CN116370393A - Acne removing composition and facial mask based on pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark extracts - Google Patents

Acne removing composition and facial mask based on pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark extracts Download PDF

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CN116370393A
CN116370393A CN202310164444.8A CN202310164444A CN116370393A CN 116370393 A CN116370393 A CN 116370393A CN 202310164444 A CN202310164444 A CN 202310164444A CN 116370393 A CN116370393 A CN 116370393A
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extract
acne
removing composition
tetrahydrocurcumin
mixture
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包建军
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Mingyuan Pharmaceutical Co ltd
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Mingyuan Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention belongs to the field of new daily chemical materials, and discloses an acne-removing composition based on extracts of pseudo-ginseng root, golden chamomile, honeysuckle and eucommia bark, which comprises a first extract mixture, tetrahydrocurcumin and snail secretion filtrate; the first extract mixture contains pseudo-ginseng root extract, golden chamomile extract, honeysuckle flower extract and eucommia bark extract; the weight ratio of the first extract mixture to the tetrahydrocurcumin to the snail secretion filtrate is 5000:5-20:5-20. The invention utilizes the basic functions of relieving, resisting inflammation and removing free radicals of the first extract mixture to cooperate with tetrahydrocurcumin and snail secretion filtrate with better acne removing function, so that the first extract mixture has obvious acne removing function. Meanwhile, the invention also provides an acne-removing and repairing mask.

Description

Acne removing composition and facial mask based on pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark extracts
Technical Field
The invention relates to the field of new daily chemical materials, in particular to an acne-removing composition and a mask based on extracts of pseudo-ginseng roots, golden chamomile, honeysuckle flowers and eucommia bark.
Background
CN113679641a discloses a mask added with peony extract and a preparation method thereof. The mask raw material comprises the following components: peony extract, nicotinamide, inositol, oil-soluble vitamin E, an emulsifier, golden chamomile, honeysuckle, pseudo-ginseng root, eucommia bark, glycerin, low-molecular hyaluronic acid, an antibacterial agent and deionized water. The skin whitening and tendering mask is formed by mixing the peony fresh flower stock solution, peony seed oil, golden chamomile, inositol, low-molecular hyaluronic acid, honeysuckle, pseudo-ginseng root and other substances to form a compound, so that the skin whitening and tendering mask suitable for modern women can effectively improve the antioxidation capability of skin, and sufficient moisture is injected into the skin to prevent the moisture in the skin cuticle from evaporating, so that the loaded plant essence is easy to absorb, the facial moistening is maintained, the whitening and restoration effects are good, free radicals in the skin can be effectively removed, the accelerated aging of the facial skin is avoided, the facial wrinkles are reduced, and the skin aging resisting and delaying effects are ideal.
The description is as follows: when the mask liquid containing the peony seed oil and the sweet almond oil is matched with mask paper for use, the mask paper tightly wraps the skin, so that the skin is isolated from the outside air, moisture slowly permeates into the stratum corneum of the epidermis, the absorption of the mask liquid by the skin is promoted, the blood microcirculation of the deep layer of the skin is accelerated, the vitality of cells of each layer of the epidermis is increased, the moisture in the film is prevented from being lost quickly, the skin elasticity is increased, and the effects of tightening, lifting, wrinkle resistance, aging resistance, inflammation diminishing and toxin expelling are achieved.
The extracts of pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark are clearly described in the scheme.
CN112494408A discloses a whitening and anti-inflammatory mask liquid and a preparation method thereof, wherein the mask liquid comprises the following raw materials in parts by weight: 5-25 parts of snakegourd fruit pulp extract, 3-6 parts of snakegourd fruit seed essential oil, 1-3 parts of grape seed oil, 5-10 parts of black garlic extract, 1-2 parts of tetrahydrocurcumin, 1-4 parts of glycerol, 30-40 parts of deionized water, 15-20 parts of sodium hyaluronate, 1-3 parts of antibacterial agent, 0.05-0.1 part of poly (acryl-dimethyl-ammonium taurate), 0.5-1 part of EDTA disodium, 1-2 parts of emulsifying agent and 1-2 parts of thickening agent. Compared with the prior art, the mask liquid has no toxic or side effect and has better functions of diminishing inflammation, resisting acne, resisting oxidation, whitening and the like.
The description is as follows: tetrahydrocurcumin is a natural functional whitening raw material, has strong activity of inhibiting tyrosinase, and has better whitening effect than arbutin; can effectively inhibit the generation of free radicals and remove the generated free radicals, and has obvious antioxidation effect. In addition, the snakegourd fruit extract, the black garlic extract and the tetrahydrocurcumin have excellent inhibition effects on staphylococcus aureus, escherichia coli, streptococcus viridis and the like, and particularly have obvious inhibition effects on propionibacterium acnes.
It is known from the prior art that the anti-acne function of tetrahydrocurcumin is demonstrated.
The technical problem to be solved by the scheme is as follows: how to improve the acne-removing effect of the composition.
Disclosure of Invention
The invention aims to provide an acne-removing composition based on extracts of pseudo-ginseng roots, golden chamomile, honeysuckle flowers and eucommia bark, and the first extract mixture has the basic functions of relieving, resisting inflammation and removing free radicals, and can have obvious acne-removing function by cooperating with the tetrahydrocurcumin and snail secretion filtrate with better acne-removing function.
Meanwhile, the invention also provides an acne-removing and repairing mask.
In order to achieve the above purpose, the present invention provides the following technical solutions:
an acne-removing composition based on extracts of pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark is characterized by comprising a first extract mixture, tetrahydrocurcumin and snail secretion filtrate;
the first extract mixture contains pseudo-ginseng root extract, golden chamomile extract, honeysuckle flower extract and eucommia bark extract;
the weight ratio of the first extract mixture to the tetrahydrocurcumin to the snail secretion filtrate is 5000:5-20:5-20.
In the acne-removing composition, the first extract mixture contains 5-20wt% of pseudo-ginseng root extract, 5-20wt% of chamomile extract, 5-20wt% of honeysuckle extract, 5-20wt% of eucommia bark extract and the balance of water and polyalcohol.
The acne-removing composition further comprises a salicylic acid preparation; the salicylic acid preparation is a product with a commodity name of AcneClear SACD 40 provided by Hangzhou Wang Biotechnology Co., ltd; the weight ratio of salicylic acid preparation to the first extract mixture is 0.5-1.5:1.
The acne-removing composition further comprises a hyaluronic acid preparation, wherein the hyaluronic acid preparation is one or more of sodium hyaluronate, sodium hyaluronate hydrolysis and sodium hyaluronate; the weight ratio of the first extract mixture to the hyaluronic acid preparation is 5000:5-20.
The acne-removing composition further comprises a yeast essence extract, wherein the yeast essence extract is a product with a trade name of yeast essence extract E100 provided by Angel Yeast Co., ltd; the weight ratio of the yeast essence extract to the first extract mixture is 0.5-1.5:1.
The acne removing composition further comprises one or more of L-arginine, purslane extract, white willow bark extract, cordate houttuynia extract, fructus forsythiae extract, sodium hyaluronate crosslinked polymer, tremella extract, kaempferia galangal root extract, peppermint extract, bighead atractylodes rhizome extract, EDTA disodium, hydroxyethyl cellulose, disodium hydrogen phosphate, sodium dihydrogen phosphate, polysorbate-60, 1, 2-pentanediol, ethylhexyl glycerol, octanoyl hydroxamic acid and phenoxyethanol.
Meanwhile, the invention also discloses an acne-removing and repairing mask, which comprises the acne-removing composition, wherein the first extract mixture in the acne-removing and repairing mask accounts for 0.2-1wt%.
The acne-removing and repairing mask further comprises:
0.3-0.5wt% of xanthan gum;
glycerol 1-3wt%;
allantoin 0.1-0.3wt%;
0.5-1.5wt% of panthenol;
3-5wt% of dipropylene glycol;
AcneClear SACD 40 0.01-0.08wt%;
0.2-0.4wt% of p-hydroxyacetophenone;
0.2-0.4wt% of 1, 2-hexanediol;
0.2-0.4wt% of butanediol;
PEG/PPG-17/6 copolymer 0.5-1.5wt%;
the balance of water.
Compared with the prior art, the invention has the beneficial effects that:
the first extract mixture has the basic functions of relieving, resisting inflammation and removing free radicals, has a certain effect on acne removal, but the acne removal performance is not obvious by singly using the first extract mixture, and can achieve very excellent acne removal effect after being compounded with a small amount of tetrahydrocurcumin and snail secretion filtrate;
the acne removing effect after the compounding can be comparable to the effect of the combination of the first extract mixture and the desmethylsuccinate and Pi Aoning.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described in the following in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Before describing the examples and comparative examples of the present invention, specifications of raw materials used in the present invention, and production places are presented, and the following table 1 is specific:
table 1 raw material information table
Figure BDA0004095442030000041
Figure BDA0004095442030000051
Figure BDA0004095442030000061
The first extracts used in the examples and comparative examples of the present invention comprise the following components:
5wt% of pseudo-ginseng root extract;
5% by weight of chamomile extract;
5wt% of honeysuckle extract;
5% by weight of eucommia bark extract;
15wt% of butanediol;
10wt% of 1, 2-hexanediol;
the balance of water.
Examples 1 to 5
An acne-removing composition comprises the following specific components in table 2:
table 2 recipe (weight ratio)
The first extract Tetrahydrocurcumin Snail secretion filtrate
Example 1 0.5 0.001 0.001
Example 2 0.5 0.0015 0.0005
Example 3 0.5 0.0005 0.0015
Example 4 0.5 0.002 0.002
Example 5 0.5 0.0005 0.0005
Example 6
The formulation of this example is substantially the same as that of example 1, except that the first extract comprises the following components:
20wt% of pseudo-ginseng root extract;
5% by weight of chamomile extract;
20wt% of honeysuckle extract;
5% by weight of eucommia bark extract;
15wt% of butanediol;
10wt% of 1, 2-hexanediol;
the balance of water.
Example 7
The formulation of this example is substantially the same as that of example 1, except that the first extract comprises the following components:
5wt% of pseudo-ginseng root extract;
20wt% of golden chamomile extract;
5wt% of honeysuckle extract;
20% by weight of eucommia bark extract;
15wt% of butanediol;
10wt% of 1, 2-hexanediol;
the balance of water.
Example 8
Substantially the same as in example 1, except that salicylic acid preparation, hyaluronic acid preparation, yeast extract, L-arginine, purslane extract, white willow bark extract, houttuynia cordata extract, fructus forsythiae extract, sodium hyaluronate cross-linked polymer, tremella extract, kaempferia galangal root extract, peppermint extract, white atractylodes rhizome extract, disodium EDTA, hydroxyethyl cellulose, disodium hydrogen phosphate, sodium dihydrogen phosphate, polysorbate-60, 1, 2-pentanediol, ethylhexyl glycerol, octanoyl hydroxamic acid, phenoxyethanol;
0.5 part of salicylic acid preparation;
0.5 part of yeast essence extract;
the hyaluronic acid preparation, the purslane extract, the white willow bark extract, the cordate houttuynia extract, the fructus forsythiae fruit extract, the sodium hyaluronate crosslinked polymer, the tremella extract, the kaempferia galangal root extract, the peppermint extract and the bighead atractylodes rhizome extract are all 0.001 part, and the balance of components are right.
Comparative examples 1 to 6
An acne-removing composition comprises the following specific components in table 3:
table 3 recipe (weight ratio)
The first extract Tetrahydrocurcumin Snail secretion filtrate Desulmin Pi Aoning
Comparative example 1 0.5 0 0.002
Comparative example 2 0.5 0.002 0
Comparative example 3 0.5 (second extract) 0.001 0.001
Comparative example 4 0.5 0 0 0.01 0.005
Comparative example 5 0.5 0 0
Comparative example 6 0.5 (butanediol) 0.001 0.001
The second extract comprises the following components:
5% by weight of purslane extract;
5wt% of white willow bark extract;
5wt% of houttuynia cordata extract;
5wt% of fructus forsythiae fruit extract;
15wt% of butanediol;
10wt% of 1, 2-hexanediol;
the balance of water.
Application formula
The mask formula is used on a non-woven fabric mask and is processed according to a conventional processing method in the field;
the mask formulation can be found in table 4 below:
table 4 recipe (weight percent unit)
Figure BDA0004095442030000101
The above mask was prepared using the acne-removing compositions of example 1 and comparative examples 1 to 6;
examples 1 and comparative examples 1 to 6 were prepared to obtain sample 1, comparative sample 2, comparative sample 3, comparative sample 4, comparative sample 5 and comparative sample 6, respectively.
Performance testing
1. Propionibacterium acnes inhibition test
The products of example 1, example 4, example 5 and comparative examples 1 to 6 were diluted with water at a concentration of 0.5%, respectively, to obtain solutions;
propionibacterium acnes at 1X 10 6 Inoculating the culture medium with the same volume as the blank control into a 96-well plate, adding the solution, and culturing for 48 hours in a constant temperature incubator at 37 ℃ under anaerobic condition. And measuring the absorbance at 600nm by using an ultraviolet spectrophotometer, and dividing the absorbance by the blank group according to the difference value of the absorbance between the blank group and the experimental group to obtain the inhibition rate.
Table 5 test results
Propionibacterium acnes inhibition rate
Example 1 84.5
Example 4 89.2
Example 5 81.8
Comparative example 1 85.2
Comparative example 2 88.4
Comparative example 3 76.1
Comparative example 4 91.3
Comparative example 5 45.3
Comparative example 6 51.4
The in vitro bacteriostasis experiment can obtain that:
the inhibition rate of tetrahydrocurcumin and snail secretion filtrate to propionibacterium acnes is important, and compared with examples 1 and 2 and 6, the tetrahydrocurcumin and snail secretion filtrate have independent antibacterial effects, and the inhibition effect to propionibacterium acnes is obvious under the condition of constant total control amount;
the pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark extract may have a more excellent antibacterial effect than the combination of other extracts;
it can be seen from a comparison of example 4 and comparative example 4 that if the amount of tetrahydrocurcumin, snail secretion filtrate is further increased in the formulation of the present invention, the antibacterial effect may be comparable to that of melezine, pi Aoning.
The antibacterial effect of comparative examples 3-5 was superior to examples 1-5 and comparative examples 1 and 2, at least demonstrating that the antibacterial properties of desipramine, pi Aoning were superior to tetrahydrocurcumin, poxosulfine.
2. Evaluation of radical scavenging Effect
Test method
(1) Treatment of control and test samples
Sample: diluting with pure water to a sample concentration of 0.5%;
positive control (vitamin E, purity > 96%): diluting with 95% ethanol to a positive control concentration of 0.5%;
negative control: pure water.
(2) Test procedure
Setting up a sample tube, a sample background tube, a DPPH tube and a solvent background tube, setting up 3 parallel tubes in each group, adding different reagent solutions into the four groups respectively, slightly and uniformly shaking, and standing for 5 minutes at room temperature. Each set of reaction solutions was transferred to a 1cm cuvette and absorbance was measured at 517 nm.
(3) Calculation formula
DPPH radical clearance (%) = (1- (T-T) 0 )/(C-C 0 ))*100%
Wherein: t is the absorbance of the sample tube, namely the absorbance of the solution after the reaction of the sample and DPPH;
T 0 -sample background absorbance;
the average value of the absorbance value of the C-DPPH tube for 3 times is that of the DPPH solution when no sample is added;
C 0 -solvent background absorbance.
(4) Data analysis
The statistical analysis software is SPSS, and the comparison among the test sample, the positive control substance and the negative control substance DPPH free radical clearance rate adopts independent sample detection.
(5) Analysis of results
Results are referred to Table 6
TABLE 6 DPPH radical scavenging Rate (in%)
Figure BDA0004095442030000121
Figure BDA0004095442030000131
3. Volunteer acne removal effect evaluation
The test refers to an evaluation method of T/TDCA 004-2021 'cosmetic acne-removing efficacy test method', and a human efficacy evaluation test is carried out on the anti-wrinkle efficacy of a sample, wherein 70 subjects participate in the test, wherein 0 person is withdrawn, and 70 effective subjects exist.
After 70 subjects continuously used the samples for 14 days, the difference between the skin a value and the basal value (before 14 days) of the sample area was used as an acne removal effect evaluation index.
1. Subject information
Sex of the subject: 45 females and 25 males.
Age of the subject: 25-60 years old.
Skin conditions of the subject: the facial skin has a certain number of acnes and acnes, and cannot be nodules or cysts which are difficult to improve by clinical preparations.
The test was included in 80 healthy subjects aged 25-60 years and the final effective data was 80.
2. Sample application method
The application part is as follows: a face.
Frequency of use: can be used in the morning and evening.
Use cycle: for 2 weeks.
The using method comprises the following steps: applying the facial mask to the face for 20min each time;
sample information: sample 1, comparative sample 2, comparative sample 3, comparative sample 4, comparative sample 5, comparative sample 6;
3. test method
Skin color probes are used for testing skin red values;
before the test: subjects visited, visual assessment by trained professional testers, subjects meeting the selection condition into groups;
clean face and wait: the subjects cleaned their faces with the facial cleansing product and wiped dry with dry facial tissues and sat for 20min in a laboratory at a temperature of 21±1 ℃,50±5%rh;
skin basal value data acquisition of test subjects: a laboratory technician operates a skin color probe (colorimeter cl 400) instrument and a facial image analyzer (VISIA 7) to measure relevant basic value indexes of a tested part of a subject;
a laboratory technician guides a subject to use the product according to the product use requirement and the use position, and provides written test notes and product use instructions;
the subject takes the sample and leaves the laboratory.
After testing: subjects return visit, clean face and wait: cleaning face with a facial cleanser, wiping skin with dry facial tissue, and sitting still in a laboratory at 21+ -1deg.C and 50+ -5% RH for 20min;
test subject skin D28 data acquisition: a laboratory technician operates a skin color probe (colorimeter cl 400) instrument and a facial image analyzer (VISIA 7) to measure relevant indexes of a tested part of a subject;
the staff checks the usage record of the subject and weighs the product;
and ending the test flow.
4. Test results
Before the test, the average value of the a values of the skin of the 8 groups of subjects is in the range of 12.7+/-0.3, which indicates that the skin conditions of the 8 groups of subjects are uniformly distributed, and the results of the 8 groups of subjects have referenceability;
calculation formula
Skin a%reduction = (Y-X)%100%/Y;
x is the average of the skin a values of each group of subjects after 14 days;
y is the average of the skin a values of each group of subjects 14 days ago
The test results were as follows:
Figure BDA0004095442030000141
Figure BDA0004095442030000151
analysis of results:
1. the propionibacterium acnes inhibition test shows that the tetrahydrocurcumin, the snail secretion filtrate and the first extract have synergistic antibacterial effect; the tetrahydrocurcumin and the first extract have synergistic antibacterial effect; the snail secretion filtrate and the first extract have synergistic antibacterial effect; the synergistic antibacterial effect among tetrahydrocurcumin, snail secretion filtrate and the first extract can be matched with that of desipramine and Pi Aoning.
2. From the experiment of the free radical scavenging effect, the combination of tetrahydrocurcumin, snail secretion filtrate and the first extract can improve the free radical scavenging effect with the maximum possibility;
3. from the view point of acne removal effect, the combination of tetrahydrocurcumin, snail secretion filtrate and the first extract can remove acne most effectively.
In terms of the principle, the main component saponin in the pseudo-ginseng extract not only has strong capability of scavenging free radicals, but also can regulate the immunity of skin, and has good antioxidation effect;
the extract of chamomile can play roles in soothing the skin, repairing the sensitive skin, reducing red blood streaks, adjusting uneven skin color and the like; in addition, the chamomile skin care product is suitable for sensitive, dry and greasy skin with water deficiency, and can play a role in well soothing and repairing sensitive skin;
honeysuckle flower extracts have broad resistance to a range of toxic bacteria and viruses; because of its cold nature, it has good anti-inflammatory effect. Has anti-inflammatory and repercussive effects on carbuncle, sore, etc., and can improve rehabilitation speed;
the eucommia bark extract Du has certain curative effects on healing wounds, skin health, moistening and the like, and has the effects of resisting bacteria, diminishing inflammation, resisting oxidation and the like;
the snail secretion filtrate can effectively avoid skin aging, contains natural collagen, high molecular weight protein, low molecular weight protein, mucopolysaccharide and the like, has the functions of strengthening connective tissues, promoting elastin generation, preventing wrinkles from appearing in advance, effectively repairing wounds, promoting cell migration, stimulating cell regeneration, accelerating wound healing, reducing wrinkles and scars, removing skin color darkness, fading color spots, resisting damage of free radicals to skin, killing certain bacteria on the skin, and eliminating acne and acne marks, wherein snail mucus is also a natural antibiotic.
Tetrahydrocurcumin is a natural functional whitening raw material, has strong activity of inhibiting tyrosinase, and has better whitening effect than arbutin; can effectively inhibit the generation of free radicals and remove the generated free radicals, and has obvious antioxidation effect. In addition, the snakegourd fruit extract, the black garlic extract and the tetrahydrocurcumin have excellent inhibition effects on staphylococcus aureus, escherichia coli, streptococcus viridis and the like, and particularly have obvious inhibition effects on propionibacterium acnes.
The first composition and the tetrahydrocurcumin have synergistic sterilization and anti-inflammatory effects, and meanwhile, the golden chamomile, eucommia bark and snail secretion filtrate has synergistic nourishing, water environment maintaining, allergy relieving and other effects in skin rehabilitation and restoration;
the combination of the first extract, tetrahydrocurcumin and snail secretion filtrate is obtained by screening a plurality of extracts, and the combination is used as 0.5% dose in a mask, so that a relatively obvious acne removing effect can be achieved.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims (8)

1. An acne-removing composition based on extracts of pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark is characterized by comprising a first extract mixture, tetrahydrocurcumin and snail secretion filtrate;
the first extract mixture contains pseudo-ginseng root extract, golden chamomile extract, honeysuckle flower extract and eucommia bark extract;
the weight ratio of the first extract mixture to the tetrahydrocurcumin to the snail secretion filtrate is 5000:5-20:5-20.
2. The acne-removing composition according to claim 1, wherein the first extract mixture contains 5-20wt% of notoginseng root extract, 5-20wt% of golden chamomile extract, 5-20wt% of honeysuckle extract, 5-20wt% of eucommia bark extract, and the balance water and polyhydric alcohol.
3. The acne-removing composition of claim 1, further comprising a salicylic acid formulation; the salicylic acid preparation is a product with a commodity name of AcneClear SACD 40 provided by Hangzhou Wang Biotechnology Co., ltd; the weight ratio of salicylic acid preparation to the first extract mixture is 0.5-1.5:1.
4. The acne-removing composition of claim 1, further comprising a hyaluronic acid preparation, wherein the hyaluronic acid preparation is one or more of sodium hyaluronate, sodium hyaluronate hydrolysate, sodium hyaluronate; the weight ratio of the first extract mixture to the hyaluronic acid preparation is 5000:5-20.
5. The acne-removing composition of claim 1, further comprising a yeast extract, said yeast extract being a product offered by Angel yeast Co., ltd under the trade name of yeast extract E100; the weight ratio of the yeast essence extract to the first extract mixture is 0.5-1.5:1.
6. The acne-removing composition of claim 1, further comprising one or more of L-arginine, purslane extract, white willow bark extract, houttuynia cordata extract, forsythia fruit extract, sodium hyaluronate cross-linked polymer, tremella extract, kaempferia galangal root extract, peppermint extract, atractylodes macrocephala rhizome extract, disodium EDTA, hydroxyethylcellulose, disodium hydrogen phosphate, sodium dihydrogen phosphate, polysorbate-60, 1, 2-pentanediol, ethylhexyl glycerol, octanoyl hydroxamic acid, phenoxyethanol.
7. An acne-removing and repairing mask, which is characterized by comprising the acne-removing composition according to any one of claims 1-6, wherein the proportion of the first extract mixture in the acne-removing and repairing mask is 0.2-1wt%.
8. The acne-removing and repairing mask of claim 7, further comprising:
0.3-0.5wt% of xanthan gum;
glycerol 1-3wt%;
allantoin 0.1-0.3wt%;
0.5-1.5wt% of panthenol;
3-5wt% of dipropylene glycol;
AcneClear SACD 40.01-0.08 wt%; 0.2-0.4wt% of p-hydroxyacetophenone;
0.2-0.4wt% of 1, 2-hexanediol;
0.2-0.4wt% of butanediol;
PEG/PPG-17/6 copolymer 0.5-1.5wt%; the balance of water.
CN202310164444.8A 2023-02-25 2023-02-25 Acne removing composition and facial mask based on pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark extracts Pending CN116370393A (en)

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CN202310164444.8A CN116370393A (en) 2023-02-25 2023-02-25 Acne removing composition and facial mask based on pseudo-ginseng root, golden chamomile, honeysuckle flower and eucommia bark extracts

Publications (1)

Publication Number Publication Date
CN116370393A true CN116370393A (en) 2023-07-04

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