CN102671144B - 治疗慢性胆囊炎中药口服液及制备方法 - Google Patents
治疗慢性胆囊炎中药口服液及制备方法 Download PDFInfo
- Publication number
- CN102671144B CN102671144B CN201210182078.0A CN201210182078A CN102671144B CN 102671144 B CN102671144 B CN 102671144B CN 201210182078 A CN201210182078 A CN 201210182078A CN 102671144 B CN102671144 B CN 102671144B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- herba
- medicine oral
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 201000001352 cholecystitis Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000012530 fluid Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 claims abstract description 13
- 241000167550 Centella Species 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 15
- 206010008617 Cholecystitis chronic Diseases 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 241000612166 Lysimachia Species 0.000 claims description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 230000002421 anti-septic effect Effects 0.000 claims description 5
- 235000012907 honey Nutrition 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000011550 stock solution Substances 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 20
- 208000002193 Pain Diseases 0.000 abstract description 16
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 230000035619 diuresis Effects 0.000 abstract description 4
- 230000008961 swelling Effects 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 2
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 241000219991 Lythraceae Species 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 9
- 210000000232 gallbladder Anatomy 0.000 description 8
- 206010023126 Jaundice Diseases 0.000 description 6
- 206010047700 Vomiting Diseases 0.000 description 6
- 210000001015 abdomen Anatomy 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 239000003708 ampul Substances 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- 206010004663 Biliary colic Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 206010061428 decreased appetite Diseases 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 208000000197 Acute Cholecystitis Diseases 0.000 description 2
- 206010008614 Cholecystitis acute Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000031361 Hiccup Diseases 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 210000002417 xiphoid bone Anatomy 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000009527 percussion Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗慢性胆囊炎中药口服液，是由下列重量份数的原料药制成的：败酱草130-270份、大黄130-270份、虎杖70-180份、积雪草70-180份、姜黄70-180份、金钱草130-270份、甘草20-60份，本发明中药口服液制备方法简单，配伍得当，疗效好，无毒副作用，诸药合理配伍，共奏清热利湿、破积行淤、消肿解毒、化瘀止痛之功。
Description
技术领域
本发明属于中药领域，特别涉及一种治疗慢性胆囊炎中药口服液及制备方法。
背景技术
慢性胆囊炎症状、体征不典型。多数表现为胆源性消化不良，厌油腻食物、上腹部闷胀、嗳气、胃部灼热等，与溃疡病或慢性阑尾炎近似，胆囊区可有轻度压痛或叩击痛；若胆囊积水，常能扪及圆形、光滑的囊性肿块。反复发作性上腹部疼痛，多发生在右上腹或中上腹部，并向右肩胛下区放射。腹痛常发生于餐后，但亦可于饮食无关，疼痛常呈持续性。可伴有反射性恶心，少有呕吐及发热、黄疸等症状。可伴有反酸、嗳气等消化不良症状，并于进油腻食物后加重。在急性发作或结石嵌顿在胆管时可有急性胆囊炎或胆绞痛的典型症状，中医药用于治疗慢性胆囊炎药物，由于具有副作用小、疗效稳定的特点，故很受人们青睐。
发明内容
本发明的目的在于提供了一种副作用小、疗效稳定，用于治疗慢性胆囊炎中药口服液及制备方法。
为实现上述目的，本发明是通过以下技术方案实现的：
一种治疗慢性胆囊炎中药口服液，是由下列重量份数的原料药制成的：
败酱草130-270份、大黄130-270份、虎杖70-180份、积雪草70-180份、姜黄70-180份、金钱草130-270份、甘草20-60份。
所述的治疗慢性胆囊炎中药口服液，是由下列重量份数的原料药制成的：
败酱草270份、大黄270份、虎杖180份、积雪草180份、姜黄180份、金钱草270份、甘草60份。
所述的治疗慢性胆囊炎中药口服液及制备方法，包括下列步骤：
取原料药败酱草270份、大黄270份、虎杖180份、积雪草180份、姜黄180份、金钱草270份、甘草60份，用水煎煮二次，每次用水量为药材重量的10倍量，煎煮二次，每次1-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
服用方法：每天早、中、晚各服用一次，一次用量10ml，20天一疗程，服药后多在5天见效，2-3个疗程治愈。本中药口服液特点是能使患者痊愈，见效快，效果好，毒副作用小，起到标本兼治、扶正不滞邪、祛邪不伤正的作用，无复发，成本低，值得临床推广应用。
本发明所选用的中药原料中，败酱草：辛、苦、微寒，归肝、胃、大肠经，功效清热解毒，消痈排脓，祛瘀止痛；大黄：苦、寒，归脾、胃、大肠、肝、心经，功效泻下攻积、清热泻火、凉血解毒、活血祛瘀；虎杖：苦、寒，归肝、胆、肺经，功效活血止痛、清热利湿、解毒、化痰止咳；积雪草：苦、辛、凉，归肝、胆、膀胱经，功效利湿通淋、清热解毒、散瘀消肿；姜黄：辛、苦、温，归肝、脾经，功效破血行气、通经止痛；金钱草：甘、咸、微寒，归肝、胆、肾、膀胱经，功效利水通淋、利湿退黄、解毒消肿，甘草：甘、平，归心、脾、肺、胃经，功效补脾益气、润肺止咳、清热解毒、缓解止痛、缓和药性。本发明中药口服液制备方法简单，配伍得当，疗效好，无毒副作用，诸药合理配伍，共奏清热利湿、破积行淤、消肿解毒、化瘀止痛之功。注意事项：孕妇禁用。
具体实施方式
实施例1：
原料药：败酱草270份、大黄270份、虎杖180份、积雪草180份、姜黄180份、金钱草270份、甘草60份。
制备：取原料药败酱草270份、大黄270份、虎杖180份、积雪草180份、姜黄180份、金钱草270份、甘草60份，用水煎煮二次，每次用水量为药材重量的10倍量，煎煮二次，每次1-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
实施例2：
原料药：败酱草200份、大黄200份、虎杖125份、积雪草125份、姜黄125份、金钱草200份、甘草40份。
制备：取原料药败酱草200份、大黄200份、虎杖125份、积雪草125份、姜黄125份、金钱草200份、甘草40份，用水煎煮二次，每次用水量为药材重量的10倍量，煎煮二次，每次1-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
实施例3：
原料药：败酱草130份、大黄130份、虎杖70份、积雪草70份、姜黄70份、金钱草130份、甘草20份。
制备：取原料药败酱草130份、大黄130份、虎杖70份、积雪草70份、姜黄70份、金钱草130份、甘草20份，用水煎煮二次，每次用水量为药材重量的10倍量，煎煮二次，每次1-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
实施例4：
1．临床试验：病例54例，其中男性34例，女性20例，年龄25-60岁，平均年龄45岁，病程最短的一年，最长的10年。
2．诊断标准：
1)病史：发病前往往有精神因素，饮食不节，寒热不适等，病人可有消化不良肝区闷胀不适等症状，既往有类似发作史，和胆道蛔虫史。
2)症状：
a)胆绞痛：90％的患者有胆绞痛史，或伴有心前区疼痛，症状剧烈，而持久，间歇性加剧。部位多在加右上腹部，及剑突下，重者疼痛如刀割样钝痛，或闷痛，轻者仅上腹部闷胀疼痛(+)，60％患者疼痛放射至右肩，或者左肩及腰背等。
b)恶心呕吐：65％患者有恶心呕吐病史，常与疼痛同时发生，口苦咽干，不欲饮食，心烦喜呕，及胸胁苦闷，吐物为胃内容及胆汁。
c)体温：慢性胆囊炎病人，一股无明显发热，急性发作时可合并发热，无寒战，体温38℃左右。
神经系统：头痛头晕，烦躁失眠；
全身症状：食欲不振，四肢发懒，乏力；大小便：尿少而黄，便秘或腹泻。
3)体检：
a)一股情况：急性发作期多有发热，有右上腹部及剑突下钝痛，辗转不安，呕吐严重者可有脱水证。
b)黄疸：急性胆囊炎仅15％呈轻度黄疸，轻者仅巩膜发黄，一股单纯性胆囊炎多无黄疸。
c)脉象：以弦滑多见。
d)舌苔：轻者舌质红，苔薄白或微黄；严重者舌红降，苔黄腻或黄燥。
e)腹部体症：右上腹部有压痛占99．1％，发作时压痛较重，缓解后较轻，右上腹部胆囊区吸气有触痛，说明胆囊有炎症存在。
3．治疗方法：
每天早、中、晚各服用一次，一次用量10ml，20天一疗程。
4．疗效判定：
显效：以上症状8项或8项以上消失。
有效：以上症状5项或5项以上消失。
无效：服用前后无明显变化。
20天为一疗程，连续服用1-3个疗程，统计最后疗效。
5．治疗结果
试验统计表明，服用本口服液患者54例，显效40例，有效10例，无效4例，总有效率92.6％。
实施例5：
典型病例：魏某，58岁，女，患有反复发作右上腹连及后背胀痛，伴恶心，呃逆，打嗝，食后胃胀，厌油腻，大便溏薄，厌食三年余、加重一个月，诊断为慢性胆囊炎，每天早、中、晚各服用一次，一次用量10ml，10天一疗程，服药后在5天见效，3个疗程治愈。
实施例6：
典型病例：萧某，42岁，女，患有右胁隐痛，牵引背部，反复发作已2年，伴呕吐发热，口干口苦，大便干结，厌食油腻，脉细弦，舌苔薄腻，每天早、中、晚各服用一次，一次用量10ml，20天一疗程，服药后在5天见效，2个疗程治愈。
Claims (1)
1.一种治疗慢性胆囊炎中药口服液的制备方法，其特征在于：包括下列步骤：
取原料药败酱草200份、大黄200份、虎杖125份、积雪草125份、姜黄125份、金钱草200份、甘草40份，用水煎煮二次，每次用水量为药材重量的10倍量，煎煮二次，每次1-2小时，滤过，滤液浓缩成在60-65℃测相对密度为1．10-1．25的清膏，加乙醇至使含乙醇量为60％，搅匀，静置，滤过，取滤液回收乙醇，浓缩成含固体重量65-67％的浸膏，加入蔗糖20％、炼蜜12％、防腐剂1-3％，原液灌封，辐照灭菌，包装成品，制成口服液，即得。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210182078.0A CN102671144B (zh) | 2012-06-04 | 2012-06-04 | 治疗慢性胆囊炎中药口服液及制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210182078.0A CN102671144B (zh) | 2012-06-04 | 2012-06-04 | 治疗慢性胆囊炎中药口服液及制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102671144A CN102671144A (zh) | 2012-09-19 |
| CN102671144B true CN102671144B (zh) | 2014-03-12 |
Family
ID=46804127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210182078.0A Expired - Fee Related CN102671144B (zh) | 2012-06-04 | 2012-06-04 | 治疗慢性胆囊炎中药口服液及制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102671144B (zh) |
-
2012
- 2012-06-04 CN CN201210182078.0A patent/CN102671144B/zh not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 张志远应用风药治疗肝胆病经验;郑国庆;《辽宁中医杂志》;19990228;第26卷(第2期);51-52 * |
| 郑国庆.张志远应用风药治疗肝胆病经验.《辽宁中医杂志》.1999,第26卷(第2期),51-52. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102671144A (zh) | 2012-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104288701A (zh) | 一种治疗胆囊炎的中药组合物 | |
| CN101284114A (zh) | 治疗风湿和类风湿疾病的药物 | |
| CN105288371A (zh) | 一种治疗痛风的中药组合物 | |
| CN102631512B (zh) | 一种治疗慢性结肠炎的中药组合物 | |
| CN103432559A (zh) | 一种治疗血滞型月经减少及痛经的中药组合物及其制备方法和用途 | |
| CN104815318A (zh) | 一种治疗痛风的中药制剂 | |
| CN102302733B (zh) | 治疗卵巢囊肿的内服中药组合物 | |
| CN104547961B (zh) | 一种治疗胆结石的中药组合物 | |
| CN102657795A (zh) | 一种促进术后刀口愈合的中药制剂 | |
| CN103100003B (zh) | 一种治疗急性痛风性关节炎的中药组合物 | |
| CN104888081A (zh) | 一种治疗肾阳亏虚型经行泄泻的冲剂及其制备方法 | |
| CN105477484A (zh) | 一种治疗过敏性哮喘的药物 | |
| CN103006980A (zh) | 一种治疗痞满的中药组合物 | |
| CN102671144B (zh) | 治疗慢性胆囊炎中药口服液及制备方法 | |
| CN104887950A (zh) | 一种治疗乳痈的中药组合物 | |
| CN105343298B (zh) | 一种治疗慢性便秘的肚脐贴及其制备方法 | |
| CN104116983A (zh) | 一种预防月子病的口服液 | |
| CN104013728B (zh) | 一种综合治疗带状疱疹的中药制剂及其制备方法 | |
| CN102961662B (zh) | 一种治疗胃溃疡的药物及其制备方法 | |
| CN102688401B (zh) | 治疗慢性肝炎茅根中药口服液及制备方法 | |
| CN104940777A (zh) | 一种治疗肝旺脾弱型经行泄泻的冲剂及其制备方法 | |
| CN102671149B (zh) | 治疗痢疾鸦胆子中药口服液及制备方法 | |
| CN102688398B (zh) | 治疗黄疸白丁香中药口服液及制备方法 | |
| CN105726849B (zh) | 一种用于治疗糖尿病后抑郁症的中药 | |
| CN104524149A (zh) | 一种防治急性肾炎的药物组合物及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YIN ZHULIANG Free format text: FORMER OWNER: HUANG YUN Effective date: 20140504 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 523120 DONGGUAN, GUANGDONG PROVINCE TO: 523000 DONGGUAN, GUANGDONG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140504 Address after: 523000 Guangdong city of Dongguan province Dongcheng District Dongcheng style pedestrian street A elegant department Patentee after: Yin Zhuliang Address before: 523120 A elegant department store, Dongcheng style walking street, Dongguan, Dongcheng District, Guangdong Patentee before: Huang Yun |
|
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Xiuzhen Inventor before: Huang Yun |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170711 Address after: 404100, No. 1, No. 118 village, sorghum Town, Wanzhou District, Chongqing Patentee after: Liu Xiuzhen Address before: 523000 Guangdong city of Dongguan province Dongcheng District Dongcheng style pedestrian street A elegant department Patentee before: Yin Zhuliang |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180129 Address after: Henan city of Xinyang province Xixian County Zhang Tao Xiang Cao Lin Cun Nan Chen Zhuang group Patentee after: Hou Xiulan Address before: 404100, No. 1, No. 118 village, sorghum Town, Wanzhou District, Chongqing Patentee before: Liu Xiuzhen |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180726 Address after: 225300 Xinghua City Economic Development Zone, Taizhou, Jiangsu, south of science and technology innovation center. Patentee after: Xinghua new era network technology Co., Ltd. Address before: Henan city of Xinyang province Xixian County Zhang Tao Xiang Cao Lin Cun Nan Chen Zhuang group Patentee before: Hou Xiulan |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140312 Termination date: 20190604 |