JPH01121205A - Skin beautifying cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin beautifying cosmetic having high safety and improved skin beautifying effect, by using kojic acid and/or its derivative in combination with extracted liquid and/or powder of aloe and compounding the mixture to a cosmetic. CONSTITUTION:The objective skin beautifying cosmetic (e.g. cream, milky lotion, face lotion, pack, powder, rouge, under-makeup, foundation or sun care) having excellent skin beautifying effect contains (A) kojic acid (5-hydroxy-2- hydroxymethyl-4-pyrone) and/or its derivative and (B) extracted liquid and/or powder of aloe. The amounts of the components A and B are preferably 0.01-10wt.% and 0.01-15wt.%, respectively.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to cosmetics with excellent whitening effects.

More specifically, the present invention relates to a whitening cosmetic composition in which kojic acid and/or its derivatives and aloe extract and/or extract powder are blended into a cosmetic base to improve the whitening effect.

[Prior art]

Cosmetics that have a skin whitening effect are of great interest to consumers, especially middle-aged women in their late 20s and above, and in particular can safely and effectively prevent age spots that appear on the skin and remove age spots. Things have been traditionally requested. Therefore, many researchers are searching for whitening ingredients and researching, developing, or providing various whitening cosmetics based on the inhibition of the activity of tyrosinase enzyme and the disappearance of active melanocytes, which are thought to be involved in the generation of age spots.

In order to obtain whitening cosmetics, peroxides such as hydrogen peroxide, zinc peroxide, and magnesium peroxide, ascorbic acid, glutathione, colloidal sulfur, and various natural products have previously been blended as whitening ingredients. However, peroxides and ascorbic acid have problems in stability, storage stability, etc., and their effects cannot be said to be sufficient. On the other hand, glutathione and colloidal sulfur have a strange odor, which makes it difficult to incorporate them into cosmetics.Furthermore, in the United States and other countries, hydroquinone is used as a skin bleaching agent, but although it has a whitening effect, it is not safe. There are problems with incorporating it into cosmetics from the viewpoint of (irritation and allergy).

Therefore, in recent years, various whitening ingredients or cosmetics that have skin whitening effects without the above-mentioned problems have been intensively developed. For example, whitening cosmetics using kojic acid and kojic acid derivatives produced from the genus Aspergillus, Penicillium, Acetobacter, etc. have been proposed (Japanese Patent Publication No. 1973-
No. 18569, JP-A No. 53-3538, JP-A No. 61-
No. 60801, Special Publication No. 5g-22151, Special Publication No. 1986
-9722). In addition, cosmetics containing quercetin and/or its derivatives as an active ingredient (Japanese Patent Application Laid-Open No. 55-92305
Cosmetics containing catechins as active ingredients (Japanese Patent Application Laid-Open No. 52-44375) have also been developed, but the stability of these whitening ingredients is difficult to find in actual use. At present, various problems remain, such as that it is still insufficient, and that although it is effective at the cellular level, it is not fully effective in animals and humans.

[Problem that the invention seeks to solve]

The present invention aims to solve the above-mentioned problems and provide a cosmetic with excellent whitening effects.

More specifically, the present invention aims to provide a cosmetic containing a concomitant substance that further improves the whitening effect of kojic acid and/or its derivatives, which are known as whitening ingredients.

[Means to solve the problem]

The present inventors investigated the morphology and physiological properties of age spots and found that the age of age spots has lower moisture content than normal areas, and the skin is hardened.

Therefore, with the aim of improving the skin condition, we investigated the effects of combining various anti-inflammatory agents, wound healing agents, and moisturizers with kojic acid and/or its derivatives, and found that kojic acid and/or its derivatives and aloe extract It has been found that the whitening effect can be further improved by combining the liquid and/or extracted powder with cosmetics. The present invention was completed based on this knowledge.

That is, the present invention provides a whitening cosmetic material containing kojic acid and/or a derivative thereof and an aloe extract and/or extract powder.

The chemical name of the kojic acid used in the present invention is 5-hydroxy-2-hydroxymethyl-4-pyrone, and it can be used in fermentation extracts produced from microorganisms such as Aspergillus, Penicillium, and Acetobacter. Purified products such as crystals or synthetic products obtained by synthetic methods can be used. Kojic acid and its salts are commercially available and can be easily obtained.

The derivatives of kojic acid in the present invention include reaction derivatives of 5- and/or 2-hydroxy groups of kojic acid. Preferred examples of such derivatives include fatty acid esters having 3 to 22 carbon atoms, aliphatic ethers having 3 to 22 carbon atoms, and polyoxyalkylene (having 2 to 3 carbon atoms) derivatives.

The aloe extract and/or extracted powder used in the present invention can be produced by pressing, crushing, crushing, etc. from the whole plant or the eastern part of Aloe vera, soap aloe, Kidachi aloe, etc. What is obtained can also be used, as well as purified products and fractionated products obtained by treatment with activated carbon to remove colored components that are prone to discoloration.

In the present invention, it is essential to contain both the above-mentioned kojic acid and/or its derivatives and aloe extract and/or extract powder, and cosmetics containing only either one of them are the objects of the present invention. Improvement in whitening effect cannot be achieved.

As for the effects of the present invention, the wound healing, cell activation, and moisturizing effects of the aloe extract and/or extract powder can be applied to stains that have abnormalities in the epidermis and dermis (reduction in water content and skin hardening), as described above. This is because the area has been improved, making it easier to remove deposited melanin, and furthermore, because the skin condition has been improved, the skin whitening agent kojic acid component can be smoothly transferred to the stratum corneum, and transdermal absorption has been improved. This is thought to be due to the increase in

The whitening cosmetics of the present invention include, for example, creams, emulsions, lotions, packs, powders, lip balms, lipsticks, under-make-up, foundations, sun care, and many others.

The amounts of the kojic acid and/or its derivatives (hereinafter also referred to as kojic acid component) and aloe extract and/or extract powder (hereinafter also referred to as aloe component) in the cosmetic may be determined according to the dosage form. Usually, the amount of kojic acid component in the cosmetic is 0.01 to 10% by weight, and the amount of aloe component is 0.01 to 10% by weight2.
It is preferable to mix so that the weight limit is 0.01 to 15. If the amount of each component is less than 0.01% by weight, the desired effects of the present invention cannot be obtained. There is no particular upper limit on the upper limit, but if a large amount is blended, the stability of the product and the feeling of use such as stickiness will be poor, so it is not preferred as a cosmetic.The upper limit of the blended amount is 10% by weight in the case of kojic acid component. In the case of aloe components, it is preferable to use 15% by weight. Moreover, the method of blending each component can be carried out in accordance with the conventional method of blending physiologically active ingredients and the like.

In addition to the above-mentioned ingredients, the cosmetic of the present invention contains additive ingredients normally used in cosmetics, such as surfactants, oils and fats, alcohols, humectants, thickeners, preservatives, antioxidants, and chelates. It is possible to incorporate agents, phi adjusters, fragrances, pigments, ultraviolet absorbing/scattering agents, water, etc. Specific examples of these additive components include, for example, as surfactants, lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerin monostearate, sorbitan monooleate, polyethylene glycol monostearate, Nonionic surfactants such as polyoxyethylene sorbitan monooleate, polyoxyethylene cetyl ether, polyoxyethylene sterol, polyoxyethylene lanolin, polyoxyethylene beeswax, polyoxyethylene hydrogenated castor oil; sodium stearate, palmitic acid Potassium, sodium cetyl sulfate, sodium lauryl phosphate, triethanolamine palmitate, polyoxyethylene sodium lauryl phosphate, N-
Examples include anionic surfactants such as sodium acylglutamate; cationic surfactants such as stearyldimethylbenzylammonium chloride and stearyltrimethylammonium chloride; and amphoteric surfactants such as alkylaminoethylglycine hydrochloride and lecithin.

Examples of oils and fats include vegetable oils such as castor oil, olive oil, cacao butter, camellia oil, coconut oil, wood wax, jojoba oil, grapeseed oil, and avocado oil; animal oils and fats such as mink oil and egg yolk oil; beeswax, and whale oil. Row.

Waxes such as lanolin, carnauba wax, and candelilla wax: liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax,
Hydrocarbons such as petrolatum; lauric acid, myristic acid,
Natural and synthetic fatty acids such as stearic acid, oleic acid, isostearic acid, behenic acid; Natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, lauryl alcohol; Isopropyl myristate, isopropyl palmitate, octyldodecyl myristate , octyldedosyl oleate, cholesterol oleate, and other esters.

Humectants include glycerin, propylene glycol,
1. Polyhydric alcohols such as 3-butylene gellicol, sorbitol, polyethylene glycol, and dipropylene glycol; amino acids, NMF components such as sodium lactate and sodium pyrrolidone carboxylate, hyaluronic acid, collagen, and mucopolysaccharides.

Examples include water-soluble polymeric substances such as chondroitin sulfate.

Thickeners include natural polymeric substances such as sodium alginate, xanthan gum, aluminum silicate, quince seed extract, 1-laganth gum, and starch; semisynthetic substances such as methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, soluble starch, and cationized cellulose. Polymeric substances; synthetic polymeric substances such as carboxyvinyl polymers and polyvinyl alcohol can be exemplified.

Preservatives include benzoates, salicylates, sorbates, dehydroacetates, paraoxybenzoic acid esters,
Examples include 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, benzalkonium chloride, hinokitiol, resorcinol, and ethanol.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate, ascorbic acid, and the like. Furthermore, as a chelating agent, edetate disodium, ethylenediaminetetraacetate, pyrophosphate, hexametaphosphate, citric acid, tartaric acid, gluconic acid, etc., PI (as a modifier,
Sodium hydroxide, triethanolamine, citric acid,
Examples include sodium citrate, boric acid, borax, and potassium hydrogen phosphate.

For ultraviolet absorbing and scattering agents, 2-hydroxy-4-
Examples include methoxybenzophenone, octyl dimethyl para-aminobenzoate, ethylhexyl para-methoxycynamate, titanium oxide, and kaolin 5-talc. Note that the optional components are not limited to these. By appropriately blending the above essential ingredients and optional ingredients, creams, emulsions, lotions, packs, powders,
It can be used in various product forms such as lip balm, lipstick, under makeup, foundation, and sun care.

To show specific examples of the cosmetics of the present invention, for example, as a skin cream: Essential ingredients: 0.02 to 10%, Oil content: 20 to 70%, Surfactant: 2 to 7%, Humectant: 5
~10%, Purified water: Balance, Preservative: Trace amount, Fragrance:
As for compositions and emulsions containing trace amounts; essential ingredients:):
02-10%.

Oil content = 10-40%, surfactant = 1-5%, humectant =
5-10%.

Purified water: balance, preservative: trace amount, fragrance: composition containing trace amount, as a lotion; essential ingredients: 0.02-10
%, alcohols: 2-50%, surfactant H1: o, 5
~2%, humectant: 2-8%, antioxidant: 0.01-0
．． 05%, chelating agent: 0.02-0.1%, PH adjuster: 0.05-0.2%, purified water: balance, preservative:
A composition containing trace amounts, pigments: trace amounts, fragrances: trace amounts, as a pack; essential ingredients: 0.02-10%, alcohols: 2-30%, moisturizing M: 2-to! g, inorganic powder:
Examples include compositions containing 0 to 20%, film forming agent = 10 to 20%, preservative: slight amount, and fragrance: trace amount.

〔Effect of the invention〕

According to the present invention, a cosmetic is provided which has a superior whitening effect and is highly safe than conventional products.

Therefore, the cosmetics of the present invention can be used in various product forms such as various cosmetic creams, milky lotions, lotions, packs, powders, lip balms, lipsticks, under makeup, foundations, sun care, etc., and especially as skin cosmetics. It can be used suitably.

〔Example〕

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 In order to prove the whitening effect of the cosmetic of the present invention, C57
Using the backs of black mice, the inhibitory effect on active melanocytes increased by UVB (ultraviolet) irradiation was investigated. The test method is as follows.

(1) Sample The component composition (weight %) of the sample is as shown in Table-1.

(2) Active melanocyte suppression effect test The backs of C57 black mice (3 mice in each group) were shaved,
After hair removal with wax, 1/2 MED amount of UVB (ultraviolet rays) is irradiated once a day for one week. The specimen was applied once a day after irradiation. Also, the evaluation period is 3 days after the end of the exam.
The suppression rate was calculated based on the number of active melanocytes in the unapplied sample. The number of active melanocytes was measured by exfoliating the epidermis with 2N sodium bromide treatment, staining with Dopa, and counting using a microscope. The results are shown in Table-1.

From the results in Table 1, it can be seen that the product of the present invention containing both a kojic acid component and an aloe component has a clearly improved suppressive effect on active melanocytes compared to a product containing only a kojic acid component.

Example 2 Furthermore, in order to prove the whitening effect of the cosmetic composition of the present invention, the bleaching effect was examined using the backs of colored guinea pigs.

The test method is as follows.

(1) A lotion was prepared containing the whitening ingredients shown in Sample Table 2 and ethanol, with the remainder being purified water.

(2) Depigmentation effect test After the backs of colored guinea pigs (3 animals in each group) were shaved, each lotion at 50 μC was applied once a day, 5 times a week, over an area of approximately 4 d for 3 weeks, and the test was conducted. On the fourth day after completion, skin color was measured using a color difference meter. The results are shown in Table-2.

From the results in Table 2, it can be seen that the lotion of the present invention containing both a kojic acid component and an aloe component has a better decolorizing effect than a lotion containing only a kojic acid component.

Example 3 Examples of various cosmetics according to the present invention are shown below.

<Cream> A: Oil phase liquid paraffin (#70) 5.0% by weight squalane 15. On cetostearyl alcohol 5.0 wax
2.0〃Glyceryl monostearate
2.0〃POE(20) Sorbitan monolaurate 2
．． 0 Propyl paraben 0.1 Glycyrrhetinic acid 0.2 lrB: Aqueous phase Kojic acid 0.5 weight Aloe extract powder 1. O Water-soluble collagen 0.2 Methylparaben
0.2〃Purified water Balance C: Fragrance Appropriate amount After mixing and dissolving the above formulations A and B at 70°C,
Add A to B and emulsify uniformly. Further add C and cool.
Prepare the cream.

<Milk> A: Oil phase liquid paraffin (#70) 10.0% by weight isopropyl myristate 2.0% by weight glycerin monostearate 0.5 stearic acid
2.0 POE (20) Stearyl ether 0.7 Allantoin
0.1 Butylparaben 0.1
B: Water phase Kojic acid 0.5% by weight Triethanolamine 0.5 Glycerin
2.0 Carbopol 941
Q, l // ethanol
10.0 // Methylparaben
0.1〃Purified water Balance C: Fragrance Mix and dissolve appropriate amounts of the above formulations A and B at 70°C,
Add A to the mixture and emulsify it uniformly. Further, add C and cool to prepare a milky lotion.

<Lotion> A: Ethyl alcohol phase Ethyl alcohol 10.0% by weight PO
E (80) Hydrogenated castor oil 0.3 Methylparaben 0.1% by weight Fragrance
Appropriate amount B: Aqueous phase Kojic acid 0.1 weight 2 Aloe extract (10% aqueous solution) l, Q n Hyaluronic acid 0.1 Ascorbic acid Magnesium phosphate 0.5 Glycerin
3.0 Purified water balance After uniformly dissolving the above formulation A, gradually add it to the aqueous phase of B while stirring to prepare a lotion.

<Pack agent> A: Ethyl alcohol phase: Ethyl alcohol 10.0% by weight polyvinyl alcohol 15. OII propylene glycol 3. OII Methylparaben
Q, l u Butylparaben
0.05 IT tocopherol acetate
0.1 7/B: Aqueous phase Sodium kojate 1.0% by weight Aloe extract powder 1. Q n Sodium pyrrolidone carboxylate 1. Q u Sodium carboxymethyl cellulose 5.0 POE (15) oleyl ether 1.0 7F
Purified water Balance C: Fragrance
Appropriate amounts of the above formulations A and B were mixed and heated and mixed uniformly at 70°C. Add Formulation C with further cooling to prepare a thickener.

Claims (2)

[Claims] (1) A whitening cosmetic characterized by containing kojic acid and/or its derivatives and aloe extract and/or extract powder. (2) In the whitening cosmetic, the amount of kojic acid and/or its derivatives is 0.01 to 10% by weight, and the amount of aloe extract and/or extracted powder is 0.01 to 15% by weight. % of the whitening cosmetic according to claim (1).