CN116869886A - Acne-removing composition, and preparation method and application thereof - Google Patents
Acne-removing composition, and preparation method and application thereof Download PDFInfo
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- CN116869886A CN116869886A CN202310930353.0A CN202310930353A CN116869886A CN 116869886 A CN116869886 A CN 116869886A CN 202310930353 A CN202310930353 A CN 202310930353A CN 116869886 A CN116869886 A CN 116869886A
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- acne
- removing composition
- extract
- component
- composition according
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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Abstract
The invention provides an acne-removing composition, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The acne-removing composition takes the cynanchum atratum extract, the centella asiatica root extract, the sophora flower extract and the liquorice extract as active substances, and other auxiliary materials are matched, so that the acne-removing composition has the effects of controlling oil and removing acnes, relieving pain and itching and repairing scars through reasonable proportion; the dextrin, the salicylic acid and the sesame amino acid are added into the acne-removing composition, so that the absorption and the utilization of the skin to the acne-removing composition can be improved, a greater effect is exerted, the stability of the product is improved, and the storage is convenient.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an acne-removing composition, and a preparation method and application thereof.
Background
Acne is also called comedo, pimple, and the like, is a chronic skin inflammation, is well developed on the face, the upper chest and the back, and is mainly clinically manifested as comedo, pimple, pustule, nodule, and the like. The mechanism responsible for acne is mainly: sebum hypersecretion, obstruction of the pilosebaceous ducts, infection with bacteria, in particular propionibacterium acnes, and inflammatory reactions. Acne is also known as "whelk" because it is common in puberty. But acne not only appears in puberty, but also skin pores are easily blocked due to long-term contact of skin with dust in air, and skin barriers of human bodies are affected due to computer radiation, unhealthy life and the like, so that irregular skin metabolism is caused, and acne can be caused to grow.
The existing anti-acne method is many, such as laser treatment, can quickly destroy the acne propionate bacillus, effectively inhibit bacterial reproduction, eliminate the stimulation and damage to tissues, but the laser treatment has too strong effect and cannot radically remove acnes. If acid therapy is used, although the acid therapy has a certain inhibition effect on acne, the fruit acid has large irritation and strong side effect. If the medicine is used for treating the skin, the medicine has quick response, but the medicine resistance problem easily occurs, and the skin-dependent dermatitis is formed after long-term use. The acne-removing product such as acne-removing cream, acne-removing essence, acne-removing gel, acne-removing mask and the like is used for resisting acne, so that the acne-removing mask is mild and free of stimulation, and has a good effect. Therefore, the development of acne-removing products has been welcome.
For example, chinese patent CNCN105012347a discloses a skin repairing agent containing water-soluble derivatives of fullerene, which comprises water-soluble derivatives of fullerene, iodine stabilizer, iodine complexing agent, surfactant, organic acid, etc., wherein iodine complex component can kill bacteria, spores, protozoa, fungi, etc. infecting skin surface with high efficiency, gel component can protect wound from external pollution, create weak acidity and moist microenvironment which is favorable for wound healing, fullerene component has higher permeability, can be absorbed by organism transdermally, adsorb free radical in a great amount on wound layer, promote repair and regeneration of damaged cells, and obviously improve uncomfortable symptoms such as pruritus.
Also, as in chinese patent CN201410386421, a mild and effective composition for acne removal and oil control is disclosed, which comprises sodium hyaluronate, glycerin, propylene glycol, hydroxyethyl fiber, urea sacs, D-panthenol, podocarpus macrophyllus extract, ethanol, white willow bark extract, purslane extract, etc. The skin moisturizing and oil ester balancing agent has the main effects of improving the skin moisturizing effect, regulating the skin oil ester balance, inhibiting sebum transitional secretion, and inhibiting the propagation of propionibacterium acnes so as to achieve the effects of controlling oil and removing acnes.
However, the existing acne removing product is easy to generate skin injury, has insufficient repairing effect on acne marks and has insufficient acne removing effect. It is therefore necessary to develop a mildly effective anti-acne product.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an acne removing composition, a preparation method and application thereof, and the acne removing composition can quickly permeate into skin through the matching of various active ingredients, achieves the purposes of safely and efficiently removing acnes, repairing skin and inhibiting the regeneration of acnes, is mild and non-irritating, and can relieve skin inflammation, inhibit sebum secretion and the like.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
an anti-acne composition comprises an active, an emulsifier, an emollient, a humectant, a surfactant, an antioxidant, a skin conditioning agent, an adsorbent, an emulsion stabilizer, a thickener, a preservative, a chelating agent, a cooling agent, a fragrance, and a solvent; wherein,,
the active substance comprises cynanchum atratum extract, centella asiatica root extract, sophora flower extract and liquorice extract in a mass ratio of 10-20:60-75:8-15:4-10.
Further, the active substance comprises cynanchum atratum extract, centella asiatica root extract, sophora japonica extract and liquorice extract in a mass ratio of 10:16:70:4.
Further, the emulsifier is at least one of cetostearyl alcohol, polysorbate-60, glycerol stearate, PEG-100 stearate, sorbitan sesquioleate, dimerized hydroxystearate, behenyl alcohol and arachidic alcohol glucoside, lauric acid, myristic acid, palmitic acid, glycerol stearate and glycerol; preferably, the emulsifier is cetostearyl alcohol, polysorbate-60, glyceryl stearate/PEG-100 stearate, myristic acid/glyceryl stearate/glycerin, and the mass ratio is 3-5:1.5-3:0.8-2:0.2-0.8. Further preferably, the emulsifier is cetostearyl alcohol, polysorbate-60, glyceryl stearate/PEG-100 stearate, myristic acid/glyceryl stearate/glycerin, and is formulated according to a mass ratio of 4.4:2.5:2:0.55.
Further, the emollient is at least one of ethylhexyl palmitate, hexyl laurate, lauryl alcohol, squalane, caprylic triglyceride, capric triglyceride, polydimethylsiloxane and jojoba seed oil; ethylhexyl palmitate is preferred.
Further, the humectant is at least one of polydimethylsiloxane, glycerol, propylene glycol, butanediol, 1, 2-pentanediol, 1, 2-hexanediol, polyethylene glycol, quaternary ammonium salt-73, inositol, sarcosine, dipeptide-15, xylitol, sorbitol, sodium hyaluronate, isopropyl palmitate and hydrolyzed glucose aminoglycans; preferably, the humectant is polydimethylsiloxane, glycerol, butanediol/1, 2-pentanediol, propylene glycol/quaternary ammonium salt-73, 1, 2-hexanediol, inositol, butanediol/sarcosine/inositol/dipeptide-15, and the humectant is compounded according to the mass ratio of 1-2:3-6:1.5-3:1.3-2:0.2-0.6:0.2-0.6:0.3-0.8; further preferably, the humectant is polydimethylsiloxane, glycerol, butanediol/1, 2-pentanediol, propylene glycol/quaternary ammonium salt-73, 1, 2-hexanediol, inositol, butanediol/sarcosine/inositol/dipeptide-15, and the mass ratio is 1.7:4.2:2:2:0.4:0.5:0.5.
Further, the surfactant is at least one of sorbitan stearate, lauryl sulfonated disodium succinate, lecithin, stearic acid, sodium dodecyl benzene sulfonate, sodium dodecyl sulfate, polysorbate and fatty glyceride; sorbitan stearate is preferred.
Further, the antioxidant is at least one of p-hydroxyacetophenone, tocopherol (vitamin E), di-tert-butyl-p-cresol, tert-butyl hydroxyanisole and propylated edible acid salt; preferably, the antioxidant is compounded by p-hydroxyacetophenone and tocopherol according to the mass ratio of 0.2-0.6:0.1-0.5.
Further, the skin conditioner is at least one of allantoin, liquid paraffin, liquid petrolatum, isopropyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, unsaturated fatty acids such as oleic acid palmitic acid, stearic acid, behenic acid, and linoleic acid, preferably allantoin.
Further, the adsorbent comprises dextrin, salicylic acid and sesame amino acids in a mass ratio of 62.8-65.6:34-37:0.2-0.4; preferably, the adsorbent comprises dextrin, salicylic acid and sesame amino acids in a mass ratio of 64.8:35:0.2.
Further, the emulsion stabilizer is at least one of polyacrylate-13, polyisobutylene, sorbitan isostearate, polysorbate-20, vitamin E acetate, butylhydroxytoluene, tert-butyl p-methoxyphenol and propyl gallate; preferably, the emulsion stabilizer is prepared from polyacrylate-13, polyisobutylene, sorbitan isostearate and polysorbate-20 according to a mass ratio of 60:30:3:2.
Further, the thickener is at least one of isopropyl myristate, xanthan gum, beeswax, xanthan gum, acrylic acid polymer, carrageenan, carbomer, pectin and cellulose; preferably, the thickening agent is isopropyl myristate and xanthan gum in a mass ratio of 6-15:0.1-0.5.
Further, the preservative is at least one of o-cymene-5-alcohol, methyl benzoate, propyl benzoate, phenoxyethanol, ethylhexyl glycerol, tert-butylhydroquinone, benzoyl ketone and sodium benzoate; preferably, o-cymene-5-ol.
Further, the chelating agent is EDTA-disodium.
Further, the cooling agent is menthol.
Further, the essence is any one or more of cosmetics usable essence, including but not limited to lavender essence, lemon essence, jasmine essence, rose essence, camellia essence, kumquat essence, strawberry essence, juicy peach essence and grapefruit essence.
Further, the solvent is any one of deionized water, distilled water, ion-exchanged water, double distilled water, high-purity water, and purified water.
Preferably, the acne-removing composition comprises the following components in percentage by weight:
component A:6-15% isopropyl myristate, 3-5% cetostearyl alcohol, 1.5-4% ethylhexyl palmitate, 1.5-3% polysorbate-60, 0.8-2% glyceryl stearate/PEG-100 stearate, 1-2% dimethicone, 1.2-2% sorbitan stearate, 0.2-0.8% myristic acid/glyceryl stearate/glycerin, and 0.1-0.5% tocopherol;
component B:50-60% of solvent, 3-6% of glycerol, 0.2-0.6% of p-hydroxyacetophenone, 0.1-0.5% of xanthan gum, 0.1-0.3% of allantoin, 0.03-0.08% of cymene-5-ol and 0.02-0.06% of EDTA-disodium;
component C:1.5-3% dextrin/salicylic acid/sesame amino acids, 0.8-1.5% polyacrylate-13/polyisobutylene/sorbitan isostearate/polysorbate-20 and 0.1-0.3% menthol;
component D:0.25-0.56% water, 1.5-3% butanediol/1, 2-pentanediol, 2-5% active substance, 1.3-2% propylene glycol/quaternary ammonium salt-73, 0.2-0.6%1, 2-hexanediol, 0.2-0.6% inositol, 0.3-0.8% butanediol/sarcosine/inositol/dipeptide-15, and 0.1-0.3% essence.
Further preferably, the acne-removing composition comprises, in weight percent:
component A:10% isopropyl myristate, 4.4% cetostearyl alcohol, 3.5% ethylhexyl palmitate, 2.5% polysorbate-60, 2% glyceryl stearate/PEG-100 stearate, 1.7% dimethicone, 1.8% sorbitan stearate, 0.55% myristic acid/glyceryl stearate/glycerin, and 0.4% tocopherol;
component B:55% solvent, 4.2% glycerol, 0.3% p-hydroxyacetophenone, 0.3% xanthan gum, 0.2% allantoin, 0.05% cymene-5-ol and 0.04% edta-disodium, the balance of solvent;
component C:2% dextrin/salicylic acid/sesame amino acid, 1% polyacrylate-13/polyisobutylene/sorbitan isostearate/polysorbate-20, 0.2% menthol;
component D:0.36% water, 2% butanediol/1, 2-pentanediol, 4% active substance, 2% propylene glycol/quaternary ammonium salt-73, 0.3%1, 2-hexanediol, 0.5% inositol, 0.5% butanediol/sarcosine/inositol/dipeptide-15, and 0.2% perfume.
The invention also provides a preparation method of the acne-removing composition, which comprises the following steps:
(1) Adding the component A into an oil phase pot, and heating and uniformly stirring to obtain an oil phase mixed solution A;
(2) Adding the component B into a water phase pot, and heating and stirring uniformly to obtain a water phase mixed solution B;
(3) Preheating a reaction kettle, vacuumizing and sucking the oil phase mixed solution A and the water phase mixed solution B, and starting stirring to perform homogenizing emulsification;
(4) Adding the component C, stirring and uniformly mixing, and preserving heat;
(5) Cooling to 45-50deg.C, adding component D, and stirring to obtain acne removing composition.
Further, in the steps (1) and (2), the stirring speed is 150-300r/min, the stirring time is 5-30min, and the heating temperature is 75-85 ℃; preferably, the stirring speed is 200r/min, the stirring time is 10min, and the heating temperature is 80 ℃.
Further, in the step (3), the stirring speed is 350-500r/min, and the homogenizing and emulsifying time is 5-20min; preferably, the stirring speed is 400r/min, and the homogenizing emulsification time is 10min.
Further, in the step (4), the temperature is reduced to 48 ℃.
Further, in the step (4), the stirring speed is 350-500r/min, and the stirring time is 10-30min; preferably, the stirring speed is 400r/min and the stirring time is 20min.
Further, in the step (4), the heat preservation time is 15-30min, preferably 20min.
The invention also provides application of the acne-removing composition in preparing cosmetics.
Compared with the prior art, the invention has the following beneficial effects:
(1) The acne-removing composition is prepared by scientifically combining a plurality of active substances and auxiliary materials, and has the functions of removing acnes, relieving pain, relieving itching and repairing scars; through reasonable proportion, the acne-removing composition is easier to smear and absorb, achieves the purposes of safely and efficiently removing acnes, repairing skin and inhibiting the regeneration of acnes, is mild and non-irritating, and can effectively inhibit bacteria, relieve skin inflammation and inflammation, sebum secretion and the like.
(2) According to the invention, the cynanchum atratum extract, the centella asiatica root extract, the sophora flower extract and the liquorice extract are used as active substances, and the excellent antibacterial performance and acne-removing and oil-controlling effects can be obtained by optimizing the proportion of the four substances.
(3) According to the acne-removing composition, the dextrin, the salicylic acid and the sesame amino acid are added, and the proportion of the dextrin, the salicylic acid and the sesame amino acid is optimized, so that the skin can absorb and utilize the acne-removing composition, a greater effect is exerted, the stability of the acne-removing composition is improved, the acne-removing composition is convenient to store and carry, and the acne-removing composition can be placed for a long time in a high-low temperature environment.
Detailed Description
The following non-limiting examples will enable those of ordinary skill in the art to more fully understand the invention and are not intended to limit the invention in any way. The following is merely exemplary of the scope of the invention as claimed and many variations and modifications of the invention will be apparent to those skilled in the art in light of the disclosure, which are intended to be within the scope of the invention as claimed.
The invention is further illustrated by means of the following specific examples. The various chemical reagents used in the examples of the present invention were obtained by conventional commercial means unless otherwise specified.
Examples 1 to 5
The acne-removing composition has the formula shown in the following table 1:
TABLE 1
Wherein, in the example 1, the mass ratio of dextrin/salicylic acid/sesame amino acid is 62.8:37:0.2, and the mass ratio of cynanchum atratum extract/centella asiatica root extract/sophora flower extract/licorice extract is 10:75:5:10;
in example 2, the mass ratio of dextrin/salicylic acid/sesame amino acid is 64.8:35:0.2, and the mass ratio of cynanchum atratum extract/centella asiatica root extract/sophora flower extract/licorice extract is 10:70:16:4;
in example 3, the mass ratio of dextrin/salicylic acid/sesame amino acid was 65.6:34:0.4, and the mass ratio of cynanchum atratum extract/centella asiatica root extract/sophora flower extract/licorice extract was 20:60:10:10;
the mass ratio of dextrin/salicylic acid/sesame amino acid in examples 4 and 5 was the same as that in example 2, and the mass ratio of cynanchum atratum extract/centella asiatica root extract/sophora japonica extract/licorice extract was the same as that in example 2.
The preparation method of the acne-removing composition comprises the following steps:
(1) Adding the component A into an oil phase pot, heating to 80 ℃, stirring for 10min at 200r/min, and uniformly mixing to obtain an oil phase mixed solution A;
(2) Adding the component B into a water phase pot, heating to 80 ℃, stirring for 10min at 200r/min, and uniformly mixing to obtain a water phase mixed solution B;
(3) Preheating a reaction kettle, vacuumizing, sucking the oil phase mixed solution A and the water phase mixed solution B, and homogenizing and emulsifying for 10min at the stirring speed of 400 r/min;
(4) Adding the component C, stirring and mixing uniformly, and preserving heat for 20min;
(5) Cooling to 48deg.C, adding component D, stirring at 400r/min for 20min, and mixing to obtain acne-removing composition.
Example 6
The difference from example 2 is that the licorice extract was replaced with an equivalent amount of centella asiatica extract.
Example 7
The difference from example 2 is that the pagodatree flower extract is replaced with the equivalent amount of centella asiatica extract.
Example 8
The difference from example 2 is that the cynanchum atratum extract is replaced with an equivalent amount of centella asiatica extract.
Example 9
The difference from example 2 is that the active substance is replaced by an equivalent amount of centella asiatica extract.
Example 10
The difference from example 2 is that the mass ratio of cynanchum atratum extract/centella asiatica root extract/sophora japonica extract/licorice extract is 5:80:3:12.
Example 11
The difference from example 2 is that the mass ratio of cynanchum atratum extract/centella asiatica root extract/sophora japonica extract/licorice extract is 25:55:18:2.
Example 12
The difference from example 2 is that the mass ratio of dextrin, salicylic acid and sesame amino acids is 61:38:1.
Example 13
The difference from example 2 is that the mass ratio of dextrin, salicylic acid and sesame amino acids is 67:32:1.
Experimental example 1
Safety evaluation
The experimental object: randomly selecting 60 women aged 20-50 years, requiring skin health without skin allergy history;
the experimental method comprises the following steps: a qualified patch tester is selected, about 0.020g-0.025g of the acne removing composition obtained in the examples 1-13 of the invention is added into the patch tester in a closed patch test mode, a special adhesive tape is externally used for coating the back of a subject, the test substance is removed after 24 hours, skin reactions are observed after 0.5, 6, 12, 24 and 48 hours respectively, and the results are recorded according to the skin reaction grading standard in cosmetic hygiene Specification.
Experimental results: the test results of the human skin patch show that after the acne removing composition obtained in the examples 1-13 is used, skin irritation reactions such as erythema, edema, pimple, stinging and the like do not appear in all groups of subjects within 48 hours, which indicates that the acne removing composition provided by the invention is safe to use.
Experimental example 2
Efficacy evaluation
Propionibacterium acnes antibacterial test
Preparation of a bilayer plate (15 mL of medium in the lower layer and 5mL of medium containing Propionibacterium acnes in the upper layer) containing Propionibacterium acnes (ATCC 11827) with a plate bacterial load of about 10 5 And (3) placing 2 oxford cups vertically on the surface of each flat plate, respectively taking 200uL of acne removing composition, placing into the oxford cups, performing anaerobic culture for 24 hours at the temperature of 36+/-1 ℃, and then measuring the diameter of a bacteriostasis ring for judging the bacteriostasis effect on propionibacterium acnes. The criteria are shown in table 2 below:
TABLE 2
Acne removing effect | Diameter D (mm) of inhibition zone |
Efficient | D≥20 |
Middle effect | 15≤D<20 |
Low efficiency | 10≤D<15 |
Invalidation of | D<10 |
The results of the antibacterial experiments of the acne-removing compositions obtained in examples 1 to 11 of the present invention are shown in the following table 3, and in order to eliminate the influence of other preservatives on the antibacterial effect, no preservative o-cymene-5-ol was added to the samples subjected to the acne-removing efficacy test. The results show that: the acne-removing composition provided by the invention has a good acne-removing effect and thus has a good acne-removing effect; the anti-acne composition obtained in examples 6-9 has a significantly lower diameter of the inhibition zone than that of example 2, and has relatively poor anti-acne effect, so that the anti-acne effect is improved by using the cynanchum atratum extract, the pagodatree flower extract, the licorice extract and the centella asiatica root extract in combination.
TABLE 3 Table 3
Group of | Diameter D (mm) of inhibition zone | Acne removing effect |
Example 1 | 30.8 | Efficient |
Example 2 | 32.1 | Efficient |
Example 3 | 31.7 | Efficient |
Example 4 | 22.8 | Efficient |
Example 5 | 24.2 | Efficient |
Example 6 | 27.6 | Efficient |
Example 7 | 19.2 | Middle effect |
Example 8 | 18.7 | Middle effect |
Example 9 | 15.8 | Middle effect |
Example 10 | 23.5 | Efficient |
Example 11 | 24.7 | Efficient |
Example 12 | 30.5 | Efficient |
Example 13 | 29.8 | Efficient |
(II) acne-removing effect experiment
Randomly selecting 110 volunteers with acne of II degree or above, and ages 15-30, and male and female halves; the acne-removing composition is applied after the face is cleaned by warm water in the morning and evening every day, and is gently rubbed to the skin to be absorbed, and the acne-removing effect is observed after 2 weeks.
Acne grading criteria: i degree: skin lesions are comedones, sporadic or multiple inflammatory rashes; II degree: superficial abscess with I degree, the number of inflammations is large, but the method is limited to the face; III degree: the second degree deepens inflammatory rash, which may have cysts, occurring on the face, neck, chest and back; IV degree: and III, adding cyst, and easily forming scar which occurs on the upper body.
The experimental results are shown in table 4 below.
TABLE 4 Table 4
The results show that: the acne-removing composition obtained in the embodiments 1-3 has an acne-removing effect up to 100%, and has a remarkable acne-removing effect; the acne-removing effect of the acne-removing composition obtained in the examples 4 and 5 is inferior to that of the acne-removing composition obtained in the examples 1 to 3, and the proportion of each component in the acne-removing composition has a larger influence on the acne-removing effect; the acne-removing effect of the acne-removing composition obtained in examples 6-11 is obviously inferior to that of example 2, and the acne-removing effect of the acne-removing composition can be effectively improved by utilizing the combination of the cynanchum atratum extract, the pagodatree flower extract, the liquorice extract and the centella asiatica root extract.
(III) oil control effect experiment
72 volunteers with more vigorous skin grease secretion are randomly selected, the ages of 18-40 years and men and women are half-aged, the right forehead half part of the subject is selected as an experimental area, and the left forehead half part is selected as a control area. The volunteer uses a SEBUMETER SM815 sebum measuring instrument to measure sebum value by using a SEBUMETER method after 30min under certain temperature and humidity conditions, and recordsIs T0; the acne-removing composition of the present invention was then applied at 1.25. Mu.L/cm 2 Uniformly applying the amount of (2) to the right half of forehead until absorption, measuring the sebum value at the moment, marking as T1, and then measuring the sebum value after 0.5, 1 and 2 hours; the change rate of the oil content is calculated as follows:
the change rate of the oil content= (oil content after application-oil content before application)/oil content before application×100%.
The experimental results are shown in table 5 below.
TABLE 5
The results show that: the acne-removing composition obtained in the embodiments 1-3 of the invention shows good oil control effect within 2 hours of application; the oil control effect of the acne-removing mixture obtained in comparative examples 4-11 is poorer than that of example 2, and it is seen that the proportion of the acne-removing composition, the type and proportion of active substances influence the oil control effect of the product, and better oil control effect can be obtained by taking the cynanchum atratum extract, the pagodatree flower extract, the licorice extract and the centella asiatica root extract as active substances; the oil control effect of the acne-removing mixture obtained in examples 12 and 13 is inferior to that of example 2, and it is seen that the proportion of the adsorbents dextrin, salicylic acid and sesaminic acid affects the absorption of the product, thereby affecting the oil control effect.
Experimental example 3
Stability test
The anti-acne compositions obtained in examples 1 to 13 of the present invention were subjected to various storage conditions for 3 months of stability observation, and the results are shown in Table 6 below.
TABLE 6
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The results show that: the acne-removing composition obtained in the examples 1-3 has no obvious change after being stored for 30 months at different temperatures, and the color and the shape are consistent with those of the acne-removing composition before experiments, which shows that the acne-removing composition provided by the invention has good stability; the acne-removing composition obtained in examples 12 and 13 has deep color and small morphological change after being stored for 3 months at 40 ℃ and 50 ℃, which indicates that the dextrin, the salicylic acid and the sesame amino acid are added in a specific proportion, so that the long-term stability of the product can be improved, the use convenience and the portability are improved, and the acne-removing cosmetic can meet the demands of people at any time.
The previous description of the embodiments is provided to facilitate a person of ordinary skill in the art in order to make and use the present invention. It will be apparent to those skilled in the art that various modifications can be readily made to these embodiments and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above-described embodiments, and those skilled in the art, based on the present disclosure, should make improvements and modifications without departing from the scope of the present invention.
Claims (17)
1. An anti-acne composition comprises an active, an emulsifier, an emollient, a humectant, a surfactant, an antioxidant, a skin conditioning agent, an adsorbent, an emulsion stabilizer, a thickener, a preservative, a chelating agent, a cooling agent, a fragrance, and a solvent; wherein,,
the active substance comprises cynanchum atratum extract, centella asiatica root extract, sophora flower extract and liquorice extract in a mass ratio of 10-20:60-75:8-15:4-10.
2. The acne-removing composition according to claim 1, wherein the active substance comprises cynanchum atratum extract, centella asiatica root extract, sophora japonica extract and licorice extract in a mass ratio of 10:16:70:4.
3. The acne-removing composition according to claim 1, wherein the emulsifier is at least one of cetostearyl alcohol, polysorbate-60, glycerol stearate, PEG-100 stearate, sorbitan sesquioleate, dimerized hydroxystearate, behenyl alcohol and arachidyl alcohol glucoside, lauric acid, myristic acid, palmitic acid, glycerol stearate, glycerol.
4. The anti-acne composition of claim 1, wherein the emollient is at least one of ethylhexyl palmitate, hexyl laurate, lauryl alcohol, squalane, caprylic triglyceride, capric triglyceride, polydimethylsiloxane, and jojoba seed oil.
5. The acne-removing composition according to claim 1, wherein the humectant is at least one of polydimethylsiloxane, glycerin, propylene glycol, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, polyethylene glycol, quaternary ammonium salt-73, inositol, sarcosine, dipeptide-15, xylitol, sorbitol, sodium hyaluronate and isopropyl palmitate, and hydrolyzed glucosamine.
6. The acne-removing composition according to claim 1, wherein the surfactant is at least one of sorbitan stearate, disodium lauryl sulfosuccinate, lecithin, stearic acid, sodium dodecylbenzenesulfonate, sodium dodecylsulfate, polysorbate, and fatty acid glyceride.
7. The acne-removing composition according to claim 1, wherein the antioxidant is at least one of p-hydroxyacetophenone, tocopherol, di-t-butyl-p-cresol, t-butyl hydroxyanisole, and propylated caproate.
8. The acne-removing composition according to claim 1, wherein the skin conditioner is at least one of allantoin, liquid paraffin, liquid petrolatum, isopropyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, unsaturated fatty acids.
9. The acne-removing composition according to claim 1, wherein the adsorbent comprises dextrin, salicylic acid and sesame amino acids in a mass ratio of 62.8-65.6:34-37:0.2-0.4.
10. The acne-removing composition according to claim 9, wherein the adsorbent comprises dextrin, salicylic acid and sesaminic acid in a mass ratio of 64.8:35:0.2.
11. The acne-removing composition according to claim 1, wherein the emulsion stabilizer is at least one of polyacrylate-13, polyisobutylene, sorbitan isostearate, polysorbate-20, vitamin E acetate, butylated hydroxytoluene, t-butyl-p-methoxyphenol, and propyl gallate.
12. The acne-removing composition of claim 1, wherein the thickener is at least one of isopropyl myristate, xanthan gum, beeswax, xanthan gum, acrylic polymer, carrageenan, carbomer, pectin, and cellulose.
13. The acne-removing composition according to claim 1, wherein the cooling agent is menthol and the chelating agent is EDTA-disodium.
14. The acne-removing composition according to any one of claims 1 to 13, comprising, in weight percent:
component A:6-15% isopropyl myristate, 3-5% cetostearyl alcohol, 1.5-4% ethylhexyl palmitate, 1.5-3% polysorbate-60, 0.8-2% glyceryl stearate/PEG-100 stearate, 1-2% dimethicone, 1.2-2% sorbitan stearate, 0.2-0.8% myristic acid/glyceryl stearate/glycerin, and 0.1-0.5% tocopherol;
component B:50-60% of solvent, 3-6% of glycerol, 0.2-0.6% of p-hydroxyacetophenone, 0.1-0.5% of xanthan gum, 0.1-0.3% of allantoin, 0.03-0.08% of cymene-5-ol and 0.02-0.06% of EDTA-disodium;
component C:1.5-3% dextrin/salicylic acid/sesame amino acids, 0.8-1.5% polyacrylate-13/polyisobutylene/sorbitan isostearate/polysorbate-20 and 0.1-0.3% menthol;
component D:0.25-0.56% water, 1.5-3% butanediol/1, 2-pentanediol, 2-5% active substance, 1.3-2% propylene glycol/quaternary ammonium salt-73, 0.2-0.6%1, 2-hexanediol, 0.2-0.6% inositol, 0.3-0.8% butanediol/sarcosine/inositol/dipeptide-15, and 0.1-0.3% essence.
15. The acne-removing composition according to claim 14, comprising, in weight percent:
component A:10% isopropyl myristate, 4.4% cetostearyl alcohol, 3.5% ethylhexyl palmitate, 2.5% polysorbate-60, 2% glyceryl stearate/PEG-100 stearate, 1.7% dimethicone, 1.8% sorbitan stearate, 0.55% myristic acid/glyceryl stearate/glycerin, and 0.4% tocopherol;
component B:55% solvent, 4.2% glycerol, 0.3% p-hydroxyacetophenone, 0.3% xanthan gum, 0.2% allantoin, 0.05% cymene-5-ol and 0.04% edta-disodium, the balance of solvent;
component C:2% dextrin/salicylic acid/sesame amino acid, 1% polyacrylate-13/polyisobutylene/sorbitan isostearate/polysorbate-20, 0.2% menthol;
component D:0.36% water, 2% butanediol/1, 2-pentanediol, 4% active substance, 2% propylene glycol/quaternary ammonium salt-73, 0.3%1, 2-hexanediol, 0.5% inositol, 0.5% butanediol/sarcosine/inositol/dipeptide-15, and 0.2% perfume.
16. The method for preparing the acne-removing composition according to any one of claims 1 to 15, comprising the steps of:
(1) Adding the component A into an oil phase pot, and heating and uniformly stirring to obtain an oil phase mixed solution A;
(2) Adding the component B into a water phase pot, and heating and stirring uniformly to obtain a water phase mixed solution B;
(3) Preheating a reaction kettle, vacuumizing and sucking the oil phase mixed solution A and the water phase mixed solution B, and starting stirring to perform homogenizing emulsification;
(4) Adding the component C, stirring and uniformly mixing, and preserving heat;
(5) Cooling to 45-50deg.C, adding component D, and stirring to obtain acne removing composition.
17. Use of the acne-removing composition of any one of claims 1-15 in the preparation of a cosmetic.
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CN105380830A (en) * | 2015-12-02 | 2016-03-09 | 广州豆乎生物科技有限公司 | Composition capable of removing pockmarks and inhibiting acne generation, and application thereof |
CN114028295A (en) * | 2021-12-10 | 2022-02-11 | 北京安德普泰医疗科技有限公司 | Antibacterial itching-relieving red-fading acne-removing repairing composition as well as preparation method and application thereof |
CN115025024A (en) * | 2022-07-29 | 2022-09-09 | 维怡美生物科技(广州)有限公司 | Acne and acne mark removing composition and application thereof |
CN115105449A (en) * | 2022-07-19 | 2022-09-27 | 广州陶妆生物科技有限公司 | Novel antibacterial anti-inflammation acne cream and preparation method thereof |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105380830A (en) * | 2015-12-02 | 2016-03-09 | 广州豆乎生物科技有限公司 | Composition capable of removing pockmarks and inhibiting acne generation, and application thereof |
CN114028295A (en) * | 2021-12-10 | 2022-02-11 | 北京安德普泰医疗科技有限公司 | Antibacterial itching-relieving red-fading acne-removing repairing composition as well as preparation method and application thereof |
CN115105449A (en) * | 2022-07-19 | 2022-09-27 | 广州陶妆生物科技有限公司 | Novel antibacterial anti-inflammation acne cream and preparation method thereof |
CN115025024A (en) * | 2022-07-29 | 2022-09-09 | 维怡美生物科技(广州)有限公司 | Acne and acne mark removing composition and application thereof |
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