CN102631512B - 一种治疗慢性结肠炎的中药组合物 - Google Patents
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Abstract
Description
一种治疗慢性结肠炎的中药组合物
技术领域
[0001] 本发明属于中药技术领域，尤其是涉及一种治疗慢性结肠炎的中药组合物。
背景技术
[0002] 慢性结肠炎是一种常见疾病，临床多表现为大便次数增多、五谷不化、或如水样、或黏滞，伴有肠鸣、腹痛，甚者脾肾俱虚，五更而泄。病位在肠，累及脾、胃、肝、肾等脏腑，日久则消瘦、倦怠。此证为临床常见脾胃病之一，发病率高，易反复发作，缠绵难愈，严重影响着人们的正常生活。目前病因不明，一般西医疗法会给身体带来很大的副作用。经过发明人的长期实践发现，本发明中药组合外治慢性结肠炎具有较好作用，取得不错效果。
发明内容
[0003] 本发明的目的在于提供一种治疗效果好、有效率高、对人体无毒副作用的治疗慢性结肠炎的中药组合物。
[0004] 本发明的目的是这样实现的，根据中医药理论，利用中药独特的药性，采用党参、茯苓、半夏、白头翁、山里红、皂角刺、虎杖、五味子、车前子、甘草按照一定的配伍要求，经过加工制成。
[0005] 制备本发明中药组合物由下述原料药制成党参10-30份、茯苓10-30份、半夏10-30份、白头翁10-30份、山里红10-20份、皂角刺10-20份、虎杖10-20份、五味子10-20份、车前子8-15份、甘草8-15份。
[0006] 本发明中药组合物原料药的最佳重量份为:党参20份、茯苓20份、半夏20份、白头翁20份、山里红15份、皂角刺15份、虎杖15份、五味子15份、车前子10份、甘草10份。
[0007] 本发明中药的药理作用如 下:
[0008] 党参:甘、平。归脾、肺经。益气、生津、养血。用于中气不足的体虚倦怠，肺气亏虚的咳嗽气促，气津两伤的气短口渴，头晕心悸等。
[0009] 茯苓:甘、淡、平。归心、脾、肺、肾经。渗湿利水，健脾和胃，宁心安神。用于小便不利，水肿胀满，痰饮咳逆，呕吐，脾虚食少，泄泻，心悸不安，失眠健忘，遗精白浊等。
[0010] 半夏:辛、温、有毒。归脾、胃、肺经。燥湿化痰，降逆止呕，消痞散结。主治咳喘痰多，胸腺疮满，头痛眩晕等。
[0011] 白头翁:苦、寒。归胃、大肠经。清热解毒，凉血止痢，燥湿杀虫。主治赤白痢疾，鼻衄，崩漏，血痔，寒热温疟，湿疹，瘰疬，眼目赤痛等。
[0012] 山里红:酸、甘、微温。归脾、胃、肝经。消食健胃，行气散瘀。用于饮食积滞，脘腹胀痛，泄泻痢疾，疝气肿痛等。
[0013] 皂角刺:辛、温。归肝、肺经。消毒透脓，搜风，杀虫。用于痈疽肿毒，瘰疬，疮疹顽癖，广后缺乳，胎衣不下等。
[0014] 虎杖:苦、寒。归肝、胆、肺经。利胆退黄，清热解毒，活血祛瘀，祛痰止咳。用于湿热黄疸，淋浊带下，痈肿疮毒，毒蛇咬伤，肺热咳嗽等。[0015] 五味子:酸、温。归肺、心、肾经。收敛固涩，益气生津，宁心安神。主治咳嗽虚喘，梦遗滑精，尿颇遗尿，久泻不止，自汗盗汗，津伤口渴，心悸失眠等。
[0016] 车前子:甘、寒，归肺、肾、肝经。利尿通淋，渗湿止泻，清肝明目，清肺化痰。用于小便淋涩，暑湿泄泻，痰热咳嗽等。
[0017] 甘草:甘、平，归心、肺、脾、胃经。益气补中，清热解毒，缓急止痛，调和药性。用于痰多咳嗽、热毒疮疡。
[0018] 慢性结肠炎中医辨病属“泄泻”、“白痢”等范畴。临床症状以慢性腹泻、腹痛，排黏液便、血便为主，呈慢性反复性发作或持续性发作，本病病程较长，多因长期饮食不慎、劳倦内伤，致脾胃虚弱。本发明中党参、茯苓补中益气、健运升降；半夏理气燥湿、醒脾化痰；白头翁、皂角刺、虎杖清热解毒、凉血止痢；山里红消补兼施、行气散瘀；五味子涩肠止泻；车前子利尿通淋、渗湿止泻；甘草调和诸药。经过临床实践发现，对慢性结肠炎具有独特的疗效，达到治疗慢性结肠炎的目的。
[0019] 本发明中药组合物于2008年至2010年临床观察慢性结肠炎120例患者，临床报告如下:
[0020] 1、一般资料
[0021] 120例患者中，年龄51-83岁，病程多在8个月到12年，平均年龄63岁。
[0022] 2、诊断标准
[0023] 国家中医药管理局颁发的《中医病证诊断疗效标准》:
[0024] 反复发作的腹痛、腹胀、腹泻、泻下粘液或脓血便，发作期大便3次/日以上，伴排便不畅或里急后重；舌苔多黄腻或白腻；全部病便均经纤维结肠镜检查确诊。
[0025] 3、治疗方法
[0026] 3.1处方:党参20g、茯苓20g、半夏20g、白头翁20g、山里红15g、皂角刺15g、虎杖15g、五味子15g、车前子10g、甘草10g。
[0027] 3.2制备及使用方法:上述药物按常规工艺制成汤剂，每日I剂，每日2次，25天为I疗程。
[0028] 4、治疗结果:
[0029] 4.1参照《中医药新药临床研究指导原则》制定:
[0030] 痊愈:临床症状、体征消失，纤维结肠镜复查正常，肠黏膜病变恢复正常；
[0031] 显效:临床症状明显减轻，体征基本消失，纤维结肠镜复查好转，肠黏膜病变明显改；
[0032] 无效:治疗前后临床症状和体征无改善，纤维结肠镜复查无好转。
[0033] 4.2结果:120例患者中，临床治愈83例(69.2% )，显效31例(25.8% )，无效6例(5% )，总有效率为95%。
[0034] 5、典型病例
[0035] 5.1孙某，男，62岁，经常性腹痛、腹泻、泻后痛减，发作期间大便次数多者可达日6〜10次，尤以晨起为甚，质稀，伴少量黏液，每遇劳累、饮食不当或生气后发作，体倦乏力，形寒肢冷，腰膝酸软，舌淡苔薄白，脉细弦。服用本发明药物，治疗I个疗程，症状明显减轻，继续服用2个疗程，痊愈，半年后随访无复发。
[0036] 5.2齐某，女，58岁，腹痛腹泻，以左下腹为甚，大便日4〜5次，质稀，带黄色粘液，便意频频，腹部下坠感，如厕则里急后重，面色萎黄、形体消瘦、口干而淡、食欲不佳、倦怠乏力，左下腹轻度压痛，肠鸣音稍有亢进，舌淡苔薄白，根厚腻微黄，脉弦细滑。服用本发明药物，每日1剂，2个疗程后，症状明显好转，继续服用2个疗程，痊愈，一年后随访无复发。
具体实施方式
[0037] 下面结合实施例对本发明作进一步的说明，下述该实施例仅用于说明本发明而对本发明没有限制。
[0038] 实施例1，一种治疗慢性结肠炎的中药组合物，是由党参10g、茯苓10g、半夏10g、白头翁10g、山里红10g、皂角刺10g、虎杖10g、五味子10g、车前子8g、甘草8g制成。
[0039] 实施例2，一种治疗慢性结肠炎的中药组合物，是由党参20g、茯苓20g、半夏20g、白头翁20g、山里红15g、皂角刺15g、虎杖15g、五味子15g、车前子10g、甘草IOg制成。
[0040] 实施例3，一种治疗慢性结肠炎的中药组合物，是由党参30g、茯苓30g、半夏30g、白头翁30g、山里红20g、皂角刺20g、虎杖20g、五味子20g、车前子15g、甘草15g制成。
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