CN110664668A

CN110664668A - Acne-removing skin-care gel containing water-soluble cannabidiol and preparation method thereof

Info

Publication number: CN110664668A
Application number: CN201911171510.4A
Authority: CN
Inventors: 王钲霖; 刘胜贵; 付彬彬; 李智高; 孔令羽
Original assignee: Yunnan Luxin Biopharmaceutical Co Ltd
Current assignee: Yunnan Luxin Biopharmaceutical Co Ltd
Priority date: 2019-11-26
Filing date: 2019-11-26
Publication date: 2020-01-10

Abstract

The invention discloses acne-removing skin-care gel containing water-soluble cannabidiol and a preparation method thereof, belonging to the field of daily chemicals. The feed comprises the following raw materials in parts by weight: 66.2-89.4 parts of water, 8-18 parts of humectant, 2-8 parts of emollient, 0.1-1 part of solubilizer, 0.1-1 part of rheology regulator, 0.3-5 parts of water-soluble cannabidiol, 0.01-0.2 part of EDTA-2Na, 0.05-0.5 part of essence and 0.1-0.3 part of preservative. The skin care gel is added with a proper amount of water-soluble cannabidiol, so that the product has the basic effect of moisturizing, can exert the excellent antibacterial and anti-inflammatory capabilities of the cannabidiol, and can effectively solve the problem of pox caused by bacterial infection. The invention has simple preparation process, exact effect and low cost, and is suitable for large-scale production.

Description

Acne-removing skin-care gel containing water-soluble cannabidiol and preparation method thereof

Technical Field

The invention belongs to the field of daily chemicals, and particularly relates to acne-removing skin-care gel containing water-soluble cannabidiol and a preparation method thereof.

Background

With age, the turnover rate of the human stratum corneum becomes slower and slower, and at the same time, the lipid synthesis capacity of keratinocytes decreases, or the cell division, growth and differentiation efficiency in the epidermis becomes lower. The stratum corneum barrier function tends to decrease due to the lack of moisturizing factors and lipids in the skin. When the moisture content of the stratum corneum is less than 10%, the skin becomes dry, elastic, wrinkled, and thus skin aging is accelerated. On the other hand, improper lifestyle such as excessive washing or bathing and adverse environmental factors such as dry air or pollutants, and inherent diseases such as allergy or senile skin diseases also cause the stratum corneum to lose its original function. The skin is exposed to heat, cold, wind, cleansers, and ultraviolet radiation, and the top layer becomes drier. Water is an important component of skin, the skin with high water content has normal metabolism of epidermal cells and sufficient energy of the epidermis, and has the appearance of young, tender, plump, bright and soft. For example, infant skin appears delicate and shiny due to its high water content, while elderly skin appears dry and withered, easily desquamated and even wrinkled due to its low water content. Therefore, how to maintain the moisture of the skin and reduce the moisture loss is very important in the development of cosmetics.

The skin-care gel is a product between lotion and cream, and the formula structure of the skin-care gel is similar to the lotion, but the use performance of the skin-care gel is similar to the cream, and the skin feel of the skin-care gel is fresher than that of the cream. In terms of transparency, skin care gels are transparent and translucent. The skin care gel type preparation overcomes the defects of greasy and emulsion type ointments, and the hydrophilic gel matrix has no greasy feeling, is easy to spread and clean, has certain adhesive force, can prolong the contact time with skin, and improves the absorption concentration of effective substances. The gel has good biocompatibility, and has the advantages of slow release, controlled release and the like for the release of effective substances.

The essential function of skin care gels is to moisturize. The product can be made into cosmetics by adding active materials, and has effects of caring skin, nourishing, removing speckle, and delaying aging. The purpose and function of various skin care gels are different, and the balance of the ingredients and the dosage is also different. At present, the skin care gel on the market is mainly used for moisturizing, and skin care gel products with specific effects are few, and the effect is not satisfactory. Therefore, a skin care gel with good effect and definite effect is developed, and the current situation that the products have single market application can be made up.

Disclosure of Invention

Aiming at the problems, the invention aims to disclose an acne-removing skin-care gel containing water-soluble cannabidiol and a preparation method thereof. The skin care gel is added with a proper amount of water-soluble cannabidiol, so that the product not only has the basic effect of moisturizing, but also can exert the excellent antibacterial and anti-inflammatory capabilities of the cannabidiol, and effectively dispel the trouble of acnes.

In order to achieve the purpose, the invention adopts the following technical scheme:

the acne-removing skin-care gel containing water-soluble cannabidiol is mainly realized by the following technical scheme and comprises the following raw materials in parts by weight:

66.2-89.4 parts of water, 8-18 parts of humectant, 2-8 parts of emollient, 0.1-1 part of solubilizer, 0.1-1 part of rheology regulator, 0.3-5 parts of water-soluble cannabidiol, 0.01-0.2 part of EDTA-2Na, 0.05-0.5 part of essence and 0.1-0.3 part of preservative.

The humectant comprises one or more of glycerol, propylene glycol, 1, 3-butanediol, glyceryl polyether-26, sodium hyaluronate, trehalose, allantoin, betaine, and oat-beta-glucan.

The emollient comprises mineral ester, mineral oil, coconut oil, sunflower oil, corn oil and rapeseed oil; myristyl myristate, octyl octanoate, oleyl oleate, hexyl laurate, isopropyl palmitate; ethoxylated glyceride, PEG-6 caprylic/capric triglyceride, PEG-60 mixed ester of corn oil and glycerol, and PEG-7 olive oleate; lauryl alcohol, oleyl alcohol, octyldodecanol, hexyldecanol; one or more of dioctyl cyclohexane.

The solubilizer comprises one or more of PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil.

The rheology regulator comprises one or more of xanthan gum, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose and acrylic acid polymer.

The fragrances include fragrances approved for use in cosmetic codes.

The antiseptic is one or more of ethylparaben, sodium benzoate, benzalkonium chloride, DMDMH (dimethylol dimethyl hydantoin), and diazolidinyl urea.

Cannabidiol (CBD) is a major active ingredient in cannabinoids, extracted from industrial cannabis. Has the function of protecting nerves, has no addiction, has the functions of resisting spasm, rheumatic arthritis and anxiety, draws wide attention in the fields of medicine and pharmacology and becomes a research hotspot in recent years. Research shows that CBD also shows excellent curative effect on antibiosis and antiphlogosis, and has certain inhibitory activity on staphylococcus and streptococcus.

The preparation method of the water-soluble cannabidiol comprises the following steps of ① dissolving high-purity CBD crystals with 2-5 times of ethanol to form a solution, ② heating and dissolving alpha-cyclodextrin with 1-5 times of pure water or ethanol-water, adding ① the solution after complete dissolution, stirring and mixing uniformly, ③ clathrating, mixing uniformly the solution formed by ① and ②, carrying out cannabidiol clathration by using a high-pressure homogenization method, carrying out reduced pressure concentration by using a rotary evaporator after the solution is completely dissolved, removing most of the solvent and water, ④ drying, and carrying out vacuum drying on the material obtained by ③ to obtain the cannabidiol clathrate (water-soluble).

An acne-removing skin-care gel containing water-soluble cannabidiol and a preparation method thereof, which comprises the following preparation steps:

(1) accurately weighing a certain amount of water in a container.

(2) While stirring water, a certain amount of water-soluble cannabidiol and EDTA-2Na are dispersed in the water and fully stirred to dissolve.

(3) Adding humectant, emollient, and rheology regulator in sequence, stirring, and dispersing.

(4) Adding antiseptic, stirring, and dispersing.

(5) And mixing the essence and the solubilizer, adding the mixture into the system, and stirring and dispersing the mixture until the system is uniform.

Compared with the prior art, the invention has the advantages and innovations that:

(1) according to the invention, under the premise of not changing the molecular structure of the cannabidiol which is insoluble in water, the CBD with higher purity is embedded by the packing material with better water solubility, so that the water solubility of the CBD is changed, and the water solubility and the utilization rate of the CBD are greatly improved.

(2) The effective active additive cannabidiol has better antibacterial and anti-inflammatory effects, and can effectively eliminate pox troubles caused by bacterial infection. And cannabidiol is a natural plant extract, is safe and has no side effect.

(3) The invention has simple preparation process, definite curative effect and low cost, is suitable for large-scale production and is a product with popularization and application values.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments.

Example 1

(1) The preparation of water-soluble cannabidiol comprises the following steps:

① accurately weighing 100g cannabidiol solid powder (purity over 99%) and 500g ethanol, adding into 1L round bottom flask, mechanically stirring for 30min to dissolve cannabidiol solid completely, and cooling to room temperature.

② adding 300g of alpha-cyclodextrin and 900g of first-class purified water into a 2L single-neck round-bottom flask, placing the flask in a 40 ℃ water bath, mechanically stirring for 30min to fully dissolve the alpha-cyclodextrin in the water to form a transparent solution, adding the solution obtained in the step ① into the solution once after the alpha-cyclodextrin is completely dissolved, and continuously stirring for 10 min.

③ clathrating, placing the mixed solution prepared in step ② into a high pressure homogenizer, starting the high pressure pump, homogenizing for 3 times at 25 deg.C under 35MPa, concentrating under reduced pressure with a rotary evaporator to remove ethanol and water, and vacuum degree of-0.1 MPa at 70 deg.C.

④ drying, vacuum concentrating to obtain crude product, mashing solid block into powder, spreading in a watch glass, vacuum drying in a vacuum drying oven at 35 deg.C under-0.08 MPa for 72 hr to obtain cannabidiol clathrate (water soluble).

(2) An acne-removing skin-care gel containing water-soluble cannabidiol comprises the following raw materials in parts by weight:

83.05 parts of water, 5 parts of glycerol, 5 parts of butanediol, 3 parts of myristic acid bean ester, 1.5 parts of PEG-7 olive oleate, 0.5 part of water-soluble cannabidiol, 0.5 part of allantoin, 0.5 part of PEG-40 hydrogenated castor oil, 0.3 part of xanthan gum, 0.3 part of rose essence, 0.2 part of sodium benzoate, 0.1 part of sodium hyaluronate and 0.05 part of EDTA-2 Na.

(3) An acne-removing skin-care gel containing water-soluble cannabidiol and a preparation method thereof, which comprises the following preparation steps:

① A container was accurately weighed with 83.05g of water.

② while stirring water, 0.5g of water-soluble cannabidiol and 0.05g of EDTA-2Na were dispersed in water and dissolved by stirring thoroughly.

③ adding glycerol 5g, butanediol 5g, allantoin 0.5g, and sodium hyaluronate 0.1g sequentially, stirring, and dispersing.

④ adding 3g of myristyl myristate, 1.5g of PEG-7 olive oleate and 0.3g of xanthan gum in sequence, stirring and dispersing uniformly.

⑤ and 0.2g sodium benzoate is added and mixed evenly.

⑥ dissolving 0.3g rose essence in 0.5g PEG-40 hydrogenated castor oil, adding into the system, and stirring to disperse until the system is uniform.

Example 2

(1) Water-soluble cannabidiol was prepared as in example 1.

82.55 parts of water, 5 parts of glycerol, 5 parts of butanediol, 3 parts of myristic acid bean ester, 1.5 parts of PEG-7 olive oleate, 1 part of water-soluble cannabidiol, 0.5 part of allantoin, 0.5 part of PEG-40 hydrogenated castor oil, 0.3 part of xanthan gum, 0.3 part of rose essence, 0.2 part of sodium benzoate, 0.1 part of sodium hyaluronate and 0.05 part of EDTA-2 Na.

① accurately weighed 82.55g of water into a container.

② while stirring water, 1g of water-soluble cannabidiol and 0.05g of EDTA-2Na were dispersed in water and dissolved by stirring thoroughly.

⑤ and 0.2g sodium benzoate is added and mixed evenly.

Example 3

(1) Water-soluble cannabidiol was prepared as in example 1.

81.55 parts of water, 5 parts of glycerol, 5 parts of butanediol, 3 parts of myristic acid bean ester, 1.5 parts of PEG-7 olive oleate, 2 parts of water-soluble cannabidiol, 0.5 part of allantoin, 0.5 part of PEG-40 hydrogenated castor oil, 0.3 part of xanthan gum, 0.3 part of rose essence, 0.2 part of sodium benzoate, 0.1 part of sodium hyaluronate and 0.05 part of EDTA-2 Na.

① 81.55g of water were accurately weighed into a container.

② while stirring water, 2g of water-soluble cannabidiol and 0.05g of EDTA-2Na were dispersed in water and dissolved by stirring thoroughly.

⑤ and 0.2g sodium benzoate is added and mixed evenly.

Skin gel stability study

And (3) centrifugal experiment: 10g of the skin care gel prepared in the example 1 is respectively put into a centrifugal tube with scales and centrifuged for 30min on a centrifuge with the rotating speed of 2500r/min, and the experimental result shows that no layering phenomenon exists.

Heat and cold resistance test: 10g of each skin care gel prepared in example 1 was put into 3 cream boxes, and placed in an oven (39 + -1 deg.C), a room temperature (25 + -3 deg.C), and a refrigerator (5 + -2 deg.C) for 30 days, and the consistency, water loss, color, uniformity, and whether there was a mildew or not were observed. The results show that the skin care gel has basically no change in consistency and no hardening and water loss phenomena under the high-temperature, normal-temperature and low-temperature environments; bright color and no color change; good uniformity and no mildew.

Experimental results show that the skin care gel prepared by the invention has good stability.

Skin care gel trial experiment

Test of moistening and moisturizing effect

1. A subject: dry skin, dry face and skinned patients. 300 adolescents and middle-aged men and women having the above-mentioned symptoms were selected as subjects.

2. Test samples: example 1 skin care gel.

3. The using method comprises the following steps: after the face is cleaned, taking a proper amount of the face cream to be uniformly smeared on the face, and cleaning after 15 min; the preparation is administered 1 time per day for 15 days.

4. And (3) evaluation standard of moistening and moisturizing effect:

and (3) satisfaction: after the face mask is applied, the face is fresh and cool and is not dry, and the face skin can still be kept full and not skinned within 6 hours after the face mask is used;

the method has the following advantages: after the face cream is applied, the face is fresh and cool and is not dry, but the duration time is not more than 2h, and the face is dried and skinned again;

and (4) invalidation: after the face mask is applied, the face is still dry and skinned.

5. According to the evaluation criteria, 300 tested persons were randomly divided into two groups, the skin care gel of example 1 was used in the experimental group, no skin care product was used in the control group, the trial effect was counted, and the statistical results are shown in table 1.

Grouping	Satisfaction (number of people)	Effective (number of people)	Invalid (number of people)
				Experimental group	127	23	0
Control group	0	0	150

As can be seen from the statistical results in Table 1, the skin care gel prepared by the invention can effectively moisten the facial skin, and can keep moisture for a long time, so that the facial skin is plump and not dry.

Anti-acne Effect test

1. A subject: the clinical manifestations are that the face presents a plurality of lesions such as papules, pustules, nodules, cysts and scars, and 200 adolescents and middle-aged men and women with the symptoms are selected as the subjects.

2. Test samples: example 1 skin care gel.

3. The using method comprises the following steps: after the face is cleaned, a proper amount of the face lotion is uniformly smeared on the face for 1 time every day and is continuously used for 15 days.

4. Anti-acne effect evaluation criteria:

and (3) healing: the symptoms completely disappeared;

the method has the following advantages: the symptoms are obviously improved or improved;

and (4) invalidation: no improvement in symptoms.

5. According to the evaluation criteria, 200 test persons were randomly divided into two groups, the test group used the skin care gel of example 1, the control group used no skin care product, and the treatment effect was counted after 1 month, and the statistical results are shown in table 2.

TABLE 2 statistics of anti-acne Effect

Grouping	Recovery (number of people)	Effective (number of people)	Invalid (number of people)
				Experimental group	65	33	2
Control group	0	14	86

As can be seen from the table 2, the skin care gel prepared by the invention has very good anti-acne effect, and the cure rate and the effective rate are as high as 98%; the skin care gel prepared by the invention has good treatment effect on pox.

The above examples are merely illustrative of the present invention and do not limit the scope of the present invention in any way. It will be apparent to those skilled in the art that equivalent embodiments or modifications without departing from the technical spirit of the present invention are within the scope of the present invention.

Claims

1. The acne-removing skin-care gel containing water-soluble cannabidiol is characterized by comprising the following raw materials in parts by weight:

2. The acne-removing skin-care gel containing water-soluble cannabidiol as claimed in claim 1, and the preparation method thereof are characterized by comprising the following preparation steps:

(1) accurately weighing a certain amount of water in a container;

(2) while stirring water, dispersing a certain amount of water-soluble cannabidiol and EDTA-2Na in the water, and fully stirring and dissolving;

(3) adding the humectant, the emollient and the rheology modifier in sequence, and stirring and dispersing uniformly;

(4) adding a preservative, and stirring and dispersing uniformly;

3. The acne-removing skin-care gel containing water-soluble cannabidiol as claimed in claim 1 and claim 2, wherein the humectant comprises one or more of glycerin, propylene glycol, 1, 3-butylene glycol, glyceryl polyether-26, sodium hyaluronate, trehalose, allantoin, betaine and oat-beta-glucan.

4. The acne-removing skin-care gel containing water-soluble cannabidiol and the preparation method thereof as claimed in claim 1 and claim 2, wherein the emollient comprises mineral ester, mineral oil, coconut oil, sunflower oil, corn oil, rapeseed oil; myristyl myristate, octyl octanoate, oleyl oleate, hexyl laurate, isopropyl palmitate; ethoxylated glyceride, PEG-6 caprylic/capric triglyceride, PEG-60 mixed ester of corn oil and glycerol, and PEG-7 olive oleate; lauryl alcohol, oleyl alcohol, octyldodecanol, hexyldecanol; one or more of dioctyl cyclohexane.

5. The acne-removing skin-care gel containing water-soluble cannabidiol as claimed in claim 1 and claim 2, wherein the solubilizer comprises one or more of PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil.

6. The acne-removing skin-care gel containing water-soluble cannabidiol as claimed in claim 1 and claim 2, wherein the rheology modifier comprises one or more of xanthan gum, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose, and acrylic polymer.

7. The acne removing skin care gel containing water soluble cannabidiol and the preparation method thereof as claimed in claim 1 and claim 2, wherein the essence comprises an essence permitted in cosmetic specifications.

8. The gel for removing acne and caring skin according to claim 1 and claim 2, wherein the antiseptic is one or more of ethylparaben, sodium benzoate, benzalkonium chloride, DMDMH (dimethyloldimethylhydantoin), diazolidinyl urea.

9. The acne-removing skin-care gel containing water-soluble cannabidiol as claimed in claim 1 and claim 2, and the preparation method thereof is characterized in that the preparation method of the water-soluble cannabidiol comprises the following steps of ① dissolving high-purity CBD crystals with 2-5 times of ethanol to form a solution, ② heating and dissolving alpha-cyclodextrin with 1-5 times of pure water or ethanol-water, adding ① the solution after complete dissolution, stirring and mixing uniformly, ③ clathrating, mixing uniformly the solutions ① and ②, clathrating the cannabidiol by using a high-pressure homogenization method, concentrating under reduced pressure by using a rotary evaporator after the solution is completely dissolved, removing most of solvent and water, ④ drying, and drying the material ③ in vacuum to obtain the cannabidiol clathrate (water-soluble cannabidiol).