CN116474038A - 一种治疗痛风的中药组合物及其制备方法 - Google Patents
一种治疗痛风的中药组合物及其制备方法 Download PDFInfo
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- CN116474038A CN116474038A CN202310582275.XA CN202310582275A CN116474038A CN 116474038 A CN116474038 A CN 116474038A CN 202310582275 A CN202310582275 A CN 202310582275A CN 116474038 A CN116474038 A CN 116474038A
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Abstract
本发明提出了一种治疗痛风的中药组合物及其制备方法，属于中药组合物技术领域。包括以下原料：黄柏、苍术、萆薢、土茯苓、车前草、秦皮、威灵仙、豨签草、红花、甘草、狗脊、车前子、广金钱草、黄芪和石膏。本发明提供一种治疗痛风性关节炎的配方，其认为痛风的主要病机是湿浊瘀滞内阻，以泻浊化瘀的指导思想组方，通过泻浊解毒、活血化瘀、通利关节以达到改善关节功能、减轻疼痛、提高生活质量的目的，在临床上取得了较好的疗效为解决上述技术问题。
Description
技术领域
本发明涉及中药组合物技术领域，具体涉及一种治疗痛风的中药组合物及其制备方法。
背景技术
痛风是由单钠尿酸盐(MSU)沉积所致的晶体相关性关节病，与嘌呤代谢紊乱和(或)尿酸排泄减少所致的高尿酸血症直接相关，特指急性特征性关节炎和慢性痛风石疾病，主要包括急性发作性关节炎、痛风石形成、痛风石性慢性关节炎、尿酸盐肾病和尿酸性尿路结石，重者可出现关节残疾和肾功能不全。痛风常伴腹型肥胖、高脂血症、高血压、2型糖尿病及心血管病等表现。痛风多见于中年男性，女性仅占5％，主要是绝经后女性，痛风发生有年轻化趋势。
痛风是属于中医“痹证”等范畴，而过多的尿酸则属“湿浊”。由于脾肾功能失调，脾失健运，致使湿浊内生；肾分清泌浊的功能失调，则湿浊排泄障碍。此时若又酗酒暴食、劳倦过度等，则促使湿浊流注于关节、肌肉，造成气血运行不畅而形成痹痛，也就是痛风关节炎。如湿浊之邪进一步伤于肾则可导致肾损害，就是痛风性肾病甚至慢性肾衰。
目前治疗痛风基本以西药为主，主要有非甾类抗炎药和糖皮质激素类，前者上使用易伴肾功能不全者伤害，同时还应注意其心血管系统的不良反应。糖皮质激素类药物更容易导体内激素失衡，导致代谢紊乱。
发明内容
本发明的目的在于提出一种治疗痛风的中药组合物及其制备方法，其认为痛风的主要病机是湿浊瘀滞内阻，以泻浊化瘀的指导思想组方，通过泻浊解毒、活血化瘀、通利关节以达到改善关节功能、减轻疼痛、提高生活质量的目的，在临床上取得了较好的疗效为解决上述技术问题。
本发明的技术方案是这样实现的：
本发明提供一种治疗痛风的中药组合物，包括以下原料：黄柏、苍术、萆薢、土茯苓、车前草、秦皮、威灵仙、豨签草、红花、甘草、狗脊、车前子、广金钱草、黄芪和石膏。
作为本发明的进一步改进，由以下原料按重量g制备而成：黄柏20-40g、苍术20-40g、萆薢20-40g、土茯苓20-40g、车前草40-60g、秦皮20-40g、威灵仙20-40g、豨签草20-40g、红花10-20g、甘草5-15g、狗脊10-20g、车前子10-20g、广金钱草10-20g、黄芪10-20g、石膏20-40g。
作为本发明的进一步改进，由以下原料按重量g制备而成：黄柏30g、苍术30g、萆薢30g、土茯苓30g、车前草50g、秦皮30g、威灵仙30g、豨签草30g、红花15g、甘草10g、狗脊15g、车前子15g、广金钱草15g、黄芪15g、石膏30g。
本发明进一步保护一种上述治疗痛风的中药组合物的制备方法，包括以下步骤：
S1.将黄柏、甘草、黄芪、车前草、土茯苓、车前子、豨签草除去杂质，置沸水中煮10-20分钟，取出，闷透，切薄片，干燥，备用；
S2.将苍术、萆薢、秦皮洗净，切片，用米泔水喷洒湿润，置锅内用文火炒至微黄色，凉透，备用；
S3.取石膏入锅内炒热，备用；
S4.将红花、广金钱草拣净杂质，除去茎叶、蒂头，晒干，备用；
S5.将狗脊、威灵仙粉碎，研细后备用；
S6.将步骤S1、S2、S4、S5制得的各原料药混合，粉碎后，研细，均匀拌入步骤S3制得的粉末，过筛，得到中药粉，加辅料蔗糖和糊精混合均匀制成颗粒，干燥、整粒后，封装成每袋10g的中药冲剂。
作为本发明的进一步改进，步骤S2中所述苍术、萆薢、秦皮的总质量和米泔水的质量比为100:10-12。
作为本发明的进一步改进，步骤S6中所述中药粉、蔗糖和糊精的质量比为30：(5-12)：(5-10)。
作为本发明的进一步改进，步骤S6中所述过筛的筛网目数为150-200目。
作为本发明的进一步改进，所述中药冲剂的冲泡方法为加入10-20倍质量开水，搅拌10-20min，即可。
本发明进一步保护一种上述治疗痛风的中药组合物的使用方法，每次10-20g，每日1-2次。
作为本发明的进一步改进，5日为一个疗程。
黄柏，性味苦、寒，归肝、胃、肺经，用于清热解毒、止血、消肿；
苍术，辛、苦，温，归脾、胃、肝经。燥湿健脾，祛风散寒。用于脘腹胀满，泄泻，风湿痹痛；
萆薢，味辛、苦，性温，具有发汗解表、祛风止痛、散寒止痛、吐故纳新之功效；
土茯苓，甘、淡，平，归心经、肺经、脾经、肾经，小便不利，水肿胀满，痰饮咳逆，呕吐，脾虚食少，泄泻，心悸不安，失眠健忘，遗精白浊；
车前草，甘、寒，归肺、肾、膀胱经，用于清热利湿、消炎解毒、利尿；
秦皮，苦、寒，归胃、脾、肝经，具有清热解毒、消炎止痛、平喘镇咳等功效；
威灵仙，苦、甘、辛，微温，归肝、胆经。具有活血通络、消肿止痛、祛风除湿等功效；
豨签草，苦、寒，归肝、胆经，具有清热解毒、凉血止血、利尿排石、消炎止痛等功效；
红花，辛，温，归心、肝经。活血通经，散瘀止痛；
甘草，甘，平、归心、肺、脾、胃经。解毒、止咳、宁喘、祛痰、润肺；
狗脊，甘、温，归肝，脾，胃经，具有补肝肾、益精血、养心安神、滋润肌肤等功效；
车前子，甘淡、微寒，归肺，胃，大肠经。具有清热利湿、利尿通便、消肿止痛、清洁血液等功效；
广金钱草，甘、平，归经为肺、脾、胃经，润肠通便、清热解毒的功效；
黄芪，甘，微温，入脾肺经，具有补气固表、益脾胃、升阳举陷、生津液等功效；
石膏，甘淡、无毒，归肺，胃经，具有凉血、解毒、通淋浊、消肿、降压等功效。
本发明具有如下有益效果：本发明提供一种治疗痛风性关节炎的配方，认为痛风的主要病机是湿浊瘀滞内阻，以泻浊化瘀的指导思想组方，通过泻浊解毒、活血化瘀、通利关节以达到改善关节功能、减轻疼痛、提高生活质量的目的，在临床上取得了较好的疗效为解决上述技术问题。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
本实施例提供一种治疗痛风的中药组合物。
原料组成(重量g)：黄柏20g、苍术20g、萆薢20g、土茯苓20g、车前草40g、秦皮20g、威灵仙20g、豨签草20g、红花10g、甘草5g、狗脊10g、车前子10g、广金钱草10g、黄芪10g、石膏20g。
制备方法包括以下步骤：
S1.将黄柏、甘草、黄芪、车前草、土茯苓、车前子、豨签草除去杂质，置沸水中煮10-20分钟，取出，闷透，切薄片，干燥，备用；
S2.将苍术、萆薢、秦皮洗净，切片，用米泔水喷洒湿润，置锅内用文火炒至微黄色，凉透，备用；所述苍术、萆薢、秦皮的总质量和米泔水的质量比为100:10；
S3.取石膏入锅内炒热，备用；
S4.将红花、广金钱草拣净杂质，除去茎叶、蒂头，晒干，备用；
S5.将狗脊、威灵仙粉碎，研细后备用；
S6.将步骤S1、S2、S4、S5制得的各原料药混合，粉碎后，研细，均匀拌入步骤S3制得的粉末，过150目筛，得到中药粉，加辅料蔗糖和糊精混合均匀制成颗粒，所述中药粉、蔗糖和糊精的质量比为30：5：5，干燥、整粒后，封装成每袋10g的中药冲剂。
实施例2
本实施例提供一种治疗痛风的中药组合物。
原料组成(重量g)：黄柏40g、苍术40g、萆薢40g、土茯苓40g、车前草60g、秦皮40g、威灵仙40g、豨签草40g、红花20g、甘草15g、狗脊20g、车前子20g、广金钱草20g、黄芪20g、石膏40g。
制备方法包括以下步骤：
S1.将黄柏、甘草、黄芪、车前草、土茯苓、车前子、豨签草除去杂质，置沸水中煮20分钟，取出，闷透，切薄片，干燥，备用；
S2.将苍术、萆薢、秦皮洗净，切片，用米泔水喷洒湿润，置锅内用文火炒至微黄色，凉透，备用；所述苍术、萆薢、秦皮的总质量和米泔水的质量比为100:12；
S3.取石膏入锅内炒热，备用；
S4.将红花、广金钱草拣净杂质，除去茎叶、蒂头，晒干，备用；
S5.将狗脊、威灵仙粉碎，研细后备用；
S6.将步骤S1、S2、S4、S5制得的各原料药混合，粉碎后，研细，均匀拌入步骤S3制得的粉末，过200目筛，得到中药粉，加辅料蔗糖和糊精混合均匀制成颗粒，所述中药粉、蔗糖和糊精的质量比为30：12：10，干燥、整粒后，封装成每袋10g的中药冲剂。
实施例3
本实施例提供一种治疗痛风的中药组合物。
原料组成(重量g)：黄柏30g、苍术30g、萆薢30g、土茯苓30g、车前草50g、秦皮30g、威灵仙30g、豨签草30g、红花15g、甘草10g、狗脊15g、车前子15g、广金钱草15g、黄芪15g、石膏30g。
制备方法包括以下步骤：
S1.将黄柏、甘草、黄芪、车前草、土茯苓、车前子、豨签草除去杂质，置沸水中煮15min，取出，闷透，切薄片，干燥，备用；
S2.将苍术、萆薢、秦皮洗净，切片，用米泔水喷洒湿润，置锅内用文火炒至微黄色，凉透，备用；所述苍术、萆薢、秦皮的总质量和米泔水的质量比为100:11；
S3.取石膏入锅内炒热，备用；
S4.将红花、广金钱草拣净杂质，除去茎叶、蒂头，晒干，备用；
S5.将狗脊、威灵仙粉碎，研细后备用；
S6.将步骤S1、S2、S4、S5制得的各原料药混合，粉碎后，研细，均匀拌入步骤S3制得的粉末，过200目筛，得到中药粉，加辅料蔗糖和糊精混合均匀制成颗粒，所述中药粉、蔗糖和糊精的质量比为30：9：7，干燥、整粒后，封装成每袋10g的中药冲剂。
测试例1
病例来源：根据纳入标准及排除标准，选取广东省水电医院痛风科及健康体检中心门诊就诊的高尿酸血症患者200例。按照完全数字随机的方法，分为对照组50例及实施例1-3干预组，每组50例。
纳入标准：①符合无症状高尿酸血症的诊断标准:空腹状态下男性血尿酸>420μmol/L，绝经前女性>360μmol/L，且未出现痛风性关节炎的发作。
排除标准：①合并有恶性肿瘤或严重心、肝、肾疾病者；②有认知障碍不能完成和(或)无法配合者；③伴有肢体活动障碍；④妊娠或者哺乳期。
剔除和脱落标准：①符合纳入标准而未按规定进行治疗为剔除病例；②受试者依从性差，发生严重不良反应、并发症或特殊生理变化，不宜再接受试验等为脱落病例。
研究方法
对照组：对照组予常规教育。嘱患者多饮水，保证每天2000ml，低嘌呤饮食，定期复查血尿酸、血肌酐、血脂、血糖指标。
干预组：除了进行如对照组一样常规教育外，另每日服用制得的中药冲剂，每次15g，每日2次，冲泡方法为加入15倍质量开水，搅拌15min，不服用任何降尿酸药物，连续服用15天。
疗效观察：通过采用问卷调查方式，评估健康管理干预前与干预6个月后患者生活习惯、生活方式改善情况，健康知识知晓情况，干预前后检测对照组及干预组血尿酸、血糖血脂和体重指数前后变化情况，并进行统计学分析。
疼痛改善情况结果见表1。
表1
注释：*为与对照组相比，P<0.05。
由上表可知，本发明实施例1-3制得的治疗痛风的中药组合物能明显改善痛风痛感。
血尿酸前后变化情况见表2。
表2
注释：*为与对照组治疗后相比，P<0.05。
由上表可知，本发明实施例1-3制得的治疗痛风的中药组合物能明显降低血尿酸的含量。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (10)
1.一种治疗痛风的中药组合物，其特征在于，包括以下原料：黄柏、苍术、萆薢、土茯苓、车前草、秦皮、威灵仙、豨签草、红花、甘草、狗脊、车前子、广金钱草、黄芪和石膏。
2.根据权利要求1所述治疗痛风的中药组合物，其特征在于，由以下原料按重量g制备而成：黄柏20-40g、苍术20-40g、萆薢20-40g、土茯苓20-40g、车前草40-60g、秦皮20-40g、威灵仙20-40g、豨签草20-40g、红花10-20g、甘草5-15g、狗脊10-20g、车前子10-20g、广金钱草10-20g、黄芪10-20g、石膏20-40g。
3.根据权利要求1所述治疗痛风的中药组合物，其特征在于，由以下原料按重量g制备而成：黄柏30g、苍术30g、萆薢30g、土茯苓30g、车前草50g、秦皮30g、威灵仙30g、豨签草30g、红花15g、甘草10g、狗脊15g、车前子15g、广金钱草15g、黄芪15g、石膏30g。
4.一种如权利要求1-3任一项所述治疗痛风的中药组合物的制备方法，其特征在于，包括以下步骤：
S1.将黄柏、甘草、黄芪、车前草、土茯苓、车前子、豨签草除去杂质，置沸水中煮10-20分钟，取出，闷透，切薄片，干燥，备用；
S2.将苍术、萆薢、秦皮洗净，切片，用米泔水喷洒湿润，置锅内用文火炒至微黄色，凉透，备用；
S3.取石膏入锅内炒热，备用；
S4.将红花、广金钱草拣净杂质，除去茎叶、蒂头，晒干，备用；
S5.将狗脊、威灵仙粉碎，研细后备用；
S6.将步骤S1、S2、S4、S5制得的各原料药混合，粉碎后，研细，均匀拌入步骤S3制得的粉末，过筛，得到中药粉，加辅料蔗糖和糊精混合均匀制成颗粒，干燥、整粒后，封装成每袋10g的中药冲剂。
5.根据权利要求4所述的制备方法，其特征在于，步骤S2中所述苍术、萆薢、秦皮的总质量和米泔水的质量比为100:10-12。
6.根据权利要求4所述的制备方法，其特征在于，步骤S6中所述中药粉、蔗糖和糊精的质量比为30：(5-12)：(5-10)。
7.根据权利要求4所述的制备方法，其特征在于，步骤S6中所述过筛的筛网目数为150-200目。
8.根据权利要求4所述的制备方法，其特征在于，所述中药冲剂的冲泡方法为加入10-20倍质量开水，搅拌10-20min，即可。
9.一种如权利要求1-3任一项所述治疗痛风的中药组合物的使用方法，其特征在于，每次10-20g，每日1-2次。
10.根据权利要求9所述的使用方法，其特征在于，5日为一个疗程。
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| CN103340936A (zh) * | 2013-07-11 | 2013-10-09 | 唐淑萍 | 治疗原发性痛风的中药 |
| CN108379379A (zh) * | 2018-03-30 | 2018-08-10 | 杭州史迪姆生物科技有限公司 | 用于痛风急性期的中药组合物 |
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| CN103340936A (zh) * | 2013-07-11 | 2013-10-09 | 唐淑萍 | 治疗原发性痛风的中药 |
| CN108379379A (zh) * | 2018-03-30 | 2018-08-10 | 杭州史迪姆生物科技有限公司 | 用于痛风急性期的中药组合物 |
Non-Patent Citations (1)
| Title |
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| 张伟杰;王志明;: "中西医结合治疗痛风的临床研究", 中国医药导报, vol. 4, no. 25, pages 91 * |
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