CN116570679A - 一种应用于糖尿病心肌损伤的降糖舒心配方 - Google Patents
一种应用于糖尿病心肌损伤的降糖舒心配方 Download PDFInfo
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- CN116570679A CN116570679A CN202310448739.8A CN202310448739A CN116570679A CN 116570679 A CN116570679 A CN 116570679A CN 202310448739 A CN202310448739 A CN 202310448739A CN 116570679 A CN116570679 A CN 116570679A
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Abstract
本发明公开了医药领域的一种应用于糖尿病心肌损伤的降糖舒心配方，包括以下重量的组成：鳖甲10‑20g、人参10‑20g、黄芪10‑20g、麦冬10‑20g、山茱萸15‑25g、生地黄10‑20g、大黄10‑20g、黄连5‑15g、丹参20‑30g、桃仁7‑17g、牡丹皮10‑20g、山药15‑25g和五味子5‑15g。本发明不仅调节心肌能量代谢和改善心肌重构，从而改善心功能，且无明显不良反应，具有较好的安全性。
Description
技术领域
本发明属于医药领域，具体是一种应用于糖尿病心肌损伤的降糖舒心配方。
背景技术
糖尿病心肌病被认为是发生于糖尿病患者且独立于冠状动脉疾病及高血压的原发性心肌损害。目前研究认为，在无心肌缺血及高血压时，糖尿病患者的心脏结构及功能改变明显，表现出心肌细胞肥大、间质纤维化、PAS阳性物质浸润、冠状小动脉基底膜增厚和心肌内微血管病变等病理特征。临床表现为左室舒张和/或收缩功能障碍，或伴有心力衰竭、心源性休克，甚至猝死。糖尿病心肌病会造成患者心脏功能下降，并最终导致严重心律失常和心衰，显著降低患者的生活质量和寿命。因此，糖尿病心肌损伤的基础研究已成为“糖尿病心脏病理学”领域的前沿和热点，有效预防和治疗糖尿病心肌损伤也是临床医疗的重要目标之一。然而，直到现在，研究者对糖尿病心肌损伤病理生理机制的了解还不是很充分，临床上也缺乏糖尿病心肌损伤防治的有效策略和措施。
目前无特效的治疗方法，可采取以下治疗措施：1、控制血糖；虽然尚不清楚严格的血糖控制是否改变糖尿病性心肌病的病程，仍应及时、有效地控制高血糖；2、降血压；治疗高血压是基本治疗措施，理想的降压药有血管紧张素转换酶抑制药、钙通道阻滞剂、α1-受体阻滞剂；3、降血脂；糖尿病患者较正常人群患高脂血症的概率高，所以有时需进行降血脂治疗；4、抗心衰治疗；5、治疗心绞痛。
虽然西药在治疗某些心肌损伤方面表现出极高的疗效，但是在实际使用时，一些西药会对患者的肝脏、肾脏等器官造成负担，还有一些西药具有毒性和依赖性，长期使用某些西药，可能会导致药物耐受性增加，使得原本有效的药物逐渐失去疗效。所以本发明提出一种应用于糖尿病心肌损伤的降糖舒心配方，以解决上述问题。
发明内容
本发明提出了一种应用于糖尿病心肌损伤的降糖舒心配方，不仅调节心肌能量代谢和改善心肌重构，从而改善心功能，且无明显不良反应，具有较好的安全性。
为了实现上述目的，本发明的技术方案如下：一种应用于糖尿病心肌损伤的降糖舒心配方，包括以下重量的组成：鳖甲10-20g、人参10-20g、黄芪10-20g、麦冬10-20g、山茱萸15-25g、生地黄10-20g、大黄10-20g、黄连5-15g、丹参20-30g、桃仁7-17g、牡丹皮10-20g、山药15-25g和五味子5-15g。
进一步，包括以下重量的组成：鳖甲10g、人参10g、黄芪10g、麦冬10g、山茱萸15、生地黄10g、大黄10g、黄连5g、丹参20g、桃仁7g、牡丹皮10g、山药15g和五味子5g。
进一步，包括以下重量的组成：鳖甲15g、人参15g、黄芪15g、麦冬15g、山茱萸20g、生地黄15g、大黄15g、黄连10g、丹参25g、桃仁12g、牡丹皮15g、山药20g和五味子10g。
进一步，包括以下重量的组成：鳖甲20g、人参20g、黄芪20g、麦冬20g、山茱萸25g、生地黄20g、大黄20g、黄连15g、丹参30g、桃仁17g、牡丹皮20g、山药25g和五味子15g。
进一步，由下列方法制成的：
步骤一：选料，并将药材的泥砂、异物精选干净，按照实施例1-4中任意一个重量称取药材；
步骤二：分别对所有药材进行研磨；
步骤三：将步骤二中研磨的药材粉末混合，搅拌均匀；
步骤四：杀菌，使用辐射杀菌对所有制备好待打包的药物进行辐射杀菌。
进一步，步骤为中的研磨药材为：将鳖甲、山茱萸、生地黄、丹参、桃仁、牡丹皮和山药，经常规水提取工艺提取，制成浸膏细粉；将人参、黄芪、麦冬、大黄、黄连和五味子分别研成细粉。
上述配方中，应用于糖尿病心肌损伤的降糖舒心的中草药各自的功效如下：
鳖甲：具有滋阴补肾、止血生肌、养颜美容和安神定志等功效，用于治疗肾阴虚、夜尿频多等症。
人参：具有益气固表、补阳壮阳、生津止渴和提神醒脑等功效，用于温补脾肺，益气固表，增强人体抗病能力。
黄芪：具有健脾补中、升阳举陷、益卫固表、利尿和托毒生肌的功效，用于治疗脾气虚证、肺气虚证、气虚自汗证、气血亏虚、疮疡难溃难腐或溃久难敛等症。
麦冬：具有养阴生津、除烦安神和润肺清心的功效，用于心阴虚有热所致的心烦、心悸怔忡等症。
山茱萸：具有补益肝肾和收敛固涩的功效，用于益肾精和助肾阳。
生地黄：具有滋阴补肾、清热除湿、养血安神和养阴润燥的功效，用于治疗失眠健忘和心悸怔忡等症。
大黄：具有泻热通肠、凉血解毒、逐瘀通经的功效，用于治疗实热积滞便秘、血热吐衄、目赤肿痛、瘀血经闭、产后瘀阻等症。
黄连：具有清热解毒、平肝清热、健胃降火和抗菌抗炎的功效，用于治疗口腔溃疡、急性肠胃、肝火旺盛和出血不止等症。
丹参：具有活血祛瘀、通经止痛、清心除烦和凉血消痈的功效，用于胸痹心痛、脘腹胁痛、症瘕积聚、热痹疼痛、心烦不眠、月经不调、痛经经闭和疮疡肿痛等症。
桃仁：具有活血祛瘀、润肠通便和止咳平喘的功效，用于经闭痛经、症瘕痞块、肺痈肠痈、跌打损伤、肠燥便秘和咳嗽气喘等症。
牡丹皮：具有清热凉血和活血化瘀的功效，用于治疗温毒发斑、吐血衄血、痈肿疮疡、经闭痛经和跌扑损伤等症。
山药：具有益气养阴、健脾益胃、补肾壮阳和改善消化功能的功效，用于治疗阴虚内热、脾虚湿盛和水肿等症。
五味子：具有收敛固涩、益气生津和补肾宁心的功能，用于治疗失眠、焦虑和咳嗽等症。
采用上述方案后实现了以下有益效果：
1、本方案中提出的应用于糖尿病心肌损伤的降糖舒心配方，其中人参、麦冬、五味子是生脉散成分，是具有滋阴、益气、生津、养心作用的名方；山茱萸、山药为左归丸的成分，具有滋肾填阴，育阴潜阳之功效；鳖甲、大黄、桃仁、牡丹皮是鳖甲煎丸的主要成分以鳖甲滋补肾阴，软坚散结消积，并清虚热，迎合消渴合并胸痹阴虚燥热、瘀毒内蕴的体质；加黄芪，配合人参益气扶正、补气生血，以达邪托毒解毒的作用；加入黄连配伍大黄清热解毒，燥湿祛浊；加人丹参配伍桃仁、牡丹皮活血散瘀。全方攻补兼施、扶正祛邪，合用共具滋阴益气、活血解毒、软坚散结消瘀的作用。
2、不仅调节心肌能量代谢和改善心肌重构，从而改善心功能，且还无明显不良反应，具有较好的安全性。
3、长时间服用本方案中提出的应用于糖尿病心肌损伤的降糖舒心配方，可以起到持久的疗效，而且可以综合调节身体的各个方面，以达到健康的目的。
附图说明
图1为本发明应用于糖尿病心肌损伤的降糖舒心配方实施例的流程图。
具体实施方式
下面详细描述本发明的实施例，所述实施例的示例在附图中示出，其中自始至终相同或类似的标号表示相同或类似的元件或具有相同或类似功能的元件。下面通过参考附图描述的实施例是示例性的，仅用于解释本发明，而不能理解为对本发明的限制。
在本发明的描述中，需要理解的是，术语“纵向”、“横向”、“竖向”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
在本发明的描述中，除非另有规定和限定，需要说明的是，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是机械连接或电连接，也可以是两个元件内部的连通，可以是直接相连，也可以通过中间媒介间接相连，对于本领域的普通技术人员而言，可以根据具体情况理解上述术语的具体含义。
下面通过具体实施方式进一步详细说明：
说明书附图中的附图标记包括：1、2、3、4、5、6、7、8、9、10。
实施例1，基本如附图1所示：一种应用于糖尿病心肌损伤的降糖舒心配方，包括以下重量的组成：鳖甲10-20g、人参10-20g、黄芪10-20g、麦冬10-20g、山茱萸15-25g、生地黄10-20g、大黄10-20g、黄连5-15g、丹参20-30g、桃仁7-17g、牡丹皮10-20g、山药15-25g和五味子5-15g。
实施例2，与上述实施例不同之处在于：包括以下重量的组成：鳖甲10g、人参10g、黄芪10g、麦冬10g、山茱萸15、生地黄10g、大黄10g、黄连5g、丹参20g、桃仁7g、牡丹皮10g、山药15g和五味子5g。
实施例3，与上述实施例不同之处在于：包括以下重量的组成：鳖甲15g、人参15g、黄芪15g、麦冬15g、山茱萸20g、生地黄15g、大黄15g、黄连10g、丹参25g、桃仁12g、牡丹皮15g、山药20g和五味子10g。
实施例4，与上述实施例不同之处在于：鳖甲20g、人参20g、黄芪20g、麦冬20g、山茱萸25g、生地黄20g、大黄20g、黄连15g、丹参30g、桃仁17g、牡丹皮20g、山药25g和五味子15g。
实施例5，与上述实施例不同之处在于：由下列方法制成的：
步骤一：选料，并将药材的泥砂、异物精选干净，按照实施例1-4中任意一个重量称取药材；
步骤二：分别对所有药材进行研磨；
步骤三：将步骤二中研磨的药材粉末混合，搅拌均匀；
步骤四：杀菌，使用辐射杀菌对所有制备好待打包的药物进行辐射杀菌。
实施例中原料的重量按照实施例1-4中任意一个进行选取。
具体实施过程如下：
步骤一：按照实施例1-4中任意一个重量称取鳖甲、人参、黄芪、麦冬、山茱萸、生地黄、大黄、黄连、丹参、桃仁、牡丹皮、山药和五味子，并将药材的泥砂、异物精选干净。
步骤二：分别对所有药材进行研磨，其中将鳖甲、山茱萸、生地黄、丹参、桃仁、牡丹皮和山药，经常规水提取工艺提取，制成浸膏细粉；将人参、黄芪、麦冬、大黄、黄连和五味子分别研成细粉。
步骤三：将步骤二中研磨的药材粉末混合，搅拌均匀；根据需要，可制成中药冲剂、颗粒剂、散剂、胶囊剂、水丸剂和片剂等剂型；
步骤四：杀菌，使用辐射杀菌对所有制备好待打包的药物进行辐射杀菌。
经临床实验，取得了较好的有益技术效果，部分临床数据如下：
1、病例选择：住院及门诊的糖尿病合并NYHA心功能分级Ⅱ～Ⅲ级糖尿病心肌损伤患者80例，按计算机产生的随机数字分为观察组和对照组，每组40例，两组性别、年龄、体质量指数(BMI)、糖尿病病程、心肌损伤病病程、心率、收缩压、舒张及心功能级别等方面的差异均无统计学意义(均P>0.05；如表1两组患者资料比较表所示)，说明两组资料均衡，有可比性。
表1两组患者资料比较表
2、治疗方法：两组患者治疗均按《中国2型糖尿病防治指南(2013年版)》控制血糖，按《扩张型心肌病诊断和治疗指南(2020)》治疗心机损伤。
对照组用药方法：服用格列喹酮(购自北京万辉双鹤药业有限责任公司)20mg，每日一次；贝那普利(购自北京诺华制药有限公司)10mg，每日一次。
观察组在常规治疗基础上加服应用于糖尿病心肌损伤的降糖舒心配方，每日1次。
疗程为2个月，治疗期间，可根据情况对其他伴发疾病给予适当处理，如合并感染进行抗感染治疗等，但禁止使用其他益气养阴、活血化瘀类中药。
3、疗效比较表：
4、结论：观察组使用本发明的配方联合常规治疗进行治疗，有效率高于对照组中使用西药治疗的有效率，对照组中的不良反应占比高于观察组，不良反应包括出现药物过敏，嗜睡、头晕、乏力等各种症状。
研究结果表明：本发明的配方联合常规治疗能降低心室充盈压，缩小形态学指标LVEDV，从而使心室分泌BNP减少，有效减轻糖尿病患者的胰岛素抵抗，控制血糖，纠正脂质代谢紊乱，调节心肌能量代谢和改善心肌重构，从而改善心功能，且无明显不良反应，具有较好的安全性。
以上所述的仅是本发明的实施例，方案中公知的具体结构和/或特性等常识在此未作过多描述。应当指出，对于本领域的技术人员来说，在不脱离本发明结构的前提下，还可以作出若干变形和改进，这些也应该视为本发明的保护范围，这些都不会影响本发明实施的效果和专利的实用性。本申请要求的保护范围应当以其权利要求的内容为准，说明书中的具体实施方式等记载可以用于解释权利要求的内容。
Claims (6)
1.一种应用于糖尿病心肌损伤的降糖舒心配方，其特征在于：包括以下重量的组成：鳖甲10-20g、人参10-20g、黄芪10-20g、麦冬10-20g、山茱萸15-25g、生地黄10-20g、大黄10-20g、黄连5-15g、丹参20-30g、桃仁7-17g、牡丹皮10-20g、山药15-25g和五味子5-15g。
2.根据权利要求1所述的应用于糖尿病心肌损伤的降糖舒心配方，其特征在于：包括以下重量的组成：鳖甲10g、人参10g、黄芪10g、麦冬10g、山茱萸15、生地黄10g、大黄10g、黄连5g、丹参20g、桃仁7g、牡丹皮10g、山药15g和五味子5g。
3.根据权利要求2所述的应用于糖尿病心肌损伤的降糖舒心配方，其特征在于：包括以下重量的组成：鳖甲15g、人参15g、黄芪15g、麦冬15g、山茱萸20g、生地黄15g、大黄15g、黄连10g、丹参25g、桃仁12g、牡丹皮15g、山药20g和五味子10g。
4.根据权利要求3所述的应用于糖尿病心肌损伤的降糖舒心配方，其特征在于：括以下重量的组成：鳖甲20g、人参20g、黄芪20g、麦冬20g、山茱萸25g、生地黄20g、大黄20g、黄连15g、丹参30g、桃仁17g、牡丹皮20g、山药25g和五味子15g。
5.根据权利要求4所述的应用于糖尿病心肌损伤的降糖舒心配方，其特征在于：由下列方法制成的：
步骤一：选料，并将药材的泥砂、异物精选干净，按照实施例1-4中任意一个重量称取药材；
步骤二：分别对所有药材进行研磨；
步骤三：将步骤二中研磨的药材粉末混合，搅拌均匀；
步骤四：杀菌，使用辐射杀菌对所有制备好待打包的药物进行辐射杀菌。
6.根据权利要求5所述的应用于糖尿病心肌损伤的降糖舒心配方，其特征在于：步骤为中的研磨药材为：将鳖甲、山茱萸、生地黄、丹参、桃仁、牡丹皮和山药，经常规水提取工艺提取，制成浸膏细粉；将人参、黄芪、麦冬、大黄、黄连和五味子分别研成细粉。
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| CN101091765A (zh) * | 2007-06-08 | 2007-12-26 | 余仁生国际有限公司 | 药物组合物及其预防和治疗糖尿病的用途 |
| CN102225149A (zh) * | 2007-07-27 | 2011-10-26 | 北京亚东生物制药有限公司 | 一种治疗糖尿病的中药组合物及其制备方法 |
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| CN102225149A (zh) * | 2007-07-27 | 2011-10-26 | 北京亚东生物制药有限公司 | 一种治疗糖尿病的中药组合物及其制备方法 |
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