KR100840988B1 - Formulation containing alginate for skin moisturizing and soothing effect - Google Patents

Abstract

The present invention relates to a skin moisturizing composition effective for skin moisturizing and soothing skin when applied topically to the skin.

Skin moisturizing composition of the present invention has a content ratio of manuronic acid / gluonic acid is between 0.5 to 2.0, the mass average molecular weight range of 10,000 to 100,000, the polymerization degree of alginic acid of 50 to 600 of the composition By containing 0.01 to 15% by weight, it has excellent water binding ability and forms a skin moisturizing film to maximize skin moisturizing power, as well as affinity with skin cells, so that it is hypoallergenic, irritating and improving skin, and skin wettability. It is possible to maximize the preservation of skin active substances into the stratum corneum by improving the skin. Therefore, the skin moisturizing composition of the present invention has excellent soothing effect on sensitive skin caused by skin drying, skin troubles caused by internal and external skin drying and irritation, and is useful for UV-induced heat erythema, acne, skin inflammation, and atopy.

Alginic acid, Moisturizing, Drying, Composition

Description

FORMULATION CONTAINING ALGINATE FOR SKIN MOISTURIZING AND SOOTHING EFFECT}

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The present invention relates to a composition for moisturizing skin containing alginic acid, and more particularly, to a composition for moisturizing skin containing alginic acid, which is effective for skin moisturizing and soothing when applied to the skin locally.

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Skin is the main organ that prevents moisture from drying out. To this end, the epidermal layer of the skin develops into a thin stratum corneum containing moisture through a process called differentiation (Biochemistry and physiology of the skin Vol. 1). Structurally, the cells of the stratum corneum act like bricks, and the intercellular lipids of the stratum corneum act as mortars and constitute the skin barrier (J. Inveast. Dermatol. 80 (Suppl.), 44-49. 1983). In addition, keratinocytes of healthy people have high concentrations of Natural Moisturing Factor (NMF) to help the skin retain moisture. For example, amino acids are water soluble, which effectively combines with moisture to dry the skin. Inhibit (J. Invest. Dermatol. 54, 24-31, 1970). Therefore, in order to moisturize normal skin, not only replenishment of intercellular lipids, but also water-soluble components are all required.

However, people tend to increase dry skin as they age, and the need for skin moisturizers increases as they are exposed to indoor heating and contaminated air. Conventionally, a method of supplementing lipids using an occlusive moisturizer as a skin moisturizer has been performed for this purpose (C & T Vol 107. 69-75, 1992). As a closed moisturizer, essential fatty acids and lipid complexes as well as lipid components such as ceramide were used (J Invest. Dermatol. (5), 731-740, 1994).

The stratum corneum of normal skin usually contains 10 to 20% of water, which gives elasticity and flexibility and maintains protection.However, when the moisture content is less than 10% due to changes in the external environment such as temperature and humidity, the skin It is known to cause a variety of skin problems by being called dry skin and losing elasticity and protective function.

In order to prevent dry skin and restore normal skin condition, a hydrophilic moisturizer is generally added to cosmetics. Commonly used moisturizers include polyol compounds such as polyethylene glycol, polypropylene glycol, dipropylene glycol, propylene glycol and butylene glycol, glycerin, sorbitol, malitol, amino acids, sodium pyrrolidone carboxylic acid, urea and lactic acid. , Hyaluronic acid and collagen. However, these moisturizers had problems of feeling at high concentration, maintaining moisture at low humidity, and limitation of initial moisturizing power at the time of use, and also causing problems of skin irritation depending on the substance used.
Accordingly, many inventors have focused on enhancing the moisturizing effect by combining a plurality of moisturizing factors and structuring them in multiplexed structures to improve skin penetration and preservation. However, this method has the disadvantage of encapsulating it with a membrane such as a lipid base or using an expensive equipment such as a microfluidizer. Also, in an emulsion containing a large amount of surfactant, the liposome structure is destroyed by the surfactant. Economics and stabilization have been mentioned as problems in the cosmetic field in which is used (Korean Patent Publication No. 99-70313). In addition, the use of a general hydrophilic moisturizer focused only on the enhancement of moisturizing power, and there were almost inadequate limitations on stimulation relief function, preservation of skin active substances and antibacterial effect.
In particular, in recent years, accelerated skin aging, generation of skin troubles, excessive skin drying and atopy, skin sensitization phenomena are caused by the harmful skin environment, and in particular, many skin problems are caused by stress. In particular, skin troubles such as dry skin and atopic dermatitis are in poor condition. Especially in the process of treating the skin, the appearance of the skin becomes irritated and sensitive, and it is necessary to protect the skin from external exposure. need.
Accordingly, the present inventors have tried to solve the problems of the conventional moisturizer and improve the moisturizing power, as well as to enhance the stimulation relief function, the preservation of the skin active substance and the antimicrobial effect, and as a result of containing the alginate which is a marine algae component, The present invention has been completed by providing a soothing effect on sensitive skin, skin troubles caused by internal and external skin drying and irritation, and identifying excellent soothing effects such as heat erythema, acne, skin inflammation, atopic dermatitis, and the like.

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It is an object of the present invention to provide a composition for moisturizing skin containing alginic acid, which is effective for moisturizing and soothing skin when applied to the skin locally.
Another object of the present invention is not only to maximize the skin moisturizing ability by forming a skin moisturizing film with excellent water binding capacity, but also has affinity with skin cells, has a hypoallergenic stimulating function and skin improvement effect, improve skin wettability It is to provide a skin moisturizing composition containing alginic acid optimized to maximize the permeability and preservation of the skin active material into the skin stratum corneum.

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In order to achieve the above object, the present invention is an alginate having a content ratio of manuronic acid / gluronic acid of 0.5 to 2.0, a mass average molecular weight of 10,000 to 100,000, and a polymerization degree of 50 to 600. It provides a skin moisturizing composition containing a weight%.
In addition, the skin moisturizing composition of the present invention may further contain an optional ingredient including essential oils extracted from skin protection active agents, skin whitening ingredients, sunscreen ingredients and natural plants in addition to the essential ingredients.
Specifically, the skin moisturizing composition of the present invention is a skin protection active agent, which is selected from the group consisting of niacinamide, retinol, retinal, retinyl palmitate, retinyl propionate, ascorbic acid and tocophenol alone or their It may further contain 0.1 to 10% by weight of two or more mixed forms.
In addition, the skin moisturizing composition of the present invention may further contain 0.1 to 10% by weight of one or more skin lightening ingredients selected from the group consisting of Mt. extract, licorice extract, kojic acid, arbutin and ascorbic acid.
Skin moisturizing composition of the present invention is dioxybenzene, methyl anthranilate, benzophenone-4, octyl salicylate, triethanolamine salicylate, synoxate, oxybenzone, octocrylene, digaloyl trioleate, Amyl paradimethyl benzoate, diethanolamine paramethoxycinnamate, octylmethoxycinnamate, paraaminobenzoic acid, glyceryl paba, ethyldihydroxypropyl paba, octyldimethyl paba, 2-phenylbenzoimidazole-5-sulfonic acid 0.5% to 10.0% by weight of at least one sunscreen component selected from the group consisting of homoslate, dromethazole, butylmethoxydibenzoylmethane, octyltrizone and 3- (4-methylbenzylidene) -campa It may contain.
Furthermore, the skin moisturizing composition of the present invention may further contain 0.01 to 10.0% by weight of one or more components of essential oils extracted from natural plants.
Hereinafter, all the measurements on the specification of this invention are performed at 25 degreeC, unless otherwise indicated.

In the context of the present invention, "local application" means applying the composition of the present invention to the skin surface.

In the context of the present invention, "dermatologically acceptable" means that the moisturizing composition or ingredients of the present invention are suitable for use on human skin without excessive toxicity, incompatibility, instability, allergic reactions.

In the context of the present invention, a "safely effective amount" is sufficient to induce a positive side effect, preferably a positive skin appearance or tactile benefit, including the benefits described herein independently, but to cause serious side effects. In a quantity sufficiently low, ie within the scope of good medical judgment, to provide a reasonable benefit to the risk ratio.

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The skin moisturizing compositions of the present invention are useful for providing substantial immediate improvement and fundamental skin improvement in terms of dry and irritated skin moisturizing and soothing after topical application and skin application of the composition. More specifically, the skin moisturizing composition of the present invention is useful for controlling skin condition, including skin dryness, heterogeneity associated with skin aging, and heterogeneity due to skin troubles such as atopy, acne, and inflammation. Such skin irritation and heterogeneity can be caused by internal and / or external factors. External factors include ultraviolet rays caused by sun exposure, environmental pollution, wind, heat, low humidity, rough surfactants, and abrasives. Internal factors include aging and other biochemical changes from inside the skin.

Control of skin conditions includes control of prophylactic and / or therapeutic skin conditions. As used herein, prophylactic skin condition control includes delaying, minimizing or preventing visible and / or tactile heterogeneity in the skin. As used herein, therapeutic skin condition control can reduce, minimize or eliminate this heterogeneity. Skin condition control is to improve skin appearance and / or feel, and to provide a softer, more even appearance and feel. As used herein, skin condition control includes skin problems caused by stimulation and control of symptoms of aging.

In the context of the present invention, the control of aging symptoms by skin drying includes prophylactic and / or therapeutic control of one or more such symptoms (similarly, given symptoms of skin aging, such as control of gold, wrinkles or pores, And prophylactic and / or therapeutic control of such symptoms.

"Symptoms of skin aging by dry skin" includes, but is not limited to, all visible and tactilely recognizable indications and any other macroscopic or microscopic consequences of skin aging. Such symptoms may be induced or induced by internal or external factors such as chronological aging and / or environmental damage. Such symptoms may include wrinkles, skin deposits, cracks, bumps, large pores (such as those associated with appendages such as sweat glands, sebaceous glands or hair follicles), insulting, flaky and / or uneven skin, including fine superficial wrinkles and coarse, deeply folded wrinkles, or Other forms of roughness, loss of skin elasticity (loss and / or inactivation of functional skin elastin), sag (including swelling around the eyes and lower jaw), loss of skin firmness, loss of skin tension, loss of skin recovery from deformation Hyperpigmented skin areas such as discoloration (including the lower part of the eye), staining, paleness, aging spots and freckles, keratin, abnormal differentiation, hyperkeratization, elastosis, collagen breakdown, and the stratum corneum, dermis, epidermis and skin vascular system ( Eg, capillary dilated or arachnoid) and tissues, including but not limited to the development of tissue heterogeneity such as wrinkles, including tissues adjacent to the skin. It is not limited.

The present invention is not intended to be limited to the control of the aforementioned `` symptoms of skin aging by skin drying '' resulting from mechanisms associated with skin aging by dry skin, but to include the control of these symptoms independent of the mechanism of origin. It should be understood that.

Dry skin problems include prophylactic and / or therapeutic control of one or more of these symptoms. Skin problems caused by drying include excessive skin sensitization, irritated and irritated skin due to inflammation, skin sensitization caused by UV and external harmful environment, skin irritation, erythema, stress skin trouble, and exfoliation during skin treatment. Include atopic dermatitis, symptoms associated with a skin condition requiring urgent sedation or regeneration.

The present invention is particularly useful for therapeutically controlling the inhomogeneity of visible and / or tactile heterogeneity in mammalian skin, including skin inhomogeneity by skin drying in skin tissue and color. For example, the object of the present invention is not only to maximize the skin moisturizing ability by forming a skin moisturizing film with excellent water binding capacity, but also has affinity with skin cells, has a hypoallergenic stimulating function and skin improvement effect, improve skin wettability To provide a topical application composition for maximizing the preservation of the skin active material inside the stratum corneum.

Hereinafter, the present invention will be described in detail.
The present invention is a moisturizing skin containing 0.01-15% by weight of alginic acid having a content ratio of only euronic acid / gluronic acid in a range of 0.5 to 2.0, a mass average molecular weight of 10,000 to 100,000, and a polymerization degree of 50 to 600. It provides a composition for.
The composition containing 0.01 to 15% by weight of alginic acid is 0.20 to 0.5% by weight of the cross-linked polyacrylate polymer and 0.1 to 5% by weight of the surfactant, depending on the composition used in the embodiment of the present invention and its content. And the remaining amount of hydrophilic liquid carrier excluding the weight.
As a preferred example of the crosslinked polyacrylate polymer, Carbopol 945 is used in the embodiment of the present invention. The carbopol 945 is a homopolymer in which acrylic acid is crosslinked with pentaerythrito, sucrose or allel ether of propylene.
The surfactants also contain dermatologically acceptable surfactants, preferably anionic, cationic, nonionic, zwitterionic, amphoteric and ampholytic surfactants, and these surfactants Is selected from the mixture. Such surfactants are well known to those skilled in the cleaning arts. Preferred amphoteric or zwitterionic surfactants are betaine, sultine and hydroxylsultine. Non-limiting examples of possible surfactants include isocetate-20, sodium methyl cocoyl taurate, sodium methyl oleyl yl taurate, sodium lauryl sulfate, sorbitan monostearate / sucrose cocoate, PEG-100 stearate Rate, sultain, and the like, and embodiments of the present invention use sorbitan monostearate / sucrose cocoate, PEG-100 stearate and / or sultine.
Hydrophilic liquid carrier in the context of the present invention allows the composition to be uniformly distributed when applied to a selected target at a dermatologically acceptable concentration. In a preferred embodiment of the present invention it corresponds to a composition consisting of phase A, phase D and phase E.

Alginate used in the skin moisturizing composition of the present invention is a natural acid polysaccharide extracted from so-called brown algae (Phaecophyceae) and has a chain structure formed of manuronic acid and gluonic acid. In general, the degree of polymerization varies depending on the type of algae used for extraction, the season from which the algae was collected, the source of the algae, and the year of growth of the algae itself.
The main species of brown algae used to obtain alginic acid are Laminaria, Ecklonia, Macrocystis, Pelvetia, Lessonia and Alaria. have. Alginic acid is found in algae as a broad component of cell walls in the form of some mixed form of its alkali salts, in particular in the form of sodium salts. The mixture is also known as Algin. These salts are usually extracted in the form of an aqueous solution using sodium carbonate solution, and the alginic acid can be obtained directly from the extract by precipitation with an inorganic acid such as hydrochloric acid, for example.

According to an indirect preparation method, an insoluble calcium salt is first added by adding a soluble calcium salt such as chloride, washed with the salt, and then treated with acid again to obtain alginic acid.

Alginic acid is widely used as a raw material for medical and food use due to its body compatibility and safety.Alginic acid has an inhibitory effect on cholesterol, total lipid and total fatty acid concentrations in liver, and it is a pollutant such as cadmium (Cd) and strontium ( In addition to the effect of Sr) absorption in the body, alginic acid has a particularly large hydration, water retention, lubricity, and moldability, so that the dressing effect is very large. In particular, alginic acid is chemically bonded to metal ions by its COOH group, and thus has a detrimental effect on the system which causes fermentation oxidation in contact with metal ions. In addition to COOH group, alginic acid is composed of H and OH groups having no side chain and strong hydrophilicity. Because of its high hydration ability, there is an effect of deodorizing the moisture required by the microorganisms in a solution having a certain concentration or more and inhibiting its development.

The properties related to the body affinity and safety, moisturizing properties and biosafety of alginic acid are advantageous properties compared to other raw materials even for application to cosmetics.                     

Alginic acid obtained from various brown algae has the following three types of polymer segments.

1) Unit consisting only of D-mannuronic acid

2) Unit consisting only of L-guluronic acid

3) A unit consisting of alternating D-mannuronic acid / L-guluronic acid units

The fraction of the three polymer units of alginic acid obtained from different types of brown algae raw materials is determined by separation into homopolymeric and alternating segments by partial acid hydrolysis. That is, the ratio of glunic acid and manuronic acid is determined by spectroscopy (pmr Spectroscopy), and the ratio of glunic acid and manuronic acid according to various brown algae is shown in Table 1 below.

Ratio of Gluonic Acid and Manuronic Acid in Alginic Acid According to Brown Algae Species Manuronic acid weight ratio (%) Gluonic acid weight ratio (%) Manuronic acid / gloonic acid ratio Macrorocystis pyrifera 61 39 1.56 Ascophyllum nodosum 65 35 1.85 Laminaria Digita 59 41 1.45 Laminaria hyperborean 31 69 0.45 Ecklonia cava and Eisenia bicyclis 62 38 1.6

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Alginic acid forms a gel by reaction with free electrons in the form of ions, and the gel thus formed is applied to a cosmetic composition to form a moisturizing film when applying the skin to increase moisturization on the skin and is effective for moisturizing the skin. That is, the alginic acid is an alkali metal ion (Na ⁺ , K ⁺ , Li ^+, etc.), an alkali metal ion (Mg ⁺ , Ca ²⁺ , Sr ²⁺ ) and a transition metal ion (Cr ³⁺ , Mn ²⁺ ) having a 3d orbital , Fe ^{2 + / 3 +} , Co ²⁺ , Zn ²⁺ , Ni ²⁺ , Cu ²⁺ , VO ^2+, etc.) to form a moisturizing film that helps increase skin moisturizing.

In particular, the alginic acid is combined with the free electrons of the skin waste due to soot, pollution, and gelation, thereby playing a very effective role in removing the waste and sebum secretion accumulated on the skin by various pollution, thereby helping to clean the skin.

For example, the gelation reaction between sodium alginate and calcium ions is as follows.

2NaAlg + Ca ²⁺ -> CaAlg ₂ + 2Na ⁺

In the formula, NaAlg represents sodium alginate, and Ca ²⁺ represents calcium ion.

CaAlg ₂ represents the binding of two sodium alginates to calcium ion, and Na ⁺ represents dissociated sodium ion.

That is, two sodium alginates bind to each other to form calcium.

The alginic acid gel thus formed forms a softer gel of elasticity when the ratio of alginic acid is high, and when the ratio of gluonic acid is high, a rigid gel of a rigid form is formed.

Alginic acid used in the composition of the present invention has a mass average molecular weight in the range of 10,000 to 100,000, and satisfies a range in which the content ratio of euuronic acid / gluronic acid is between 0.5 and 2.0 when the polymerization degree is 50 to 600. Should be. At this time, the case where the content ratio of manuronic acid / gluronic acid is in the range of 0.5 to 2.0 is used as a skin topical application composition to form a moisturizing film, increase skin moisturizing power, and skin fit of the formed moisturizing film when applying the skin. The safety is excellent.

If the content ratio of manuronic acid / gluronic acid is less than 0.5, the content of the gluonic acid is so large that the formed moisturizing film is too brittle, and the skin wearability is not good, and the stability of the viscosity side of the composition when forming the skin topically applied composition is formed. Also deteriorates. On the other hand, when the content ratio of manuronic acid / gluronic acid exceeds 2.0, the amount of manuronic acid is large and the formed moisturizing film is too weak, so that the skin moisturizing property is lowered.

In addition, the range of the mass average molecular weight of the alginic acid used in the composition of the present invention is 10,000 to 100,000, when the degree of polymerization is 50 to 600, excellent moisturizing properties by forming a skin moisturizing film when applied as a skin topical application composition, the skin Fit, skin hypoallergenicity and viscosity stability of the composition are preferred.

At this time, if the range of the mass average molecular weight is less than 10,000, or the polymerization degree is less than 50, the moisturizing properties of the moisturizing film formed when applying the skin topical composition is lowered, while the range of the mass average molecular weight is more than 100,000, or the polymerization degree is more than 600 In the case, the skin fit and the skin hypoallergenic properties were poor, and the stability of the viscosity side of the composition was also lowered when the skin topical application composition was formed.
The skin moisturizing composition of the present invention may further contain a skin protection active agent, a skin whitening component, a sunscreen component and an essential oil extracted from a natural plant. Hereinafter, the components that may be further contained are as follows.

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Skin protection actives

The present invention may contain one or more skin care actives in a proportion of 0.1 to 10% by weight of the total composition, and representative skin care actives include niacinamide, retinol, retinal, retinyl palmitate, retinyl propionate, ascorb It is to use alone or a mixture of two or more thereof selected from the group consisting of acid and tocophenol. Skin protection active agents of the present invention provide the effect of helping to regenerate the skin and protect the skin from damage caused by harmful environments such as skin aging and UV irradiation.

Skin whitening ingredients

The present invention may contain one or more skin whitening components in a ratio of 0.1 to 10% by weight of the total composition, and representative skin whitening components are one selected from the group consisting of biloba extract, licorice extract, kojic acid, arbutin and ascorbic acid. The above is to use.

Sunscreen

The present invention may contain one or more sunscreen ingredients in a proportion of 0.5 to 10% by weight of the total composition, and representative sunscreens include dioxybenzene, methylanthranilate, benzophenone-4, octylsalicylate, triethanolamine Salicylate, synoxate, oxybenzone, octocrylene, digaloyl trioleate, paradimethylbenzoic acid amyl, diethanolamine paramethoxycinnamate, octylmethoxycinnamate, paraaminobenzoic acid, glyceryl pava, ethyl Dihydroxypropylpava, octyldimethylpava, 2-phenylbenzoimidazole-5-sulfonic acid, homosalate, drometrizol, butylmethoxydibenzoylmethane, octyltrizone and 3- (4-methylbenzylidene) One or more types selected from the group consisting of campers can be used.

The exact amount of sunscreen or sunscreen agent used will vary depending on the sunscreen chosen and the desired sun protection index (SPF).
Essential oils extracted from natural plants
The present invention may further contain 0.01 to 10.0% by weight of one or more components of the essential oil extracted from natural plants.
Essential oils extracted from natural plants should be hypoallergenic enough to be applied to the skin, and examples thereof include lavender and chamomile, and the soothing function of the skin affinity in comparison to the synthetic ingredients added to the skin moisturizing composition of the present invention. To increase the role.
The essential oil extracted from the natural plant preferably contains 0.01 to 10.0% by weight, based on the total composition, when the content is less than 0.01% by weight, the skin soothing effect is mild, and when the content exceeds 10.0% by weight There is a difficulty in determining the stability of formulation in containing too essential oil component which is an oil-soluble component in a cosmetic composition containing such a water-soluble base.

Humectant or moisturizer

The composition of the present invention may further comprise one or more humectants or humectants. The humectant or humectant may be used without particular limitation in a wide range of known materials, each of which may use 0.1 to 20% by weight, more preferably 0.5 to 10% by weight and most preferably 1 to 5% by weight. Preferred examples of wetting agents include, for example, guanidine; Glycolic acid and glycolate salts (eg, ammonium and quaternary alkyl ammonium); Lactic acid and lactate salts (eg, ammonium and quaternary alkyl ammonium); Various forms of aloe vera (eg, aloe vera gel); Polyhydroxy alcohols (eg, sorbitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol, etc.); Polyethylene glycol; Sugars and starches; Sugar and starch derivatives (eg, alkoxylated glucose); Hyaluronic acid; Lactamide monoethanolamine; Acetamide monoethanolamine and mixtures thereof.

The skin moisturizing composition of the present invention is preferably in the form of an emulsion, and representative product forms include lotions and creams, cleansing compositions and foundations. These product forms are also described as follows.

As mentioned, the moisturizing composition of the present invention, which is not limited to lotions and creams, may contain a dermatologically acceptable hydrophobic component. A wide range of suitable hydrophobic components are known and can be used herein. See Sagarin, Cosmetics, Science and Technology , 2nd edition, Vol. 1, pp 32-43 (1972), include various examples of materials suitable as hydrophobic components.

Lotions and creams according to the present invention generally contain a solution carrier system and one or more hydrophobic ingredients. Lotions are typically 1-20%, more preferably 2-10% of a hydrophobic component; And 50 to 90%, more preferably 60 to 80% of water. Creams typically contain 2-50%, more preferably 3-20%, of hydrophobic ingredients; And 45 to 85%, more preferably 50 to 75% of water.

The present invention useful as a cleansing composition is formulated with a suitable carrier, for example as described above, and preferably contains a safe effective amount of one or more dermatologically acceptable surfactants for cleansing. The preferred amount of use is 1 to 90%, more preferably 5 to 10% of a dermatologically acceptable surfactant. Surfactants are suitably selected from anionic, cationic, nonionic, zwitterionic, amphoteric and ampholytic surfactants, and mixtures of these surfactants. Such surfactants are well known to those skilled in the cleaning arts. Preferred amphoteric or zwitterionic surfactants are betaine, sultine and hydroxylsultine. Non-limiting examples of possible surfactants include isocetate-20, sodium methyl cocoyl taurate, sodium methyl oleyl yl taurate, sodium lauryl sulfate, sorbitan monostearate / sucrose cocoate, PEG-100 stearate Rate, stein, and the like. The cleaning composition may optionally contain other materials conventionally used in the cleaning composition at a level where technology is proven.

The physical form of the cleaning composition is not critical. The composition can be formulated, for example, as a liquid, shampoo, bath gel, paste, or mousse. A cleansing composition, such as a shampoo, which is desired to be rinsed away includes a suitable delivery system so that a sufficient level of active agent is deposited on the skin and scalp.

As used herein, "foundation" refers to liquid, semi-liquid, or semi-solid skin cosmetics, including but not limited to lotions, creams, gels, pastes, and the like. Foundations are typically used on entire areas of the skin, such as the face, to provide a distinctive appearance. Foundation is typically used to provide an attachment base for color cosmetics such as rouge, cheek paper, and the like and conceal and soften skin defects in the appearance of the skin as well. The foundation of the present invention includes a dermatologically acceptable carrier for the essential particulate material and may include conventional ingredients such as oils, colorants, pigments, emollients, fragrances, waxes, stabilizers and the like.

Compositions of the present invention are generally prepared by conventional methods, such as those known in the art for preparing topical compositions. Such methods typically involve mixing components in a relatively uniform state in one or more steps with or without performing such as heating, cooling, vacuum application, and the like.

Typically, one or more of the components described above may be mixed with the charged particulate material in any order via conventional methods. The resulting mixture is adjusted to range from pH 4 to 8.5. Preferably, the components are first mixed together in any order. The charged particulate material is then adjusted to the pH 4 to 8.5 range and then added to the mixture.

Hereinafter, the present invention will be described in detail by way of examples.
The following examples are merely illustrative of the present invention, but the scope of the present invention is not limited to the following examples.

<Examples 1-3 and Comparative Examples 1-3>

Phase A components in appropriately sized containers are mixed using a propeller type mixer and heated to 65-75 ° C. Mix phase B components in separate vessel and heat to 55-70 ° C. Add phase B component to phase A component with continued stirring at 55-70 ° C. Thereafter, phase C is added to the batch mixture of phases A / B with continued mixing. The phase C component above neutralizes the mixture. In a separate vessel add phase D ingredients until the mixture is homogenous and add to the batch mixture of phase A / B / C prepared above. The mixture is cooled to 50 ° C. Thereafter, additional phase E components are added to the batch mixture of phases A / B / C / D until the mixture is homogeneous and then cooled to about 35 ° C. Mixing continues until the resulting batch mixture is homogeneous.
The skin moisturizing composition of the present invention was prepared from the components of Table 2 below using conventional emulsion compounding techniques.
Preparation of skin moisturizing composition Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Phase A water to 100 ¹ to 100 to 100 to 100 to 100 to 100 Disodium EDTA 0.10 0.10 0.10 0.10 0.10 0.10 Carbopol 954 0.30 0.26 0.35 0.30 0.25 0.25 Sorbitan Monostearate / Sucrose Cocoate 1.00 1.00 1.00 1.00 1.00 1.00 Phase B Isopropyl Isostearate 1.33 1.33 1.33 1.33 1.33 1.33 Sugar fatty acid ester ² 0.67 0.67 0.67 0.67 0.67 0.67 Isohexadecane 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl alcohol 0.60 0.60 0.60 0.60 0.60 0.60 PEG-100 Stearate 0.11 0.11 0.11 0.11 0.11 0.11 Stein 0.3 0.3 0.3 0.3 0.3 0.3 Phase C NaOH 0.2 0.25 0.25 0.2 0.25 0.25 Phase D water 10.00 10.00 10.00 10.00 6.00 6.00 Sodium Alginate ^A 2.0 - 1.0 - - - Sodium Alginate ^B - - - - 2.0 - Sodium alginate ^C - - - - - 2.0 Potassium Alginate ^D - 2.0- 2.0 - - - Phase E water 5.00 5.00 5.00 5.00 5.00 5.00 Dexpanthenol 0.50 0.50 0.50 0.50 0.50 0.50 Niacinamide 2.00 2.00 2.00 2.00 2.00 2.00 Imidazolidinylurea 0.05 0.05 0.05 0.05 0.05 0.05

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1 in Table 2 represents the water component of phase A, which is the sum of all components of all other phases except the water component of phase A, subtracted from 100, that is, the water component of phase A = 100 − (all of the other phases) Sum of the components).

Tables 2 to 2 above show C ₁ to C ₃₀ monoesters or polyesters of the sugars described herein with at least one carboxylic acid moiety, preferably having a degree of esterification of 7 to 8, wherein the fatty acid moiety is C ₁₈ day-and And / or sucrose polyesters having a molar ratio of unsubstituted and behenic and unsaturated: behenic between 1: 7 and 3: 5, more preferably containing about 7 Behen fatty acid moieties and about 1 oleic acid in the molecule. Octaesters of sucrose, for example sucrose esters of cottonseed oil fatty acids, more specifically SEFA cotonates.

In Table 2, A has a content ratio of manuronic acid / gluronic acid of 1.2, a mass average molecular weight of 50,000, and sodium alginate having a polymerization degree of 300.

In Table 2, B has a content ratio of manuronic acid / gluronic acid of 0.4, a mass average molecular weight of 10,000, and sodium alginate having a polymerization degree of 50.

In Table 2, C has a content ratio of manuronic acid / gluronic acid of 1.8, a mass average molecular weight of 110,000, and sodium alginate having a polymerization degree of 650.

In Table 2, D has a content ratio of only euronic acid / gluronic acid, 1.4, a mass average molecular weight of 60,000, and potassium alginate having a degree of polymerization of 500.

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구 분 무도포 실시예 1 실시예 2 실시예 3 비교예 1 비교예 2 비교예 3 W.H.C (%) 도포후즉시 33.72 31.55 35.42 33.27 37.18 33.38 35.17 1시간 후 28.95 32.33 36.82 37.51 33.07 30.52 33.57 △W.H.C -4.77 0.78 1.40 4.24 -4.11 -2.86 -1.60 무도포 대비 △W.H.C - 5.55 6.17 3.84 0.66 1.91 3.17 Experimental Example 1 Evaluation of Water Retention Capacity
In order to evaluate the moisturizing ability of the compositions prepared in Examples 1 to 3 and Comparative Examples 1 to 3 by measuring the water holding capacity in the stratum corneum, a water holding capacity test was performed as follows.
Moisture meter (Skicon-200) was used for 20 test subjects, and it was evaluated while maintaining a constant temperature of 25 ° C. and 50% relative humidity for accurate experiments. The amount of skin application is applied to the skin with 0.03g of sample per 9cm2 of skin, and immediately after application (0, 30, 60, 120 seconds) and 1 hour (0, 30, 60, 90, 120, 120). After measuring the electrical conductivity (conductance) in each second to measure the water retention capacity, the moisture retention capacity was evaluated by calculating the amount of change by the following equation (1 ).

division No coating Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 WHC (%) Immediately after application 33.72 31.55 35.42 33.27 37.18 33.38 35.17 1 hour later 28.95 32.33 36.82 37.51 33.07 30.52 33.57 △ WHC -4.77 0.78 1.40 4.24 -4.11 -2.86 -1.60 △ WHC compared to no coating - 5.55 6.17 3.84 0.66 1.91 3.17

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From the results of Table 3 , in the case of Examples 1 to 3, the water retention ability was superior to Comparative Examples 1 to 3, and in the case of Comparative Example 3, the water retention ability is good, but the measured skin safety side is lowered. Results.

Experimental Example 2 Anti-inflammatory Effect
The above embodiments 1 to 3 and Comparative related, heat erythema soothing effect with respect to the compositions prepared in Examples 1 to 3 levels of capillary blood flow values decrease, the measurement value decreased capillary blood flow associated with UV-induced erythema soothing, Table 4 described.
In the method for measuring the anti-inflammatory effect, the composition of Examples 1 to 3 and Comparative Examples 1 to 3 was carried out in an in vivo experiment in which the effect obtained by the actual consumer was measured by measuring the volunteers. In order to measure the sedative effect of different inflammation depending on the type of stimulus applied to the skin, the erythema caused by overexposure to infrared light and the actinic erythema caused by overexposure to ultraviolet light and the inhibition of skin microorganisms The effect of the composition of the present invention was tested. Volunteers were divided into a panel of 20 women aged 21 to 60 years old and a panel of 10 males and 10 females aged 18 to 29 years.
Inflammation sedative effect by anti-inflammatory effect was counted by measuring Cutaneous microcirculation, skin erythema and skin temperature.
Subcutaneous capillary blood flow was measured using a thermal conductivity measuring instrument (Hematron). The conductivity decreases as the capillary contracts and increases as it expands. Reduction in inflammation is an indication that swelling (edema) subsides due to contraction of the swollen capillaries. Skin erythema was measured using a Minolta CR300 chromameter and skin temperature was also measured using Hematron.
IR Phillips 250 S was used to induce heat erythema. Irradiation intensity was 70mW / ㎠ and irradiated at a distance of 50cm for 30 minutes to induce heat erythema. The irradiation site was 14 cm 2. Ultraviolet radiation was irradiated to 4 cm 2 site at 100W intensity using a UV irradiation apparatus (SUNTEST / ORIGINAL HANAU) equipped with a Xenon lamp. After that, the survey was conducted after determining the Minimal Erythemal Dose (MED) for each volunteer. The soothing effect by the composition of the present invention was measured 24 hours after irradiation with ultraviolet light.
Anti-inflammatory effect Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Capillary blood circulation decrease associated with erythema sedative effect (mW / cm · ℃) 0.72 0.76 0.88 0.05 0.17 0.07 Capillary blood circulation decrease associated with UV-induced erythema sedative effect (mW / cm · ℃) 0.75 0.65 0.83 0.02 0.03 0.13

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In Comparative Examples 1 to 3, the decrease in capillary blood circulation was lower than that in Examples.

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Experimental Example 3 Human closed patch test
The human patch test is widely used as a method to search for primary irritants (Matsumura et al , 1995), but dermatologically refers to a diagnostic patch test for the diagnosis of allergic contact dermatitis. do.

For 30 healthy adults and females, 40 μl of the compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were placed in the back using a kit (Finn chamber), and then fixed to the skin with a tape (scanpore tape). It was. After 24 hours it was removed from the skin and after 4 hours the results were determined. The degree of erythema and edema is indicated according to the following criteria, which were in accordance with the criteria of the International Contact Dermatitis Research Group (ICDRG) (Wooding et al, 1967; Rietschell, 1982; Fischer & Maibach, 1984; Aberer et al, 1993), the results for the stimulus degree (%) of the closed patch test was calculated by the following equation (2) , and the results are shown in Table 5 below.

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(Criteria)

0 = no redness

1 = erythema

2 = redness and papules

3 = redness, papules and vesicles

4 = severe edema and vesicles

실시예1 실시예2 실시예3 비교예1 비교예2 비교예3 폐쇄첩포검사의 자극도(%) 1.12 1.27 1.35 27.35 9.67 12.35
상기 표 3의 결과로부터, 실시예 1∼3 및 비교예 1∼3의 조성물 각각에 대하여 60명의 지원자들에 대한 폐쇄첩포검사의 자극도(%)를 측정한 결과, 실시예 1∼3의 경우에는 자극도가 최대 1.35% 이상으로 나타남으로써, 본 발명의 조성물에 의한 피부 안정성 효과가 뛰어난 것으로 나타났다.
반면에, 비교예 1∼2의 경우에는 폐쇄첩포검사의 자극도(%)가 실시예에 비해 크게 나타나 피부 안정성이 저하되는 것으로 나타났다.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Stimulus of closed patch test (%) 1.12 1.27 1.35 27.35 9.67 12.35
From the results of Table 3, the stimulus degree (%) of the closed patch test for 60 volunteers was measured for each of the compositions of Examples 1-3 and Comparative Examples 1-3, and in the case of Examples 1-3. It appears that the irritation degree of up to 1.35% or more, it was excellent in the skin stability effect by the composition of the present invention.
On the other hand, in Comparative Examples 1 and 2, the stimulation degree (%) of the closed patch test was greater than that of the examples, indicating that the skin stability was lowered.

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As described above, the present invention is a skin moisturizing composition containing alginic acid has affinity with the skin cells, has a hypoallergenic and stimulating effect and improve the skin, improve the skin wettability, the skin activity inside the stratum corneum layer Since it maximizes the preservation of the material, it is excellent in the soothing effect on sensitive skin caused by skin drying, skin problems caused by internal and external skin drying and irritation, and is useful for UV-induced heat erythema, acne, skin inflammation, and atopy.
Although the present invention has been described in detail only with respect to the embodiments described, it will be apparent to those skilled in the art that various modifications and variations are possible within the technical spirit of the present invention, and such modifications and variations belong to the appended claims. .

Claims (5)

A composition for moisturizing skin containing alginic acid having a content ratio of manuronic acid / gluronic acid of 0.5 to 2.0, a mass average molecular weight of 10,000 to 100,000, and a polymerization degree of 50 to 600, of 0.01 to 15% by weight of the composition. The method according to claim 1, wherein niacinamide, retinol, retinal, retinyl palmitate, retinyl propionate, ascorbic acid and tocophenol are selected from the group consisting of 0.1 or 10 or more skin protection active agents thereof. The composition for moisturizing the skin, characterized in that it further contains by weight. The composition for moisturizing skin according to claim 1, further comprising 0.1 to 10% by weight of one or more skin whitening ingredients selected from the group consisting of Mt. extract, licorice extract, kojic acid, arbutin and ascorbic acid. The method of claim 1, wherein the dioxybenzene, methyl anthranilate, benzophenone-4, octyl salicylate, triethanolamine salicylate, synoxate, oxybenzone, octocrylene, digaloyltrioleate, paradimethyl Amyl benzoate, diethanolamine paramethoxycinnamate, octylmethoxycinnamate, paraaminobenzoic acid, glyceryl pava, ethyldihydroxypropylpava, octyldimethylpava, 2-phenylbenzoimidazole-5-sulfonic acid, homo It further contains 0.5 to 10.0% by weight of at least one sunscreen component selected from the group consisting of salate, dromethazole, butylmethoxydibenzoylmethane, octyltrizone and 3- (4-methylbenzylidene) -campa The skin moisturizing composition, characterized in that. The skin moisturizing composition according to claim 1, further comprising 0.01 to 10.0% by weight of one or more components of essential oils extracted from natural plants.