CN116549612A - Antibacterial composition containing plant stem cell factor and preparation method thereof - Google Patents

Antibacterial composition containing plant stem cell factor and preparation method thereof Download PDF

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Publication number
CN116549612A
CN116549612A CN202310535092.2A CN202310535092A CN116549612A CN 116549612 A CN116549612 A CN 116549612A CN 202310535092 A CN202310535092 A CN 202310535092A CN 116549612 A CN116549612 A CN 116549612A
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stem cell
plant stem
cell factor
extract
ginseng
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杨栩楷
杨尚鹉
欧文
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Fanghua International Holdings Guangdong Co ltd
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Fanghua International Holdings Guangdong Co ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract

The invention belongs to the technical field of preparation of antibacterial compositions containing plant stem cell factors, and discloses an antibacterial composition containing plant stem cell factors and a preparation method thereof. The composition can be used for sterilizing and inhibiting the growth of various bacteria, has various effects of moisturizing, repairing, resisting oxidation and the like, and can treat various bacterial infections, and the composition has better biocompatibility and safety because the composition is prepared from natural plant extracts/derivatives.

Description

Antibacterial composition containing plant stem cell factor and preparation method thereof
Technical Field
The invention belongs to the technical field of preparation of antibacterial compositions containing plant stem cell factors, and particularly relates to an antibacterial composition containing plant stem cell factors and a preparation method thereof.
Background
The stem cell factor is a signal protein which can stimulate cell proliferation and differentiation, has the function of promoting cell regeneration and repair, has wide application prospect in the medical and cosmetic fields, is a common and serious problem in the medical and sanitary fields, is widely applied to the medical and sanitary fields, has strong drug resistance aiming at partial bacteria although a plurality of antibiotics are used for treating the bacterial infection, and gradually weakens the antibacterial effect of the antibiotics, and meanwhile, the traditional antibiotic treatment has strong pertinence, can cause the drug resistance and other side effects of the antibiotics, has poor treatment and moisturizing effects, so that a natural antibacterial agent which has a broad-spectrum antibacterial effect and can simultaneously achieve various repairing and moisturizing effects has important clinical application value, and therefore, the antibacterial composition containing the plant stem cell factor and the preparation method thereof are provided.
Disclosure of Invention
The invention aims to provide a bacteriostatic composition containing plant stem cell factors and a preparation method thereof, which are used for solving the problems in the background technology.
In order to achieve the above object, the present invention provides the following technical solutions:
a bacteriostatic composition containing plant stem cell factors, which comprises the following components:
(1) Ginseng plant stem cell factor;
(2) One or more antimicrobial agents;
(3) Positively charged plant extracts/derivatives;
(4) A natural humectant;
(5) A biologically active substance;
(6) One or more auxiliary materials.
Preferably, the ginseng plant stem cell factor is ginsenoside, and the ginseng plant stem cell factor obtained by extracting, purifying and drying ginseng has antibacterial, antiviral and antitumor biological activities.
Preferably, the antibacterial agent may be selected from one or more of berberine, dencichine, lonicera japonica extract, pachyman, rehmanniae radix Preparata glycoside, cortex Mori extract, and Echinacoside,
(1) Berberine is extracted from Coptidis rhizoma as main ingredient;
(2) Dencichine is a main component extracted from Notoginseng radix:
(3) The honeysuckle extract is extracted from flos Lonicerae;
(4) Pachyman is the main ingredient extracted from Poria;
(5) The prepared rehmannia root glycoside is extracted from the main component of prepared rehmannia root;
(6) The cortex Mori extract is prepared from cortex Mori:
(7) Echinacoside is the main ingredient extracted from Echinacoside,
the berberine, the sanchinin, the honeysuckle extract, the pachyman, the prepared rehmannia root glycoside, the sanguisorba officinalis extract and the echinacoside have broad-spectrum antibacterial, antiviral and antitumor biological activities, and the berberine and the honeysuckle extract also have good inhibition effects on intestinal pathogens and respiratory pathogens.
Preferably, the natural humectant is one or more of hyaluronic acid, glycerol, natural plant essence, squalane and the like, and the bioactive substances are one or more of vitamin E, collagen, honey and the like.
Preferably, the auxiliary material is one or more substances selected from the following compositions:
(1) The buffer comprises the components of the baical skullcap root extract, the lightyellow sophora root extract and the white paeony root extract, has the functions of clearing heat and detoxicating, diminishing inflammation and easing pain, resisting bacteria and resisting viruses, and can effectively relieve symptoms such as gastrointestinal inflammation, ulcer and the like;
(2) The auxiliary agent comprises polymer and solvent;
(3) Other auxiliary materials include antioxidants and preservatives.
Preferably, the plant extract/derivative comprises extract/derivative of one or more plants selected from radix Ophiopogonis, glycyrrhrizae radix, radix Platycodi, folium Mori, flos Chrysanthemi, mume fructus and flos Lonicerae, and the positive charge of the plant extract/derivative is achieved by: the plant extracts/derivatives are subjected to a plasma chemical reaction in a plasma reactor and then spread on a negatively charged wafer substrate to attract positive charges to chelate with the plant extracts/derivatives and to wick away negative charges through the positively charged wafer substrate disposed in the opposite direction.
The preparation method of the antibacterial composition containing the plant stem cell factor comprises the following steps:
s1: firstly, ginseng is taken, water is added, distillation and extraction are carried out under the conditions of the temperature of 65 ℃ to 75 ℃ and the vacuum degree of 0.06Mpa to 0.07Mpa, when the volume of distillate is half of the water adding amount, distillation is stopped, and collection is carried out, and at the moment, a first distillate can be obtained;
s2: continuously adding water into the rest feed liquid, then distilling and extracting at 70-80 ℃ and 0.05-0.06 Mpa, stopping distillation when the volume of the distillate is half of the water adding amount, and collecting, wherein a second distillate can be obtained;
s3: mixing the first distillate and the second distillate obtained in the step S1, and obtaining an extract containing the ginseng plant stem cell factor;
s4: the extract containing the ginseng plant stem cell factor is purified by adopting an ethanol fractional precipitation method, and the precipitation amounts are respectively 1.68%, 1.37%, 3.47%, 41.70%, 15.26%, 7.25%, 4.71% and 3.13%, the precipitation I is detected to the precipitation 8 by HPLC, and the detection result shows that the proportion of the main peak of the precipitation component is gradually increased along with the increase of the ethanol addition amount, and the proportion of the main peak of the precipitation component is increased from 72.3% of the precipitation 1 to 96.6% of the precipitation 8. The purity of the sediment 5 to the sediment 8 is above 96 percent, and the molecular mass is about 1800D, which can be regarded as the same substance, and then the substances are combined, and the purified substance containing the ginseng plant stem cell factor can be obtained at the moment;
s5: mixing the purified ginseng plant stem cell factor-containing material with one or more antimicrobial agents, and then obtaining a primary ginseng plant stem cell factor-containing mixture;
s6: preparing extracts/derivatives of one or more plants selected from radix Ophiopogonis, glycyrrhrizae radix, radix Platycodi, folium Mori, flos Chrysanthemi, mume fructus and flos Lonicerae, treating the extracts/derivatives in a plasma reactor for 0-24 hr for plasma chemical reaction, spreading on negatively charged wafer substrate to attract positive charges to chelate with the extracts/derivatives, sucking negative charges away via positively charged wafer substrate arranged in opposite direction to obtain positively charged extracts/derivatives, and mixing the positively charged extracts/derivatives with primary mixture containing Ginseng plant stem cell factor to obtain secondary mixture containing Ginseng plant stem cell factor;
s7: mixing the secondary mixture containing the ginseng plant stem cell factor with one or more natural moisturizers and bioactive substances, and then obtaining a tertiary mixture containing the ginseng plant stem cell factor;
s8: adding one or more auxiliary materials into the tertiary mixture containing the ginseng plant stem cell factor, and mixing to prepare the antibacterial composition containing the ginseng plant stem cell factor.
Preferably, in the preparation method S5, S6 and S8 steps of the bacteriostatic composition: the total mass percentage of the antibacterial agent is 0.1 to 10 percent; the concentration of the positively charged plant extract/derivative ranges from 0.0001mg/ml to 100mg/ml, and the total mass percentage of the auxiliary material is 90% to 99.9%.
Preferably, the ratio of the antibacterial agent, the natural humectant and the bioactive substances mixed in the steps S5 and S7 of the preparation method of the antibacterial composition is 3:1:1.
Preferably, the antibacterial composition containing plant stem cell factor in the preparation method S8 can be prepared into oral medicines of 0.1 to 10 g, external medicines of 0.5 to 5 g and injections of 0.05 to 1 g.
The beneficial effects of the invention are as follows:
1. the invention obtains a purified product containing the purified ginseng plant stem cell factor by extracting the ginseng plant stem cell factor and then purifying the extract, then mixes the purified ginseng plant stem cell factor with one or more antibacterial agents to obtain a primary mixture, then mixes the primary mixture with positively charged plant extracts/derivatives to obtain a secondary mixture, then mixes the secondary mixture with one or more natural moisturizing agents and bioactive substances to obtain a tertiary mixture containing the ginseng plant stem cell factor, finally adds one or more auxiliary materials into the tertiary mixture, thereby preparing a bacteriostatic composition containing the ginseng plant stem cell factor, wherein the positively charged plant extracts/derivatives can enable the bacteriostatic composition to contain stable positive charges, and the positive charges in the bacteriostatic composition can absorb viruses when in use due to the negatively charged areas on the surfaces of the viruses, so that the viral envelopes can be broken down and the viral structures can be destroyed, and the antibacterial agents in the bacteriostatic composition are combined, so that the effects of killing and inhibiting the growth of various bacteria can be achieved, meanwhile, the bacteriostatic composition has the effects of moisturizing, repairing and antioxidation effects and the like can be used for treating various infections, and the natural and/or the like can be prepared with the natural and safe and compatible bacteriostasis composition.
Drawings
FIG. 1 is a bar graph of the fractional precipitation of a plant stem cell extract of the present invention.
Description of the embodiments
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Examples
The embodiment of the invention provides a bacteriostatic composition containing plant stem cell factors, which comprises the following components:
(1) Ginseng plant stem cell factor;
(2) One or more antimicrobial agents;
(3) Positively charged plant extracts/derivatives;
(4) A natural humectant;
(5) A biologically active substance;
(6) One or more auxiliary materials.
In one embodiment, the ginseng plant stem cell factor is ginsenoside, and the ginseng plant stem cell factor obtained by extracting, purifying and drying ginseng has antibacterial, antiviral and antitumor biological activities.
In one embodiment, the antimicrobial agent may be selected from one or more of berberine, dencichine, lonicera japonica essence, pachyman, rehmanniae radix Preparata glycoside, kaempferide, and Echinacoside,
(1) Berberine is extracted from Coptidis rhizoma as main ingredient;
(2) Dencichine is a main component extracted from Notoginseng radix:
(3) The honeysuckle extract is extracted from flos Lonicerae;
(4) Pachyman is the main ingredient extracted from Poria;
(5) The prepared rehmannia root glycoside is extracted from the main component of prepared rehmannia root;
(6) The cortex Mori extract is prepared from cortex Mori:
(7) Echinacoside is the main ingredient extracted from Echinacoside,
berberine, sanchinin, lonicera japonica extract, pachyman, prepared rehmannia root glycoside, sanguisorba officinalis extract and echinacoside have broad-spectrum antibacterial, antiviral and antitumor biological activities, and berberine and lonicera japonica extract also have good inhibition effects on intestinal pathogens and respiratory pathogens.
In one embodiment, the natural humectant is one or more of hyaluronic acid, glycerol, natural plant essence, squalane, etc., and the bioactive substance is one or more of vitamin E, collagen, mel, etc.
In one embodiment, the auxiliary material is one or more substances selected from the following compositions:
(1) The buffer comprises the components of the baical skullcap root extract, the lightyellow sophora root extract and the white paeony root extract, has the functions of clearing heat and detoxicating, diminishing inflammation and easing pain, resisting bacteria and resisting viruses, and can effectively relieve symptoms such as gastrointestinal inflammation, ulcer and the like;
(2) The auxiliary agent comprises polymer and solvent;
(3) Other auxiliary materials include antioxidants and preservatives.
In one embodiment, the plant extract/derivative comprises extract/derivative of one or more plants selected from radix Ophiopogonis, glycyrrhrizae radix, radix Platycodi, folium Mori, flos Chrysanthemi, mume fructus, and flos Lonicerae, and the positive charge of the plant extract/derivative is achieved by: the plant extracts/derivatives are subjected to a plasma chemical reaction in a plasma reactor and then spread on a negatively charged wafer substrate to attract positive charges to chelate with the plant extracts/derivatives and to wick away negative charges through the positively charged wafer substrate disposed in the opposite direction.
Example 2: the preparation method of the antibacterial composition containing the plant stem cell factor comprises the following steps:
s1: firstly, ginseng is taken, water is added, distillation and extraction are carried out under the conditions of the temperature of 65 ℃ to 75 ℃ and the vacuum degree of 0.06Mpa to 0.07Mpa, when the volume of distillate is half of the water adding amount, distillation is stopped, and collection is carried out, and at the moment, a first distillate can be obtained;
s2: continuously adding water into the rest feed liquid, then distilling and extracting at 70-80 ℃ and 0.05-0.06 Mpa, stopping distillation when the volume of the distillate is half of the water adding amount, and collecting, wherein a second distillate can be obtained;
s3: mixing the first distillate and the second distillate obtained in the step S1, and obtaining an extract containing the ginseng plant stem cell factor;
s4: the extract containing the ginseng plant stem cell factor is purified by adopting an ethanol fractional precipitation method, and the precipitation amounts are respectively 1.68%, 1.37%, 3.47%, 41.70%, 15.26%, 7.25%, 4.71% and 3.13%, the precipitation I is detected to the precipitation 8 by HPLC, and the detection result shows that the proportion of the main peak of the precipitation component is gradually increased along with the increase of the ethanol addition amount, and the proportion of the main peak of the precipitation component is increased from 72.3% of the precipitation 1 to 96.6% of the precipitation 8. The purity of the sediment 5 to the sediment 8 is above 96 percent, and the molecular mass is about 1800D, which can be regarded as the same substance, and then the substances are combined, and the purified substance containing the ginseng plant stem cell factor can be obtained at the moment;
s5: mixing the purified ginseng plant stem cell factor-containing material with one or more antimicrobial agents, and then obtaining a primary ginseng plant stem cell factor-containing mixture;
s6: preparing extracts/derivatives of one or more plants selected from radix Ophiopogonis, glycyrrhrizae radix, radix Platycodi, folium Mori, flos Chrysanthemi, mume fructus and flos Lonicerae, treating the extracts/derivatives in a plasma reactor for 0-24 hr for plasma chemical reaction, spreading on negatively charged wafer substrate to attract positive charges to chelate with the extracts/derivatives, sucking negative charges away via positively charged wafer substrate arranged in opposite direction to obtain positively charged extracts/derivatives, and mixing the positively charged extracts/derivatives with primary mixture containing Ginseng plant stem cell factor to obtain secondary mixture containing Ginseng plant stem cell factor;
s7: mixing the secondary mixture containing the ginseng plant stem cell factor with one or more natural moisturizers and bioactive substances, and then obtaining a tertiary mixture containing the ginseng plant stem cell factor;
s8: adding one or more auxiliary materials into the tertiary mixture containing the ginseng plant stem cell factor, and mixing to prepare the antibacterial composition containing the ginseng plant stem cell factor.
In one embodiment, the preparation method of the bacteriostatic composition comprises the steps of S5, S6 and S8: the total mass percentage of the antibacterial agent is 0.1 to 10 percent; the concentration of the positively charged plant extract/derivative ranges from 0.0001mg/ml to 100mg/ml, and the total mass percentage of the auxiliary material is 90% to 99.9%.
In one embodiment, the ratio of the antimicrobial agent, the natural humectant and the bioactive substances mixed in steps S5 and S7 of the preparation method of the bacteriostatic composition is 3:1:1.
In one embodiment, the antibacterial composition containing plant stem cell factor in the preparation method S8 of the antibacterial composition can be prepared into oral medicines of 0.1 to 10 g, external medicines of 0.5 to 5 g and injections of 0.05 to 1 g.
In one embodiment, the bacteriostatic composition comprising plant stem cell factor in step S8 of the preparation method of the bacteriostatic composition can be used for treating various bacterial infections including, but not limited to, pneumococcal infection, escherichia coli infection, staphylococcus aureus infection, streptococcus infection.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (10)

1. A bacteriostatic composition containing plant stem cell factor, which is characterized in that: the plant stem cell factor-containing antibacterial composition comprises ginseng plant stem cell factor, one or more antibacterial agents, positively charged plant extracts/derivatives, natural moisturizers, bioactive substances and one or more auxiliary materials.
2. A bacteriostatic composition according to claim 1, comprising plant stem cell factor, characterized in that: the ginseng plant stem cell factor is ginsenoside, and the ginseng plant stem cell factor obtained by extracting, purifying and drying ginseng has the biological activities of resisting bacteria, viruses and tumors.
3. A bacteriostatic composition according to claim 1, comprising plant stem cell factor, characterized in that: the antibacterial agent can be selected from berberine, dencichine, lonicera extract, pachymaran, radix rehmanniae Preparata glycoside, cortex Mori extract, and Echinacea glycoside,
the berberine is a main component extracted from rhizoma Coptidis;
the dencichine is a main component extracted from pseudo-ginseng:
the honeysuckle extract is a main component extracted from honeysuckle;
the pachyman is the main component extracted from Poria cocos;
the prepared rehmannia root glycoside is a main component extracted from prepared rehmannia root;
the cortex Mori extract is prepared from cortex Mori:
the Echinacoside is the main component extracted from Echinacoside,
the berberine, the sanchinin, the honeysuckle extract, the pachyman, the prepared rehmannia root glycoside, the sanguisorba officinalis extract and the echinacoside have broad-spectrum antibacterial, antiviral and antitumor biological activities, and the berberine and the honeysuckle extract also have good inhibition effects on intestinal pathogens and respiratory pathogens.
4. A bacteriostatic composition according to claim 1, comprising plant stem cell factor, characterized in that: the natural humectant is one or more of hyaluronic acid, glycerol, natural plant essence, squalane, etc., and the bioactive substances are one or more of vitamin E, collagen, mel, etc.
5. A bacteriostatic composition according to claim 1, comprising plant stem cell factor, characterized in that: the auxiliary material may be selected to constitute one or more of a buffer and an auxiliary agent,
the components of the buffer are radix scutellariae extract, radix sophorae flavescentis extract and radix paeoniae alba extract, and the buffer has the effects of clearing heat and detoxicating, diminishing inflammation and easing pain, resisting bacteria and resisting viruses and can effectively relieve symptoms such as gastrointestinal inflammation and ulcer;
the auxiliary agent comprises a polymer and a solvent.
6. A bacteriostatic composition according to claim 1, comprising plant stem cell factor, characterized in that: the plant extract/derivative comprises extracts/derivatives of one or more plants selected from dwarf lilyturf tuber, liquorice, platycodon root, mulberry leaf, chrysanthemum, dark plum fruit and double flowers, and the positive charge of the plant extract/derivative is realized by the following steps: the plant extracts/derivatives are subjected to a plasma chemical reaction in a plasma reactor and then spread on a negatively charged wafer substrate to attract positive charges to chelate with the plant extracts/derivatives and to wick away negative charges through the positively charged wafer substrate disposed in the opposite direction.
7. A process for preparing a bacteriostatic composition comprising a plant stem cell factor according to claims 1-6, characterized in that:
s1: firstly, ginseng is taken, water is added, distillation and extraction are carried out under the conditions of the temperature of 65 ℃ to 75 ℃ and the vacuum degree of 0.06Mpa to 0.07Mpa, when the volume of distillate is half of the water adding amount, distillation is stopped, and collection is carried out, and at the moment, a first distillate can be obtained;
s2: continuously adding water into the rest feed liquid, then distilling and extracting at 70-80 ℃ and 0.05-0.06 Mpa, stopping distillation when the volume of the distillate is half of the water adding amount, and collecting, wherein a second distillate can be obtained;
s3: mixing the first distillate and the second distillate obtained in the step S1, and obtaining an extract containing the ginseng plant stem cell factor;
s4: the extract containing the ginseng plant stem cell factor is purified by adopting an ethanol fractional precipitation method, and the precipitation amounts are respectively 1.68%, 1.37%, 3.47%, 41.70%, 15.26%, 7.25%, 4.71% and 3.13%, the precipitation I is detected to the precipitation 8 by HPLC, and the detection result shows that the proportion of the main peak of the precipitation component is gradually increased along with the increase of the ethanol addition amount, and the proportion of the main peak of the precipitation component is increased from 72.3% of the precipitation 1 to 96.6% of the precipitation 8. The purity of the sediment 5 to the sediment 8 is above 96 percent, and the molecular mass is about 1800D, which can be regarded as the same substance, and then the substances are combined, and the purified substance containing the ginseng plant stem cell factor can be obtained at the moment;
s5: mixing the purified ginseng plant stem cell factor-containing material with one or more antimicrobial agents, and then obtaining a primary ginseng plant stem cell factor-containing mixture;
s6: preparing extracts/derivatives of one or more plants selected from radix Ophiopogonis, glycyrrhrizae radix, radix Platycodi, folium Mori, flos Chrysanthemi, mume fructus and flos Lonicerae, treating the extracts/derivatives in a plasma reactor for 0-24 hr for plasma chemical reaction, spreading on negatively charged wafer substrate to attract positive charges to chelate with the extracts/derivatives, sucking negative charges away via positively charged wafer substrate arranged in opposite direction to obtain positively charged extracts/derivatives, and mixing the positively charged extracts/derivatives with primary mixture containing Ginseng plant stem cell factor to obtain secondary mixture containing Ginseng plant stem cell factor;
s7: mixing the secondary mixture containing the ginseng plant stem cell factor with one or more natural moisturizers and bioactive substances, and then obtaining a tertiary mixture containing the ginseng plant stem cell factor;
s8: adding one or more auxiliary materials into the tertiary mixture containing the ginseng plant stem cell factor, and mixing to prepare the antibacterial composition containing the ginseng plant stem cell factor.
8. The method for preparing a bacteriostatic composition containing plant stem cell factors according to claim 6, which is characterized in that: the preparation method of the antibacterial composition comprises the steps of S5, S6 and S8: the total mass percentage of the antibacterial agent is 0.1 to 10 percent; the concentration of the positively charged plant extract/derivative ranges from 0.0001mg/ml to 100mg/ml, and the total mass percentage of the auxiliary material is 90% to 99.9%.
9. The method for preparing a bacteriostatic composition containing plant stem cell factors according to claim 6, which is characterized in that: the ratio of the antibacterial agent, the natural humectant and the bioactive substances mixed in the steps S5 and S7 of the preparation method of the antibacterial composition is 3:1:1.
10. The method for preparing a bacteriostatic composition containing plant stem cell factors according to claim 7, which is characterized in that: the antibacterial composition containing the plant stem cell factor in the step S8 of the preparation method of the antibacterial composition can be prepared into oral medicines of 0.1 to 10 g, external medicines of 0.5 to 5 g and injections of 0.05 to 1 g.
CN202310535092.2A 2023-05-12 2023-05-12 Antibacterial composition containing plant stem cell factor and preparation method thereof Pending CN116549612A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117100679A (en) * 2023-10-07 2023-11-24 佰东靶向(深圳)生物科技有限公司 Plant stem cell factor and preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117100679A (en) * 2023-10-07 2023-11-24 佰东靶向(深圳)生物科技有限公司 Plant stem cell factor and preparation method and application thereof

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