CN111821236B

CN111821236B - Essence milk and preparation method thereof

Info

Publication number: CN111821236B
Application number: CN202010768559.4A
Authority: CN
Inventors: 刘鹏飞
Original assignee: Guangzhou Lize Cosmetics Co ltd
Current assignee: Guangzhou Lize Cosmetics Co ltd
Priority date: 2020-08-03
Filing date: 2020-08-03
Publication date: 2022-05-24
Anticipated expiration: 2040-08-03
Also published as: CN111821236A

Abstract

The application relates to essence milk and a preparation method thereof, and the essence milk comprises the following steps: oriental cherry flower extract; bisabolol; a Uncaria tomentosa extract; hydrogenated lecithin; glyceryl stearate citrate; polyglyceryl-3 methyl glucose distearate; sodium lauroyl lactylate; a solvent; also relates to a preparation method of the essence milk, which comprises the following steps: step 1, mixing hydrogenated lecithin and a solvent to obtain a first mixture; step 2, mixing glycerol stearate citrate and polyglycerol-3-methyl glucose distearate to obtain a second premix; step 3, uniformly mixing the second premix with the first mixture to obtain a second mixture; step 4, mixing the sodium lauroyl lactylate, the bisabolol and the second mixture to obtain a third mixture; and 5, mixing the cherry blossom extract, the Uncaria tomentosa extract and the third mixture to obtain the essence milk. The application has multiple anti-aging effects.

Description

Essence milk and preparation method thereof

Technical Field

The application relates to the field of skin care products, in particular to essence milk and a preparation method thereof.

Background

At present, with the progress of social development, the life rhythm of people is accelerated, the life pressure of people is increased when people grow with age, the phenomenon of staying up all night is aggravated, the sleep quality of most people is poor, the metabolism of the human body is easy to slow, the aging of the human body is accelerated, but the requirement of people on self maintenance is higher and higher, therefore, people pay more and more attention to resisting aging, and the attention of people to resisting aging products is higher and higher.

The skin aging is a result of a plurality of reasons, photoaging reaction, saccharification reaction, oxidation reaction, inflammation, metabolism slowing and the like are all important reasons of the skin aging, and the existing anti-aging mainly achieves the purpose of comprehensively delaying the skin aging by adding components with different efficacies and preventing the skin aging in different aspects.

The above prior art solutions have the following drawbacks:

in order to meet the requirements of health and innocuity, plant extracts are usually adopted as active ingredients in skin care products, one plant extract can only produce one to two anti-aging effects, better anti-aging is desired, aging is preferably inhibited from multiple aspects, aging reactions of various different types are slowed down, and therefore, the matching of multiple plant extracts is required, but when the plant extracts are matched with each other, positive overlapping effects can not always be achieved, drug effects can conflict or can be mutually counteracted, and therefore, few products for resisting aging from multiple directions on the market are available, the market requirements are difficult to meet, and therefore, the improvement space is provided.

Disclosure of Invention

In view of the defects of the prior art, the invention aims to provide the essence milk which has multiple anti-aging effects.

In view of the defects of the prior art, the invention also aims to provide a preparation method of the essence milk, which has the effect that the effective components of the extracts are not easily damaged.

The above object of the present invention is achieved by the following technical solutions:

the essence milk mainly comprises the following components in percentage by mass:

1% -5% of oriental cherry extract;

0.1 to 0.3 percent of bisabolol;

0.1 to 0.5 percent of the Uncaria tomentosa extract;

0.8% -1.2% of hydrogenated lecithin;

1% -2% of glycerol stearate citrate;

polyglycerol-3 methylglucose distearate 0.5% -1.5%;

0.1 to 0.4 percent of lauroyl sodium lactylate;

the balance of solvent;

the total mass percentage is 100 percent.

By adopting the technical scheme, the oriental cherry extract can inhibit the generation of advanced glycosylation end products by adding the oriental cherry extract, thereby reducing the condition that the advanced glycosylation end products are combined with specific receptors, ensuring that the elasticity of the skin is not easy to reduce, improving dark yellow skin color, recovering cell skeletons, recovering the tightness and elasticity of the skin, reducing wrinkles, and simultaneously having certain effect of promoting skin metabolism, and the oriental cherry extract also has certain effect of removing free radicals, thereby having antioxidant effect and ensuring better anti-aging effect. By adding the bisabolol, the bisabolol has good stability and good compatibility with skin, has antibacterial and anti-inflammatory effects, can reduce the release of interleukin IL-1lalpha, accelerates the healing of skin wounds, promotes metabolism, promotes cell regeneration, effectively protects and repairs cells, delays skin aging, and has certain antioxidant effect and better anti-aging effect by removing free radicals to a certain extent. By adding the harpagne extract, the harpagne extract contains rich galactan, is beneficial to resisting adverse environment, and can reduce the content of middle-stage glycosylation products and end-stage glycosylation products, so that the elasticity of the skin is not easy to reduce, the skin is recovered to a young state, and the anti-aging effect is good. By adding the hydrogenated lecithin, the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the sodium lauroyl lactylate, the interfacial tension in the solvent is reduced, so that the dispersing effect of each component is better, stable emulsion droplets are formed, and the essence emulsion is kept in a stable emulsion state. By adding the cherry blossom extract, the bisabolol and the Uncaria japonica extract, the formula has multiple anti-aging effects, the capacity of the cherry blossom extract for reducing the content of the advanced glycosylation end product is improved, the Uncaria japonica extract relieves the inhibition effect of the cherry blossom extract on the anti-inflammatory effect of the bisabolol, the effect of promoting skin metabolism is also improved, the Uncaria japonica extract also obviously enhances the anti-oxidation effect of the cherry blossom extract, and the multiple anti-aging effect of the product is better. The interface tension is reduced to a greater extent by matching the hydrogenated lecithin, the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the sodium lauroyl lactylate in a specific proportion, so that the emulsification effect of each component in a solvent is better, the emulsification state of each component is more stable, and the oil phase and the water phase of the essence milk are not easy to separate.

The present invention in a preferred example may be further configured to: the paint also comprises the following components in percentage by mass:

2% -5% of squalane;

magnesium gluconate 0.2% -0.5%;

chicory extract 0.2% -0.5%;

0.1% -0.5% of Chondrus crispus extract;

0.2 to 0.5 percent of the broccoli extract;

0.2 to 0.4 percent of fucus serratus extract;

0.1 to 0.3 percent of sargassum obtusifolia extract;

0.5 to 2 percent of yeast fermentation product filtrate.

By adopting the technical scheme, the squalane is added, has better oxidation resistance and immunity stimulation, can be quickly dissolved with moisture or grease in the skin to form a skin protection barrier, improves rough and dark skin, and recovers the tender touch of the skin. By adding the magnesium gluconate, the magnesium gluconate is beneficial to helping the skin to refresh and relieve skin inflammation, so that the skin keratinocytes are kept in a relatively healthy state, and the invasion of the external environment is better resisted. By adding the chicory extract, the chicory extract can better eliminate free radicals and has better oxidation resistance. By adding Chondrus crispus extract, the Chondrus crispus extract can promote keratinocyte differentiation of skin, improve rough skin, and increase water content of skin. By adding the agar-agar extract, the agar-agar extract contains rich trace elements, which is beneficial to nourishing and protecting skin. By adding Fucus serratus extract, the Fucus serratus extract can prevent excessive expansion of blood capillary, is effective in preventing and treating red blood streak, can remove free radicals and inhibit elastase activity, and has antiaging and anti-wrinkle effects. By adding the sargassum blunt extract, the sargassum blunt extract can promote the activity of fibroblast and has better oxidation resistance, so that the anti-aging effect is better, and meanwhile, the sargassum blunt extract has a promoting effect on the generation of hyaluronic acid and can effectively keep the moisture in the skin. By adding the yeast fermentation product filtrate, the yeast fermentation product filtrate has excellent deep moisturizing and repairing effects, reduces skin inflammation, helps skin to resist oxidation, and delays skin aging. Through the matching of the components in a specific proportion, the components can exert respective effects to a greater extent, so that the repairing effect and the anti-aging and anti-wrinkle effect of the essence milk are better, the essence milk is mild, stimulation to skin is not easy to cause, and the experience effect of sensitive skin is better.

3.75% -11.5% of a skin conditioner;

the skin conditioner comprises one or more of ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, 1-methylhydantoin-2-imide, cyanocobalamin, caprylic hydroxamic acid, glyceryl caprylate and p-hydroxyacetophenone.

By adopting the technical scheme, the ceramide 1 has the function of repairing a sebum membrane by adding the ceramide 1, so that the barrier function of skin on the surface layer of the skin is promoted, the water loss is reduced, and the moisturizing effect is achieved. By adding the ceramide 3, the ceramide 3 can help the skin to lock moisture, so that dryness can be repaired, damaged skin can be repaired, and the skin is in a relatively healthy state. By adding ceramide 6II, ceramide 6II helps the skin to lock water and also helps the skin to metabolize rapidly in the stratum corneum, so that the skin is smoother. By adding phytosphingosine, the phytosphingosine has similar structure with substances forming skin horny layer, so that the phytosphingosine can quickly permeate into skin, and can be combined with water in horny layer to form a net structure, thereby locking water, simultaneously being beneficial to promoting the generation of ceramide on the skin and protecting skin barrier. By adding cholesterol, the cholesterol has strong permeability to skin, can maintain moisture on the surface of the skin, promote skin metabolism, inhibit skin inflammation, is easy to push away, and has refreshing feeling after use. By adding the 1-methylhydantoin-2-imide and the 1-methylhydantoin-2-imide, the synthesis of tyrosinase and melanin protein is inhibited, the skin is helped to improve metabolism, the renewal of epidermal cell groups is accelerated, the transitional keratinization of cells is reduced, and the cells are rich in elasticity. By adding cyanocobalamin, the cyanocobalamin can strengthen the capillary vessels of the skin and relieve inflammation, and has the effects of promoting metabolism and helping the skin to regenerate. By adding the caprylyl hydroximic acid, the effect of the caprylyl hydroximic acid on inhibiting bacteria is better, the effect is not easily influenced by other components, and the bacteriostatic effect can be exerted more stably. By adding the glyceryl caprylate, lipophilic carbon chains of the glyceryl caprylate are easy to permeate and adsorb on lipid parts of human skin, and hydrophilic groups can better keep moisture in the stratum corneum and can convey or retain oily components on the skin surface layer. By adding the p-hydroxyacetophenone, the p-hydroxyacetophenone has the effects of resisting oxidation, calming and relieving, can better protect skin barriers, and also has a better antiseptic function, so that the product can keep a stable state for a longer time.

The present invention in a preferred example may be further configured to: the skin conditioner comprises the following components in percentage by mass:

by adopting the technical scheme, the components are matched in a specific proportion, so that the components are not easy to cause irritation to the skin after being added, and the skin can be better conditioned to a greater extent, so that the skin can be recovered to a healthy state.

3.31 to 14.7 percent of humectant;

the humectant is one or more of glycerol, 1, 3-propylene glycol, creatine, hydrolyzed hyaluronic acid, maltose and 1, 2-pentanediol.

By adopting the technical scheme, the moisturizing agent is favorable for keeping the skin moist by adding the moisturizing agent, so that the moisture of the skin is not easy to run off, the barrier of the skin is not easy to damage, and meanwhile, the skin is favorable for self-repairing of the skin, so that the skin is easy to be in a relatively healthy state. The moisturizing agent is one or more of glycerin, 1, 3-propylene glycol, creatine, hydrolyzed hyaluronic acid, maltose and 1, 2-pentanediol, so that the moisturizing agent has a good moisturizing effect, is good in skin moisturizing effect and is beneficial to keeping the skin in a healthy state.

The present invention in a preferred example may be further configured to: the humectant comprises the following components in percentage by mass:

2% -6% of glycerol;

3% -5% of 1, 3-propylene glycol;

0.3% -0.5% of creatine;

0.1 to 0.4 percent of hydrolyzed hyaluronic acid;

0.01 to 0.1 percent of hyaluronic acid;

0.05% -0.2% of maltose;

0.05% -0.3% of 1, 2-pentanediol.

The components are matched in a specific proportion, so that the product has a good keeping effect, the skin barrier can normally play a role, and the skin is not easy to be damaged by the external environment.

3.2% -7.8% of emollient;

the emollient is one or two of olive unsaponifiable matter and polydimethylsiloxane.

By adding the olive fruit unsaponifiable matter, the olive fruit unsaponifiable matter can eliminate free radicals and repair skin sunburn, and has good oxidation resistance and repair performance. By adding polydimethylsiloxane, a layer of uniform protective film with waterproof performance can be formed after the protective film is smeared on the skin, and meanwhile, sticky and greasy feeling is not easy to generate.

The present invention in a preferred example may be further configured to: the emollient comprises the following components in percentage by mass:

3% -7% of olive fruit unsaponifiable matter;

0.2 to 0.8 percent of polydimethylsiloxane.

The olive fruit and the polydimethylsiloxane are matched in a specific proportion, so that the effects of reducing flaky skin and improving skin appearance are better, and the effect of helping the skin to be soft and smooth when the product is used is better.

The present invention in a preferred example may be further configured to: the method comprises the following steps:

step 1), mixing hydrogenated lecithin and a solvent, heating to 83-88 ℃, and stirring until the hydrogenated lecithin is completely dissolved to obtain a first mixture;

step 2), mixing and heating glycerol stearate citrate and polyglycerol-3-methyl glucose distearate, and stirring until the polyglycerol-3-methyl glucose distearate and the glycerol stearate citrate are completely dissolved to obtain a second premix;

step 3), uniformly mixing the second pre-mixture and the first mixture to obtain a second mixture;

step 3), adding sodium lauroyl lactylate into the second mixture, uniformly stirring, preserving the temperature at 83-88 ℃ for 28-32 minutes, reducing the temperature to 68-72 ℃, adding bisabolol, and uniformly stirring to obtain a third mixture;

And 5) cooling the third mixture to below 40 ℃, adding the oriental cherry flower extract and the Uncaria tomentosa extract into the third mixture, and uniformly stirring to obtain the essence milk.

By adopting the technical scheme, the hydrogenated lecithin and the solvent are mixed, then the mixture is heated to 83-88 ℃, and the mixture is stirred until the hydrogenated lecithin is completely dissolved, so that the hydrogenated lecithin can be favorably emulsified in the solvent. The glycerol stearate citrate and the polyglycerol-3-methyl glucose distearate are mixed and heated to ensure that the components are mixed better to form a second pre-mixture. The second pre-mixture is uniformly mixed with the first mixture, and the sodium lauroyl lactylate is added into the second mixture and uniformly stirred, so that the emulsification effect of the components of the second mixture in the solvent is better. By first keeping the temperature at 83-88 ℃ for 28-32 minutes, the gas in the solvent is easier to discharge due to the violent thermal motion of the solvent molecules at 83-88 ℃, so that the dispersing effect of each substance in the second mixture is better. After the heat preservation is carried out for 28-32 minutes, the temperature is reduced to 68-72 ℃, then the bisabolol is added and stirred uniformly, so that the addition of the active ingredients of the bisabolol is not easy to damage and the dispersion effect is better. The cherry blossom extract can be better exerted by cooling the third mixture to below 40 ℃, then adding the cherry blossom extract and the Uncaria tomentosa extract into the third mixture, and uniformly stirring to ensure that the active ingredients in the cherry blossom extract can be easier to keep better activity.

The invention in a preferred example may be further configured to: the method is characterized in that: in the step 1), glycerol, 1, 3-propylene glycol, creatine, p-hydroxyacetophenone and hydrogenated lecithin are added into a solvent, heated to 83-88 ℃, added with hydrolyzed hyaluronic acid, hyaluronic acid and 1-methylhydantoin-2-imide and stirred until all the components are completely dissolved;

in the step 2), squalane, polydimethylsiloxane, olive unsaponifiable matter, glycerol stearate citrate and polyglycerol-3-methyl glucose distearate are mixed and heated, and stirred until the mixture is completely dissolved;

in the step 4), adding ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol and sodium lauroyl lactylate into the second mixture, and uniformly stirring;

in the step 5), adding magnesium gluconate, chicory extract, carrageen crispatus extract, agar-agar extract, fucus rudis extract, sargassum blunt, yeast fermentation product filtrate, cyanocobalamin, caprylyl hydroximic acid, caprylic acid ester, 1, 2-pentanediol, cherry blossom extract and Uncaria tomentosa extract into the third mixture, and stirring uniformly.

By adopting the technical scheme, in the step 1), the glycerol, the 1, 3-propylene glycol, the creatine, the p-hydroxyacetophenone and the hydrogenated lecithin are added into the solvent together, so that the interface tension is reduced by the hydrogenated lecithin, the dissolving effect of the oil phase and the water phase is better, and a stable emulsion state is formed. The hydrolyzed hyaluronic acid, the hyaluronic acid and the 1-methylhydantoin-2-imide are added after being heated to 83-88 ℃, and stirred until all the components are completely dissolved, so that all the components are rapidly dispersed at a higher temperature. The squalane, the polydimethylsiloxane, the olive unsaponifiable matter, the glycerol stearate citrate and the polyglycerol-3-methyl glucose distearate are mixed and heated, and the squalane is oily and is more uniformly distributed after being mixed with the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the olive unsaponifiable matter. The ceramide 1, the ceramide 3, the ceramide 6II, the phytosphingosine, the cholesterol and the sodium lauroyl lactylate are added into the second mixture together and stirred uniformly, so that the interfacial tension can be reduced by the sodium lauroyl lactylate, and the components are mixed in the second mixture more uniformly. By adding magnesium gluconate, chicory extract, carrageen crispus extract, agar extract, fucus serratus extract, gulfweed extract, yeast fermentation product filtrate, cyanocobalamine, caprylyl hydroximic acid, caprylic glyceride, maltose, 1, 2-pentanediol, sakura flower extract and uncaria extract into the third mixture, because the temperature is lower at the moment, all the components are kept in a stable state, the effective components of all the extracts are not easily damaged, and the components can better exert respective effects.

In summary, the invention includes at least one of the following beneficial technical effects:

1. by adding the cherry blossom extract, the bisabolol and the Uncaria tomentosa extract, the formula has multiple anti-aging effects, the capacity of the cherry blossom extract for reducing the content of the advanced glycosylation end products is improved, the antibacterial and anti-inflammatory effects of the bisabolol are improved, and the anti-aging effect of the product is better.

2. One or more of ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, 1-methylhydantoin-2-imide, cyanocobalamine, caprylic hydroxamic acid, glyceryl caprylate and p-hydroxyacetophenone are compounded, so that the skin is not easy to be stimulated after the composition is added, the skin barrier can be effectively protected, and the skin can be recovered to a healthy state.

3. By adding the olive unsaponifiable matter and the polydimethylsiloxane, a layer of uniform protective film with waterproof performance can be formed while the protective film has good oxidation resistance and repairing performance, meanwhile, the sticky and greasy feeling is not easy to generate, and the skin moistening effect is good.

Drawings

Fig. 1 is a schematic flow diagram illustrating a method for preparing essence milk according to the present invention.

Detailed Description

In the following examples and comparative examples, the information on the source of each raw material is shown in Table 1.

TABLE 1

Examples 1 to 3

An essence milk comprises the following components:

cherry blossom extract, bisabolol, Uncaria tomentosa extract, hydrogenated lecithin, glyceryl stearate citrate, polyglycerol-3-methyl glucose distearate, sodium lauroyl lactylate, and solvent.

The solvent is water.

In examples 1-3, the amounts (in Kg) of each component added are specified in Table 2

TABLE 2

	Example 1	Example 2	Example 3
				Oriental cherry flower extract	1	3	5
Bisabolol	0.1	0.15	0.3
				Uncaria tomentosa extract	0.1	0.2	0.5
Water (W)	96.4	92.95	89.1
				Hydrogenated lecithin	0.8	1	1.2
Glycerol stearate citrate	1	1.5	2
				Polyglyceryl-3-methylglucose distearate	0.5	1	1.5
Lauroyl sodium lactylate	0.1	0.2	0.4

Referring to fig. 1, the method for preparing the essence milk of examples 1 to 3 includes the steps of:

step 1), adding hydrogenated lecithin and water into a first stirring kettle at a rotating speed of 60r/min, heating to 85 ℃ while stirring, and continuously stirring until the hydrogenated lecithin is completely dissolved to obtain a first mixture;

step 2), then putting the glycerol stearate citrate and the polyglycerol-3-methyl glucose distearate into a second stirring kettle, rotating at the speed of 120r/min, heating while stirring until the polyglycerol-3-methyl glucose distearate and the glycerol stearate citrate are completely dissolved, and discharging into a container to obtain a second premix;

Step 3), adding the second pre-mixture into the first mixture, stirring for 3min at the rotating speed of 60r/min, and uniformly mixing to obtain a second mixture;

step 4), adding sodium lauroyl lactylate into the second mixture, stirring at a rotation speed of 60r/min for 3min, uniformly stirring, heating to 85 ℃, keeping the temperature for 30min, cooling to 70 ℃, then adding bisabolol at a rotation speed of 60r/min, stirring for 3min, and uniformly mixing to obtain a third mixture;

and 5) cooling the third mixture to 40 ℃, adding the oriental cherry flower extract and the Uncaria tomentosa extract into the third mixture, stirring for 3min at the rotating speed of 60r/min, and uniformly stirring to obtain the essence milk.

Example 4

Compared with example 2, the difference is only that:

in step 1), water was mixed with hydrogenated lecithin and heated to 88 ℃.

In the step 4), the temperature is firstly increased to 88 ℃ and kept for 32min, and then the temperature is reduced to 72 ℃.

In step 5), the third mixture was cooled to 39 ℃.

Example 5

Compared with example 2, the difference is only that:

in step 1), water was mixed with hydrogenated lecithin and heated to 83 ℃.

In the step 4), the temperature is firstly increased to 83 ℃ and is kept for 28min, and then the temperature is reduced to 68 ℃.

In step 5), the third mixture was cooled to 38 ℃.

Examples 6 to 8

The essential milk also comprises the following components:

squalane, magnesium gluconate, herba Cichorii extract, Chondrus crispus extract, Eucheuma Gelatinosum extract, Fucus serratus extract, Sargassum blunt, and yeast fermentation product filtrate.

In examples 6 to 8, the amounts (in Kg) of squalane, magnesium gluconate, chicory extract, Chondrus crispus extract, Eucheuma Gelatinosum extract, Fucus serratus extract, Sargassum blunt, yeast fermentation product filtrate added are shown in Table 3

TABLE 3

Adding squalane, glycerol stearate, citric acid ester and polyglycerol-3-methyl glucose distearate into a stirring kettle in the step 2), and uniformly stirring.

Magnesium gluconate, herba Cichorii extract, Chondrus crispus extract, Eucheuma Gelatinosum extract, Fucus serratus extract, Sargassum blunt, and yeast fermentation product filtrate in step 5) are added into the third mixture together with the extract of Ornithogalum prunifolium and the extract of Uncaria tomentosa, and stirred uniformly.

Examples 9 to 11

Compared with example 2, the difference is only that:

the components of the essence milk also comprise a skin conditioner.

The skin conditioner is a compound of ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, 1-methylhydantoin-2-imide, cyanocobalamin, caprylyl hydroxamic acid, glyceryl caprylate and p-hydroxyacetophenone.

In examples 9-11, the amounts of skin conditioning agents (in Kg) are detailed in Table 4

TABLE 4

Adding p-hydroxyacetophenone, hydrogenated lecithin and water into a stirring kettle in the step 1), uniformly stirring, heating to 85 ℃, adding 1-methylhydantoin-2-imide, and stirring until the mixture is completely dissolved.

Ceramide 1, ceramide 3, ceramide 6II, phytosphingosine and cholesterol are added into the second mixture together with sodium lauroyl lactylate in the step 4), and the mixture is stirred uniformly.

Cyanocobalamin, octanoyl hydroximic acid, glyceryl caprylate are added to the third mixture in step 5) together with the cherry blossom extract and the Uncaria tomentosa extract, and stirred uniformly.

Examples 12 to 14

Compared with example 2, the difference is only that:

the essential milk also comprises a humectant.

The humectant is prepared from glycerol, 1, 3-propylene glycol, creatine, hydrolyzed hyaluronic acid, maltose, and 1, 2-pentanediol.

In examples 12 to 14, the amounts (in Kg) of the moisturizers added are specified in Table 5

TABLE 5

Adding glycerol, 1, 3-propylene glycol and creatine, hydrogenated lecithin and water into a stirring kettle in the step 1), uniformly stirring, heating to 85 ℃, adding hydrolyzed hyaluronic acid and hyaluronic acid, and stirring until the hydrolyzed hyaluronic acid and the hyaluronic acid are completely dissolved.

Maltose, 1, 2-pentanediol are added to the third mixture in step 5) together with the oriental cherry flower extract and the Uncaria tomentosa extract, and are stirred uniformly.

Examples 15 to 17

Compared with example 2, the difference is only that:

the components of the essence milk also comprise an emollient.

The emollient is the compound of olive fruit unsaponifiable matter and polydimethylsiloxane.

In examples 15-17, the amounts (in Kg) of emollient added are detailed in Table 6

TABLE 6

	Example 15	Example 16	Example 17
				Olive fruit unsaponifiable matter	0.2	0.5	0.8
Polydimethylsiloxane	0.1	0.15	0.2

Adding olive unsaponifiable matter and polydimethylsiloxane, glycerol stearate citrate and polyglycerol-3-methyl glucose distearate into the stirring kettle in the step 2), and uniformly stirring.

Examples 18 to 20

Compared with example 2, the difference is only that:

the components of the essence milk also comprise a chelating agent and a pH regulator.

The chelating agent is EDTA disodium;

the pH regulator is arginine.

In examples 18 to 20, the amounts (in Kg) of chelating agent and pH adjuster added are shown in Table 7

TABLE 7

	Example 18	Example 19	Example 20
				Arginine	0.1	0.15	0.2
EDTA disodium salt	0.01	0.03	0.05

Adding the disodium EDTA, the hydrogenated lecithin and the water into the stirring kettle in the step 1), and uniformly stirring.

Adding arginine and bisabolol together when the temperature is reduced to 70 ℃ in the step 4), stirring for 3min at the rotation speed of 60r/min, and uniformly mixing.

Examples 21 to 23

Compared with example 2, the only difference is that:

the components of the essence milk also comprise a thickening agent and a preservative.

The thickening agent is a compound of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, carbomer and xanthan gum;

the preservative is a compound of methyl hydroxybenzoate and ethylparaben.

In examples 21 to 23, the amounts (in Kg) of the thickener and the antiseptic added are shown in Table 8

TABLE 8

Adding the acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, hydrogenated lecithin and water into a stirring kettle in the step 1), and uniformly stirring.

Carbomer, xanthan gum, methylparaben and ethylparaben are added to the second mixture in step 4) together with the sodium lauroyl lactylate and stirred uniformly.

Examples 24 to 26

Compared with example 2, the difference is only that:

the essential milk also comprises the following components:

squalane, magnesium gluconate, chicory extract, Chondrus crispus extract, Eucheuma Gelatinosum extract, Fucus serratus extract, Sargassum blumea extract, yeast fermentation product filtrate, skin conditioner, humectant, emollient, chelating agent, pH regulator, thickener, and antiseptic.

The skin conditioner is a compound of ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, 1-methylhydantoin-2-imide, cyanocobalamin, caprylyl hydroxamic acid, glyceryl caprylate and p-hydroxyacetophenone;

The humectant is prepared by compounding glycerol, 1, 3-propylene glycol, creatine, hydrolyzed hyaluronic acid, maltose and 1, 2-pentanediol;

the emollient is the compound of unsaponifiable matter of olive fruit and polydimethylsiloxane;

the chelating agent is EDTA disodium;

the pH regulator is arginine;

the preservative is the compound of methylparaben and ethylparaben.

In examples 24 to 26, the amounts (in Kg) of the respective components charged are shown in Table 9

TABLE 9

Adding glycerol, 1, 3-propylene glycol, creatine, EDTA disodium, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and p-hydroxyacetophenone, hydrogenated lecithin and water into a stirring kettle in the step 1), uniformly stirring, heating to 85 ℃, adding hydrolyzed hyaluronic acid, hyaluronic acid and 1-methylhydantoin-2-imide, and stirring until the materials are completely dissolved.

Adding squalane, dimethicone olive unsaponifiable matter, glycerol stearate, citric acid ester, and polyglyceryl-3-methyl glucose distearate into a stirring kettle in step 2), and stirring.

Ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, carbomer, xanthan gum, methylparaben and ethylparaben are added into the second mixture together with the sodium lauroyl lactylate in the step 4), the mixture is stirred uniformly, arginine and bisabolol are added together when the temperature is reduced to 70 ℃, the rotating speed is 60r/min, the mixture is stirred for 3min, and the mixture is mixed uniformly.

Magnesium gluconate, chicory extract, Chondrus crispus extract, Eucheuma Gelatinosum extract, Fucus serratus extract, Sargassum blumerium extract, yeast fermentation product filtrate, maltose, 1, 2-pentanediol, cyanocobalamin, caprylyl hydroximic acid, and glyceryl caprylate are added to the third mixture together with the cherry blossom extract and the Uncaria tomentosa extract in step 5), and stirred uniformly.

Comparative example 1

Compared with example 2, the difference is only that:

in the step 4), the same amount of water is adopted to replace the hydrargyri oxydum rubrum.

In the step 5), the cherry blossom extract and the Uncaria tomentosa extract are replaced by the same amount of water.

Comparative example 2

Compared with example 2, the difference is only that:

In the step 5), the hook sand vegetable extract is replaced by the same amount of water.

Comparative example 3

Compared with example 2, the difference is only that:

Comparative example 4

Compared with example 2, the difference is only that:

In the step 5), the cherry blossom extract is replaced by equal amount of water.

Comparative example 5

Compared with example 2, the difference is only that:

Comparative example 6

Compared with example 2, the difference is only that:

Comparative example 7

Compared with example 2, the difference is only that:

Experimental example 1

DPPH radical scavenging Rate experiment

Taking a DPPH-anhydrous methanol solution with the concentration of 3mL0.0178mmol/L, adding 3mL of a solution to be detected prepared from the essence milk prepared in each example and each comparative example, uniformly mixing, immediately measuring the light absorption value at the wavelength of 517nm, marking the light absorption value as A1, then storing the solution at 37 ℃ in the dark for 30min, marking the solution as A2, and calculating the DPPH free radical clearance according to the following formula, wherein a blank control group is a solution prepared by only adding DPPH-anhydrous methanol, and the light absorption value is marked as A3: DPPH radical clearance (%) [1- (a1-a2)/A3] 100%, averaged over three measurements.

Experimental example 2

XTT is a tetrazole nitrogen derivative, can be degraded and reduced into water-soluble brown yellow formazan products by mitochondrial dehydrogenase in living cells, and the generation amount of the formazan is positively correlated with the activity of cell mitochondria, so that the XTT method can be used for detecting the activity of the mitochondria so as to react the metabolic capability of the cells.

Inoculating human immortalized keratinocyte (HaCaT) cells into a limiting keratinocyte serum-free medium (DK-SFM), placing the cells in a constant-temperature incubator with the temperature of 37 ℃ and the CO2 volume fraction of 5% for 5 days until the cells are fused, and changing the culture solution every other day. For the experiment, the cell culture flask was taken out, HaCaT cells were digested with trypsin for 4min, and then the cells were inoculated and incubated with 96-well plates for 24h, 200 μ L of essence milk prepared from each of examples and comparative examples with a solid content of 0.1mg/mL diluted with DK-SFM culture solution was added to each well, and the measurement was performed after 48h in the incubator. Adding medicine, incubating, and dissolving XTT by preheating at 60 deg.CAfter removing the culture medium from the 96-well plate as a 0.2mg/mL solution, XTT/PMS (200:1) (PMS means phenazine methosulfate) was added to each well, and the resulting mixture was incubated at 37 ℃ for 2 hours, and the absorbance OD was measured at a wavelength of 450nm on a microplate reader according to the absorbance 0D measured in comparative example 1₀As a reference value, the ratio of mitochondrial activity to OD/0D was obtained by dividing the absorbance of each example or each comparative example by the absorbance of comparative example 1 and multiplying by 100%₀The absorbance 0D of comparative example 1 was subtracted from the absorbance OD of each example or each comparative example by calculation ₀The boosted value is obtained, and the boosted value is divided by the light absorption value 0D of each example or each comparative example and multiplied by 100% to obtain the boosting ratio.

Experimental example 3

The essence milk prepared in each embodiment and comparative example is uniformly smeared on the inner side skin of a normal forearm until the skin is completely absorbed, an instrument is calibrated, a subject takes a sitting position, the left hand is fixed on a groove fixing position of a detection instrument, about 1cm x 1cm of the inner side skin of the forearm coated with the essence milk prepared in each embodiment and comparative example is selected as an illumination part, the forearm is contacted with a detection probe, a dark shading cloth is covered on the forearm, the probe emits an excitation light source, monochromatic light with the wavelength of 300-.

Experimental example 4

The equivalent amount of 0.25% Sodium Dodecyl Sulfate (SDS) was added to the formulation, and after 24 hours, the degree of skin module injury was observed, and the amount of IL-lalpha (cytokine) at a wavelength of 450nm was examined by an ELISA plate reader, and the result of inflammatory reaction was evaluated by taking the absorbance measured in comparative example 1 as a reference value, dividing the absorbance of each example or each comparative example by the absorbance of comparative example 1, and multiplying the result by 100%.

The data obtained in experiments 1-4 are detailed in Table 10

Watch 10

According to the comparison of the data of comparative example 2 and comparative example 1 in table 10, the content of AGEs in the skin is obviously reduced after the oriental cherry flower extract is added, and the effect of reducing the content of AGEs in the skin is better, so that AGEs are not easy to accumulate, collagen fibers of the skin are not easy to solidify, the reduction of the elasticity reduction and the yellowing and darkness of the skin is reduced, the improvement of the free radical clearance rate is obvious, and the oriental cherry flower extract is proved to have better capability of eliminating free radicals, and has certain improvement in the anti-aging effect.

As can be seen from comparison of data in table 10 in comparative example 3 and comparative example 1, after the bisabolol is added, the absorbance is significantly increased, which indicates that IL-lalpha causing cell inflammation is reduced, and the bisabolol can reduce cell damage caused by detergent contact, effectively repair damaged cells, reduce inflammation caused by cell division, and simultaneously improve the mitochondrial activity ratio, thereby proving that the metabolism speed is increased, the radical scavenging rate is improved to a certain extent, and proving that the antioxidant ability is enhanced, and further the anti-aging ability is improved to a certain extent.

According to the comparison of the data of comparative example 4 and comparative example 1 in table 10, the content of AGEs in the skin is reduced to a certain extent after the harpagne extract is added, so that the collagen fibers are not easy to solidify, the decrease of the light absorption rate is not obvious, and the anti-inflammatory effect of the harpagne extract is general.

According to the comparison of the data of comparative example 5 and comparative example 3 in table 10, the light absorption rate is reduced significantly after the bisabolol and the henry sage extract are added, which indicates that the henry sage extract can effectively improve the anti-inflammatory ability and the metabolism speed of the bisabolol, so that the anti-aging effect is improved to a certain extent.

According to the comparison of the data of comparative example 6 and comparative example 2 in table 10, the skin AGEs content is further reduced after the oriental cherry extract and the Uncaria rhynchophylla extract are added, which shows that the oriental cherry extract and the Uncaria rhynchophylla extract have a superposition effect on the capability of reducing the skin AGEs content, thereby reducing the reduction of the skin elasticity, the Uncaria rhynchophylla extract also improves the metabolism promoting capability of the oriental cherry extract, the free radical clearance rate is obviously improved, the Uncaria rhynchophylla extract is proved to have a synergistic effect on the oxidation resistance of the oriental cherry extract, the oxidation resistance is obviously enhanced, and the anti-aging effect is further improved.

As can be seen from comparison of the data in table 10 in comparative example 7 and comparative example 2, the skin AGEs content increased significantly after the addition of bisabolol, which indicates that bisabolol has an inhibitory effect on the effect of sakura extract on reducing the skin AGEs content, the radical clearance rate decreased, and that bisabolol has an inhibitory effect on the antioxidant ability of sakura extract, thereby deteriorating the anti-aging property to some extent.

As can be seen from comparison of the data in table 10 in comparative example 7 and comparative example 3, the content of skin AGEs is significantly increased after the addition of the sakura extract, which indicates that the sakura extract also has an inhibitory effect on the effect of bisabolol in reducing the content of skin AGEs, and that the absorbance is reduced at the same time, which indicates that the anti-inflammatory effect of bisabolol is also inhibited by the sakura extract, and the ability to promote metabolism is also inhibited, thereby deteriorating anti-aging to some extent.

According to comparison of the data of example 2 and comparative example 5 in table 10, the content of AGEs in the skin is significantly reduced by adding the sakura extract, which indicates that the sakura extract further reduces the solidification of collagen fibers, and has a significant effect on reducing the decrease in skin elasticity, so that the anti-aging effect is further improved.

As can be seen from comparison of the data of example 2 and comparative example 6 in table 10, the absorbance was significantly reduced by the addition of bisabolol, indicating that skin inflammation was reduced, and the inflammation-reducing effect of bisabolol was further improved, and metabolism was also accelerated.

As can be seen from comparison of the data in table 10 in example 2 and comparative example 7, the content of skin AGEs is significantly reduced by adding the harpagoside extract, which indicates that the harpagoside extract not only relieves the inhibitory effect of bisabolol on the sakura extract, but also keeps the good effect of reducing the content of skin AGEs in the sakura extract, and simultaneously significantly reduces the light absorption rate, relieves the inhibitory effect of the anti-inflammatory effect of the sakura extract on bisabolol, improves the anti-inflammatory effect of bisabolol, significantly improves the ability to promote metabolism, and improves the anti-aging effect in each aspect, thereby achieving multiple anti-aging effects.

According to comparison of the data of examples 6 to 8 and example 2 in table 10, the concentrations of the advanced glycosylation end products are maintained at a preferable level by adding bisabolol, the harpagophytum extract, squalane, magnesium gluconate, the chicory extract, the carrageen crispa extract, the gelidium amansii extract, the fucus rudis extract, the sargassum obtusifolia extract, and the yeast fermentation product filtrate, so that the advanced glycosylation end products are not easily accumulated, the skin elasticity is not easily reduced, the absorbance is also reduced to a certain extent, and the metabolism is promoted to a certain extent, so that the inflammation reduction effect is further improved, the radical clearance rate is significantly improved, the antioxidant effect is enhanced, and the multiple anti-aging effect is further improved.

As can be seen from comparison of the data of examples 9 to 11 and example 2 in table 10, the addition of the skin conditioner reduces the concentration and absorbance of the advanced glycosylation end product, reduces the decrease in skin elasticity and the decrease in cell inflammation, and also promotes metabolism, and the radical clearance is improved to some extent, so that the antioxidant ability is enhanced, thereby helping the skin to have a further improved anti-aging effect.

According to the comparison of the data of examples 12 to 14 and example 2 in Table 10, the skin barrier is not easily damaged by adding the moisturizer, so that the skin is more resistant to detergent, thereby reducing the inflammation rate and further enhancing the multiple anti-aging effect.

The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.

Claims

1. The essence milk is characterized in that: the paint comprises the following components in parts by mass:

1-5% of oriental cherry flower extract;

0.1 to 0.3 percent of bisabolol;

0.1 to 0.5 percent of the Uncaria tomentosa extract;

0.8% -1.2% of hydrogenated lecithin;

1% -2% of glycerol stearate citrate;

polyglycerol-3 methylglucose distearate 0.5% -1.5%;

0.1 to 0.4 percent of sodium lauroyl lactylate;

the balance of solvent;

the total mass percentage is 100 percent.

2. The essence of claim 1, wherein: the following components in percentage by mass are also added:

2% -5% of squalane;

magnesium gluconate 0.2% -0.5%;

chicory extract 0.2% -0.5%;

0.1% -0.5% of Chondrus crispus extract;

0.2 to 0.5 percent of the broccoli extract;

0.2-0.4% of Fucus serratus extract;

0.1 to 0.3 percent of sargassum obtusifolia extract;

0.5 to 2 percent of yeast fermentation product filtrate.

3. The essence milk according to claim 1, characterized in that: the following components are also added in percentage by mass:

3.75% -11.5% of a skin conditioner;

4. The essence milk according to claim 1, characterized in that: the following components in percentage by mass are also added:

10.5% -1% of ceramide;

30.5 to 1 percent of ceramide;

0.3 to 0.6 percent of ceramide 6 II;

phytosphingosine 0.3% -0.6%;

0.2% -0.5% of cholesterol;

cyanocobalamin 0.2% -0.7%;

0.1% -0.4% of caprylyl hydroximic acid;

0.05% -0.2% of glycerol caprylate;

0.1 to 0.5 percent of p-hydroxyacetophenone;

0.5 to 1 percent of 1-methylhydantoin-2-imide.

5. The essence milk according to claim 1, characterized in that: the following components in percentage by mass are also added:

5.51 to 12.5 percent of humectant;

6. The essence of claim 5, wherein: the humectant comprises the following components in percentage by mass:

2% -6% of glycerol;

3% -5% of 1, 3-propylene glycol;

0.3% -0.5% of creatine;

0.1 to 0.4 percent of hydrolyzed hyaluronic acid;

0.01 to 0.1 percent of hyaluronic acid;

0.05% -0.2% of maltose;

0.05% -0.3% of 1, 2-pentanediol.

7. The essence of claim 1, wherein: the following components in percentage by mass are also added:

3.2% -7.8% of emollient;

8. The essence of claim 7, wherein: the emollient comprises the following components in percentage by mass:

3% -7% of olive fruit unsaponifiable matter;

0.2 to 0.8 percent of polydimethylsiloxane.

9. A method for preparing the essence milk according to claim 1, characterized in that: the method comprises the following steps:

step 2), mixing and heating glycerol stearate citric acid ester and polyglycerol-3-methyl glucose distearate, and stirring until the polyglycerol-3-methyl glucose distearate and the glycerol stearate citric acid ester are completely dissolved to obtain a second premix;

step 4), adding sodium lauroyl lactylate into the second mixture, uniformly stirring, preserving the temperature at 83-88 ℃ for 28-32 minutes, reducing the temperature to 68-72 ℃, adding bisabolol, and uniformly stirring to obtain a third mixture;

10. The method for preparing essence milk according to claim 9, characterized in that: in the step 1), glycerin, 1, 3-propylene glycol, creatine, p-hydroxyacetophenone and hydrogenated lecithin are added into a solvent together, the solvent is heated to 83-88 ℃, then hydrolyzed hyaluronic acid, hyaluronic acid and 1-methylhydantoin-2-imide are added, and the mixture is stirred until all the components are completely dissolved;

In the step 2), squalane, polydimethylsiloxane, olive unsaponifiable matter, glycerol stearate, citric acid ester and polyglycerol-3 methyl glucose distearate are taken, mixed and heated, and stirred until the mixture is completely dissolved;

in the step 5), magnesium gluconate, chicory extract, carrageen abomasum extract, agar-agar extract, fucus extract, sargassum blunt, yeast fermentation product filtrate, cyanocobalamin, caprylyl hydroximic acid, caprylic glycerol, 1, 2-pentanediol and cherry blossom extract are added into the third mixture and stirred uniformly.