CN1162399C - 氨基酸碘络合物 - Google Patents
氨基酸碘络合物 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
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Abstract
一种用于制备饲料和食品添加剂以及用于制备消毒剂、杀菌剂和药物的氨基酸碘络合物，其配位中心是碘分子，络合剂是氨基酸；由于氨基酸是营养剂，它的引入既增加了络合物的营养功能，又更有利于保护环境，并具有好的稳定性，提高了碘对细菌和病毒的消杀能力。
Description
本发明涉及化学领域，特别是用于制备饲料和食品添加剂，以及用于制备消毒剂、杀菌剂和药物的氨基酸碘络合物。
碘是必需的营养素之一，碘酊作为消毒杀菌剂已有长久的历史。碘是治疗甲状腺肿的特效药物。由于碘分子易于升华，不稳定是其最大的缺点。为了制备稳定性碘，德国专利DE-2941387和DE-3060935提供了聚乙烯吡咯烷酮碘(简称PVP-碘)，是一种络合物，其中PVP是络合剂，PVP-碘的稳定性比较好，但络合剂PVP并不是动物体所需要的。用季胺盐制成的络合碘也存在同样的问题。
本发明的目的在于针对现有技术的不足，提供一种能使碘分子稳定，络合剂又可作为营养剂的氨基酸碘络合物。
依据络合原理，络合剂的选择是关键。碘是非金属，同时又具金属的特性。氨基酸可作络合剂，又是营养剂，其络合能力适中，有利于通过生物的新陈代谢提高消杀能力。因此使氨基酸与碘发生络合，就可形成稳定的活性氨基酸碘络合物。
本发明氨基酸碘络合物，其配位中心是碘分子，络合剂是氨基酸，其化学结构式为：
其中R1、R2代表氨基酸中的侧链基，m，n分别代表组成络合物的氨基酸分子的数目。
R1、R2可以相同也可以不同，R1＝R2时络合剂由同种氨基酸构成，R1、R2不同时络合剂由不同氨基酸构成。当R1或R2＝H时上式中的氨基酸为甘氨酸(Gly)，当R1或R2＝CH3时上式的氨基酸为丙氨酸(Ala)，其余类推。
作为络合剂的氨基酸，可以是同种或不同种的简单氨基酸，例如丙氨酸(Ala)、精氨酸(Arg)、天冬酰胺(Asn)、天冬氨酸(Asp)、胱氨酸(Cys)、谷氨酰胺(Gln)、谷氨酸(Glu)、甘氨酸(Gly)、组氨酸(His)、异亮氨酸(Ile)、亮氨酸(Leu)、赖氨酸(Lys)、甲硫氨酸(蛋氨酸，Met)、苯丙氨酸(Phe)、脯氨酸(Pro)、丝氨酸(Ser)、苏氨酸(Thr)、色氨酸(Trp)、酪氨酸(Tyr)、缬氨酸(Val)。
所述络合剂除了可以是氨基酸外，还可以是上述简单氨基酸的衍生物，例如乙酰蛋氨酸、蛋氨酸羟基类似物；或是简单氨基酸形成的简单肽，例如赖氨酸天冬氨酸盐、赖氨酸谷氨酸盐；还可以是动物蛋白和/或植物蛋白经水解所产生的复合氨基酸等。
根据氨基酸不同和使用要求的不同，氨基酸对碘分子的克分子比不同，一般在1-20比较适宜，最佳范围是1-5。
本发明与现有技术相比具有如下优点：
1、由于氨基酸是营养剂，它的引入既增加了络合物的营养功能，又更有利于保护环境；
2、由于本发明的氨基酸碘络合物是一种以碘分子为配位中心的络合物，因此具有较好的稳定性。
3、氨基酸同碘有协合作用，因而提高了碘对细菌和病毒的消杀能力，灭菌效果提高了数倍。
4、使用安全性显著超过了PVP-碘。
5、氨基酸碘络合物具有良好的溶解性能，它的制剂易于溶解，降低了成本和毒性。
6、提升和扩大了碘的用途。在养殖业、种植业、医疗卫生、营养药物等方面都将广为应用。它将成为病毒和细菌的强力杀手。护卫人类的健康和绿色产业。
本发明可以按照下列实施例进行实施。
实施例一 甘氨酸碘的制备。
在带有加热和磁性搅拌的250ml圆底烧瓶中(下同)，加入水100ml，搅拌升温至55℃，加入甘氨酸20g，待溶解完全后，逐步加入碘25g，搅拌150min，过滤，滤液浓缩干燥，所得产物经化验，含碘22.1g，含甘氨酸19.0g。
实施例二 赖氨酸碘的制备。
设备同实施例一。向圆底烧瓶中，加入水85ml，搅拌升温至75℃，加入赖氨酸盐酸盐24g，待溶解完全后，逐步加入碘19g，搅拌130min，过滤，滤液浓缩干燥，所得产物经化验，含碘16.1g，含赖氨酸盐酸盐23.5g。
实施例三 精氨酸碘的制备
设备同实施例一。向圆底烧瓶中，加入水150ml，搅拌升温至80℃，加入精氨酸26g，待溶解完全后，逐步加入碘4.4g，搅拌110min，冷却，静置180min，过滤，分离，滤液浓缩干燥，所得产物经化验，含碘2.3g，含精氨酸23.7g。
实施例四 天冬酰胺碘的制备。
设备同实施例一。向圆底烧瓶中，加入水105ml，搅拌升温至65℃，加入天冬酰胺6g，逐步加入碘1.0g，搅拌110min，过滤，滤液浓缩干燥，所得产物经化验，含碘0.94g，含天冬酰胺2.40g。
实施例五 蛋氨酸碘的制备。
设备同实施例一。向圆底烧瓶中，加入乙醇120ml，搅拌升温至55℃，加入碘3.5g，待溶解完全后，逐步加入蛋氨酸15g，搅拌180min，过滤，滤液浓缩干燥，所得产物经化验，含碘3.01g，含蛋氨酸7.94g。
实施例六 酪氨酸碘的制备。
设备同实施例一。向圆底烧瓶中，加入水200ml，搅拌升温至70℃，加入酪氨酸500mg，搅拌下逐步加入碘1.0g，搅拌200min，静置，过滤，滤液浓缩干燥，所得产物经化验，含碘0.10g，含酪氨酸0.48g。
实施例七 甘氨酸赖氨酸碘的制备。
设备同实施例一。向圆底烧瓶中，加入水150ml，搅拌升温至68℃，加入甘氨酸3.4g，赖氨酸盐酸盐8.0g，待溶解完全后，逐步加入碘7.2g，搅拌128min，过滤，滤液浓缩干燥，所得产物甘氨酸赖氨酸碘，经化验，含碘5.5g，含甘氨酸3.3g，赖氨酸盐酸盐7.8g。
实施例八 复合氨基酸碘的制备。
设备同实施例一。明胶经盐酸水解获得复合氨基酸，氮含量5.87％。向圆底烧瓶中，加入水解氨基酸85g，搅拌升温至72℃，加入碘6.6g，搅拌192min，过滤，滤液浓缩干燥，所得产物经化验，含碘4.5g，含氮5.7％。
实施例九 赖氨酸谷氨酸碘的制备。
设备同实施例一。向圆底烧瓶中，加入水110ml，搅拌升温至65℃，加入赖氨酸谷氨酸盐25g，待溶解完全后，逐步加入碘9.7g，搅拌220min，过滤，滤液浓缩干燥，所得产物经化验，含碘8.5g，含赖氨酸谷氨酸盐23.2g。
其它简单氨基酸或复合氨基酸的碘络合物，均可用类似的方法制备。
本发明的应用。
应用本发明制成含活性碘5％的甘氨酸碘络合物浓缩液。在1.6公顷的虾塘中，水深1.1M，放养白对虾60万尾。夜晚观察，发现水体发光，查明是发光弧菌。次日晚用含碘0.01ppm的本发明，进行水体消毒。40分钟后，发光现象已经消失。氨基酸碘对发光弧菌有很好的杀灭作用。
应用本发明制成含活性碘4％的复合氨基酸碘络合物浓缩液。在1.1公顷的虾塘中，育有斑节对虾42万尾，体长已达8.5cm。100尾虾中有一尾出现白斑。经查是杆状病毒病。按每公斤饲料拌和4g与10g鱼油混合后的本发明，连续投喂4天，白斑病获得了控制。此后每天投喂一次拌饵，斑节对虾长至12cm，成活率80％。
本发明对西红柿的早晚疫病防治，餐具、医疗器械的消毒等均有良好的效果。本发明开拓了人类健康事业的新途径。
Claims (5)
1、一种氨基酸碘络合物，其特征在于其配位中心是碘分子，络合剂是氨基酸，具有如下化学结构：
其中R1、R2代表氨基酸中的侧链基，m，n分别代表组成络合物的氨基酸分子的数目，R1、R2可以相同也可以不同。
2、根据权利要求1所述的氨基酸碘络合物，其特征在于作为络合剂的氨基酸，可以是同种或不同种的简单氨基酸。
3、根据权利要求2所述的氨基酸碘络合物，其特征在于简单氨基酸是丙氨酸、精氨酸、天冬酰胺、天冬氨酸、胱氨酸、谷氨酰胺、谷氨酸、甘氨酸、组氨酸、异亮氨酸、亮氨酸、赖氨酸、甲硫氨酸、苯丙氨酸、脯氨酸、丝氨酸、苏氨酸、色氨酸、酪氨酸、缬氨酸。
4、根据权利要求1所述的氨基酸碘络合物，其特征在于氨基酸对碘分子的克分子比是1-20。
5、根据权利要求4所述的氨基酸碘络合物，其特征在于氨基酸对碘分子的克分子比是1-5。
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011146664A CN1162399C (zh) | 2001-04-28 | 2001-04-28 | 氨基酸碘络合物 |
| CNB018116701A CN1207271C (zh) | 2001-04-28 | 2001-10-19 | 氨基酸碘络合物 |
| PCT/CN2001/001490 WO2002088068A1 (fr) | 2001-04-28 | 2001-10-19 | Complexe d'acide amine-iodine |
| US10/312,521 US7195772B2 (en) | 2001-04-28 | 2001-10-19 | Amino-acid iodine complex |
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| CNB011146664A CN1162399C (zh) | 2001-04-28 | 2001-04-28 | 氨基酸碘络合物 |
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| CN1162399C true CN1162399C (zh) | 2004-08-18 |
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| US (1) | US7195772B2 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB9920351D0 (en) * | 1999-08-28 | 1999-11-03 | Strachen John S | Sparse constructive node stimulation of cell surface molecular resonance in vivo |
| CN1480134A (zh) * | 2003-07-18 | 2004-03-10 | 曾雄飞 | 氨基酸碘组合物及其制备方法和应用 |
| CN101967203B (zh) * | 2010-09-21 | 2012-05-30 | 农业部规划设计研究院 | 寡聚酸碘及其制备方法与应用 |
| ES2476240T3 (es) * | 2010-12-30 | 2018-03-06 | Aktsionernoye Obshchestvo "Nauchnyi Tsentr Protivoinfektsionnyh Preparatov" | Agente antibacteriano para el tratamiento de enfermedades infecciosas de origen bacteriano |
| US9149057B2 (en) * | 2011-03-01 | 2015-10-06 | Zinpro Corporation | Enhanced bioavailable iodine molecules |
| CN102715189A (zh) * | 2011-03-30 | 2012-10-10 | 天津博莱恩科技发展有限公司 | 一种含碘的动物养殖室环境杀菌消毒剂 |
| CN105213431A (zh) * | 2015-11-07 | 2016-01-06 | 昆明赛诺制药有限公司 | 一种康复新碘络合物的制备方法 |
| CN107098314B (zh) | 2017-05-27 | 2019-03-19 | 农业部规划设计研究院 | 一种原子态流体碘及其衍生的纳米碘及制备方法与用途 |
| CN108143744A (zh) * | 2017-11-17 | 2018-06-12 | 浙江师范大学 | 一种用于两栖类动物人工冬眠的抗低温应激保护剂 |
| CN108719360A (zh) * | 2018-07-23 | 2018-11-02 | 安徽华星化工有限公司 | 一种杀螟丹和阿维菌素复配农药 |
| CN109718247A (zh) * | 2019-01-23 | 2019-05-07 | 山东菏泽三仪生物工程有限公司 | 一种蛋氨酸碘溶液及其配置方法 |
| JPWO2021215325A1 (zh) * | 2020-04-23 | 2021-10-28 | ||
| CN111825776A (zh) * | 2020-06-10 | 2020-10-27 | 青岛海大生物集团有限公司 | 一种卤化海藻多糖的制备工艺及应用 |
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| US2517651A (en) * | 1944-10-16 | 1950-08-08 | Burnham Soluble Iodine Company | Treatment of waters for human consumption and iodine-diglycine hydriodide composition useful in such treatment |
| JPH10203916A (ja) * | 1997-01-20 | 1998-08-04 | Mitsui Chem Inc | 固形ヨードホール組成物 |
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- 2001-10-19 WO PCT/CN2001/001490 patent/WO2002088068A1/zh active Application Filing
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| CN1318539A (zh) | 2001-10-24 |
| CN1438990A (zh) | 2003-08-27 |
| US7195772B2 (en) | 2007-03-27 |
| WO2002088068A1 (fr) | 2002-11-07 |
| CN1207271C (zh) | 2005-06-22 |
| US20030171598A1 (en) | 2003-09-11 |
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