MX2023003610A - Compuestos de heteroarilo fusionado y su uso como inhibidores de proteína cinasa ii dependiente de calcio/calmodulina (camkii). - Google Patents
Compuestos de heteroarilo fusionado y su uso como inhibidores de proteína cinasa ii dependiente de calcio/calmodulina (camkii).Info
- Publication number
- MX2023003610A MX2023003610A MX2023003610A MX2023003610A MX2023003610A MX 2023003610 A MX2023003610 A MX 2023003610A MX 2023003610 A MX2023003610 A MX 2023003610A MX 2023003610 A MX2023003610 A MX 2023003610A MX 2023003610 A MX2023003610 A MX 2023003610A
- Authority
- MX
- Mexico
- Prior art keywords
- fused heteroaryl
- heteroaryl compounds
- present
- camkii inhibitors
- camkii
- Prior art date
Links
- 229940043709 CaM kinase II inhibitor Drugs 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- 102000004657 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Human genes 0.000 abstract 1
- 108010003721 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Proteins 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 201000000015 catecholaminergic polymorphic ventricular tachycardia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- -1 heteroaryl compound Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
La presente invención proporciona un compuesto de heteroarilo fusionado que tiene una acción inhibidora de CaMKII, que se espera que sea útil como agente para la profilaxis o el tratamiento de enfermedades cardíacas (particularmente taquicardia ventricular polimórfica catecolaminérgica, fibrilación auricular postoperatoria, insuficiencia cardíaca, arritmia fatal) y similares. La presente invención se refiere a un compuesto representado por la fórmula (I): en donde cada símbolo es como se define en la descripción, o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063084217P | 2020-09-28 | 2020-09-28 | |
| PCT/US2021/052025 WO2022067082A1 (en) | 2020-09-28 | 2021-09-24 | Fused heteroaryl compounds and their use as camkii inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003610A true MX2023003610A (es) | 2023-07-20 |
Family
ID=80821052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023003610A MX2023003610A (es) | 2020-09-28 | 2021-09-24 | Compuestos de heteroarilo fusionado y su uso como inhibidores de proteína cinasa ii dependiente de calcio/calmodulina (camkii). |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11795172B2 (es) |
| EP (1) | EP4216948A1 (es) |
| JP (1) | JP2023543038A (es) |
| KR (1) | KR20230107551A (es) |
| CN (1) | CN116940354A (es) |
| AU (1) | AU2021350015A1 (es) |
| CA (1) | CA3196946A1 (es) |
| CL (1) | CL2023000894A1 (es) |
| CO (1) | CO2023005189A2 (es) |
| IL (1) | IL301480A (es) |
| MX (1) | MX2023003610A (es) |
| PE (1) | PE20240148A1 (es) |
| TW (1) | TW202229273A (es) |
| WO (1) | WO2022067082A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116425757A (zh) * | 2022-01-13 | 2023-07-14 | 浙江同源康医药股份有限公司 | 多环类化合物及其用途 |
| CN115160235B (zh) * | 2022-08-10 | 2023-12-15 | 宜宾学院 | 一种2,3-二氢喹唑啉-4(1h)-酮类化合物及其超声合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1635890A (zh) | 2000-08-08 | 2005-07-06 | 奥索-麦克尼尔药品公司 | 神经保护性2－吡啶胺组合物和相关方法 |
| CA2423050A1 (en) | 2000-09-20 | 2002-03-28 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
| CA2537141A1 (en) | 2003-09-02 | 2005-03-10 | Merck And Co., Inc. | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 |
| CA2682504C (en) | 2007-04-05 | 2012-10-30 | Amgen Inc. | Aurora kinase modulators and method of use |
| EP2763976B1 (en) | 2011-10-05 | 2016-05-18 | Merck Sharp & Dohme Corp. | 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors |
| EP2840080B1 (en) | 2012-04-17 | 2017-12-06 | FUJIFILM Corporation | Nitrogen-containing heterocyclic compound or salt thereof |
| WO2014100695A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US10543212B2 (en) | 2017-03-27 | 2020-01-28 | Cardurion Pharmaceuticals, Llc | Substituted amines for treating cardiac diseases |
| EP3911317A2 (en) * | 2019-01-17 | 2021-11-24 | BioSplice Therapeutics, Inc. | Methods of treating cartilage disorders through inhibition of clk and dyrk |
-
2021
- 2021-09-24 IL IL301480A patent/IL301480A/en unknown
- 2021-09-24 CN CN202180079818.5A patent/CN116940354A/zh active Pending
- 2021-09-24 CA CA3196946A patent/CA3196946A1/en active Pending
- 2021-09-24 AU AU2021350015A patent/AU2021350015A1/en active Pending
- 2021-09-24 EP EP21873547.0A patent/EP4216948A1/en active Pending
- 2021-09-24 PE PE2023001229A patent/PE20240148A1/es unknown
- 2021-09-24 WO PCT/US2021/052025 patent/WO2022067082A1/en active Application Filing
- 2021-09-24 MX MX2023003610A patent/MX2023003610A/es unknown
- 2021-09-24 US US17/485,137 patent/US11795172B2/en active Active
- 2021-09-24 KR KR1020237014351A patent/KR20230107551A/ko unknown
- 2021-09-24 TW TW110135508A patent/TW202229273A/zh unknown
- 2021-09-24 JP JP2023519291A patent/JP2023543038A/ja active Pending
-
2023
- 2023-03-28 CL CL2023000894A patent/CL2023000894A1/es unknown
- 2023-04-24 CO CONC2023/0005189A patent/CO2023005189A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021350015A1 (en) | 2023-06-08 |
| US11795172B2 (en) | 2023-10-24 |
| JP2023543038A (ja) | 2023-10-12 |
| WO2022067082A1 (en) | 2022-03-31 |
| CN116940354A (zh) | 2023-10-24 |
| CA3196946A1 (en) | 2022-03-31 |
| US20220098207A1 (en) | 2022-03-31 |
| KR20230107551A (ko) | 2023-07-17 |
| IL301480A (en) | 2023-05-01 |
| EP4216948A1 (en) | 2023-08-02 |
| TW202229273A (zh) | 2022-08-01 |
| PE20240148A1 (es) | 2024-02-06 |
| CO2023005189A2 (es) | 2023-08-09 |
| CL2023000894A1 (es) | 2023-09-15 |
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