CN116940354A - 稠合的杂芳基化合物及其作为CaMKII抑制剂的用途 - Google Patents

稠合的杂芳基化合物及其作为CaMKII抑制剂的用途 Download PDF

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Publication number
CN116940354A
CN116940354A CN202180079818.5A CN202180079818A CN116940354A CN 116940354 A CN116940354 A CN 116940354A CN 202180079818 A CN202180079818 A CN 202180079818A CN 116940354 A CN116940354 A CN 116940354A
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China
Prior art keywords
group
alkyl
optionally substituted
alkoxy
mono
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CN202180079818.5A
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English (en)
Chinese (zh)
Inventor
松永伸之
白井淳也
大川友洋
宫本泰史
盐川善右
中畑崇
渋谷章人
河田彰
M·玛科斯
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Cardurion Pharmaceuticals Inc
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Cardurion Pharmaceuticals Inc
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Publication of CN116940354A publication Critical patent/CN116940354A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN202180079818.5A 2020-09-28 2021-09-24 稠合的杂芳基化合物及其作为CaMKII抑制剂的用途 Pending CN116940354A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063084217P 2020-09-28 2020-09-28
US63/084,217 2020-09-28
PCT/US2021/052025 WO2022067082A1 (en) 2020-09-28 2021-09-24 Fused heteroaryl compounds and their use as camkii inhibitors

Publications (1)

Publication Number Publication Date
CN116940354A true CN116940354A (zh) 2023-10-24

Family

ID=80821052

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180079818.5A Pending CN116940354A (zh) 2020-09-28 2021-09-24 稠合的杂芳基化合物及其作为CaMKII抑制剂的用途

Country Status (14)

Country Link
US (2) US11795172B2 (https=)
EP (1) EP4216948A4 (https=)
JP (1) JP7824282B2 (https=)
KR (1) KR20230107551A (https=)
CN (1) CN116940354A (https=)
AU (1) AU2021350015A1 (https=)
CA (1) CA3196946A1 (https=)
CL (1) CL2023000894A1 (https=)
CO (1) CO2023005189A2 (https=)
IL (1) IL301480A (https=)
MX (1) MX2023003610A (https=)
PE (1) PE20240148A1 (https=)
TW (1) TW202229273A (https=)
WO (1) WO2022067082A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7824282B2 (ja) * 2020-09-28 2026-03-04 カーデュリオン・ファーマシューティカルズ・インコーポレイテッド 縮合ヘテロアリール化合物およびＣａＭＫＩＩ阻害剤としてのその使用
WO2023134692A1 (zh) * 2022-01-13 2023-07-20 浙江同源康医药股份有限公司 多环类化合物及其用途
CN115160235B (zh) * 2022-08-10 2023-12-15 宜宾学院 一种2,3-二氢喹唑啉-4(1h)-酮类化合物及其超声合成方法
US20250145630A1 (en) * 2023-11-07 2025-05-08 Cardurion Pharmaceuticals, Inc. Polymorphs of a pyridinylimidazo[1,2-b]pyridazine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051366A2 (en) * 2001-12-13 2003-06-26 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
US20140228343A1 (en) * 2012-12-21 2014-08-14 Epizyme, Inc. Prmt5 inhibitors and uses thereof
CN107074856A (zh) * 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII抑制剂及其用途
TW201831487A (zh) * 2016-11-30 2018-09-01 美商基利科學股份有限公司 作為cam激酶抑制劑之稠合雜環化合物
WO2020068846A1 (en) * 2018-09-25 2020-04-02 Heterocyclic Compound Heterocyclic compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1317266A2 (en) 2000-08-08 2003-06-11 Ortho-McNeil Pharmaceutical, Inc. Neuroprotective 2-pyridinamine compositions and related methods
HK1054393B (en) 2000-09-20 2009-08-28 Ortho-Mcneil Pharmaceutical, Inc. Pyrazine derivatives as modulators of tyrosine kinases
JP2007504229A (ja) 2003-09-02 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体−５のモジュレーターとしてのビピリジルアミン類およびエーテル類
US7776857B2 (en) 2007-04-05 2010-08-17 Amgen Inc. Aurora kinase modulators and method of use
US9216173B2 (en) 2011-10-05 2015-12-22 Merck Sharp & Dohme Corp. 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
HRP20180037T1 (hr) 2012-04-17 2018-03-23 Fujifilm Corporation Heterociklični spoj koji sadrži dušik ili njegovu sol
CN110799190B (zh) 2017-03-27 2024-04-19 卡都瑞恩医药有限公司 杂环化合物
JP7447098B2 (ja) 2018-09-25 2024-03-11 カーデュリオン・ファーマシューティカルズ・インコーポレイテッド アミノピリミジン化合物
US20230000842A1 (en) 2019-01-17 2023-01-05 Samumed, Llc Methods of treating cartilage disorders through inhibition of clk and dyrk
JP7824282B2 (ja) * 2020-09-28 2026-03-04 カーデュリオン・ファーマシューティカルズ・インコーポレイテッド 縮合ヘテロアリール化合物およびＣａＭＫＩＩ阻害剤としてのその使用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051366A2 (en) * 2001-12-13 2003-06-26 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
US20140228343A1 (en) * 2012-12-21 2014-08-14 Epizyme, Inc. Prmt5 inhibitors and uses thereof
CN107074856A (zh) * 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII抑制剂及其用途
TW201831487A (zh) * 2016-11-30 2018-09-01 美商基利科學股份有限公司 作為cam激酶抑制劑之稠合雜環化合物
WO2020068846A1 (en) * 2018-09-25 2020-04-02 Heterocyclic Compound Heterocyclic compound

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KEITH W. WOODS ET AL.: ""Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors"", 《BIOORGANIC & MEDICINAL CHEMISTRY》, vol. 14, 14 July 2006 (2006-07-14), pages 6832 *

Also Published As

Publication number Publication date
AU2021350015A1 (en) 2023-06-08
EP4216948A1 (en) 2023-08-02
JP7824282B2 (ja) 2026-03-04
IL301480A (en) 2023-05-01
US12528816B2 (en) 2026-01-20
US20220098207A1 (en) 2022-03-31
JP2023543038A (ja) 2023-10-12
CL2023000894A1 (es) 2023-09-15
PE20240148A1 (es) 2024-02-06
AU2021350015A9 (en) 2024-10-03
MX2023003610A (es) 2023-07-20
TW202229273A (zh) 2022-08-01
CA3196946A1 (en) 2022-03-31
WO2022067082A1 (en) 2022-03-31
CO2023005189A2 (es) 2023-08-09
US20240182474A1 (en) 2024-06-06
KR20230107551A (ko) 2023-07-17
US11795172B2 (en) 2023-10-24
EP4216948A4 (en) 2024-08-28

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