715A (en) | 2006-06-11 |
| KR20010046941A (ko) | 2001-06-15 |
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