CN116549372B - Antioxidant composition enhanced by heat as well as preparation method and application thereof - Google Patents
Antioxidant composition enhanced by heat as well as preparation method and application thereof Download PDFInfo
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- CN116549372B CN116549372B CN202310677695.6A CN202310677695A CN116549372B CN 116549372 B CN116549372 B CN 116549372B CN 202310677695 A CN202310677695 A CN 202310677695A CN 116549372 B CN116549372 B CN 116549372B
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- SLBXZQMMERXQAL-UHFFFAOYSA-M sodium;1-dodecoxy-4-hydroxy-1,4-dioxobutane-2-sulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O SLBXZQMMERXQAL-UHFFFAOYSA-M 0.000 description 1
- LMWHCJFWODXSMN-UHFFFAOYSA-M sodium;1-dodecoxydodecane;octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCOCCCCCCCCCCCC LMWHCJFWODXSMN-UHFFFAOYSA-M 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
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- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
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- 235000019330 stearyl citrate Nutrition 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application discloses an antioxidant composition enhanced by heat, and a preparation method and application thereof, and belongs to the technical field of cosmetics. According to the application, the thermophilic thermus fermentation product, the seaweed oligosaccharide and the vitamin are compounded in a specific mass ratio, and the obtained antioxidant composition can effectively avoid the problem of inactivation of active ingredients in a high-temperature environment. The antioxidation composition has the effect of stronger antioxidation capability when the temperature is higher in the temperature range of 20-40 ℃; and has synergistic effects in relieving skin, whitening skin, resisting oxidation and wrinkle, etc.; the synergistic effect of the seaweed oligosaccharide and the thermophilic thermus fermentation product can produce better skin barrier repairing effect; the antioxidant composition is also effective in reducing vitamin irritation.
Description
Technical Field
The application relates to an antioxidant composition enhanced by heat, and a preparation method and application thereof, belonging to the technical field of cosmetics.
Background
Environmental pollution conditions rapidly worsen throughout the world and become more evident in the daily life of consumers. Contamination damage to human skin is also becoming more and more evident. Human skin is subject to various damage by external factors such as Ultraviolet (UV) radiation, environmental pollution, wind, heat, infrared radiation, low humidity, irritating surfactants, abrasives and the like. Recent studies have shown that in addition to UV radiation, other environmental factors also contribute to the development of solar moles, in particular air pollution. Ultimately, these factors cause visible signs of skin damage. Typical skin lesions include fine lines, wrinkles, pigmentation, yellowish-brown, sagging, dark circles, eye puffiness, enlarged pores, visible dead skin, i.e., scaling, dryness and roughness. Besides skin damage, environmental pollution can cause discomfort such as irritation, itching, dryness, roughness, allergy and the like. Inhibition of active oxygen species may be critical to anti-fouling. For example, exhaust particulates and fumes can up-regulate matrix metalloproteins, thereby affecting the integrity of the skin.
Antioxidants are chemicals and biologicals that destroy harmful oxygen radicals, and the use of products containing antioxidant components in daily skin care is a mainstream antioxidant concept today, and antioxidant components and products are many in the market and in various forms. Vitamin C and its derivatives are substances with powerful antioxidant activity, and can slow down skin aging, prevent wrinkles and color spots, inhibit the synthesis of collagenase, promote wound healing, promote skin metabolism, improve skin immunity and strengthen skin. The seaweed oligosaccharide is a saccharide substance obtained by taking marine algae as a raw material through chemical or biological enzymatic degradation, has good antioxidant capacity, can effectively remove common active oxygen free radicals in the body, is beneficial to improving the skin anti-aging capacity, and can have obvious protective effect on skin oxidative damage by improving the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX). However, the stronger the antioxidant activity of the antioxidant, the more easily the antioxidant is oxidized, especially in the case of an increase in temperature, such as skin temperature increase due to sun or exercise; although vitamin C and its derivatives and trehalose have good effects on skin antioxidation and free radical removal, their stability is a major problem in development and utilization, especially at high skin temperature, so how to improve the thermal stability of antioxidants is a problem to be solved by antioxidants at present.
Disclosure of Invention
The application aims to overcome the defects of the prior art and provides an antioxidant composition enhanced by heat, and a preparation method and application thereof; the antioxidant composition can resist the influence of temperature on the stability of active ingredients, and has the effect of stronger antioxidant capacity when the temperature is higher in the temperature range of 20-40 ℃; the antioxidant composition has good skin applicability, is mild and has no stimulation, and has remarkable gain effects in the aspects of moisturizing and moisturizing skin, delaying aging and whitening skin.
In order to achieve the above purpose, the technical scheme adopted by the application is as follows: an antioxidant composition comprises Thermus thermophilus fermentation product, trehalose and vitamins; the mass ratio of the thermophilic thermus fermentation product to the seaweed oligosaccharide to the vitamins is that the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-3): (0.01-5); the vitamin is vitamin C and/or vitamin C derivative.
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-3): (0.01-2).
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-0.5): (0.01-2).
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (1-5): (0.1-0.5): (0.01-0.5).
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (3-5): (0.1-0.5): (0.01-0.5).
In one embodiment, the alginate oligosaccharides are at least one of brown alginate oligosaccharides, agar oligosaccharides, carrageenan oligosaccharides.
In one embodiment, the vitamin C derivative is at least one of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, ascorbyl palmitate, ascorbyl tetraisopalmitate, ascorbyl palmitate phosphate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbyl ether.
In one embodiment, the vitamin C derivative is at least one of ascorbyl palmitate, ascorbyl glucoside, 3-O-ethyl ascorbate.
Another aspect of the application relates to the provision of the use of the antioxidant composition for the preparation of cosmetics.
In one embodiment, the cosmetic is at least one of a lotion, an emulsion, a cream, a mask, an essence, a spray, a sunscreen spray, and a sunscreen emulsion.
Another aspect of the application relates to a cosmetic comprising the antioxidant composition.
In one embodiment, the antioxidant composition is present in the cosmetic in an amount of 0.5 to 5% by weight.
In one embodiment, the cosmetic further comprises at least one cosmetically acceptable adjuvant.
In one embodiment, the cosmetic is at least one of a lotion, an emulsion, a cream, a mask, an essence, a spray, a sunscreen spray, and a sunscreen emulsion.
In one embodiment, the cosmetic is a serum, and the serum comprises the following components in weight percent: 20.01-0.5% of carbopol U, 0.01-1% of hyaluronic acid, 0.1-1% of yellow gelatin, 2-8% of glycerin, 0.01-0.1% of disodium ethylenediamine tetraacetate, 1-20% of butanediol, 0.1-5% of p-hydroxyacetophenone, 0.1-5% of 1, 2-hexanediol, 0.5-5% of antioxidant composition, 0.1-10% of D-panthenol, 0.1-1% of arginine and the balance of water.
Compared with the prior art, the application has the beneficial effects that:
(1) According to the application, the thermophilic thermus fermentation product, the seaweed oligosaccharide and the vitamin are compounded in a specific mass ratio, so that the problem of inactivation of the seaweed oligosaccharide and the vitamin in a high-temperature environment can be effectively avoided, and the obtained antioxidant composition has the effects of higher temperature and stronger antioxidant capacity in the temperature range of 20-40 ℃; the high-temperature oxidation resistance of the three components is higher than that of the independent components;
(2) The antioxidant composition can effectively reduce the irritation of vitamins, and meanwhile, the efficacy of the vitamins is not affected;
(3) The antioxidant composition has synergistic effects on relieving skin, whitening skin, resisting oxidation, resisting wrinkles and the like, and the synergistic effects of the seaweed oligosaccharide and the thermophilic thermus fermentation product can generate better skin barrier repairing effect.
(4) The antioxidant composition can be used as a raw material to be added into cosmetics such as cream, emulsion, lotion, essence, spray, sun cream, facial mask and the like, and can bring good antioxidant effect to the products, and the cosmetics have the effects of moisturizing, whitening and anti-wrinkle after being applied.
(5) The antioxidant composition and the cosmetic have the advantages of simple preparation process, convenient use, simple method and easy operation, are suitable for standardized production and popularization and application, and the preparation method does not influence the effectiveness of components and the final use effect of the product.
Drawings
FIG. 1 is a graph showing the ability of the antioxidant compositions obtained in examples 1-5 to scavenge superoxide anions;
FIG. 2 is a graph showing the ability of the antioxidant compositions obtained in examples 6-9 to scavenge superoxide anions;
FIG. 3 is the ability of the antioxidant compositions obtained in examples 10-14 to scavenge superoxide anions;
FIG. 4 is a graph showing the ability of the antioxidant compositions obtained in examples 15-19 to scavenge superoxide anions;
FIG. 5 is a graph showing the ability of the antioxidant compositions of comparative examples 1-6 to scavenge superoxide anions;
FIG. 6 is a graph showing the ability of the antioxidant compositions obtained in comparative examples 7-11 to scavenge superoxide anions.
Detailed Description
Advantages and features of the present application and methods of accomplishing the same may be understood more readily by reference to the following detailed description of embodiments. The present application may, however, be embodied in various other forms and should not be construed as limited to the embodiments set forth herein. The embodiments disclosed herein are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the application to those skilled in the art.
The terminology used in the description is for the purpose of describing particular embodiments only and is not intended to be limiting of the application in any way. Unless expressly used otherwise, the expression in the singular includes the meaning of the plural.
Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Any term defined in a comprehensive dictionary should be interpreted as having the same meaning in the context of the relevant art and, unless explicitly defined otherwise, should not be interpreted as having an ideal sense or an excessively formal sense.
The term "skin whitening" as used herein generally refers to a scheme of increasing the brightness of skin having reduced brightness due to excessive pigment (e.g., melanin) or maintaining the brightness of skin at a certain level, and the brightness of skin is increased by the above scheme.
Furthermore, the term "skin wrinkles" as used herein refers to fine lines formed on the skin due to skin weakening, which may be caused by genetic factors, collagen and elastin reduction present in the dermis of the skin, the external environment, and the like.
In addition, the term "anti-skin wrinkles/anti-wrinkle" as used herein refers to suppressing or inhibiting the production of wrinkles on the skin or alleviating already produced wrinkles.
The term "antioxidant" as used herein means to inhibit oxidation of cells by free radicals (FREE RADICAL) or reactive oxygen species (reactive oxygen species; ROS) having high reactivity according to oxidative stress caused by the influence of intracellular metabolism or ultraviolet rays, and to reduce damage to cells by removing free radicals or reactive oxygen species, thereby exhibiting an effect of preventing skin aging. In the present invention, the antioxidant effect of the antioxidant composition was confirmed by the ability to scavenge superoxide ions confirmed in the experiments.
The term "skin moisturization" as used herein means to increase skin moisture sensation and to suppress moisture loss, thereby maintaining a moist state.
According to a first aspect of the present invention there is provided an antioxidant composition comprising a thermophilic thermus fermentation product, a trehalose and a vitamin; the mass ratio of the thermophilic thermus fermentation product to the seaweed oligosaccharide to the vitamins is that the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-3): (0.01-5); the vitamin is vitamin C and/or vitamin C derivative.
The thermophilic thermus fermentation product, the trehalose and the vitamins are typically but not limited to mass ratios such as thermophilic thermus fermentation product: seaweed oligosaccharide: vitamins =0.025:0.1:0.01、0.025:3:0.01、0.025:3:5、5:0.1:0.01、5:3:0.01、5:3:5、1:0.5:3、3:0.5:3、5:0.5:3、3:0.5:0.5、4:0.5:0.5 or 5:0.5:0.5.
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-3): (0.01-2).
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-0.5): (0.01-2).
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (1-5): (0.1-0.5): (0.01-0.5).
In one embodiment, the mass ratio of the thermophilic thermus fermentation product, the alginate oligosaccharides and the vitamins is the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (3-5): (0.1-0.5): (0.01-0.5).
Thermophilic thermus fermentation product: thermus thermophilus (THERMUS THERMOPHILLUS) fermentation product is produced by biological fermentation technology, is a multifunctional heat-activated stable enzyme, has the effects of resisting injury caused by infrared rays and reducing inflammation, maintains the integrity of mitochondria under the stress condition, optimizes the capacity generation, maintains the normal physiological structure of skin and reduces the generation of wrinkles. The Thermus thermophilus fermentation product can be selected from commercial products, preferably Thermus thermophilus fermentation product manufactured by sederma company.
Seaweed oligosaccharide: the saccharide substance obtained by taking marine algae as a raw material through chemical or biological enzymatic degradation has better antioxidation capability, can effectively remove common active oxygen free radicals in the body, is beneficial to improving the skin anti-aging capability, and can have obvious protection effect on skin oxidative damage by improving the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX). Reducing inflammatory reaction and stimulation, regulating flora balance on the surface of the skin, stabilizing the skin, and as a saccharide, the natural moisturizing factor NMF belongs to an important class, so that the skin can repair sebum membranes, lock water, improve microcirculation of the skin and accelerate permeation of other active ingredients in the formula into the skin while moisturizing the skin.
Vitamin C and/or vitamin C derivatives: vitamin C and/or vitamin C derivative is a substance with powerful antioxidant activity, can slow down the aging speed of skin, prevent wrinkles and color spots, is a well known whitening active substance, can inhibit the synthesis of the collagenase, can promote the synthesis of collagen, accelerate the wound healing, promote the metabolism of skin, improve the immunity of skin and strengthen the skin. The vitamin C and/or vitamin C derivatives may be selected from commercially available products.
The application selects the thermophilic thermus fermentation product, the seaweed oligosaccharide and the vitamin with specific mass ratio to be compounded as the antioxidant composition, and the antioxidant composition has the effect that the higher the temperature is, the higher the content of superoxide dismutase is generated and the stronger the antioxidant capability is in the temperature range of 20-40 ℃; skin temperatures exceeding 40 ℃ are unusual and are not considered; the problem of inactivation of the generation of the trehalose and the vitamins in a high-temperature environment can be avoided; the antioxidant composition has higher antioxidant capacity at high temperature than that of thermophilic Thermus fermentation product, seaweed oligosaccharide and vitamins used alone, and has the function of compounding synergy. When the mass ratio of the thermophilic thermus fermentation product, the seaweed oligosaccharide and the vitamin is that of the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-1): (0.01-3), the antioxidation effect of the antioxidation composition is better; the mass ratio of the thermophilic thermus fermentation product to the seaweed oligosaccharide to the vitamins is that the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (1-5): (0.1-0.5): (0.01-3), the antioxidant composition has a better antioxidant effect.
The vitamin C and/or the vitamin C derivative has strong antioxidant activity, but has strong irritation to skin, especially to sensitive muscles with fragile barriers, and the stinging discomfort is stronger, and the sensitive muscles can not play a role in resisting oxidation by using a product containing the vitamin C and/or the vitamin C derivative, and can possibly further damage the skin barrier, so that the irritation to skin of the vitamin C and/or the vitamin C derivative limits the application range of the vitamin C and/or the vitamin C derivative. According to the invention, the thermophilic thermus fermentation product, the seaweed oligosaccharide and the vitamin are compounded, so that the stimulus of the vitamin C and/or the vitamin C derivative is reduced and the skin adaptability of the antioxidant composition is improved while the antioxidant effect of the vitamin C and/or the vitamin C derivative is enhanced.
In the antioxidation composition, the thermophilic thermus fermentation product has the effects of photoprotection, relaxation and aging delay, and the vitamin C and/or the vitamin C derivative has the effects of whitening, antioxidation and collagen regeneration promotion, and the seaweed oligosaccharide not only can resist inflammation, regulate flora balance, resist oxidization and ease sensitivity, but also can improve skin microcirculation and improve cell permeability, so that the effective components are absorbed and utilized by the skin to the greatest extent, and the three components form stronger synergistic effects in the aspects of antioxidation, whitening and aging resistance. Meanwhile, the trehalose can also directly form a protective film against free radicals on the surface of the skin, and can generate better skin barrier repairing effect by cooperation with a thermophilic thermus fermentation product, so that the requirements of high efficacy and low stimulation of sensitive muscles can be met.
In one embodiment, the seaweed oligosaccharide used in the present application is at least one of alginate oligosaccharide, agar oligosaccharide and carrageenan oligosaccharide. Compared with other trehalose, the trehalose is added into the antioxidant composition, and the antioxidant composition has better antioxidant effect; the trehalose is selected from commercial products, preferably trehalose from sea health technology (Qingdao) Limited.
In one embodiment, the vitamin C derivative is at least one of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, ascorbyl palmitate, ascorbyl tetraisopalmitate, ascorbyl palmitate phosphate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbyl ether; preferably, the vitamin C derivative is at least one of ascorbyl palmitate, ascorbyl glucoside and 3-O-ethyl ascorbyl ether; the antioxidant composition provided by the application can further improve the antioxidant effect of the antioxidant composition by selecting the vitamin C derivative.
The thermophilic thermus fermentation product, the seaweed oligosaccharides and the vitamins can be mixed uniformly by means known in the art by a person skilled in the art to obtain an antioxidant composition, such as mechanical stirring, homogenization, ultrasound, or the like.
Specifically, the preparation method of the antioxidant composition comprises the following steps: mixing Thermus thermophilus fermentation product, trehalose and vitamins to obtain antioxidant composition.
After mixing, a uniform and stable antioxidant composition is obtained, so that the active ingredients are fully mixed, and the active ingredients are fully released.
Another aspect of the application relates to the provision of the use of the antioxidant composition for the preparation of cosmetics.
Another aspect of the application relates to a cosmetic comprising the antioxidant composition.
In one embodiment, the antioxidant composition is present in the cosmetic in an amount of 0.5 to 5% by weight.
The weight percent of the antioxidant composition in the cosmetic may be 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2.0%, 2.2%, 2.5%, 2.8%, 3.0%, 3.2%, 3.5%, 3.8%, 4.0%, 4.2%, 4.5%, 4.8%, 5.0%; the weight percentage of the antioxidant composition in the cosmetic may also be in the range of any two values recited above.
The antioxidant composition with a specific proportion is added into the cosmetics, so that good antioxidant effect can be brought to the cosmetics. When the cosmetic of the present application contains less than 0.5% by weight of the above-described antioxidant composition of the present application, sufficient enhancement of skin elasticity or improvement of wrinkles cannot be expected; or moisturizing skin, and when it is contained in an amount exceeding 5% by weight, an undesired reaction such as allergy or the like may occur or there is a problem in skin safety.
In one embodiment, the cosmetic may be in the form of a general emulsion formulation and a solubilized formulation. For example, there may be provided a lotion such as a skin softening lotion or a nourishing lotion, an emulsion such as a facial lotion, a body lotion, a cream such as a nourishing cream, a moisturizing cream, an eye cream, an essence, a cosmetic ointment, a balm (balm), a spray, a gel, a mask, a sun cream, a pre-makeup base lotion, a liquid type, a solid type, a spray type, or the like foundation, a powder, a makeup remover such as a cleansing cream, a cleansing lotion, a cleansing oil, and the like, a dosage form such as a cleansing foam, a soap, a shower gel, and the like.
The cosmetic also comprises at least one cosmetically acceptable auxiliary; such as fatty substances, humectants, moisturizers, conditioners, softeners, thickeners, organic solvents, suspending agents, solubilizers, concentrates and gelling agents, antioxidants, stabilizers, foaming agents (foaming agents), fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion blocking and chelating agents, preservatives, vitamins, blocking agents, humectants, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles, or any other ingredient commonly used in cosmetics.
The fatty substance may be of animal, vegetable, mineral or synthetic origin. For example, the fatty compound may comprise natural oils, synthetic oils, mineral oils, hydrogenated oils, silicone oils, hydrocarbon-based compounds, saturated or unsaturated fatty acids, fatty acid esters, liquid waxes, fatty alcohols and mixtures thereof of vegetable, animal or marine origin. In some cases, the one or more fatty compounds are natural fatty compounds. For example, the one or more fatty substances may be natural vegetable oils. Non-limiting examples of natural vegetable oils include shea butter, almond oil, rice bran oil, olive oil, and mixtures thereof.
Humectants are ingredients that help maintain moisture levels in the skin. The wetting agent may be selected from the group consisting of polyols, water-soluble alkoxylated nonionic polymers, and mixtures thereof. Polyols which may be used herein include the aforementioned polyols and glycerin, hexylene glycol, ethoxylated glucose, 1, 2-hexanediol, dipropylene glycol, trehalose, diglycerol, maltitol, maltose, glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, pyrrolidone carbonate, glucosamine, cyclodextrin, and mixtures thereof. Water-soluble alkoxylated nonionic polymers useful herein include polyethylene glycols and polypropylene glycols having a molecular weight of up to about 1000 (such as those under the CTFA name PEG-200, PEG-400, PEG-600, PEG-1000) and mixtures thereof. Additional humectants include arginine acetyl, algae extract, aloe vera (aloe barbadensis) leaf extract, 2, 3-butanediol, chitosan lauroyl glycinate, diglycerol polyether-7 malate, diglycerol, guanidine diglycol succinate, erythritol, fructose, glucose, glycerol, honey, hydrolyzed protein, hydroxypropyl trimethylammonium hyaluronate (hydroxypropyltrimonium hyaluronate), inositol, lactitol, maltitol, maltose, mannitol, mannose, methoxypolyethylene glycol, myristamide butylguanidine acetate, polyglycerol sorbitol, potassium Pyrrolidone Carboxylate (PCA), propylene glycol, butylene glycol, sodium Pyrrolidone Carboxylate (PCA), sorbitol, sucrose, dextran sulfate (i.e., of any molecular weight), natural moisturizing factors, and/or urea.
Skin conditioning agents may include, but are not limited to, guanidine, urea, glycolic acid, glycolate salts (e.g., ammonium and quaternary alkylammonium), salicylic acid, lactic acid, lactate salts (e.g., ammonium and quaternary alkylammonium), aloe vera in any of its various forms (e.g., aloe vera gel), polyols such as sorbitol, mannitol, xylitol, erythritol, hexanetriol, butanetriol, propylene glycol, butylene glycol, hexylene glycol, and the like, polyethylene glycol, propoxylated glycerin, sugars (e.g., melibiose), starches, sugars and starch derivatives (e.g., alkoxylated glucose, fructose, glucosamine), C1-C30 mono-and polyesters of sugars and related substances, hyaluronic acid, lactosamine monoethanolamine, acetamide monoethanolamine, panthenol, dexpanthenol, allantoin, and mixtures thereof. Skin conditioning agents may also include fatty acids, fatty acid esters, lipids, ceramides, cholesterol esters, beeswax, petrolatum and mineral oil.
Softeners generally refer to ingredients that can help the skin maintain a soft, smooth, and pliable appearance. Softeners generally remain on the skin surface or in the stratum corneum and act as moisturizers or lubricants and reduce exfoliation. Some examples of softeners include acetyl arginine, acetylated lanolin, algae extract, almond oil polyethylene glycol-6-ester, avocado oil polyethylene glycol-11 ester, di-polyethylene glycol-4-dimethylpolysiloxane, butoxyethyl stearate, ethylene glycol ester, alkyl lactate, xin Xianyi glycol, cetyl esters, cetyl laurate, coconut oil polyethylene glycol-10 ester, alkanol tartaric acid ester, diethyl sebacate, dihydrocholesterbutyrate, dimethiconol (dimethiconol), dimyristol tartaric acid ester, distearol polyether-5-lauroyl glutamate, ethyl avocado oleate, ethylhexyl myristate, glycerol isostearate, glycerol oleate, hexyl decyl stearate, hexyl isostearate, hydrogenated palmitoyl glyceride hydrogenated soy glyceride, hydrogenated tallow glyceride, isostearyl pivalate, isostearyl palmitate, isotridecyl isononanoate, laureth-2-acetate, laurylpolyglyceryl-6-cetostearyl glycol ether, methylgluceth-20 benzoate, mineral oil, palm oil, coconut oil, myristyl polyether-3 palmitate, octyldecanol, octyldodecanol, golden Odum algae oil (odontella aurita oil), 2-oleamido-1, 3-octadecanediol, glyceryl palmitate, polyethylene glycol avocado glyceride, polyethylene glycol castor oil, polyethylene glycol-22/dodecylethylene glycol copolymer, polyethylene glycol shea butter glyceride, phytol, raffinose, stearyl citrate, sunflower seed oil glyceride, petrolatum, silicone oils, including but not limited to octanoyl polydimethylsiloxane and/or tocopheryl glucoside.
Thickeners may contribute to a pleasant texture and/or feel; thickeners useful herein include polysaccharide thickeners and gums; useful thickeners include polysaccharide thickeners. Non-limiting examples of polysaccharide thickeners include gellan gum, xanthan gum, neutral gum (rhamsan gum), welan gum (welan gum), carrageenan, guar gum, locust bean gum, tragacanth gum, succinoglucan gum (succinoglucangum), and mixtures thereof. Non-limiting examples of gums include gum arabic, agar-agar, algin, alginic acid, ammonium alginate, pullulan, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar hydroxypropyl trimethylammonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar gum, karaya gum, seaweed (kelp), locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum (sclerotium gum), sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.
Suspending agents are effective to suspend the water-insoluble material in the cosmetic in dispersed form or to alter the viscosity of the cosmetic; suspending agents useful herein include anionic polymers and nonionic polymers. Useful herein are vinyl polymers such as crosslinked acrylic polymers of CTFA name carbomer, cellulose derivatives, and modified cellulose polymers such as methylcellulose, ethylcellulose, nitrocellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum, acacia gum, galactan, locust bean gum, pectin, starches (rice, corn, potato, wheat), algin (seaweed extract), microbial polymers such as dextran, succinoglucan, pulleran, starch-based polymers such as carboxymethyl starch, methyl hydroxypropyl starch, alginic acid-based polymers such as sodium alginate, propylene glycol alginate, acrylic acid polymers such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethylenimine, and inorganic water-soluble materials such as bentonite, magnesium aluminum silicate, lithium algae clay, hectorite, and anhydrous silicic acid. The active substances mentioned above as thickeners may also be used herein as suspending agents.
Emulsifiers include a wide variety of nonionic, cationic, anionic, zwitterionic, and amphoteric surfactants such as those known in the art and discussed below. Hydrophilic surfactants (cationic, anionic, zwitterionic, amphoteric) useful herein may comprise a single surfactant, or any combination of suitable surfactants. The exact surfactant (or surfactants) selected will depend on the pH and other components present in the composition. Non-limiting examples of emulsifiers selected herein include cetyl polyether-6, cetyl polyether-10, cetyl polyether-12, cetostearyl polyether-6, cetyl stearyl polyether-10, cetyl polyether-12, stearyl polyether-6, stearyl polyether-10, stearyl polyether-12, stearyl polyether-21, PEG-6 stearate, PEG-10 stearate, PEG-100 stearate, PEG-12 stearate, PEG-20 glyceryl stearate, cetostearyl polyether-12, sucrose cocoate, stearyl polyether-100, PEG-100 stearate, polyoxyethylene 20 sorbitan trioleate (polysorbate 85), sorbitan monolaurate, polyoxyethylene 4 lauryl ether sodium stearate, polyglyceryl 4-isostearate, hexyl laurate, PPG-2 methyl glucose ether distearate, behenyl propyl PG dimethyl ammonium chloride, dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristoyl dimethyl ammonium chloride, palmityl dimethyl ammonium chloride, sodium N-stearyl sodium sulfosuccinate, sodium lauryl sulfosuccinate; tetra sodium coco dimethyl carboxymethyl betaine, lauryl dimethyl alpha-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine, cetostearyl glucoside, coco ethyl glucoside, coco glucoside disodium citrate, coco glucoside disodium sulphosuccinate, lauroyl ethyl glucoside, myristoyl ethyl glucoside, octyl polydimethylsiloxane ethoxy glucoside, oleoyl ethyl glucoside, sodium coco glucoside tartrate, and mixtures thereof.
The organic solvents useful herein may be those comprising one or more C3-10 alkanediols and optionally glycerol. Non-limiting examples of C3-10 alkanediols include 1, 2-propanediol, 1, 3-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 4-butanediol, 2, 3-butanediol, 1, 2-pentanediol, 1, 4-pentanediol, 1, 5-pentanediol, 2, 4-pentanediol, 1, 2-hexanediol, 1, 5-hexanediol, 1, 6-hexanediol, 2, 5-hexanediol, 1, 7-heptanediol, 1, 2-octanediol, 1, 8-octanediol, 1, 9-nonanediol, 1, 2-decanediol, 1, 10-decanediol, neopentyl glycol, and mixtures thereof.
The above-mentioned ingredients contained in the composition according to the present application may each preferably be contained in the composition of the present application within a range not exceeding the maximum usage amount as specified in the specifications stipulated by the respective national government.
In one embodiment, the cosmetic is at least one of a lotion, an emulsion, a cream, a mask, an essence, a spray, a sunscreen cream, a sunscreen spray, and a sunscreen emulsion.
In one embodiment, the cosmetic is a serum, and the serum comprises the following components in weight percent: 20.01-0.5% of carbopol U, 0.01-1% of hyaluronic acid, 0.1-1% of yellow gelatin, 2-8% of glycerin, 0.01-0.1% of disodium ethylenediamine tetraacetate, 1-20% of butanediol, 0.1-5% of p-hydroxyacetophenone and 0.1-5% of 1, 2-hexanediol; 0.5-5% of antioxidant composition, 0.1-10% of D-panthenol, 0.1-1% of arginine and the balance of water.
Typically, but not limited to, 0.01%, 0.05%, 0.10%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.45%, or 0.5% by weight of carbopol U20.
Typical, but non-limiting, weight percentages of hyaluronic acid are 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1.0%.
The weight percent of the yellow gelatin is typically, but not limited to, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%.
Glycerol is typically, but not limited to, 2%, 3%, 4%, 5%, 6%, 7% or 8% by weight.
Typical but non-limiting percentages by weight of disodium edetate are 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09% or 0.1%.
The butanediol is typically, but not limited to, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19% or 20% by weight.
Typical, but non-limiting, weight percentages of p-hydroxyacetophenone are 0.1%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%, 3.5%, 4.0%, 4.5% or 5.0%.
Typical but non-limiting percentages by weight of 1, 2-hexanediol are 0.1%, 0.4%, 0.8%, 1.2%, 1.6%, 2.0%, 2.5%, 3.0%, 3.4%, 3.8%, 4.2%, 4.6% or 5.0%.
Typical, but non-limiting, weight percentages of the antioxidant composition are 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2.0%, 2.2%, 2.5%, 2.8%, 3.0%, 3.2%, 3.5%, 3.8%, 4.0%, 4.2%, 4.5%, 4.8% or 5.0%.
Typical, but non-limiting, weight percentages of D-panthenol are 0.1%、0.5%、1.0%、1.4%、1.9%、2.5%、3.0%、3.6%、4.1%、4.4%、5.0%、5.5%、6.0%、6.3%、6.7%、7.0%、7.4%、7.7%、8.0%、8.5%、9.0%、9.5% or 10.0%.
Arginine is typically, but not limited to, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1.0% by weight.
Cosmetic "comprising" means that it may comprise, in addition to said raw materials, other raw materials which impart different properties to the cosmetic. In addition, the "including" of the present invention may be replaced by "being" or "consisting of … …" which are closed.
It should be noted that the balance of water refers to the balance of water and is the remainder of the raw materials of the essence of the application except carbopol U20, hyaluronic acid, xanthene gum, glycerin, disodium ethylenediamine tetraacetate, butylene glycol, p-hydroxyacetophenone, 1, 2-hexanediol, antioxidant composition, D-panthenol, arginine and optionally other components; the sum of the weight percentages of carbopol U20, hyaluronic acid, xanthene gum, glycerol, disodium edentate, butanediol, p-hydroxyacetophenone, 1, 2-hexanediol, antioxidant compositions, D-panthenol, arginine and optionally other components is 100%.
The antioxidant composition with the content of 0.5-5% is added into the essence, so that the essence has antioxidant and moisturizing effects, and meanwhile, the essence is matched with other cosmetic raw materials to bring good skin care effects, and the skin care effect is remarkable in whitening, anti-wrinkle and moisturizing effects after the essence is smeared.
Another aspect of the present application relates to a preparation method of the essence, comprising the steps of:
Heating and preserving heat of the component A and the component B respectively, fully homogenizing, uniformly mixing, cooling, adding the component C, and mixing to obtain essence; wherein the component A comprises carbopol U20, hyaluronic acid, yellow gelatin, glycerol, disodium ethylenediamine tetraacetate, butanediol and water; the component B is butanediol, p-hydroxyacetophenone and 1, 2-hexanediol; the component C is antioxidant composition and D-panthenol.
Homogenization, also called homogenization, is a process of micronizing and homogenizing a dispersion in a suspension (or emulsion) system, which simultaneously serves to reduce the size of the dispersion and to increase the uniformity of the dispersion distribution, preferably by stirring at low speeds of less than 1000 r/min.
The uniform and stable essence can be obtained by fully homogenizing the components of the essence, and the method is suitable for standardized production.
Specifically, the preparation method of the essence comprises the following steps:
(a) Mixing carbopol U20, hyaluronic acid, yellow gelatin, glycerol, disodium ethylenediamine tetraacetate and water, heating, maintaining the temperature, and homogenizing to obtain a prefabricated component A;
(b) Mixing butanediol, p-hydroxyacetophenone and 1, 2-hexanediol, heating and preserving heat to obtain a prefabricated component B;
(c) Mixing the antioxidant composition with D-panthenol to obtain a prefabricated C component;
(d) Uniformly mixing the prefabricated A component and the prefabricated B component to obtain a mixed solution;
(e) And (3) cooling, adding the prefabricated component C, uniformly mixing, and regulating the pH value to obtain the essence.
The prefabricated A component, the prefabricated B component and the prefabricated C component are obtained by mixing the raw materials of the component A, the component B and the component C under certain conditions, so that the post-processing is convenient.
In one embodiment, the mixing speed in step (a) is 500 to 1000rpm, such as 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm; and/or the number of the groups of groups,
The mixing time is 10-20 min, such as 10min, 12min, 14min, 15min, 16min, 18min or 20min; and/or the number of the groups of groups,
The temperature is raised to 60-70 ℃, such as 60 ℃, 61 ℃, 62 ℃, 63 ℃, 64 ℃, 65 ℃, 66 ℃, 67 ℃, 68 ℃, 69 ℃ or 70 ℃; and/or the number of the groups of groups,
The homogenizing speed is 1000-1500 rpm, such as 1000rpm, 1100rpm, 1200rpm, 1300rpm, 1400rpm or 1500rpm; and/or the number of the groups of groups,
The homogenization time is 3 to 5 minutes, for example 3 minutes, 4 minutes or 5 minutes.
In one embodiment, the mixing speed in step (b) is 500 to 1000rpm, such as 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm; and/or the number of the groups of groups,
The mixing time is 10-20 min, such as 10min, 12min, 14min, 15min, 16min, 18min or 20min; and/or the number of the groups of groups,
The temperature is raised to 60 to 70 ℃, for example 60 ℃, 61 ℃, 62 ℃, 63 ℃, 64 ℃, 65 ℃, 66 ℃, 67 ℃, 68 ℃, 69 ℃ or 70 ℃.
In one embodiment, the mixing speed in step (c) is 500 to 1000rpm, such as 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm; and/or the number of the groups of groups,
The mixing time is 10 to 20 minutes, for example 10 minutes, 12 minutes, 14 minutes, 15 minutes, 16 minutes, 18 minutes or 20 minutes.
In one embodiment, the mixing speed in step (d) is 500 to 1000rpm, such as 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm; and/or the number of the groups of groups,
The mixing time is 10-20 min, such as 10min, 12min, 14min, 15min, 16min, 18min or 20min; and/or the number of the groups of groups,
The temperature is raised to 60 to 70 ℃, for example 60 ℃, 61 ℃, 62 ℃, 63 ℃, 64 ℃, 65 ℃, 66 ℃, 67 ℃, 68 ℃, 69 ℃ or 70 ℃.
By mixing the pre-formed A component and the pre-formed B component at a temperature of 75-85 ℃ and maintaining the temperature, a uniform and stable emulsion can be obtained.
In one embodiment, step (e) is carried out at a reduced temperature of 40 to 45 ℃, such as 40 ℃, 41 ℃, 42 ℃, 43 ℃,44 ℃ or 45 ℃; and/or the number of the groups of groups,
The mixing speed is 300 to 500rpm, for example 300rpm, 400rpm or 500rpm; and/or the number of the groups of groups,
The mixing time is 15 to 25 minutes, for example 15 minutes, 20 minutes or 25 minutes.
The mixed liquid is cooled to 40-45 ℃ and then added with the component C to obtain the essence, so that the active ingredients in the component C are prevented from being damaged by high temperature, and the effect is prevented from being influenced.
By preparing under certain conditions, uniform and stable emulsion can be obtained, the structure and activity of active ingredients can not be destroyed in the preparation process, and the use effect of the essence is ensured.
More specifically, the preparation method of the essence comprises the following steps:
(1) Mixing the component A, starting stirring and heating to 60-70 ℃, stirring for 10-20min at the rotation speed of 500-1000rpm, homogenizing for 3-5min at the rotation speed of 1000-1500rpm, and preserving heat for later use to obtain a prefabricated component A;
(2) Mixing the component B, starting stirring and heating to 60-70 ℃, and stirring at 500-1000rpm for 10-20min to obtain a prefabricated component B;
(3) Mixing the component C, starting stirring, and stirring at 500-1000rpm for 10-20min to obtain prefabricated component C;
(4) Adding the prefabricated component A into a water phase pot, heating to 75-85 ℃, starting stirring, adding the prefabricated component B heated to 75-85 ℃ at the rotating speed of 600-1000rpm, and uniformly stirring to obtain a mixed solution;
(5) Cooling the mixed solution to 40-45deg.C, adding the prefabricated component C, stirring at 300-500rpm for 15-25min, adjusting pH, and discharging to obtain essence.
In order to further understand the present application, the antioxidant composition of the present application, the preparation method and effect thereof will be described in further detail with reference to specific examples. The raw materials involved in the application are all available commercially.
Thermus thermophilus (TH 789+ ERMUS THERMOPHILLUS) fermentation products were purchased from sederma; brown alginate oligosaccharides, model MGSD-2, were purchased from marine health technologies (Qingdao) Inc. The other raw materials are all commercial products.
Examples 1 to 19 and comparative examples 1 to 11
The components and parts by weight of the antioxidant compositions described in examples 1 to 19 and comparative examples 1 to 11 are shown in Table 1, and the method for preparing the antioxidant compositions described in examples and comparative examples comprises the steps of: stirring was started, and the components were added to a vessel in parts by weight in accordance with Table 1 at a rotation speed of 800rpm, and stirred for 30 minutes to obtain an antioxidant composition.
TABLE 1
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Effect example 1
Effect example the effect of temperature on the antioxidant compositions obtained in each example and comparative example was tested.
Superoxide dismutase (SOD enzyme) is commonly existing in animals and plants, and is an enzyme for scavenging superoxide anion free radicals, and superoxide anion free radicals (O 2-) are generated through a xanthine and xanthine oxidase reaction system. Superoxide dismutase can be used for determining the enzyme activity by adopting an ultraviolet-visible spectrophotometry method of nitrogen blue tetrazolium. In the presence of an oxidizing substance, riboflavin may be photo-reduced, and the reduced riboflavin is highly susceptible to reoxidation under aerobic conditions to give O 2-, which reduces azulene to blue methylhydrazone, which has a maximum absorption at 560 nm. Whereas superoxide anion inhibitors (e.g., SOD) scavenge O 2-, thereby inhibiting the formation of methyl hydrazone. Thus, the deeper the blue color of the reaction solution after the photoreduction reaction, the lower the superoxide anion inhibition capability of the raw material, and the higher the superoxide anion inhibition capability of the raw material, and the capability of the composition for inhibiting superoxide anions can be calculated according to the higher the superoxide anion inhibition capability.
The test method is as follows:
preparing a solution:
130mmol/L methionine (Met) solution: 1.9389g of Met is weighed, dissolved by phosphate buffer solution and fixed to 100ml; can be stored in a refrigerator at the temperature of 4 ℃ for 1-2 d.
750 Μmol/L solution of Nitrogen Blue Tetrazolium (NBT): weighing 0.06133gNBT, dissolving with phosphate buffer solution to a constant volume of 100ml, and storing in a dark place; can be stored in a refrigerator at the temperature of 4 ℃ for 2-3 d.
20. Mu. Mol/L riboflavin solution: weighing 0.0075g of riboflavin, dissolving with phosphate buffer to 1000mL, and storing in dark.
100. Mu. Mol/L EDTA-2Na solution: 0.0372g of EDTA-2Na was weighed and the volume was set to 1000mL with distilled water.
Sample solution: the mass of the antioxidant compositions obtained in each of the examples and comparative examples in Table 1 was complemented with a sterile PBS buffer so that the total mass of the antioxidant compositions obtained in each of the examples and comparative examples was 100 parts by weight.
The testing steps are as follows:
taking 5 clean and dried transparent ep tubes for each group, numbering, adding each reagent and enzyme solution according to the table 2, and enabling the total volume of a reaction system to be 3mL; after vortex mixing, each tube reacts for 10min under different temperatures (20 ℃,25 ℃, 35 ℃, 40 ℃) and 4000-4500 lx sunlight (the light receiving condition of each tube is required to be consistent, the reaction color and enzyme activity of a control tube under the condition of light are properly adjusted according to the reaction time), and the No. 5 tube is subjected to light-shielding treatment at the same temperature; after the reaction, the reaction was stopped by covering with black cloth, the reaction was terminated with the No. 5 tube as a blank, the absorbance of the reaction solution of the No. 1-4 tube was measured at 560nm, the measurement data was recorded, and each experiment was repeated 3 times.
TABLE 2 sample tube configuration meter
Reagent (mL) | Measuring tube (No. 1-3 tube) | Light control tube (No. 4 tube) | Dark control tube (No. 5) |
PBS | 1.5 | 1.5 | 1.5 |
Met solution | 0.3 | 0.3 | 0.3 |
NBT solution | 0.3 | 0.3 | 0.3 |
EDTA-Na2 | 0.3 | 0.3 | 0.3 |
Riboflavin solution | 0.3 | 0.3 | 0.3 |
Sample of | 0.1 | / | / |
PBS | / | 0.1 | 0.1 |
Distilled water | 0.2 | 0.2 | 0.2 |
Total volume of | 3.0 | 3.0 | 3.0 |
The calculation formula is as follows:
the SOD activity of the antioxidant compositions obtained in each example and comparative example was calculated as formula 1, with SOD-like enzyme activity expressed as the ability of the sample to inhibit superoxide anions, and known SOD activity units expressed as 50% of the enzyme activity units inhibiting the photochemical reduction of NBT:
SOD total activity (U/mL) = (a 0-As)×V/50%×A0×Vs (1))
SOD total Activity is expressed as enzyme units per mL of sample (U/mL)
In the formula 1, A 0 is absorbance of a control tube under light; a s sample measurement tube absorbance; v, total volume of sample extracting solution (mL); v s sample extract (mL) was taken during the measurement.
The test results are shown in Table 3 and FIGS. 1-6.
TABLE 3 Table 3
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As can be seen from Table 3 and FIGS. 1-6, the antioxidant compositions obtained in examples 1-19 have an increased capacity to scavenge superoxide anions with increasing temperature over the temperature range of 20-40 ℃; the antioxidant composition has the effect of resisting oxidation when meeting heat.
As is clear from comparative examples 1, 15 and 18 to 19, the antioxidant effect of the antioxidant derivative is better when the vitamin C derivative is at least one of ascorbyl palmitate, ascorbyl glucoside and 3-O-ethyl ascorbyl ether.
From the experimental data of example 1 and comparative examples 1 to 2, it can be seen that the antioxidant effect of the obtained antioxidant composition is significantly reduced when the mass ratio of the Thermus thermophilus fermentation product, the seaweed oligosaccharide and the vitamins in the antioxidant composition deviates from the range to be protected by the present application;
as can be seen from comparative example 1 and comparative examples 3 to 5, the antioxidant composition obtained by compounding the thermophilic thermus strain fermentation product, the seaweed oligosaccharide and the vitamin eliminates the negative influence of high temperature on the antioxidant active ingredient in the temperature range of 20 to 40 ℃, has better antioxidant effect than the effect of independently using each component, and achieves the effect of compounding synergism.
Comparative examples 3-8 show that there is no synergy between the antioxidant compositions in the combination of the two components compared to the individual components alone.
Comparative example 1 and comparative examples 9 to 11 show that the effect of the obtained antioxidant composition is significantly reduced by using superoxide dismutase instead of Thermus thermophilus fermentation product, using chitosan oligosaccharide as trehalose, or using catechin as antioxidant.
Effect example 2
This effect example the antioxidant compositions obtained in the examples and comparative examples were tested for skin irritation.
The testing method comprises the following steps:
30 volunteers with ages of 20-50 years old are selected, the holes of the spot testers are numbered, and the sample to be tested is respectively placed into the holes of the spot testers with corresponding numbers, wherein the dosage is 0.02mL per cell; the patch test with the test object was applied to the forearm of the subject on the curved side with hypoallergenic tape, and applied to the skin uniformly by gentle palm pressure for 24 hours. The plaque tester was then removed, the skin condition at the site of the wound was observed, the identification criteria are shown in Table 4, and the results of the irritation verification are shown in Table 5.
TABLE 4 Table 4
TABLE 5
From the experimental data in Table 5, the antioxidant composition obtained in the embodiment of the application has smaller irritation to skin, and meets the requirement of cosmetic hygiene Specification on no irritation to skin care products; comparative example 5 contained only vitamin C powder and the resulting antioxidant composition showed a significant irritation, indicating that the antioxidant composition of the present application can effectively improve the irritation of vitamin C and/or vitamin C derivatives to skin.
Examples 20 to 23 and comparative examples 12 to 15
The components and mass percentages of the essences of examples 20-23 and comparative examples 12-15 are shown in Table 6, wherein examples 20, 22 and 23 use the antioxidant composition of example 1, example 21 uses the antioxidant composition of example 2, comparative example 12 uses the antioxidant composition of comparative example 3, comparative example 13 uses the antioxidant composition of comparative example 4, and comparative example 14 uses the antioxidant composition of comparative example 5; the preparation method of the essence comprises the following steps:
(1) Mixing carbopol U20, hyaluronic acid, yellow gelatin, glycerol, EDTA-2Na and water according to the mass percentage of Table 6, starting stirring and heating to 65 ℃, and stirring for 20min at 800 rpm; homogenizing for 5min at 1200rpm, and keeping the temperature for standby to obtain a prefabricated component A;
(2) Mixing butanediol, p-hydroxyacetophenone and 1, 2-hexanediol according to the mass percentage of Table 6, starting stirring and heating to 65 ℃, and stirring for 20min at 800rpm to obtain a prefabricated B component;
(3) Mixing the antioxidant composition and D-panthenol according to the mass percentage of Table 6, starting stirring, and stirring at 800rpm for 15min to obtain a prefabricated C component;
(4) Adding the prefabricated component A into a water phase pot, heating to 80 ℃, starting stirring, adding the prefabricated component B heated to 80 ℃ at the rotating speed of 800rpm, and uniformly stirring to obtain a mixed solution;
(5) Cooling the mixed solution to 40 ℃, adding the prefabricated component C, stirring for 20min at a rotation speed of 400rpm, then adding arginine to adjust the pH, and discharging to obtain the essence.
TABLE 6
Effect example 3
Effect example the effect of the essence obtained in each example and comparative example was tested.
The testing method comprises the following steps:
28 volunteers 35-50 years old were included in the test and equally divided into 4 groups of 8 individuals each. All volunteers signed informed consent. Volunteers in the group were scheduled to use the essence of one example and one comparative example once daily on the morning and evening half face for 4 weeks, and were interviewed on days 1 (initial value), 14 days and 28 days and passed through skin moisture measurement probes CM 825 measured skin moisture content, TEWL value of skin by percutaneous moisture loss probe TEWAMETER TM Hex, skin color content by skin color probe Colorimeter CL400, improvement of under-eye fine wrinkles by Visia, all tests were performed after cleansing the face with a uniform cleansing and sitting still in experimental environment (temperature 20±1 ℃, humidity 50±10%) for 30min, and the efficacy of the serum was expressed as improvement rate (%) = (post-use data-pre-use data)/pre-use data×100%; in this effect example, data were processed and plotted using GraphPad prism8.0 software, single factor analysis of variance (P < 0.5) was performed using SPSS 20.0 software, and all experiments were repeated 3 times. The test results are shown in Table 7.
TABLE 7
Note that: ". Times." indicates a significant difference in improvement rate from the initial value, P < 0.05.
From the experimental data in table 7, the essence obtained in the application can obviously improve the water content of the face, TEWL, whiteness and under-eye fine wrinkles of a subject after being used for 14 days, and the water content of the face, TEWL, whiteness and under-eye fine wrinkles of the subject are further improved after being used for 28 days, which indicates that the essence has the effects of moisturizing, repairing barriers, brightening skin colors and resisting wrinkles.
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the application, and that those skilled in the art will understand that the technical scheme of the application may be modified or equally substituted without departing from the spirit and scope of the technical scheme of the application.
Claims (12)
1. An antioxidant composition comprising a Thermus thermophilus fermentation product, a trehalose and a vitamin; the mass ratio of the thermophilic thermus fermentation product to the seaweed oligosaccharide to the vitamins is that the thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (0.025-5): (0.1-0.5): (0.01-2); the vitamin is vitamin C and/or vitamin C derivative;
The seaweed oligosaccharide is at least one of alginate oligosaccharide, agar oligosaccharide and carrageenan oligosaccharide;
The vitamin C derivative is at least one of ascorbyl palmitate, ascorbyl glucoside and 3-O-ethyl ascorbyl ether.
2. The antioxidant composition of claim 1, wherein the mass ratio of thermophilic thermus fermentation product, trehalose and vitamins is thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (1-5): (0.1-0.5): (0.01-0.5).
3. The antioxidant composition of claim 2, wherein the mass ratio of thermophilic thermus fermentation product, trehalose and vitamins is thermophilic thermus fermentation product: seaweed oligosaccharide: vitamin= (3-5): (0.1-0.5): (0.01-0.5).
4. Use of an antioxidant composition according to any one of claims 1 to 3 for the preparation of cosmetics.
5. The use of the antioxidant composition of claim 4 in the preparation of a cosmetic product, wherein the cosmetic product is at least one of a lotion, an emulsion, a cream, a mask, an essence, and a spray.
6. Use of the antioxidant composition according to claim 4 for the preparation of a cosmetic product, wherein the cosmetic product is at least one of a sunscreen cream, a sunscreen spray, a sunscreen emulsion.
7. A cosmetic product, characterized in that it comprises the antioxidant composition according to any one of claims 1 to 3.
8. The cosmetic product of claim 7, wherein the antioxidant composition is present in the cosmetic product in an amount of from 0.8 to 5% by weight.
9. The cosmetic product of claim 7, wherein the cosmetic product further comprises at least one cosmetically acceptable auxiliary.
10. The cosmetic product according to any one of claims 7 to 9, wherein the cosmetic product is at least one of a lotion, an emulsion, a cream, a mask, an essence, and a spray.
11. The cosmetic product according to any one of claims 7 to 9, wherein the cosmetic product is at least one of a sunscreen cream, a sunscreen spray, a sunscreen emulsion.
12. The cosmetic product of claim 10, wherein the cosmetic product is a serum and the serum comprises the following components in weight percent: 20.01-0.5% of carbopol U, 0.01-1% of hyaluronic acid, 0.1-1% of yellow gelatin, 2-8% of glycerin, 0.01-0.1% of disodium ethylenediamine tetraacetate, 1-20% of butanediol, 0.1-5% of p-hydroxyacetophenone, 0.1-5% of 1, 2-hexanediol, 0.8-5% of antioxidant composition, 0.1-10% of D-panthenol, 0.1-1% of arginine and the balance of water.
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