CN116236591B - 用于将核酸递送至耳蜗和前庭细胞的材料和方法 - Google Patents

用于将核酸递送至耳蜗和前庭细胞的材料和方法

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Publication number
CN116236591B
CN116236591B CN202211693839.9A CN202211693839A CN116236591B CN 116236591 B CN116236591 B CN 116236591B CN 202211693839 A CN202211693839 A CN 202211693839A CN 116236591 B CN116236591 B CN 116236591B
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promoter
mice
cells
aav
harmonin
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Chinese (zh)
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CN116236591A (zh
Inventor
K.斯坦科维奇
L.H.范登伯格
J.霍尔特
G.加莱奥克
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Boston Childrens Hospital
University of California San Diego UCSD
Massachusetts Eye and Ear
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Boston Childrens Hospital
Massachusetts Eye and Ear Infirmary
University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0046—Ear
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202211693839.9A 2015-12-11 2016-12-12 用于将核酸递送至耳蜗和前庭细胞的材料和方法 Active CN116236591B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562266462P 2015-12-11 2015-12-11
US201562266477P 2015-12-11 2015-12-11
US62/266,477 2015-12-11
US62/266,462 2015-12-11
CN201680079432.3A CN109310745B (zh) 2015-12-11 2016-12-12 用于将核酸递送至耳蜗和前庭细胞的材料和方法
PCT/US2016/066225 WO2017100791A1 (en) 2015-12-11 2016-12-12 Materials and methods for delivering nucleic acids to cochlear and vestibular cells

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CN116236591B true CN116236591B (zh) 2026-02-27

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CN202211693839.9A Active CN116236591B (zh) 2015-12-11 2016-12-12 用于将核酸递送至耳蜗和前庭细胞的材料和方法

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US (2) US11167042B2 (https=)
EP (2) EP3386537B1 (https=)
JP (3) JP6990182B2 (https=)
KR (1) KR102794870B1 (https=)
CN (2) CN109310745B (https=)
AU (1) AU2016366846B2 (https=)
CA (1) CA3007476A1 (https=)
ES (1) ES2903000T3 (https=)
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