CN116870125A - 一种治疗痛风的中药配方及其制备方法 - Google Patents
一种治疗痛风的中药配方及其制备方法 Download PDFInfo
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- CN116870125A CN116870125A CN202211530219.3A CN202211530219A CN116870125A CN 116870125 A CN116870125 A CN 116870125A CN 202211530219 A CN202211530219 A CN 202211530219A CN 116870125 A CN116870125 A CN 116870125A
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- treating gout
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Abstract
本发明公开了一种治疗痛风的中药配方及其制备方法,一种治疗痛风的中药配方,其包括以下的药物原料:桂枝、白芍、甘草、生姜、麻黄、防风,本发明的有益效果是本配方通过多种祛风、无毒副作用的中药配伍组成,其组成成分的药性不会出现相互干扰的现象,制造成本低,具有祛风除湿、通阳散寒、佐以清热的功效,可增加尿酸排泄,减少尿酸生产,消除尿酸结晶,并具有一定的消炎止痛的功效,可有效治疗痛风以及诸关节疼痛,疗程短,生效快,其制备方法简单,有效保留了药物的药性,在制作过程中可留存不同状态的药物制剂以根据使用者的病情进行灵活治疗应用。
Description
技术领域
本发明涉及中医药技术领域,尤其是涉及一种治疗痛风的中药配方及其制备方法。
背景技术
在现有技术中,痛风是一种由于嘌呤生物合成代谢增加,尿酸产生过多或因尿酸排泄不良而致血中尿酸升高,尿酸盐结晶沉积在关节滑膜、滑囊、软骨及其他组织中引起的反复发作性炎性疾病。其临床特征为:高尿酸血症及尿酸盐结晶、沉积所致的特征性急性关节炎、痛风石、间质性肾炎,严重者见关节畸形及功能障碍,常伴尿酸性尿路结石。病因分为原发性和继发性两大类。痛风患者多有先天禀赋不足及后天饮食不节史,包括过食肥甘厚味或贪饮酒浆等,长期饮食不节则损伤脾胃,脾胃运化失健,导致痰湿、湿热等浊邪内生,阻滞经络,痹阻气血,引发痛风。明代名医龚廷贤在《万病回春》中指出:“一切痛风肢体痛者,痛属火,肿属湿……所以膏粱之人,多食煎炒、炙煿,酒肉,热物蒸脏腑,所以患痛风,恶疮痈疽者最多。”故认为痛风是过食膏粱厚味、内生湿热阻痹所致。而关节疼痛急性发作是急性痛风的典型症状。疾病发作多在轻微损伤、饮食过量或相关疾病以后,特别好发于肢体远端关节,典型的症状发于足趾(足痛风),也可因尿酸盐结石引起肾绞痛。慢性痛风以破坏性关节变化为特征。现代医学多采用秋水仙碱、丙磺舒、别嘌呤醇等来减轻症状,降低血尿酸,但这一类西药会产生胃肠道反应,影响肝肾功能,对人体副作用大。因此,西医治疗痛风受到了一定限制。
申请号为:201610367760.5的中国发明专利公开了一种治疗痛风的中药配方,由下述重量比的原料组成:桂枝5-20g,白芍10-30g,知母10-20g,防巴10-15g,苍术6-12g,制附子3-15g,麻黄2-12g,生甘草5-15g,土茯苓15-65g,猪苓6-12g,泽泻6-15g,滑石粉10-20g,川萆藓6-10g。然而该种治疗痛风的中药配方的组成成分较为复杂,其中个别组分的药性相克,会降低配方的药效,导致其配方制造成本提升的同时延长了治疗的疗程。
发明内容
本发明的目的是提供一种治疗痛风的中药配方及其制备方法。
为实现上述目的,本发明提出的技术方案是:
一种治疗痛风的中药配方,其包括以下的药物原料:桂枝、白芍、甘草、生姜、麻黄、防风。
其包括以下重量份药物原料:
在上述基础上再加入:
苍术 3.5~4.5份。
在上述基础上再加入:
炙附子 2.5~3.5份。
一种治疗痛风的中药配方,其包括以下重量份药物原料:
一种治疗痛风的中药配方的制备方法,包括如下步骤:
a、称药:按量称取桂枝、白芍、甘草、生姜、麻黄、防风、苍术、炙附子并将其进行混合,充分混合后,粉碎为药粉;
b、提取:对步骤a中制得的药粉进行提取,提取完成后,将药渣废弃,提取出混合药液;
c、过滤:对混合药液,对混合药液进行过滤,将滤液贮藏,将其中部分滤液进行灌装留存,灌装规格为50ml/瓶;
d、浓缩:对步骤c中剩余的滤液进行真空浓缩以得到流浸膏状态的药剂,将其中部分流浸膏状态的药剂进行冷藏留存;
e、干燥:对步骤d中剩余的流浸膏状态的药剂进行干燥处理,以得到干浸膏状态的药剂;
f、压片:对步骤e中制得的干浸膏状态的药剂进行压片处理,从而得到糖果状的药剂压片。
步骤c中留存的滤液以及步骤d中留存的流浸膏状态的药剂可以根据使用者的病情以按照医嘱配合药剂压片进行外用。
本发明的有益效果是:
本配方通过多种祛风、无毒副作用的中药配伍组成,其组成成分的药性不会出现相互干扰的现象,制造成本低,具有祛风除湿、通阳散寒、佐以清热的功效,可增加尿酸排泄,减少尿酸生产,消除尿酸结晶,并具有一定的消炎止痛的功效,可有效治疗痛风以及诸关节疼痛,疗程短,生效快,其制备方法简单,有效保留了药物的药性,在制作过程中可留存不同状态的药物制剂以根据使用者的病情进行灵活治疗应用。
附图说明
图1是本发明制备方法流程图。
具体实施方式
下面结合附图对本发明作进一步详细描述,
实施例一:
一种治疗痛风的中药配方,其包括以下的药物原料:桂枝、白芍、甘草、生姜、麻黄、防风。
其包括以下重量份药物原料:
其中,桂枝、白芍、甘草、生姜、麻黄、防风的重量份比例为:4:3:2:5:4:4。
实施例二:
在实施例一的基础上再加入:
苍术 3.5~4.5份。
其中,桂枝、白芍、甘草、生姜、麻黄、防风、苍术的重量份比例为:4:3:2:5:4:4:4。
实施例三:
在实施例二的基础上再加入:
炙附子 2.5~3.5份。
其中,桂枝、白芍、甘草、生姜、麻黄、防风、苍术、炙附子的重量份比例为:4:3:2:5:4:4:4:3。
实施例四:
一种治疗痛风的中药配方,其包括以下重量份药物原料:
一种治疗痛风的中药配方的制备方法,包括如下步骤:
a、称药:按量称取桂枝、白芍、甘草、生姜、麻黄、防风、苍术、炙附子并将其进行混合,充分混合后,粉碎为药粉;
b、提取:对步骤a中制得的药粉进行提取,提取完成后,将药渣废弃,提取出混合药液;
c、过滤:对混合药液,对混合药液进行过滤,将滤液贮藏,将其中部分滤液进行灌装留存,灌装规格为50ml/瓶;
d、浓缩:对步骤c中剩余的滤液进行真空浓缩以得到流浸膏状态的药剂,将其中部分流浸膏状态的药剂进行冷藏留存;
e、干燥:对步骤d中剩余的流浸膏状态的药剂进行干燥处理,以得到干浸膏状态的药剂;
f、压片:对步骤e中制得的干浸膏状态的药剂进行压片处理,从而得到糖果状的药剂压片。
步骤c中留存的滤液以及步骤d中留存的流浸膏状态的药剂可以根据使用者的病情以按照医嘱配合药剂压片进行外用,本发明制备方法流程图如图1所示。
其中,药剂压片的规格为2g/片,本方案中药配方的服用方法为:一天两次,一次两粒,每日早晚饭后半小时服用,重症使用者可加倍服用。
临床典型案例:
案例1:李某,男,48岁,2019年6月出现手指、足趾关节肿痛,医院就诊检查血尿酸超过900μmol/L,确诊为“痛风”。服用别嘌呤醇、丙硫酸,只能起到抑制病情的作用,无法根除,2021年6月服用本方案中的“通风十日消”,一个疗程之后,临床痛风症状全部消失,检测血尿酸降至正常范围。
案例2:钱某,女,64岁,2016年出现关节疼痛,并伴高尿酸血症,医院诊疗结果显示尿酸指数超过690μmol/L,确诊为痛风,后经西医治疗效果不明显,2018年1月服用本方案中的“通风十日消”,一个疗程之后,痛风未见发作,至今无复发。
案例3:黄某,男,32岁,2019年7月开始反复发作关节痛,其腿部关节多处肿胀,疼痛,由于其工作需要经常应酬,并且其个人喜好碳酸饮料,疼痛进行性加重,未就医,2020年6月于家中晕倒,后经医院抢救并进行急诊,急诊显示尿酸指数超过840μmol/L,后长期口服秋水仙碱、别嘌醇,病情无改善,期间需注意饮食,无法食用寒性与酸性食物,2021年7月服用本方案中的“通风十日消”,一个疗程之后,痛风症状消失,饮食恢复正常,至今未复发。
其中,本发明的中药组合物原料特点、辨证用药、组方原理及功效:
桂枝:味辛甘,温,入膀胱、心、肺经,具有发汗解表、散寒止痛、通阳化气、温通经脉、平冲降气的功效,其主治风寒感冒、寒凝血滞诸痛症、痰饮、蓄水证、心悸。
白芍:味苦、酸,性微寒,归肝、脾经,具有养血调经,敛阴止汗,柔肝止痛,平抑肝阳的功效,其主治血虚萎黄,月经不调,自汗,盗汗,胁痛,腹痛,四肢挛痛,头痛眩晕,肝脾不和,胸胁脘腹疼痛,四肢挛急疼痛,肝阳上亢,头痛眩晕,其敛阴,有止汗之功。
甘草:味甘,性平;归心、肺、脾、胃经,具有益气补中,润肺止咳,清热解毒,缓急止痛,调和药性的功效,其主治脾虚倦怠,心虚悸动,咳嗽气喘,痈疽喉痹,药食中毒,脘腹、四肢挛急疼痛。
生姜:味辛,性温;归肺、脾、胃经,具有解表散寒,温中止呕,温肺止咳,解毒的功效,其主治风寒感冒:辛散温通,能发汗解表,祛风散寒,但作用较弱,故适用于风寒感冒轻证;脾胃寒证:能温中散寒,对寒犯中焦或脾胃虚寒之胃脘冷痛、食少、呕吐者,可收祛寒开胃、止痛止呕之效;胃寒呕吐:辛散温通,能温胃散寒,和中降逆,其止呕功良,素有“呕家圣药”之称,随证配伍可治疗多种呕吐;肺寒咳嗽:辛温发散,能温肺散寒、化痰止咳,对于肺寒咳嗽,不论有无外感风寒,或痰多痰少,皆可选用。
麻黄:味辛、微苦,性温,归肺经、膀胱经,具有发汗解表,宣肺平喘,利水消肿的功效,其主治胸闷喘咳,风水浮肿,风湿痹痛,阴疽,痰核,其性温偏润,辛散发汗作用缓和,增强了润肺止咳之功,以宣肺平喘止咳力胜,多用于表症已解,气喘咳嗽。
防风:味辛、甘,性微温;归膀胱、肝、脾经,具有祛风解表,胜湿止痛,止痉的功效,其主治外感表证:辛温发散,气味俱升,以辛散祛风解表为主,虽不长于散寒,但又能胜湿、止痛,且甘缓微温不峻烈,故外感风寒、风湿、风热表证均可配伍使用;风疹瘙痒:辛温发散,能祛风止痒,可以治疗多种皮肤病,其中尤以风邪所致之瘾疹瘙痒较为常用,本品以祛风见长,药性平和,风寒、风热所致之瘾疹瘙痒皆可配伍使用;风湿痹痛:辛温,功能祛风散寒,胜湿止痛,为较常用之祛风湿、止痹痛药;破伤风证:既能辛散外风,又能息内风以止痉。
苍术:味辛,性苦,性温;归脾、胃、肝经,具有燥湿健脾,祛风散寒的功效,其主治湿阻中焦证:苦温燥湿以祛湿浊,辛香健脾以和脾胃。对湿阻中焦,脾失健运而致脘腹胀闷,呕恶食少,吐泻乏力,舌苔白腻等症;风湿痹证:辛散苦燥,长于祛湿;风寒挟湿:辛香燥烈,能开肌腠而发汗,祛肌表之风寒表邪;尚能明目,用于夜盲症及眼目昏涩。
炙附子:味辛、甘,大热;有毒,归心、肾、脾经,具有回阳救逆,补火助阳,逐风寒湿邪的功效,其主治亡阳虚脱,肢冷脉微,心阳不足,胸痹心痛,虚寒吐泻,脘腹冷痛,肾阳虚衰。
工作原理:
本方案由桂枝、白芍、甘草、生姜、麻黄、防风、苍术、炙附子配伍组成“通风十日消”配方,通过其中散寒祛湿的桂枝、生姜、防风、苍术祛除患者体内的湿寒毒气,并通过其中回阳救逆的炙附子,配合其中养血益气的白芍、甘草、麻黄对患者进行通阳散寒,从而从根本上起到祛风除湿、通阳散寒、佐以清热的作用。
本发明的有益效果是本配方通过多种祛风、无毒副作用的中药配伍组成,其组成成分的药性不会出现相互干扰的现象,制造成本低,具有祛风除湿、通阳散寒、佐以清热的功效,可增加尿酸排泄,减少尿酸生产,消除尿酸结晶,并具有一定的消炎止痛的功效,可有效治疗痛风以及诸关节疼痛,疗程短,生效快,其制备方法简单,有效保留了药物的药性,在制作过程中可留存不同状态的药物制剂以根据使用者的病情进行灵活治疗应用。
以上对本发明的一个实施例进行了详细说明,但所述内容仅为本发明的较佳实施例,不能被认为用于限定本发明的实施范围。凡依本发明申请范围所作的均等变化与改进等,均应仍归属于本发明的专利涵盖范围之内。
Claims (7)
1.一种治疗痛风的中药配方,其特征在于,其包括以下的药物原料:桂枝、白芍、甘草、生姜、麻黄、防风。
2.如权利要求1所述的一种治疗痛风的中药配方,其特征在于,其包括以下重量份药物原料:
3.如权利要求2所述的一种治疗痛风的中药配方,其特征在于,在上述基础上再加入:
苍术 3.5~4.5份。
4.如权利要求3所述的一种治疗痛风的中药配方,其特征在于,在上述基础上再加入:
炙附子 2.5~3.5份。
5.如权利要求4所述的一种治疗痛风的中药配方,其特征在于,其包括以下重量份药物原料:
6.一种如权利要求5所述的治疗痛风的中药配方的制备方法,其特征在于,包括如下步骤:
a、称药:按量称取桂枝、白芍、甘草、生姜、麻黄、防风、苍术、炙附子并将其进行混合,充分混合后,粉碎为药粉;
b、提取:对步骤a中制得的药粉进行提取,提取完成后,将药渣废弃,提取出混合药液;
c、过滤:对混合药液,对混合药液进行过滤,将滤液贮藏,将其中部分滤液进行灌装留存,灌装规格为50ml/瓶;
d、浓缩:对步骤c中剩余的滤液进行真空浓缩以得到流浸膏状态的药剂,将其中部分流浸膏状态的药剂进行冷藏留存;
e、干燥:对步骤d中剩余的流浸膏状态的药剂进行干燥处理,以得到干浸膏状态的药剂;
f、压片:对步骤e中制得的干浸膏状态的药剂进行压片处理,从而得到糖果状的药剂压片。
7.如权利要求6所述的一种治疗痛风的中药配方的制备方法,其特征在于,步骤c中留存的滤液以及步骤d中留存的流浸膏状态的药剂可以根据使用者的病情以按照医嘱配合药剂压片进行外用。
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CN110638990A (zh) * | 2019-10-14 | 2020-01-03 | 成都中医药大学 | 一种桂枝芍药知母处方制剂提取物的提取工艺 |
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