CN107397858B - One kind treats dermopathic externally applied drug and preparation method - Google Patents

One kind treats dermopathic externally applied drug and preparation method Download PDF

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CN107397858B
CN107397858B CN201710724884.9A CN201710724884A CN107397858B CN 107397858 B CN107397858 B CN 107397858B CN 201710724884 A CN201710724884 A CN 201710724884A CN 107397858 B CN107397858 B CN 107397858B
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钟南京生
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Changting Hi Tech Biological Technology Co Ltd
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
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    • AHUMAN NECESSITIES
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/20Aceraceae (Maple family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/33Cactaceae (Cactus family), e.g. pricklypear or Cereus
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses one kind to treat dermopathic externally applied drug and preparation method, belongs to the field of Chinese medicines, and the raw material composition of medicine of the present invention is:Maple leaves, maple root, kyllinga brevifolia, radix boehmeriae, broomwort, fresh cactus, fresh needles;Medicinal material compatibility is suitable selected by medicine of the present invention, meets traditional Chinese medicine and pharmacy theory, and with dispelling wind and eliminating dampness, the effect of promoting qi circulation and relieving pain, desinsection be antipruritic, solution taking poison and growing muscle due, swelling and pain relieving, clearing heat and promoting diuresis;There is significant curative effect to treatment eczema, skin tinea, skin tinea concurrent bacterial infectious disease, cure rate is high, and recurrence rate is extremely low;And there is the effect of fine to treatment neurodermatitis, suppurative dermatosis, rhinitis, tympanitis, lip bubble rash;To burning, scalding, wound etc. there is the effect of anti-inflammatory analgetic, prevent to fester, quickly heal.

Description

One kind treats dermopathic externally applied drug and preparation method
Technical field
The present invention relates to one kind to treat dermopathic externally applied drug and preparation method, belongs to the technical field of Chinese medicine.
Background technology
Eczema external curing Western medicine is now more based on hormone, antibiotic formulations;Skin tinea external curing Western medicine is now more with anti- Based on fungi medicine, side effect is big, curative effect is general, easily recurrence.With present doctor trained in Western medicine theory using Western medicine external curing eczema, skin Tinea, it is necessary to separately with different drug therapies, it is important to which the symptom of eczema is similar to the symptom of skin tinea, if judging and differentiating Error, can be difficult to cure.When skin tinea concurrent bacterial infects, using Western medicine external curing, should anti-bacterial therapies first, only , just can be with antifungal therapy after bacterium infection control.Diagnosed using western medicine eczema and skin tinea with differentiating that difficult, program is multiple It is miscellaneous, curative effect is general, side effect is big.
In addition, also there is the externally applied drug of some treatment eczemas etc. at present, CN1280853A discloses a kind of Baicao skin lotion, should Medicine include redleaf litse root, tangerine tree root, teak root, tangerine tree root, kudzu, Chinese fir twig, pine branch, pine and cypress branch, Chinese toon branch, maple branch, Willow leaf, taro sesame slices, honeysuckle, kyllinga brevifolia, centipede, the centipede that passes by one's way, climb root grass and snake crow, the medicine have treatment pin The skin disease such as gas, psoriasis, psoriasis, eczema, CN105079635A disclose a kind of infantile eczema moisturizing ointment, the ointment by Following crude drug in whole composition:Honeysuckle, Radix Angelicae Sinensis, folium artemisiae argyi, Herba Andrographitis, cordate houttuynia, purslane, cactus, gingko, Radix Isatidis, a thousand li Light, smilax, cicada slough, chrysanthemum indicum, kuh-seng, the tuber of stemona and the fruit of summer cypress, the medicine can solve the problem that the eczema problem of baby, treatment effect Fruit is notable, and recurrence rate is low, but the complicated component of above-mentioned externally applied drug, and many price of medicinal materials are expensive, and natural resources are rare, raw material It is difficult to ensure that matter must be measured, adds cost of manufacture and final product quality risk.The content of the invention
In order to solve the above mentioned problem present in prior art, the present invention is discussed using outside Chinese herbal and crude drugs preparations with traditional Chinese medical science pharmacology It not differentiate separated, Classification treatment with treatment eczema, skin tinea, skin tinea concurrent bacterial infectious disease, can synchronously be cured with medicine, easily Diagnosis, good effect, cure rate is up to 99%, and recurrence rate is extremely low, and the lighter's medication 1 week, severe one medication can fully recover for 2-5 weeks, this Outside, the price of medicinal material that uses is cheap in the present invention, prescription compatibility is simple, abundant in natural resources, convenient material drawing, reduces and is fabricated to This, and finished product can guarantee both quality and quantity.
Technical scheme is as follows:
One kind treats dermopathic externally applied drug, is made by following medicinal material:
Maple leaves;
Maple root;
Kyllinga brevifolia;
Broomwort;
Radix boehmeriae;
Fresh cactus;With
Fresh needles.
Further, the described dermopathic externally applied drug for the treatment of includes the medicinal material of following parts by weight:2 parts -23 parts of maple leaves, 1 part -16 parts of maple root, 1 part -18 parts of kyllinga brevifolia, 0.5 part -16 parts of broomwort, 0.5 part -35 parts of radix boehmeriae, fresh cactus 2 2 parts -23 parts of -16 parts of part and fresh needles.
Further, the described dermopathic externally applied drug for the treatment of includes the medicinal material of following parts by weight:5 parts -20 parts of maple leaves, 4 parts -14 parts of maple root, 6 parts -16 parts of kyllinga brevifolia, 3 parts -13 parts of broomwort, 2 parts -30 parts of radix boehmeriae, 4 part -13 of fresh cactus 5 parts -20 parts of part and fresh needles.
Further, the described dermopathic externally applied drug for the treatment of includes the medicinal material of following parts by weight:18 parts of maple leaves, maple 15 parts of 12 parts of root, 15 parts of kyllinga brevifolia, 10 parts of broomwort, 18 parts of radix boehmeriae, 12 parts of fresh cactus and fresh needles.
Present invention additionally comprises a kind of preparation method that dermopathic externally applied drug is treated using above-mentioned parts by weight medicinal material, including such as Lower step:
(1) maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, add the 1-10 times of purified water measured, Boil and allow 30 parts -70 parts of water evaporation, obtain extract solution;Then the filter residue after extraction is added into purified water, boils and allow water evaporation 30 parts -70 parts, obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2) radix boehmeriae is cleaned to smash and be put into container, add 2-5 times of dimethyl sulfoxide (DMSO), sealing immersion 24-54 hours Afterwards, extract, obtain radix boehmeriae extract solution;
(3) fresh cactus and fresh needles are cleaned and are put into container, smash centrifuging and taking and obtain juice, filter off removal of impurities Matter, it is standby to obtain juice;
(4) solution obtained by step (1) and step (2) is mixed, boil to when thering is the grease to emerge surface, stopping plus Heat, after thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5) solution obtained by step (3) and step (4) is mixed and stirred for uniformly, producing the dermopathic external application for the treatment of Medicine.
Present invention additionally comprises a kind of application for treating dermopathic externally applied drug, the dermopathic externally applied drug of described treatment is being made Application in standby treatment eczema, skin tinea, skin tinea concurrent bacterial infection disease drug.
The present invention has the advantages that:
The present invention is theoretical concurrently thin using Chinese herbal and crude drugs preparations external curing eczema, skin tinea, skin tinea with traditional Chinese medical science pharmacology Bacterium infectious disease not differentiate separate, Classification treatment, can with medicine synchronously cure, easily diagnosis, treat, cure rate height, the lighter's medication 1 Week, severe one medication can be fully recovered for 2-5 weeks, and treatment neurodermatitis, suppurative dermatosis, rhinitis, tympanitis, lip are steeped Rash has the effect of fine;To burning, scalding, wound etc. there is the effect of anti-inflammatory analgetic, prevent to fester, quickly heal;In addition, this Invention is followed the example of using Chinese medicine conventional preparation techniques (boiling, fresh squeezing) and alembroth dimethyl sulfoxide (DMSO) bubble, can obtain Chinese medicine comprehensively Composition, curative effect is prominent, stably, do not produce resistance.Row are such as:Ground dysentery is popular in China in 1958, and the coptis is highly effective simply Medicine, because stock was limited at that time, dosage uprush causes for the moment it is out of stock.State Council then requires to treat dysentery from other traditional Chinese medicine extractions The active ingredient berberine of disease, for clinic, treatment dysentery effect is all fine within 1 or three years.However, again with Huang after 1961 Even extract for treating dysentery is nearly unavailable, because shigella dysenteriae generates drug resistance, and is continuing with coptis treatment dysentery effect It is still fine;So the present invention can obtain traditional Chinese medicine ingredients comprehensively, the active ingredient of prodrug complex can effectively treat healing in Eczema, skin tinea, skin tinea concurrent bacterial infectious disease, and do not produce drug resistance.
Embodiment
It is several embodiments of the present invention below, further illustrates the present invention, but the present invention is not limited only to this.
The property of medicine of Chinese herbal medicine used in the present invention is as follows:
Maple leaves:It is bitter, flat;Dispelling wind and eliminating dampness, promoting qi circulation and relieving pain, desinsection is antipruritic, solves taking poison and growing muscle due;For enteritis, dysentery, stomachache; Poisonous wasp sting, skin eczema are controlled in external application;
Maple root:Bitter, temperature;Wind-expelling pain-stopping, for rheumatic arthralgia, toothache;
Kyllinga brevifolia:It is pungent, flat;Scattered wind dehumidifying, subdhing swelling and detoxicating, desinsection are antipruritic;
Broomwort:It is sweet, cool in nature;Clearing heat and promoting diuresis, dispelling wind cough-relieving.Cure mainly cold, fever, cough with lung heat, abscess of throat, small Just unfavorable, tinea pedis oedema, eczema, prickly heat;
Radix boehmeriae:It is cold in nature, sweet;Clearing heat and promoting diuresis, removing toxicity for detumescence, cooling blood and hemostasis, insecticidal power are strong, wherein, ramie has two kinds, A kind of is draft, and selected by the present invention is undershrub, has stickiness;
Fresh cactus:Cold in nature, bitter;Swelling and pain relieving, the promoting flow of qi and blood circulation, clearing heat and detoxicating, apocenosis myogenic;
Fresh needles:It is warm-natured, bitter, sour;Dispel pathogenic wind and remove dampness, desinsection is antipruritic, blood activating and promoting tissue regeneration.
Embodiment one:
One kind treats dermopathic externally applied drug, includes the medicinal material of following parts by weight:7 parts of maple leaves, 5 parts of maple root, water Wu 5 parts of 7 parts of centipede, 3 parts of broomwort, 8 parts of radix boehmeriae, 6 parts of fresh cactus and fresh needles.
The preparation method of dermopathic externally applied drug is treated using above-mentioned parts by weight medicinal material, is comprised the following steps:
(1) maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, add the purified water of 10 times of amounts, boil Boiling allows 50 parts of water evaporation, obtains extract solution;Then the filter residue after extraction is added into purified water, boils and allow 50 parts of water evaporation, obtain Obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2) radix boehmeriae is cleaned to smash and be put into container, add 3.5 times of dimethyl sulfoxide (DMSO), after sealing is soaked 48 hours, Extraction, obtain radix boehmeriae extract solution;
(3) fresh cactus and fresh needles are cleaned and are put into container, smash centrifuging and taking and obtain juice, filter off removal of impurities Matter, it is standby to obtain juice;
(4) solution obtained by step (1) and step (2) is mixed, boil to when thering is the grease to emerge surface, stopping plus Heat, after thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5) solution obtained by step (3) and step (4) is mixed and stirred for uniformly, producing the dermopathic external application for the treatment of Medicine.
Embodiment two:
One kind treats dermopathic externally applied drug, includes the medicinal material of following parts by weight:16 parts of maple leaves, 10 parts of maple root, water 12 parts of 13 parts of centipede, 7 parts of broomwort, 17 parts of radix boehmeriae, 10 parts of fresh cactus and fresh needles.
The preparation method of dermopathic externally applied drug is treated using above-mentioned parts by weight medicinal material, is comprised the following steps:
(1) maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, add the purified water of 10 times of amounts, boil Boiling allows 50 parts of water evaporation, obtains extract solution;Then the filter residue after extraction is added into purified water, boils and allow 50 parts of water evaporation, obtain Obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2) radix boehmeriae is cleaned to smash and be put into container, add 3.5 times of dimethyl sulfoxide (DMSO), after sealing is soaked 48 hours, Extraction, obtain radix boehmeriae extract solution;
(3) fresh cactus and fresh needles are cleaned and are put into container, smash centrifuging and taking and obtain juice, filter off removal of impurities Matter, it is standby to obtain juice;
(4) solution obtained by step (1) and step (2) is mixed, boil to when thering is the grease to emerge surface, stopping plus Heat, after thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5) solution obtained by step (3) and step (4) is mixed and stirred for uniformly, producing the dermopathic external application for the treatment of Medicine.
Embodiment three:
One kind treats dermopathic externally applied drug, includes the medicinal material of following parts by weight:18 parts of maple leaves, 12 parts of maple root, water 15 parts of 15 parts of centipede, 10 parts of broomwort, 18 parts of radix boehmeriae, 12 parts of fresh cactus and fresh needles.
The preparation method of dermopathic externally applied drug is treated using above-mentioned parts by weight medicinal material, is comprised the following steps:
(1) maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, add the purified water of 10 times of amounts, boil Boiling allows 50 parts of water evaporation, obtains extract solution;Then the filter residue after extraction is added into purified water, boils and allow 50 parts of water evaporation, obtain Obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2) radix boehmeriae is cleaned to smash and be put into container, add 3.5 times of dimethyl sulfoxide (DMSO), after sealing is soaked 48 hours, Extraction, obtain radix boehmeriae extract solution;
(3) fresh cactus and fresh needles are cleaned and are put into container, smash centrifuging and taking and obtain juice, filter off removal of impurities Matter, it is standby to obtain juice;
(4) solution obtained by step (1) and step (2) is mixed, boil to when thering is the grease to emerge surface, stopping plus Heat, after thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5) solution obtained by step (3) and step (4) is mixed and stirred for uniformly, producing the dermopathic external application for the treatment of Medicine.
Example IV:
One kind treats dermopathic externally applied drug, includes the medicinal material of following parts by weight:19 parts of maple leaves, 13 parts of maple root, water 14 parts of 16 parts of centipede, 11 parts of broomwort, 19 parts of radix boehmeriae, 13 parts of fresh cactus and fresh needles.
The preparation method of dermopathic externally applied drug is treated using above-mentioned parts by weight medicinal material, is comprised the following steps:
(1) maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, add the purified water of 10 times of amounts, boil Boiling allows 50 parts of water evaporation, obtains extract solution;Then the filter residue after extraction is added into purified water, boils and allow 50 parts of water evaporation, obtain Obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2) radix boehmeriae is cleaned to smash and be put into container, add 3.5 times of dimethyl sulfoxide (DMSO), after sealing is soaked 48 hours, Extraction, obtain radix boehmeriae extract solution;
(3) fresh cactus and fresh needles are cleaned and are put into container, smash centrifuging and taking and obtain juice, filter off removal of impurities Matter, it is standby to obtain juice;
(4) solution obtained by step (1) and step (2) is mixed, boil to when thering is the grease to emerge surface, stopping plus Heat, after thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5) solution obtained by step (3) and step (4) is mixed and stirred for uniformly, producing the dermopathic external application for the treatment of Medicine.
Embodiment five:
One kind treats dermopathic externally applied drug, includes the medicinal material of following parts by weight:20 parts of maple leaves, 14 parts of maple root, water 18 parts of 17 parts of centipede, 14 parts of broomwort, 25 parts of radix boehmeriae, 15 parts of fresh cactus and fresh needles.
The preparation method of dermopathic externally applied drug is treated using above-mentioned parts by weight medicinal material, is comprised the following steps:
(1) maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, add the purified water of 10 times of amounts, boil Boiling allows 50 parts of water evaporation, obtains extract solution;Then the filter residue after extraction is added into purified water, boils and allow 50 parts of water evaporation, obtain Obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2) radix boehmeriae is cleaned to smash and be put into container, add 3.5 times of dimethyl sulfoxide (DMSO), after sealing is soaked 48 hours, Extraction, obtain radix boehmeriae extract solution;
(3) fresh cactus and fresh needles are cleaned and are put into container, smash centrifuging and taking and obtain juice, filter off removal of impurities Matter, it is standby to obtain juice;
(4) solution obtained by step (1) and step (2) is mixed, boil to when thering is the grease to emerge surface, stopping plus Heat, after thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5) solution obtained by step (3) and step (4) is mixed and stirred for uniformly, producing the dermopathic external application for the treatment of Medicine.
In order to prove that the present invention treats the therapeutic effect of dermopathic externally applied drug, clinic collects eczema, skin tinea, skin tinea Concurrent bacterial infectious disease, neurodermatitis, suppurative dermatosis, rhinitis, tympanitis, the patient 350 of lip bubble rash, wherein man Property patient 170, female patient 180, age 5-60 year;Wherein eczema patients, skin tinea patient, skin tinea concurrent bacterial sense Contaminate disease patient 200, neurodermatitis patient 25, suppurative dermatosis patient 25, rhinitis and tympanitis patient 40, mouthful Lip bubble rash patient 30 and burn, scald, traumatic patient 30.
Application method:Externally applied drug of the present invention is embrocated in clean affected part, daily medication 2-3 times.
Clinical effectiveness statistics shows that the externally applied drug is controlled for eczema, skin tinea, skin tinea concurrent bacterial infectious disease patient More rate up to 96%, wherein, the externally applied drug of embodiment 3, cure rate is up to 100%, the lighter's medication 1 week, severe one medication 2-5 weeks Recovery from illness, while have the effect of fine to treatment neurodermatitis, suppurative dermatosis, rhinitis, tympanitis, lip bubble rash;To burning Wound, scald, wound etc. have the effect of anti-inflammatory analgetic, prevent fester, quickly heal;It is and concurrent to eczema, skin tinea, skin tinea The clinical data of microbism patient is counted, referring specifically to following table:
Group Use medicine Recovery from illness It is effective It is invalid Total effective rate
Test group 1 Embodiment 1 28 1 1 96.67%
Test group 2 Embodiment 2 27 2 1 96.67%
Test group 3 Embodiment 3 48 1 0 100%
Test group 4 Embodiment 4 27 2 1 96.67%
Test group 5 Embodiment 5 28 1 1 96.67%
Test group 6 Hydrocortisone ointment 12 8 10 66.67%
As can be seen from the above table, the treatment up to 20 days is carried out to test group 1-6, externally applied drug of the invention is for skin For the cure rate of patient up to more than 96.67%, its effect is far above commercially available hydrocortisone ointment.
By microbiological analysis inspection center of Guangdong Province, (report number is the present invention:2017FM02536R01) it have selected Staphylococcus aureus has carried out the experiment of nertralizer suspension Quantitative measurement, detection method:《Disinfection technology standard》Version in 2002- 2.1.1.5.5;The peptone of+0.5% sodium thiosulfate+0.5%L- histidines of 3% Tween-80 of nertralizer+0.5%+ + 1.43% soft cysteine of phosphatide+0.1% of 0.8% sodium chloride.
Learnt by upper table, the nertralizer is qualified.
The present invention delivers to microbiological analysis inspection center of Guangdong Province to the externally applied drug prepared by embodiment 3, and (report number is: 2017FM04408R01,2017FM04408R02), it have selected Escherichia coli, staphylococcus aureus, Candida albicans, barber's itch Trichophyta carries out the bacteriostasis property test of 24 hours, detection method:《Disinfection technology standard》Version -2.1.11.3.2 in 2002, knot Fruit such as following table:
Learnt by upper table, the externally applied drug is to Escherichia coli, staphylococcus aureus, Candida albicans and alpha fungus Stronger antibacterial action is respectively provided with, wherein Escherichia coli, staphylococcus aureus is true to cause a disease to the thin mattress of disease, Candida albicans Bacterium, alpha fungus are the most common pathogenic tinea bacterium of skin tinea.Eczema, dermatophytosis all make affected part because itch feels bad scratching Skin injury postoperative infection bacterium or fungi aggravate that sb.'s illness took a turn for the worse again;Skin is golden yellow because of wound, scald, burn and post-operative infection Staphylococcus causes wound suppuration, the symptom such as refractory of festering;The present invention, which passes through Clinical practice, to be cured synchronously, simultaneously, with medicine Above-mentioned skin disease.
Meanwhile microbiological analysis inspection center of Guangdong Province is delivered to the externally applied drug prepared by embodiment 3 (report number is: 2017FM05969R01), staphylococcus aureus, the sterilization of methicillin-resistant staphylococcus aureus progress 6 hours be have selected Performance test, detection method:《Disinfection technology standard》Version -2.1.11.3.1 in 2002;As a result such as following table:
Learnt by upper table, the externally applied drug is respectively provided with to staphylococcus aureus and methicillin-resistant staphylococcus aureus Stronger killing action.It is now clinical very intractable using the treatment of western medicine methicillin-resistant staphylococcus aureus infection One of problem, it is important to it is known as multidrug resistant to many antibiosis, and vancomycin is current clinical treatment methicillin-resistant Infection of staphylococcus aureus, the antibiotic of unique curative effect certainly, but vancomycin toxic side effect is big.Externally applied drug warp of the present invention Microbiological analysis inspection center of Guangdong Province test result is that its sterilizing rate to methicillin-resistant staphylococcus aureus is 99.98%, a large amount of clinical treatments confirm that its is evident in efficacy to process for many years, Chinese medicine antibacterial, securely and reliably, are worthy to be popularized.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair The equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks Domain, it is included within the scope of the present invention.

Claims (5)

1. one kind treats dermopathic externally applied drug, it is characterised in that is made by the medicinal material of following parts by weight:2 part -23 of maple leaves Part, 1 part -16 parts of maple root, 1 part -18 parts of kyllinga brevifolia, 0.5 part -16 parts of broomwort, 0.5 part -35 parts of radix boehmeriae, fresh cactus 2 parts -16 parts and 2 parts -23 parts of fresh needles.
2. dermopathic externally applied drug is treated as claimed in claim 1, it is characterised in that be made by the medicinal material of following parts by weight: It is 5 parts -20 parts of maple leaves, 4 parts -14 parts of maple root, 6 parts -16 parts of kyllinga brevifolia, 3 parts -13 parts of broomwort, 2 parts -30 parts of radix boehmeriae, new 5 parts -20 parts of 4 parts -13 parts of fresh cactus and fresh needles.
3. dermopathic externally applied drug is treated as claimed in claim 2, it is characterised in that:It is made by the medicinal material of following parts by weight: 18 parts of maple leaves, 12 parts of maple root, 15 parts of kyllinga brevifolia, 10 parts of broomwort, 18 parts of radix boehmeriae, 12 parts of fresh cactus and fresh pine 15 parts of pin.
A kind of 4. preparation method of dermopathic externally applied drug for the treatment of as described in any one of claims 1 to 3, it is characterised in that Comprise the following steps:
(1)Maple leaves, maple root, kyllinga brevifolia and broomwort are cleaned and are put into container, adds the purified water of 10 times of amounts, boils and allow 30 parts -70 parts of water evaporation, obtain extract solution;Then the filter residue after extraction is added into purified water, boils and allow 30 part -70 of water evaporation Part, obtain extract solution;Above-mentioned extract solution twice is mixed, filtering, it is standby to obtain filtrate;
(2)Radix boehmeriae is cleaned to smash and is put into container, adds 2-5 times of dimethyl sulfoxide (DMSO), after sealing immersion 24-54 hours, Extraction, obtain radix boehmeriae extract solution;
(3)Fresh cactus and fresh needles are cleaned and are put into container, smashes centrifuging and taking and obtains juice, filter off the removal of impurity, take It is standby to obtain juice;
(4)By step(1)And step(2)Obtained solution mixing, boil to when thering is the grease to emerge surface, stop heating, After thering is precipitation to produce solution left standstill cooling, refilter, it is standby to obtain filtrate;
(5)By step(3)And step(4)Obtained solution is mixed and stirred for uniformly, producing the dermopathic externally applied drug for the treatment of.
5. the dermopathic externally applied drug for the treatment of according to any claim in claims 1 to 3 is preparing treatment eczema, skin Application in skin tinea, skin tinea concurrent bacterial infection disease drug.
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CN101732205B (en) * 2009-12-29 2012-11-21 北京工商大学 Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof

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CN103784491A (en) * 2013-02-24 2014-05-14 王茜 Cactus gum

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