CN105288371A - 一种治疗痛风的中药组合物 - Google Patents
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Abstract
本发明涉及一种治疗痛风的中药组合物，它是由下列重量配比的中药原料组成的：茯苓20-40g，桂枝10-20g，苍术10-20g，薏米20-40g，土茯苓20-40g，泽泻10-20g，萆薢10-20g，黄芪10-20g，川牛膝10-20g，羌活10-20g，独活10-20g，防己10-20g，黄柏5-15g，金钱草10-20g，桃仁5-15g，红花5-15g，赤芍5-15g，姜半夏10-20g，陈皮10-20g。本发明的中药组合物采用天然的中药原料，具有理气健脾，清热解毒，祛风除湿利尿，活血通络，散瘀止痛的功效，其配制简便、药源广、成本低，疗效显著，药性平和，有效率达97.67%，治愈率达59.3%。
Description
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，具体地说是一种治疗痛风的中药组合物。
背景技术
痛风是一种因嘌呤代谢障碍,使尿酸累积而引起的疾病,属于关节炎的一种,又称代谢性关节炎。痛风最重要的生化基础是高尿酸血症，正常成人每日约产生尿酸750mg，其中80%为内源性，20%为外源性尿酸，这些尿酸进入尿酸代谢池（约为1200mg），每日代谢池中的尿酸约60%进行代谢，其中1/3（约200mg）经肠道分解代谢，2/3（约400mg）经肾脏排泄，从而可维持体内尿酸水平的稳定，其中任何环节出现问题均可导致高尿酸血症。痛风依病因不同可分为原发性和继发性两大类。原发性痛风指在排除其他疾病的基础上，由于先天性嘌呤代谢紊乱和（或）尿酸排泄障碍所引起；继发性痛风指继发于肾脏疾病或某些药物所致尿酸排泄减少、骨髓增生性疾病及肿瘤化疗所致尿酸生成增多等。
大型流行病学研究发现，痛风与饮酒(尤其是啤酒)及肉类(尤其是内脏)和海产摄取有关，亦有研究指出碳酸饮料及果糖也可能导致痛风。酒精引发痛风的原因是因为酒精在肝组织代谢时，大量吸收水份,使血浓度加强,使得原来已经接近饱和的尿酸，加速进入软组织形成结晶，导致身体免疫系统过度反应(敏感)而造成炎症。一些食品经过代谢后,其中部分衍生物可以引发原来积蓄在软组织的尿酸结晶重新溶解,这时可诱发并加重关节炎。此外，剧烈运动、肥胖及压力亦会导致尿酸浓度上升，诱发痛风。
西医治疗治疗痛风目的：①迅速控制急性发作；②预防复发；③纠正高尿酸血症，预防尿酸盐沉积造成的关节破坏及肾脏损害；④手术剔除痛风石，对毁损关节进行矫形手术，提高生活质量。
中医角度来讲，导致痛风出现的因素可以分为三个方面：内因，主要是先天禀赋不足和正气亏虚。禀赋不足，肝肾亏损，精血不足则筋骨经脉失养，或肾司二便功能失调，湿浊内聚，流注关节、肌肉，闭阻经脉，均可形成痹痛；禀赋不足，阴阳失衡则累及其它脏腑，主要累及于脾，使之运化失调，尤其对厚味、酒食运化不及，致痰浊肉生，凝滞于关节，或化源不足，气血无以充养关节经脉，亦可导致痹病。正气亏虚，可为素体虚弱，亦可由其它疾病内耗，产后气血不足，或劳倦、饮食、情志所伤，或过服某些化学药品内伤元气所致。正气亏虚，一则筋骨经脉失养，二则无力抵御外邪；外因，主要是感受风、寒、湿、热之邪。由于居处潮湿，劳作环境湿冷，或冒雨涉水，或阴雨、暑湿天气缠绵，或汗出当风等原因，在正气不足，卫外不固之时，风寒湿邪，或风湿之邪，或寒湿之邪，即可入侵人体经脉，留着于肢体、筋骨、关节之间，闭阻不通，发为本病；诱因，主要是在正虚邪侵，或邪滞经脉之时，复加过度劳累，七情所伤，内耗正气；或饮食不节，酗酒厚味，损伤脾胃，内生痰浊愈甚；或复感外伤，或关节损伤等，均可加重经脉痹阻，气血运行不畅而诱发本病。根据中医理论，针对痛风的发病机理，以理气健脾，清热解毒，祛风除湿利尿，活血通络，散瘀止痛为治疗原则，以达到标本兼治的目的。
发明内容
本发明的目的就是为了克服上述现有的技术不足，根据中医理论，通过数年的药物筛选和反复临床验证，提供一种配伍合理，药源广，成本低，疗效显著，无副作用，具有理气健脾，清热解毒，祛风除湿利尿，活血通络，散瘀止痛的功能的治疗痛风的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓20-40g，桂枝10-20g，苍术10-20g，薏米20-40g，土茯苓20-40g，泽泻10-20g，萆薢10-20g，黄芪10-20g，川牛膝10-20g，羌活10-20g，独活10-20g，防己10-20g，黄柏5-15g，金钱草10-20g，桃仁5-15g，红花5-15g，赤芍5-15g，姜半夏10-20g，陈皮10-20g。
本发明的优选技术方案是：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓30g，桂枝15g，苍术15g，薏米30g，土茯苓30g，泽泻15g，萆薢15g，黄芪15g，川牛膝15g，羌活15g，独活15g，防己15g，黄柏10g，金钱草15g，桃仁10g，红花10g，赤芍10g，姜半夏15g，陈皮15g。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方，其原料成本低，治疗痛风病疗效高，无毒副作用。本发明中药组合物中：茯苓【性味】甘、淡，平【归经】归心、脾、肾经【功能主治】利水消肿，渗湿，健脾，宁心，主治小便不利，水肿胀满，痰饮咳逆，呕逆，恶阻，泄泻，遗精，淋浊，惊悸，健忘等症。桂枝【性味】辛、甘，温【归经】归肺、心、膀胱经【功能主治】散寒解表，温通经脉，通阳化气。主治风寒表证，寒湿痹痛，四肢厥冷，经闭痛经，癥瘕结块，胸痹，心悸，痰饮，小便不利。苍术【性味】温，辛、苦【归经】归脾、胃、肝经【功能主治】燥湿健脾，祛风湿，明目。主治湿困脾胃，倦怠嗜卧，胞痞腹胀，食欲不振，哎吐泄泻，痰饮，湿肿，表证夹湿，头身重痛，痹证温性，肢节酸痛重着，夜盲。薏米【性味】甘、淡，凉【归经】归脾、肺、肾经【功能主治】利水、健脾、除痹、清热排脓。主治风湿身痛，湿热脚气，湿热筋急拘挛，湿痹，水肿，肺萎肺痈，咳吐脓血，喉痹痈肿，肠痈热淋。土茯苓【性味】甘、淡，平【归经】归肝、脾、胃经【功能主治】清热除湿，泄浊解毒，通利关节。主治梅毒，淋浊，泄泻，筋骨挛痛，脚气，痈肿，疮癣，瘰疬，瘿瘤及汞中毒。泽泻【性味】甘，寒【归经】归肾、膀胱经【功能主治】利水，渗湿，泄热。治小便不利，水肿胀满，呕吐，泻痢，痰饮，脚气，淋病，尿血。萆薢【性味】苦，平【归经】归肝、胃、膀胱经【功能主治】祛风湿，利湿浊。主治膏淋，白浊，带下，疮疡，湿疹，风湿痹痛。黄芪【性味】甘，温【归经】归肺、脾经【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。川牛膝【性味】甘、微苦，平【归经】归肝、肾经【功能主治】活血祛瘀，祛风利湿。主治血瘀经闭，难产，胞衣不下，产后瘀血腹痛，热淋，石淋，痛经，风湿腰膝疼痛。羌活【性味】辛、苦，温【归经】归肾、膀胱经【功能主治】解表散寒，祛风胜湿，利关节，止痛。主治感冒风寒，头痛无汗，风寒湿痹，项强筋急，骨节酸疼，风水浮肿，痈疽疮毒。用于阳痿遗精，遗尿尿频，腰膝冷痛，肾虚作喘，五更泄泻，外用治白癜风，斑秃。独活【性味】辛、苦，微温【归经】归肾、膀胱经【功能主治】祛风除湿，痛痹止痛。主治风寒湿痹，腰膝酸痛，手脚挛痛，慢性气管炎，头痛，齿痛等病症。防己【性味】辛、苦，寒【归经】归肺、膀胱经【功能主治】祛风止痛，利水消肿。主治风湿痹痛，水肿脚气，小便不利，湿疹疮毒。黄柏【性味】苦，寒【归经】归肾、膀胱、大肠经【功能主治】清热燥湿，泻火除蒸，解毒疗疮。主治热痢，泄泻，消渴，黄疸，梦遗，淋浊，痔疮，便血，赤白带下，骨蒸劳热，目赤肿痛，口舌生疮，疮疡肿毒。金钱草【性味】甘、微苦，凉【归经】归肝、胆、肾、膀胱经【功能主治】利水通淋，清热解毒，散瘀消肿。主治肝胆及泌尿系结石，热淋，肾炎水肿，湿热黄疸，疮毒痈肿，毒蛇咬伤，跌打损伤。桃仁【性味】苦，平【归经】归肺、肝、大肠经【功能主治】补肾温肺，破血行瘀，润肠通便。主治经闭，症瘕，热病蓄血，风痹，疟疾，跌打损伤，瘀血肿痛，血燥便秘。红花【性味】辛，温【归经】归心、肝经【功能主治】活血通经，散瘀止痛。用于经闭，痛经，恶露不行，症瘕痞块，跌扑损伤，疮疡肿痛。赤芍【性味】苦，微寒【归经】归肝经【功能主治】清热凉血，清肝明目，活血祛瘀止痛。主治用于热人营血，温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，瘾瘕腹痛，跌扑损伤，痈肿疮疡。姜半夏【性味】辛，温，有毒【归经】归脾，肺，胃经【功能主治】燥湿化痰，降逆止呕，消痞散结，外用消肿止痛。用于呕吐反胃，胸脘痞闷，梅核气。陈皮【性味】温、苦，辛【归经】归脾、肺经【功能主治】理气健脾，燥湿化痰，主治脘腹胀满，食少吐泻，咳嗽痰多。本发明具有理气健脾，清热解毒，祛风除湿利尿，活血通络，散瘀止痛的功效，对痛风达到标本兼治的目的。
本发明组合物的组分采用天然的中药原料，其配制简便、药源广、成本低。其遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证，其疗效显著，作用可靠，药性平和，未出现毒副作用，总有效率97.67%，治愈率达59.3%。
具体实施方式
实施例1：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓20g，桂枝10g，苍术10g，薏米20g，土茯苓20g，泽泻10g，萆薢10g，黄芪10g，川牛膝10g，羌活10g，独活10g，防己10g，黄柏5g，金钱草10g，桃仁5g，红花5g，赤芍5g，姜半夏10g，陈皮10g。
实施例2：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓25g，桂枝12g，苍术12g，薏米25g，土茯苓25g，泽泻12g，萆薢12g，黄芪12g，川牛膝12g，羌活12g，独活12g，防己12g，黄柏8g，金钱草12g，桃仁8g，红花8g，赤芍8g，姜半夏12g，陈皮12g。
实施例3：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓28g，桂枝16g，苍术16g，薏米28g，土茯苓28g，泽泻16g，萆薢16g，黄芪16g，川牛膝16g，羌活16g，独活16g，防己16g，黄柏15g，金钱草16g，桃仁15g，红花15g，赤芍15g，姜半夏16g，陈皮16g。
实施例4：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓35g，桂枝20g，苍术20g，薏米35g，土茯苓35g，泽泻20g，萆薢20g，黄芪20g，川牛膝20g，羌活20g，独活20g，防己20g，黄柏10g，金钱草20g，桃仁10g，红花10g，赤芍10g，姜半夏20g，陈皮20g。
实施例5：一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓40g，桂枝18g，苍术18g，薏米40g，土茯苓40g，泽泻18g，萆薢18g，黄芪16g，川牛膝16g，羌活16g，独活16g，防己16g，黄柏12g，金钱草15g，桃仁12g，红花12g，赤芍12g，姜半夏15g，陈皮18g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：取本发明组方的中药原料药物放入容器中，先加水浸泡，加冷水漫过药面，浸泡20～30分钟，再加水没过药面约10厘米，进行第一次煎煮，先用武火煎煮，煮沸后用文火煎煮20～30分钟，滤出取药液汁200ml；第二煎煮，加水没过药面约8厘米，水沸后煎煮20～25分钟，滤出取药液汁200ml。两次煎煮取得药液汁合并。
一种治疗痛风的中药组合物，临床疗效总结：
一、一般性资料：本中药组合物应用于临床观察病86例，其中男68例，女18例，年龄26～76岁。病程最短者2个月，最长者达25年。
二、诊断标准：
1.关节液中有特征性尿酸盐结晶。
2.用化学方法或偏振光显微镜证实痛风结节中含尿酸盐结晶。
3.具备以下12条中6条或6条以上者：
（1）急性关节炎发作多于1次；（2）炎症反应在1天内达高峰；（3）急性单关节炎发作；（4）患病关节可见皮肤呈暗红色；（5）第一跖趾关节疼痛或肿胀；（6）单侧关节炎发作，累及第一跖趾关节；（7）单侧关节炎发作，累及跗骨关节；（8）有可疑痛风结节（9）高尿酸血症；（10）X线摄片检查显示不对称关节内肿胀；（11）X线摄片检查显示不伴侵蚀的骨皮质下囊肿；（12）关节炎发作期间关节液微生物培养阴性。
符合以上一、二、三中任何一个条件者即可诊断为痛风。
三、用法用量：临床应用时，组合物中的组分、用量根据患者的体重、年龄及症状酌情增减。12剂为一疗程，一天一剂，水煎两遍取汁约400ml，分早、晚两次饭前半小时温热服用。
四、疗效标准：
完全缓解：临床症状完全消失。
部分缓解：临床症状改善。
无效：临床症状无变化或加重。
五、治疗效果：临床观察病例中，服药1-8个疗程，治愈51例，有效33例，无效2例。治疗期间未发生毒副作用。
六、典型病例：
1、李某，男，41岁，患痛风3年，每年发作1-2次。两个月前去医院检，尿酸408，肌酐140。一个月前扭伤右脚引发痛风，服秋水仙碱有好转，但左脚大趾疼，医院检查尿酸492，肌酐169，治疗一轮后左脚有所缓解，却又轮到右脚面疼了，服用本发明的中药组合物制备的药剂2个疗程，疼痛消失，尿酸降至389，肌酐130。
2、姜某，男，38岁，2011年发病，确诊痛风，至今4年病史，每年发作2-3次，先是右脚踝痛，再是左脚踝痛，后来左膝痛，最近这次左脚踝及左膝都痛及红肿，药物治疗效果不佳，多次尿酸检测记录，基本在500-600之间，最高一次660，服用本发明的中药组合物制备的药剂4个疗程，目前症状明显好转，红肿消失，疼痛减轻，尿酸指标在360-390之间。
3、郭某，男，60岁，痛风18年，现在两个踝关节长满了痛风石，曾做过两次切除痛风石手术，后痛风每个月必犯一次。犯病时就是秋水仙碱和戴芬类止痛药。一般三天左右过去，再等下一次来犯，服用本发明的中药组合物制备的药剂5个疗程，目前症状明显，疼痛减轻，半年没有再犯。
Claims (2)
1.一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓20-40g，桂枝10-20g，苍术10-20g，薏米20-40g，土茯苓20-40g，泽泻10-20g，萆薢10-20g，黄芪10-20g，川牛膝10-20g，羌活10-20g，独活10-20g，防己10-20g，黄柏5-15g，金钱草10-20g，桃仁5-15g，红花5-15g，赤芍5-15g，姜半夏10-20g，陈皮10-20g。
2.根据权利要求1所述的一种治疗痛风的中药组合物，其特征在于它是由下列重量配比的中药原料组成的：茯苓30g，桂枝15g，苍术15g，薏米30g，土茯苓30g，泽泻15g，萆薢15g，黄芪15g，川牛膝15g，羌活15g，独活15g，防己15g，黄柏10g，金钱草15g，桃仁10g，红花10g，赤芍10g，姜半夏15g，陈皮15g。
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| CN106266463B (zh) * | 2016-11-08 | 2020-04-28 | 四圣网络科技（上海）有限公司 | 一种用于治疗高尿酸血症的中药组合物及其应用 |
| CN107661464A (zh) * | 2017-10-27 | 2018-02-06 | 于忠和 | 一种治疗痛风的中药的制备方法 |
| CN110141629A (zh) * | 2019-05-27 | 2019-08-20 | 河南中医药大学 | 一种治疗高尿酸血症的中药 |
| CN110141629B (zh) * | 2019-05-27 | 2021-07-23 | 河南中医药大学 | 一种治疗高尿酸血症的中药 |
| CN111214596A (zh) * | 2020-03-12 | 2020-06-02 | 朱红付 | 麒麟痛风丸 |
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