CN1169948C - 生物相容的支架的制备方法及由该方法制备的支架 - Google Patents
生物相容的支架的制备方法及由该方法制备的支架 Download PDFInfo
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- CN1169948C CN1169948C CNB001326376A CN00132637A CN1169948C CN 1169948 C CN1169948 C CN 1169948C CN B001326376 A CNB001326376 A CN B001326376A CN 00132637 A CN00132637 A CN 00132637A CN 1169948 C CN1169948 C CN 1169948C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/0014—Use of organic additives
- C08J9/0023—Use of organic additives containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
Description
柠檬酸浓度 | 孔直径(微米) | 孔体积(毫升/克) | 孔隙率(%) |
20 | 122.03±22.56 | 8.0603 | 98.03 |
40 | 142.49±36.24 | 8.396 | 98.04 |
60 | 163.44±0.74 | 9.2803 | 98.11 |
过饱和的 | 186.24±22.86 | 9.9842 | 98.64 |
盐∶聚合物(重量比) | 孔隙率(%) | 压缩模量(KPa) |
10∶1 | 98.64 | 29.24±0.40 |
15∶1 | 98.92 | 16.45±7.75 |
20∶1 | 99.11 | 11.91±0.54 |
支架 | 孔直径(微米) | 孔隙率(%) | 表面积(平方米/克) |
PLGA50∶50(3毫米厚) | 121.59 | 86.60 | 89.21 |
PLGA65∶35(3毫米厚) | 206.4 | 89.21 | 89.89 |
PLGA65∶35(5毫米厚) | 210.51 | 88.73 | 91.96 |
PLGA75∶25(3毫米厚) | 199.27 | 89.89 | 93.49 |
PLGA75∶25(5毫米厚) | 208.71 | 91.96 | 91.15 |
孵化细胞的量(104/支架) | 存活率(在开始阶段存活的细胞数%) | 分泌的白蛋白(pg/细胞) |
14 | 37.924504 | 49.690272±4.049649 |
28 | 26.150778 | 35.523805±6.834733 |
42 | 25.298302 | 37.590655±2.815256 |
56 | 23.543620 | 34.181293±0.199821 |
Claims (19)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-1999-0050922A KR100372751B1 (ko) | 1999-11-16 | 1999-11-16 | 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법 |
KR50922/1999 | 1999-11-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1297042A CN1297042A (zh) | 2001-05-30 |
CN1169948C true CN1169948C (zh) | 2004-10-06 |
Family
ID=19620369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB001326376A Expired - Fee Related CN1169948C (zh) | 1999-11-16 | 2000-11-16 | 生物相容的支架的制备方法及由该方法制备的支架 |
Country Status (10)
Country | Link |
---|---|
KR (1) | KR100372751B1 (zh) |
CN (1) | CN1169948C (zh) |
AR (1) | AR026510A1 (zh) |
AU (1) | AU780321B2 (zh) |
BR (1) | BR0005413B1 (zh) |
CA (1) | CA2326057A1 (zh) |
HU (1) | HUP0004498A3 (zh) |
IL (1) | IL139715A (zh) |
NZ (1) | NZ508148A (zh) |
SG (1) | SG92758A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101147810B (zh) * | 2007-11-01 | 2010-05-19 | 南昌大学第一附属医院 | 细胞-生物可降解材料复合物及其制备方法和应用 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101491703B (zh) * | 2001-12-24 | 2013-02-20 | 财团法人工业技术研究院 | 体外组织的培养方法及其多孔隙载体 |
KR100629392B1 (ko) * | 2002-05-10 | 2006-09-29 | 주식회사 리젠 바이오텍 | 스케폴드를 이용한 체외에서의 정자 배양방법 |
KR100499096B1 (ko) * | 2002-09-13 | 2005-07-01 | 이진호 | 조직공학용 다공성 고분자 지지체의 제조방법 |
US20060275230A1 (en) | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
TW200637618A (en) | 2004-12-10 | 2006-11-01 | Talima Therapeutics Inc | Compositions and methods for treating conditions of the nail unit |
CN100431622C (zh) * | 2005-12-08 | 2008-11-12 | 东南大学 | 组织工程用聚合物多孔支架材料的方法及其制备装置 |
WO2007107038A1 (fr) * | 2006-03-20 | 2007-09-27 | Hua Liu | Construction d'un modèle tumoral in vitro et application |
KR100760511B1 (ko) * | 2006-11-16 | 2007-10-04 | 한국과학기술연구원 | 과산화수소를 이용한 조직공학용 다공성 생분해 고분자지지체의 제조 방법 |
KR100963435B1 (ko) | 2008-06-19 | 2010-06-17 | 한국과학기술연구원 | 서방형 약물전달 및 조직재생용 덮인 다공성 생분해성고분자 미립구의 제조 방법 |
KR101003749B1 (ko) | 2008-09-19 | 2010-12-23 | 문형순 | 폴리락타이드를 이용한 다공성 소재의 제조 방법 |
WO2013081122A1 (ja) * | 2011-12-01 | 2013-06-06 | 富士ソフト株式会社 | 軟骨細胞が付着した多孔質体の長期保存方法 |
RU2015143995A (ru) | 2013-03-14 | 2017-04-20 | Халлюкс, Инк. | Способ лечения инфекций, заболеваний или расстройств ногтевого ложа |
CN106701570A (zh) * | 2015-08-18 | 2017-05-24 | 重庆润泽医药有限公司 | 一种组织细胞培养装置 |
WO2017099261A1 (ko) * | 2015-12-07 | 2017-06-15 | 주식회사 글로원 | 염침출 및 침지침강법을 이용한 스캐폴더 제조방법 및 그 스캐폴더 |
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CN110947035B (zh) * | 2019-10-30 | 2022-04-05 | 中山大学附属第六医院 | 一种p4hb补片表面多孔化改性的方法及p4hb补片 |
CN114958709B (zh) * | 2021-12-07 | 2024-04-19 | 中科睿极(海宁)生物科技有限公司 | 可快速崩解的微载体聚集体及其制备方法 |
CN115645609A (zh) * | 2021-12-30 | 2023-01-31 | 盐城工业职业技术学院 | 一种三维多孔生物可降解聚合物人工食管支架及其制备方法 |
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US5514378A (en) * | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
US5502092A (en) * | 1994-02-18 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Biocompatible porous matrix of bioabsorbable material |
US5723508A (en) * | 1996-01-25 | 1998-03-03 | Northwestern University | Method of fabricating emulsion freeze-dried scaffold bodies and resulting products |
US5817343A (en) * | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
US6165486A (en) * | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
KR100288488B1 (ko) * | 1999-03-18 | 2001-04-16 | 윤덕용 | 발포성 염을 이용한 생체조직공학용 다공성 고분자 지지체의 제조방법 |
DE60035775T2 (de) * | 1999-03-18 | 2008-04-30 | Korea Advanced Institute Of Science And Technology | VERFAHREN ZUR HERSTELLUNG VON PORöSEN, BIOLOGISCH ABBAUBAREN UND BIOKOMPATIBLEN POLYMEREN STüTZGEWEBEN ZUR GEWEBETECHNOLOGIE |
US6103255A (en) * | 1999-04-16 | 2000-08-15 | Rutgers, The State University | Porous polymer scaffolds for tissue engineering |
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CN101147810B (zh) * | 2007-11-01 | 2010-05-19 | 南昌大学第一附属医院 | 细胞-生物可降解材料复合物及其制备方法和应用 |
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HU0004498D0 (zh) | 2001-01-29 |
IL139715A (en) | 2006-06-11 |
CN1297042A (zh) | 2001-05-30 |
AU7160000A (en) | 2001-05-17 |
KR20010046941A (ko) | 2001-06-15 |
BR0005413B1 (pt) | 2012-08-07 |
HUP0004498A3 (en) | 2003-10-28 |
BR0005413A (pt) | 2001-08-07 |
IL139715A0 (en) | 2002-02-10 |
HUP0004498A2 (hu) | 2001-10-28 |
NZ508148A (en) | 2002-05-31 |
AU780321B2 (en) | 2005-03-17 |
SG92758A1 (en) | 2002-11-19 |
KR100372751B1 (ko) | 2003-02-17 |
CA2326057A1 (en) | 2001-05-16 |
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