KR20050051069A - Formulation with amphoteric property for safe keratin scaling - Google Patents

Abstract

The present invention is a composition consisting of AHA (α-Hydroxy Acid) or BHA (β-Hydroxy Acid) component, Arginine (Arginine) component, hydrophilic liquid carrier component to minimize the skin irritation when applied to the skin and at the same time excellent skin exfoliation effect It relates to a skin topical application composition.

Arginine neutralizes with alpha hydroxy acids to form positive hydroxy acids to maintain good clinical efficacy in terms of exfoliation of AHAs, while at the same time significantly alleviating potential stimuli and negative sensitive reactions of AHAs. Let

In particular, it contains a high amount of AHA to remove skin stratum corneum safely and effectively, suggesting application as a topical application for skin peeling and scaling, and is very useful for improving pigmented skin such as blemishes and freckles, wrinkled skin and acne skin. This is possible.

Description

Formulation with amphoteric property for safe keratin scaling}

The present invention is a composition consisting of AHA (α-Hydroxy Acid) or BHA (β-Hydroxy Acid) component, Arginine (Arginine) component, hydrophilic liquid carrier component to minimize the skin irritation when applied to the skin and at the same time excellent skin exfoliation effect It relates to a skin topical application composition.

Skin, the largest organ that makes up the human body, protects various organs inside the skin from the outside and provides various physiological functions such as barrier function, temperature control function, excretion function, respiratory function, etc. It is a very important organization in charge.

However, as the skin ages, the thickness of the skin becomes thinner, so that the skin barrier function is lowered, and the skin's physiological function decreases due to the drastic decrease in the moisture content of the skin. In addition, highly reactive free radicals and free radicals generated by increased UV radiation, air pollution, excessive fatigue and stress of modern people, oxidize or denature biological components such as proteins, nucleic acids and cell membrane lipids, thereby deteriorating skin's physiological function. It causes skin irritation easily by small external stimulus. In addition, skin irritation such as wrinkles, blemishes, freckles, and pigmentation occurs as the skin ages.

Therefore, in order to improve the above problems, using alpha hydroxy acid (AHA: α-Hydroxy Acid) to improve the skin by promoting the exfoliation and the activity of the skin cells, it will be described in detail as follows.

The alpha hydroxy acid (AHA: α-Hydroxy Acid) is a compound in which an alcohol group or an hydroxy group is added to the carbon at the α position of the carboxylic acid to give ionic binding energy of keratinocytes. By lowering the dead skin cells or promoting the formation of new cells to shorten the period of keratinization process, which is longer as the skin ages, it promotes the activity of skin cells to improve the skin. In addition, by promoting the production of collagen (Collagen) and elastin (Elastin) by the fibroblasts to make the skin elastic, soft and promote the production of mucopolysaccharides, an important extracellular matrix component of the dermis Improves skin moisturizing

Alpha hydroxy acid, which has such a function, has been used for a long time. The ancient Egyptians used to bathe lactic acid, a type of alpha hydroxy acid produced when fermented milk to keep skin healthy and beautiful. 200 years ago, French aristocrats applied old wine to their faces to keep their skin soft and clean, including malic and tartaric acid, the alpha-hydroxy acids found in old wine. I used it.

Alpha hydroxy acid, which has been used for a long time as described above, has recently been patented by Dr.EJScott, a dermatologist at Temple University Hospital in the United States for the prevention and improvement of pigmentation deposition (clinical experiment) such as anti-aging, acne improvement, blemishes and freckles (USP4105783). ) Has been registered, a number of patents associated with it.

Currently, alpha hydroxy acid is fermented milk or lactic acid (Lactic acid, MW = 90.08) obtained by enzymatic reaction, citric acid (MW = 210.14) which is contained in fruit such as lemon or orange, apple, grape, strawberry, etc. Large amounts of malic acid (Malic acid, MW = 130.98) and tartaric acid (Tartaric acid, MW = 150.09) obtained from grapes are widely used. In particular, lactic acid is excellent in cell regeneration effect, moisture control effect and hyper keratin removal effect, and is the most used as cosmetics in AHA due to low skin irritation.

On the other hand, glycolic acid (Giycolic acid, MW = 76.05) obtained from sugar cane has the smallest molecular weight among AHAs, so the skin penetrates quickly, so it is effective, but there are problems such as severe irritation in the skin and lack of balanced peeling. Although its use has been limited, in recent years, the use of a composition containing a high content of glycolic acid as a composition for skin peeling and scaling for medical skin care or medical use has emerged. In particular, the use of a high content of glycolic acid or other AHA content of the product has been required for the stability of the skin irritation.

Recently, various studies have been conducted to solve the skin irritation of AHA, and among them, the use of BHA is an alternative substrate.

The beta hydroxy acid (BHA: β-Hydroxy Acid) is a compound having a structure attached to the alcohol group (Alcohol group) or hydroxy group (Hydroxyl group) on the carbon at the β position of the carboxylic acid (Carboxylic acid) molecular weight (105-194 ) Is larger than AHA (76.1-210.1), so it does not penetrate easily into the skin and is expected to have less skin irritation. However, the skin irritation caused by BHA is also very large and there is a problem as an alternative substrate of AHA, such as less skin moisturizing effect, cell regeneration effect, whitening effect, wrinkle improvement effect, skin elasticity effect and the like compared to AHA.

In addition to the problems described above, by using AHA alone, it may react with a substance in the skin to produce or neutralize salts (SALT), thereby reducing its effectiveness. In addition, in order to have physiological activity, the acidity (pH) of the product should be between 2 and 3, which is accompanied by very strong irritation to the skin, ie burning, redness, dryness and other side effects of the skin.

Therefore, the encapsulation of AHA in the form of liposomes reduces the skin irritation by formulating a pH between 5 and 6, but at this time, the effect is inferior. ), Various attempts have been made to minimize the skin irritation caused by acidity (pH 3.8-4.0) and increase the effect. However, there is still a problem of irritation to the skin, and research is needed to solve it.

The present invention contains a high content of AHA while minimizing skin irritation and at the same time

Its excellent expression properties make it safe for exfoliation of skin, and it is effective in improving pigmented skin such as blemishes and freckles, wrinkles, and acne skin by removing dead skin layers. The present invention provides a skin peeling and scaling composition that stably expresses an exfoliating effect while reducing skin irritation.

It is an object of the present invention to provide a skin topical application composition which reduces the skin irritation of AHA as described above even when it contains a high content of AHA, thereby increasing stability in skin application and at the same time not reducing the skin action properties of AHA. To this end, by introducing the arginine component of the acidic properties of AHA to impart neutral (Amphoteric) properties to significantly reduce the skin irritation of AHA and at the same time to provide a composition excellent in skin exfoliation properties.

The composition of the present invention relates to a composition having skin hypoallergenic properties while providing a skin exfoliation effect upon topical application of the skin, characterized by containing the following composition.

(A) 0.05 to 70% by weight of the total composition of at least one of AHA (α-Hydroxy Acid) or BHA (β-Hydroxy Acid) components

(B) 0.01 to 50% by weight of arginine component of the total composition

(C) containing 1 to 99% by weight of the total composition of the hydrophilic liquid carrier

The composition

The composition is a skin topical application composition that can be effectively used as a skin scaling or peeling agent by maintaining skin safety while reducing the skin irritation even when it contains a high content of AHA or BHA, while maintaining the safety side effect of skin exfoliation of AHA or BHA. It is about.

In the present invention, the alphahydroxy acid functioning as a function of exfoliation effect is as follows.

First, there is a wrinkle removal effect. As the hydroxy acid is not observed with the naked eye, minute peeling action is continued without irritation, which accelerates the regeneration period of the skin, increases the amount of collagen produced in the papillary dermis layer, restores elasticity, and leaves the skin shiny and fine. .

Second, it is effective in removing blemishes, freckles and blotch. Pigmentation, which is caused by the thickening of dead keratinocyte layers and excessive production of melanin by the action of ultraviolet and progesterone, a female hormone, gradually causes peeling, freckle, and blotch by skin peeling and skin regeneration by continuous peeling. It is a natural therapy that is removed and is fundamentally different from temporary bleaching effects such as medicated creams.

Third, acne is effective in removing. Acne is created by the buildup of dead skin cells around the hair follicles, preventing the sebum from leaking out of the pores. By continually peeling to prevent excessive keratinization, pores are cleaned naturally and the skin is always clean, so acne is removed and prevented, and the rate of improvement to neutral skin is faster.

Alpha hydroxy acid is a generic term for substances that have a hydroxyl group on the first carbon of an organic acid (also called carboxylic acid). There are many ways to name a substance, which can be called by different names, but the substance itself is the same. Glycolic acid may be called as follows. Hydroxyacetic acid, alpha-hydroxy acetic acid, and alpha-hydroxyethanoic acid. Lactic acid is also called 2-hydroxypropanoic acid. Alpha hydroxy acids are often referred to as AHAs for short. On the other hand, when the second carbon of the carboxylic acid has a hydroxyl group, it is called beta-hydroxy acid (commonly called BHA), which is extracted from the bark of the willow tree and the most commonly used salicylic acid. Salicylic acid has less irritation and stronger lipophilic properties than glycolic acid, so it is widely used for general exfoliants and acne healing products. In addition, MHA (Multi hydroxy acid) refers to a mixture of salicylic acid and fruit acid.

Typical types and characteristics of alpha hydroxy acids are shown in the following table.

name original language Characteristic Glycolic acid glycolic acid Contained in sugar cane, the smallest molecular weight among AHAs Lactic acid lactic acid It is contained in high-end milk and is a moisturizing effect. It is obtained by fermentation by adding oxidase to lactose. Malic acid malic acid It's found in apples, peaches, and so on. Tartaric acid tartaric acid It is contained in new grapes, also called grape acid. Citric acid citric acid Orange, lemon, etc. It is widely used as a cosmetic pH adjuster.

In the present invention, arginine forms positive hydroxy acids (Amphoteric Hydroxyacids) through neutralization with alpha hydroxy acids to regulate the irritation and skin penetration rate of AHA.

In other words, the determination of the possible content of AHA in terms of optimal transport mode depends on the clinical efficacy of the skin penetration of the AHA composition. To maximize the bioavailability of AHAs, the composition pH must be acidic. At a pH of 3.8 (pKa of glycolic acid), about 50% of glycolic acid is in an unionized, pre-acidic form suitable for bioavailability.

The arginine component forms ionic bonds with AHAs, thus preventing immediate skin penetration of neutralized acids. Unneutralized acid will remain easy to penetrate. Positive hydroxy acid technology uses positive amino acids as a neutralizing system, thereby adjusting the composition pH, attracting free glycolic acids, forming temporary complexes, slowing penetration of the free acid, while lowering skin irritation. It is to maintain the properties of AHA. This is shown to play a role in relieving stimulation and burn by delaying the start of activation, in particular, since the complex is temporary by natural binding, the efficacy of the composition is not impaired.

In other words, the complex of AHA / arginine acts as a kind of polyhydroxy acid (PHA) component, alleviating potential stimuli and negative sensitive reactions of AHA while maintaining excellent clinical efficacy. Amino acid of arginine, which naturally coordinates the delivery and stimulating forms of AHA. The benefits of skin care by the addition of amino acids are related to the amphoteric properties of amino acids that promote the formation of molecular complexes with alphahydrosiic acids. These complexes allow the slow release of free alphahydroxyacids without significant change in pH, and allow AHAs to penetrate more slowly and smoothly, alleviating the potential for irritation, burns, and the like.

The positive hydroxy acid techniques of this invention exhibit clinical advantages including:

Less stimulation compared to non-positive AHA composition

Hypersensitivity stimulation is less than a non-positive AHA composition

Efficacy of AHA similar to non-positive AHA composition

-Suitable for skin application composition using positive technology

In the present invention, in addition to the above-mentioned arginine, it is possible to add an alkali component together in a range that does not inhibit the characteristic expression of AHA intended by the present invention, which can be used as a neutralizing agent of AHA.

Hydrophilic liquid carriers of the present invention, such as water or other hydrophilic diluents, contain about 1 to about 99 weight percent, preferably about 5 to about 95 weight percent, more preferably about 20 to about 90 weight percent, based on the composition. . Thus, the hydrophilic liquid carrier may contain water or a combination of water and one or more water soluble or dispersible ingredients. Hydrophilic liquid carriers containing water are preferred.

The hydrophilic liquid carrier component may contain any dermatologically acceptable carrier that can introduce the necessary thickeners and any other materials to allow AHA and optional components to be delivered to the skin at appropriate concentrations. The hydrophilic liquid carrier thus ensures that AHA / arginine is applied to the selected target at a suitable concentration and evenly distributed.

The carrier may contain one or more dermatologically acceptable semisolid or liquid fillers, diluents, solvents, extenders, and the like. The liquid carrier may also contain gel material. Preferred carriers are substantially liquid. The carrier itself may be inert or possess a dermatological benefit by itself.

The concentration of the hydrophilic liquid carrier may vary depending on the carrier selected and the intended concentration of the required and optional ingredients.

Suitable hydrophilic carriers include known carriers that are conventionally or otherwise dermatologically acceptable. The carrier must also be physically or chemically compatible with the essential ingredients described herein and must not unduly impair stability, efficacy or other use advantages with respect to the compositions of the present invention. Preferred components of the composition of the present invention should be able to be mixed with each other in such a way that there is no interaction that substantially reduces the efficacy of the composition under normal use conditions.

The type of hydrophilic carrier used in the present invention depends on the type of product type desired for the composition. Topical compositions useful in the present invention can be prepared in various types of products known in the art. This includes, but is not limited to, lotions, creams, gels, sprays, pastes, powders, mousses, and cosmetics (such as semi-solid or liquid makeup, foundations, eye makeup, dyed or undyed lip treatments, etc.) It doesn't happen. Such product types may contain, but are not limited to, various types of carriers including solutions, aerosols, emulsions, gels and liposomes.

Preferred hydrophilic carriers may contain a dermatologically acceptable, non-aqueous hydrophilic diluent. Non-limiting examples of hydrophilic diluents include organic hydrophilic diluents such as lower monohydric alcohols (e.g. C ₁ -C ₄ ) and low molecular weight glycols and propylene glycols, polyethylene glycols (e.g. molecular weight 200-600 g / mole), polypropylene glycols ( Eg molecular weight 425-2025 g / mole), glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol ester, butanediol, ether Organic hydrophilic diluents such as polyols, including propanol, ethoxylated ethers, propoxylated ethers and combinations thereof.

As described below, the hydrophilic liquid carrier may contain various components that are water soluble or water miscible, capable of one or more skin conditioning or skin treatment functions. Compositions containing a hydrophilic liquid carrier component containing thickened, dispersed positively charged AHA materials may contain a hydrophobic phase resulting in an emulsion of the emulsion.

The present invention may further contain the following components in addition to the main components of the AHA (α-Hydroxy Acid) or BHA (β-Hydroxy Acid) component, arginine (Arginine) component, hydrophilic liquid carrier.

Seaweed ingredients

Among the seaweed components, the seaweeds used in the composition include kelp, laminaria japonica, seaweed, green radish, ascopiram, fucales, large horsetail, Okinawa large horsetail, brown algae such as Himantalia, urticaria and coralinaseae , Palmaria, Chondrus ocellatus, seaweeds such as seaweed, green algae such as seaweed, etc., in addition to the above-mentioned seaweed, other types of seaweed or seaweed extracts within the scope of the purpose of the present invention together with Can be used.

Natural soothing ingredients

Natural soothing ingredients such as candelilla wax, alpha bisabolol, aloe vera, manjistar, gugal, cola extract, green tea extract, ginkgo extract, seaweed extract, lavender, chamomile, tea tree It enhances the effect, and at the same time, the functional ingredients of the plant extracts penetrate into the skin, which is effective for soothing and moisturizing the skin and substantially improving the skin.

Skin protection and actives

The present invention may contain one or more skin protection and active agents in a proportion of 0.1% to 10% by weight of the total composition, and representative skin protection and active agents include niacinamide, retinol, retinal, retinyl palmitate, retinyl pro Cationate, ascorbic acid, tocophenols and derivatives, and mixtures thereof. Skin protection and active agents are useful for helping to regenerate and protect the skin from skin damage caused by harmful environments such as skin aging and UV irradiation.

Whitening ingredients

The present invention may contain one or more skin whitening components in a proportion of 0.1% to 10% by weight of the total composition, and representative skin whitening components include a mulberry extract, licorice extract, kojic acid, arbutin, ascorbic acid and derivatives thereof Group consisting of mixtures;

The following examples describe and demonstrate in more detail embodiments that are within the scope of the present invention. The examples are illustrative only and not intended to limit the invention, and many modifications are possible without departing from the spirit and scope of the invention.

Example 1-5 and Comparative Example 1-3

Skin soothing and protective compositions are prepared from the following ingredients using conventional formulation techniques.

Classification ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Soothing ingredients Aloe vera - 2 - One - Green Tea Extract - - 2 One - Neutralization Arginine - 3 3 5 5 2 One - - - NaOH - One 2 - - BHA Ingredients salicylic acid 5 5 - 5 5 AHA Ingredients glycolic acid - - 15 10 15 lactic acid 5 - 10 5 - malic acid 5 - 5 5 5 tartaric acid 5 - - 5 - citric acid - 5 - - 5 Liquid carrier water - 56.05 56.05 56.05 56.05 Disodium EDTA One One One One One Carbopol 954 2.9 2.9 2.9 2.9 2.9 Sorbitan Monostearate / Sucrose Cocoate - 3 3 3 3 Imidazolidinylurea 0.05 0.05 0.05 0.05 0.05

Classification ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Soothing ingredients Aloe vera - 2 - Green Tea Extract - - 2 Neutralization Arginine - - - 5 - 3 NaOH - 5 2 BHA Ingredients salicylic acid 5 5 - AHA Ingredients glycolic acid - - 15 lactic acid 5 - 10 malic acid 5 - 5 tartaric acid 5 - - citric acid - 5 - Liquid carrier water - 56.05 56.05 Disodium EDTA One One One Carbopol 954 2.9 2.9 2.9 Sorbitan Monostearate / Sucrose Cocoate - 3 3 Imidazolidinylurea 0.05 0.05 0.05

Human closed patch test

The human patch test is widely used as a method to search for primary irritants (Matsumura et al , 1995), but dermatologically, it refers to a diagnostic patch test for the diagnosis of allergic contact dermatitis. do.

In the back of each healthy adult male and female, 40 μl was put in a kit (Finn chamber), which was fixed to the skin with a tape (scanpore tape). After 3 minutes it was removed from the skin and the application site was rinsed with water and after 4 hours the results were determined. The degree of erythema and edema is indicated numerically. The criteria for acceptance were in accordance with the criteria of the International Contact Dermatitis Research Group (ICDRG) (Wooding et al , 1967; Rietschell, 1982; Fischer & Maibach, 1984; Aberer et al , 1993).

(Criteria)

0 = no redness

1 = erythema

2 = redness and papules

3 = redness, papules and vesicles

4 = severe edema and vesicles

Stimulus (%) = (responsiveness of positive response / response of self population) × 100

Example 1 Example 2 Example 3 Example 4 Example 5 Stimulus of closed patch inspection (%)  1.07  1.02  1.19 1.12  0.99

Comparative Example 1 Comparative Example 2 Comparative Example 3 Stimulus of closed patch inspection (%) 3.78  2.91  3.07

Effect on Skin Stability

The stimulus intensity (%) of the closed patch test for 60 volunteers was measured for each of the compositions of Examples 1-5 and Comparative Examples 1-3, and the stimulation degree of Example 1-5 was 1.19% at maximum. It appears that the skin stability effect by the composition of the present invention is excellent.

In Comparative Examples 1 to 3, the irritation degree (%) of the closed patch test was greater than that of the example, indicating that the skin stability was lowered.

Skinting Potential Test

In order to conduct skin irritation experiments on the skin protection cosmetics of Examples 1-5 and Comparative Examples 1-3, a steam generator was used for 20 subjects (mean age 22 years, age distribution 19-34 years) for each composition. After swept for 15 minutes using, apply the Example to the left part of the face and the Comparative Example to the right part while rubbing strongly around the nose and the cheeks. Stinging grades were evaluated as classified as intense stinging within 30 seconds, mild stinging within 2.5 minutes, moderate stinging within 5 minutes, and delayed stinging within 8 minutes after application. Psoriasis, eczema, and other skin lesion holders, or those who are pregnant, nursing or contraceptives, or antihistamines, were excluded from this study.

Determination was made by applying a sample (Example, Comparative Example) to the face and observing skin reactions (itch, itching, soreness, redness, swelling, etc.) for 8 minutes and measuring the response score to the number of subjects (n). The stimulus was evaluated by dividing the response rate (%). The degree of skin irritation according to the response rate (%) was determined according to the criteria of the following table and the results are shown in the following table.

Criterion for stinging potential test

Grade Response rate (%) Judgment One 0.00-0.75 Non-irritating 2 0.76-1.50 Unstimulated 3 1.51-2.50 Light stimulation 4 2.51-4.00 Heavy stimulation 5 4.01 or more Strong stimulation

 Stinging Potential Test

Example 1 Example 2 Example 3 Example 4 Example 5 Response rate (%) 1.20 1.15 1.25 1.11 1.02 Judgment Unstimulated Unstimulated Unstimulated Unstimulated Unstimulated Grade 2 2 2 2 2

Comparative Example 1 Comparative Example 2 Comparative Example 3 Response rate (%) 3.82 3.90 4.14 Judgment Heavy stimulation Heavy stimulation Strong stimulation Grade 4 4 5

As shown in the table, the skin safety test results according to the skin irritation test results (Response rate (%): 1.02-1.25) has a very low skin irritation compared to the comparative example (Response rate (%): 3.82-4.14) In general, it can be seen that the composition arginine of the present invention effectively inhibits and alleviates skin irritation of AHA, in view of the fact that cosmetics containing AHA have strong irritation, thereby providing a very safe cosmetic.

Exfoliation effect and skin irritation of the composition

In order to examine the skin exfoliation effect of AHA exfoliation, namely, the improvement of skin color brightness and softness of Examples and Comparative Examples, for 10 healthy adult men and women with blemishes, freckles and pigmentation by each composition After applying twice a week for 6 weeks, the degree of hyperkeratosis was measured by chromatometer (Minolta CR300) and the change in brightness of color (ΔL) was measured. The following evaluation criteria (grade 7) were evaluated, and the average value of the result is shown in the following table | surface.

In addition, in order to determine the incidence (ΔE) of skin erythema caused by AHA, the color change (ΔL) measurement site of the color was measured using an MEXAMETER (C + K electronic GmbH. The Erythema Index (E) was measured before and after using, and ΔE was calculated. As the ΔE value increases, the degree of skin erythema increases, and the skin irritation caused by AHA is severe, and the stimulation level of the skin irritation is determined by the ΔE value, and the average value of the results is shown in the following table.

Exfoliate effect

Subject Change in brightness of skin color (ΔL) Subjective Evaluation of the Subject Example 1 5.8 3 Example 2 6.1 2 Example 3 6.3 3 Example 4 5.9 3 Example 5 6.5 3 Comparative Example 1 4.8 2 Comparative Example 2 4.9 3 Comparative Example 3 4.3 2

* Evaluation standard :

-3: very worse, -2: worse, -1: slightly worse, 0: no change

1: slightly improved, 2: improved, 3: highly improved

Skin erythema due to hyperkeratosis

Before use after use ΔE Example 1 590.5 592.9 2.4 Example 2 587.7 590.9 3.2 Example 3 592.3 595.7 3.4 Example 4 582.1 553.9 1.8 Example 5 575.6 577.1 1.5 Comparative Example 1 590.4 606.7 16.3 Comparative Example 2 583.2 600.3 17.1 Comparative Example 3 585.6 609.1 23.5

As can be seen from the table, in the case of applying the cosmetic composition containing the arginine and AHA of the present invention, the average ΔL value showed a result of 5.8-6.3, respectively, and in the case of the comparative example containing no arginine component The ΔL values showed the results of 4.3-4.9 respectively. Therefore, it can be seen that the compositions of Examples and Comparative Examples show a very effective result in the exfoliation.

However, the experimental results showing the degree of skin irritation according to the exfoliation of AHA, it can be seen that the ΔE value of the comparative example is 16.3-23.5, the skin is severely reddened and the skin irritation is severe. On the other hand, the degree of skin redness (erythema) of the embodiment is difficult to distinguish the degree of erythema with the naked eye with ΔE value 1.5-3.4. In other words, almost no skin irritation.

Therefore, the examples containing arginine and AHA showed similar results in terms of the exfoliating effect of the comparative example containing AHA without arginine and the use effect of the subject, while maintaining the exfoliating effect of AHA, but rather using the same. The degree of skin irritation according to this embodiment shows a much lower result, and it can be seen that it significantly alleviates the skin irritation caused by exfoliation of AHA.

It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the present invention by describing the individual embodiments through the embodiments of the present invention. All modifications outside the scope of the invention will be protected within the scope of the appended claims.

The present invention is effective in improving pigmented skin such as blemishes and freckles, wrinkled skin and acne skin by removing the stratum corneum, and at the same time, by neutralizing the arginine component, stably expressing the exfoliating effect while reducing potential skin irritation of AHA. Application to skin peeling, scaling compositions.

Claims (3)

A composition having skin hypoallergenic properties while providing a skin exfoliation effect upon topical application of skin, characterized by containing the following composition: (A) 0.05 to 70% by weight of the total composition of at least one of AHA (α-Hydroxy Acid) or BHA (β-Hydroxy Acid) components (B) 0.01 to 50% by weight of arginine component of the total composition (C) containing 1 to 99% by weight of the total composition of the hydrophilic liquid carrier 2. A composition according to claim 1 further comprising at least one alkali component which neutralizes the AHA or BHA component. 2. The composition of claim 1, wherein the pH of the composition is between 2.0 and 6.0 by neutralization of the AHA (α-Hydroxy Acid) or BHA (β-Hydroxy Acid) components.