CN116963782A - 包含抗trop-2抗体的抗体药物偶联物 - Google Patents
包含抗trop-2抗体的抗体药物偶联物 Download PDFInfo
- Publication number
- CN116963782A CN116963782A CN202180046682.8A CN202180046682A CN116963782A CN 116963782 A CN116963782 A CN 116963782A CN 202180046682 A CN202180046682 A CN 202180046682A CN 116963782 A CN116963782 A CN 116963782A
- Authority
- CN
- China
- Prior art keywords
- adc
- trop
- antibody
- cancer
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2020/088565 | 2020-05-03 | ||
| CN2020088565 | 2020-05-03 | ||
| CNPCT/CN2021/086849 | 2021-04-13 | ||
| CN2021086849 | 2021-04-13 | ||
| PCT/US2021/030198 WO2021225892A1 (en) | 2020-05-03 | 2021-04-30 | Antibody-drug conjugates (adcs) comprising an anti-trop-2 antibody, compositions comprising such adcs, as well as methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116963782A true CN116963782A (zh) | 2023-10-27 |
Family
ID=76012056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180046682.8A Pending CN116963782A (zh) | 2020-05-03 | 2021-04-30 | 包含抗trop-2抗体的抗体药物偶联物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240082415A1 (https=) |
| EP (1) | EP4146283A1 (https=) |
| JP (1) | JP2023527962A (https=) |
| KR (1) | KR20230087414A (https=) |
| CN (1) | CN116963782A (https=) |
| AU (1) | AU2021267995A1 (https=) |
| CA (1) | CA3177562A1 (https=) |
| IL (1) | IL297830A (https=) |
| MX (1) | MX2022013768A (https=) |
| TW (1) | TW202200212A (https=) |
| WO (1) | WO2021225892A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4265275A4 (en) * | 2020-12-18 | 2024-03-20 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | ANTIBODY-DRUG CONJUGATE TARGETING TROP2, PREPARATION METHOD AND USE THEREOF |
| CN116199784A (zh) * | 2021-11-30 | 2023-06-02 | 泽达生物医药有限公司 | 抗trop-2/pd-l1双特异性抗体 |
| CA3256048A1 (en) | 2022-04-13 | 2023-10-19 | Arcus Biosciences, Inc. | POLYTHERAPY FOR THE TREATMENT OF CANCERS EXPRESSING A TUMOR ANTIGEN |
| JP2025512384A (ja) | 2022-04-13 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｒｏｐ－２発現がんを治療するための併用療法 |
| US20250381283A1 (en) * | 2022-06-27 | 2025-12-18 | Bio-Thera Solutions, Ltd. | Method for treating solid tumor |
| WO2024207177A1 (en) * | 2023-04-04 | 2024-10-10 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody, linkers, payload, conjugates and applications thereof |
| WO2024097812A1 (en) | 2022-11-04 | 2024-05-10 | Gilead Sciences, Inc. | Therapy for treating bladder cancer |
| WO2024155761A1 (en) * | 2023-01-20 | 2024-07-25 | Adcentrx Therapeutics Inc. | Drug conjugates and methods of preparing and using the same |
| WO2024199466A1 (zh) | 2023-03-31 | 2024-10-03 | 应世生物科技(南京)有限公司 | 提高大分子药物在肿瘤组织中的浓度的方法 |
| AU2024288808A1 (en) | 2023-07-07 | 2026-01-22 | Shanghai Escugen Biotechnology Co., Ltd. | Linker-drug molecule and antibody drug conjugate, preparation method therefor and use thereof |
| WO2025110502A1 (ko) | 2023-11-20 | 2025-05-30 | 이화여자대학교 산학협력단 | 이량체 tctp의 수용체인 cd300c 및 이의 용도 |
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| WO2016165580A1 (zh) * | 2015-04-17 | 2016-10-20 | 江苏恒瑞医药股份有限公司 | 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 |
-
2021
- 2021-04-30 TW TW110115782A patent/TW202200212A/zh unknown
- 2021-04-30 CN CN202180046682.8A patent/CN116963782A/zh active Pending
- 2021-04-30 KR KR1020227042480A patent/KR20230087414A/ko active Pending
- 2021-04-30 IL IL297830A patent/IL297830A/en unknown
- 2021-04-30 AU AU2021267995A patent/AU2021267995A1/en not_active Abandoned
- 2021-04-30 EP EP21726806.9A patent/EP4146283A1/en active Pending
- 2021-04-30 WO PCT/US2021/030198 patent/WO2021225892A1/en not_active Ceased
- 2021-04-30 MX MX2022013768A patent/MX2022013768A/es unknown
- 2021-04-30 CA CA3177562A patent/CA3177562A1/en active Pending
- 2021-04-30 JP JP2022567119A patent/JP2023527962A/ja active Pending
-
2022
- 2022-11-02 US US18/052,056 patent/US20240082415A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4146283A1 (en) | 2023-03-15 |
| KR20230087414A (ko) | 2023-06-16 |
| MX2022013768A (es) | 2023-01-05 |
| IL297830A (en) | 2023-01-01 |
| CA3177562A1 (en) | 2021-11-11 |
| TW202200212A (zh) | 2022-01-01 |
| WO2021225892A1 (en) | 2021-11-11 |
| JP2023527962A (ja) | 2023-07-03 |
| US20240082415A1 (en) | 2024-03-14 |
| AU2021267995A1 (en) | 2022-12-08 |
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