CN116236550A - Light traditional Chinese medicine formula preparation for treating novel coronavirus infection and preparation method thereof - Google Patents

Light traditional Chinese medicine formula preparation for treating novel coronavirus infection and preparation method thereof Download PDF

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Publication number
CN116236550A
CN116236550A CN202310070991.XA CN202310070991A CN116236550A CN 116236550 A CN116236550 A CN 116236550A CN 202310070991 A CN202310070991 A CN 202310070991A CN 116236550 A CN116236550 A CN 116236550A
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coronavirus infection
light
chinese medicine
traditional chinese
novel coronavirus
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曾钟德
曾宪忠
田琦
张梦
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/41Crassulaceae (Stonecrop family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A light traditional Chinese medicine formula preparation for treating novel coronavirus infection and a preparation method thereof are provided, wherein the raw materials and the weight ratio are respectively as follows: 2 parts of night hansu, kylin grass respectively, 1 part of Chinese fevervine herb, tartary buckwheat, rhodiola rosea, honeysuckle leaves, bergenia, and 0.75 part of Cordyceps militaris respectively. Pulverizing to above 120 mesh in pulverizer, and sieving with seventh sieve; packaging 6g of the powder into polyethylene plastic bags for sealing. The invention has positive significance for developing traditional Chinese medicine and enriching traditional Chinese medicine, can be widely used for treating the symptoms of light and common cold wind-cold dampness and dryness caused by the novel coronavirus infection, adds an effective, convenient, safe, economical and suitable therapeutic medicament for treating the symptoms of light and common cold wind-cold dampness and dryness caused by the novel coronavirus infection, has a lower price of , and provides a novel safe, economical, convenient and suitable way for selecting the medicament for patients suffering from the symptoms of light and common cold wind-cold dampness and dryness caused by the novel coronavirus infection.

Description

Light traditional Chinese medicine formula preparation for treating novel coronavirus infection and preparation method thereof
Technical Field
The invention relates to a light traditional Chinese medicine formula preparation for treating novel coronavirus infection and a preparation method thereof, belonging to the field of traditional Chinese medicine formula preparation.
Background
The folk medicine is a medical treasury produced in the process of long-term fight against diseases of Chinese nations, is an important component of the traditional Chinese medicine resources of China, and can be used for developing a new medicine formula for treating common diseases, frequently-occurring diseases, difficult diseases and the like. The novel coronavirus infection is a very infectious disease, and the clinical manifestations of the novel coronavirus infection are mainly aversion to cold and fever, muscle soreness, dry cough, cough with little phlegm, phlegm sticky and difficult to get, pharyngalgia, itching throat, light taste and tasteless or anorexia, anorexia and hypodynamia, listlessness, diarrhea, nasal obstruction and nasal discharge or even hypoolfaction, eye pain and itching or conjunctivitis. Wind and cold are combined to attack lung and defensive qi, so that aversion to cold, nasal obstruction, running nose or even hyposmia are caused, and heat is caused by depression to transform into heat, so that fever and pharyngalgia are caused; wind-cold with dampness, pathogenic factors attacking the muscle and skin striae, which can cause muscular soreness, damp obstruction of middle energizer, poor appetite, debilitation, listlessness, diarrhea, nausea and emesis; wind-cold with dryness, pathogenic qi affecting the lung or resolving heat and burning lung-fluid and promoting the production of internal dryness causing lung failing to disperse and descend, dry cough, cough with little phlegm, sticky phlegm and difficult pain and itching throat; wind-cold-dampness invading liver meridian, it is manifested as eye pain, itching and dry eyes or conjunctivitis. The current folk traditional Chinese medicine medicines for treating the symptoms of light and common cold wind-cold dampness and dryness of the novel coronavirus infection are relatively few, and aiming at the current situation, the novel traditional Chinese medicine medicines with different compatibility for treating the symptoms of light and common cold wind-cold dampness and dryness of the novel coronavirus infection are explored and developed, and a novel way for selecting the medicines for treating the symptoms of light and common cold wind-cold dampness and dryness of the novel coronavirus infection is provided.
Disclosure of Invention
The invention aims to solve the technical problem of providing a new way for selecting medicines for treating the symptoms of novel coronavirus infection, light weight and common cold wind-cold dampness.
In order to solve the technical problems, the invention adopts the following technical scheme:
the light traditional Chinese medicine formula preparation for treating the novel coronavirus infection comprises the following raw materials in parts by weight: 2 parts of night cold threo, 2 parts of eucheuma, 1 part of Chinese fevervine, 1 part of tartary buckwheat, 1 part of rhodiola rosea, 1 part of lonicera japonica leaves, 1 part of bergenia, 1 part of cordyceps militaris and 0.75 part of bitter apricot kernel.
The preparation method of the light traditional Chinese medicine formula preparation for treating the novel coronavirus infection comprises the following steps:
step one: 2 parts of night hansu, 2 parts of eucheuma, 1 part of Chinese fevervine, 1 part of tartary buckwheat, 1 part of rhodiola rosea, 1 part of lonicera japonica, 1 part of bergenia, 1 part of cordyceps militaris and 0.75 part of bitter apricot kernel are put into a pulverizer to be pulverized into more than 120 meshes, and the mixture powder is obtained through a seventh sieve for standby;
step two: and (3) subpackaging 6g of the mixed powder obtained in the step one per small bag, and packaging the subpackaged powder into polyethylene plastic bags for sealing.
The mixed powder is matched with corresponding pharmaceutical excipients to be prepared into capsules, tablets, pills, medicinal granules and granules, and each bag is packaged into 6 g.
The formula preparation adopting the traditional Chinese medicine has the beneficial effects that:
the invention has positive significance for developing and enriching traditional Chinese medicine, can be widely used for treating the novel coronavirus infection with light weight and common cold wind-cold dampness and dryness, adds effective, convenient, safe, economical and suitable treatment medicaments for treating the novel coronavirus infection with light weight and common cold wind-cold dampness and dryness, has the characteristics of good curative effect and is convenient to store and transport; the formula is a plurality of Chinese herbal medicines from folk, so that the use of various traditional Chinese medicine and medical institutions is less, and the medicine sources are rich and have a certain guarantee. The price is lower , and a novel safe, economical, convenient and proper way for selecting and using medicines is provided for patients with novel coronavirus infection with light and common cold and wind-cold dampness.
Detailed Description
The present invention is described in further detail below:
the light traditional Chinese medicine formula preparation for treating the novel coronavirus infection comprises the following raw materials in parts by weight: 2 parts of night cold threo, 2 parts of eucheuma, 1 part of Chinese fevervine, 1 part of tartary buckwheat, 1 part of rhodiola rosea, 1 part of lonicera japonica leaves, 1 part of bergenia, 1 part of cordyceps militaris and 0.75 part of bitter apricot kernel.
The preparation method of the light traditional Chinese medicine formula preparation for treating the novel coronavirus infection comprises the following steps:
step one: 2 parts of night hansu, 2 parts of eucheuma, 1 part of Chinese fevervine, 1 part of tartary buckwheat, 1 part of rhodiola rosea, 1 part of lonicera japonica, 1 part of bergenia, 1 part of cordyceps militaris and 0.75 part of bitter apricot kernel are put into a pulverizer to be pulverized into more than 120 meshes, and the mixture powder is obtained through a seventh sieve for standby;
step two: and (3) subpackaging 6g of the mixed powder obtained in the step one per small bag, and packaging the subpackaged powder into polyethylene plastic bags for sealing.
The mixed powder is matched with corresponding pharmaceutical excipients to be prepared into capsules, tablets, pills, medicinal granules and granules, and each bag is packaged into 6 g.
The traditional Chinese medicine formula preparation has the effects of relieving exterior syndrome, clearing interior, strengthening spleen, reducing phlegm, moistening lung and relieving cough, and is used for patients who meet the requirements of the novel coronavirus infection diagnosis and treatment scheme (tenth trial edition) of light coronavirus infection and common cold wind-cold dampness and dryness. Symptoms are aversion to cold and fever (body temperature <38.5 ℃), muscle soreness, dry cough, cough with little phlegm, difficult phlegm, sore throat, itching throat, pale mouth or anorexia, anorexia and debilitation, nasal obstruction and nasal discharge or even hyposmia, red or pale red tongue, yellow greasy or white greasy coating, and superficial and tight or rapid pulse.
The usage amount is as follows: children and adults over 12 years old take 6-9 g each time, and children of 6-12 years old take 3-6g each time, 3 times daily, and take after meals. If the patients with eye pain, itching and dry eyes or conjunctivitis take the preparation 6-9 g by soaking 10g of chrysanthemum and dendrobium respectively in water, and taking the preparation after meals. Contraindications: forbidden for pregnant women, the new coronavirus infection diagnosis and treatment scheme (tenth edition of trial) is serious, and the medicine is cautiously used for medium and serious types of women with body temperature of more than 38.5 ℃ and fever of more than 3 days, patients with target organ injury of basic diseases, patients with poor control of basic diseases and infants, and the new coronavirus infection diagnosis and treatment scheme (tenth edition of trial).
The novel coronavirus infection is light and the common cold is cold with dampness, and the symptoms of dryness are caused by the combination of wind and cold, so that the symptoms of aversion to cold, nasal obstruction, nasal discharge or even hyposmia are caused, and the symptoms of heat generation and pharyngalgia are caused by depression; wind-cold with dampness, pathogenic factors attacking the muscle and skin striae, with symptoms of muscular soreness, headache, and damp obstruction of middle energizer, with symptoms of pale mouth, inappetence, debilitation, listlessness, diarrhea, nausea, and emesis; wind-cold with dryness, pathogenic qi affecting the lung or resolving heat and burning lung-fluid and promoting the production of internal dryness causing lung failing to disperse and descend, dry cough, cough with little phlegm, sticky phlegm and difficult pain and itching throat; wind-cold-dampness invading liver meridian, it is manifested as eye pain, itching and dry eyes or conjunctivitis. The night cold and the threo are used as monarch drugs for relieving exterior syndrome, dispelling cold, dispelling wind, relieving pain, warming middle-jiao, invigorating stomach and eliminating pathogenic factors; the eucheuma (Solidago canadensis) has the functions of clearing heat, detoxicating, eliminating dampness and clearing away internal heat, and modern pharmacology proves that the eucheuma has the pharmacological actions of easing pain, relieving cough, eliminating phlegm, resisting oxidation and resisting inflammation, and is used as a ministerial drug; the Chinese fevervine herb stomach strengthening and digestion promoting, phlegm reducing and cough relieving, heat clearing and detoxicating, pain relieving and auxiliary improvement of fever, pharyngalgia, cough and expectoration, headache and body pain caused by the novel coronavirus, oral cavity weakness or anorexia, anorexia and fatigue, nausea and vomiting caused by the novel coronavirus, the Chinese fevervine herb stomach strengthening and digestion promoting, heat clearing and detoxicating, pus expelling and stasis removing and auxiliary improvement of fever, pharyngalgia, cough and expectoration, headache and body pain, oral cavity weakness or anorexia, anorexia and fatigue, fatigue and fatigue caused by the novel coronavirus, the rhodiola rosea spleen strengthening and qi benefiting, lung heat clearing and cough relieving, blood activating and stasis removing auxiliary improvement of cough and phlegm, headache and body pain, oral cavity weakness or anorexia, anorexia and fatigue, nausea and vomiting caused by the novel coronavirus, the Chinese febrile herb has the functions of resisting fatigue and anoxia, and the three medicines all have the functions of strengthening spleen to promote the growth of gold, promote the diet and ensure the nutrition of human body and achieve the effect of improving immunity; the lonicera japonica leaves have the effects of clearing heat and detoxicating to improve depression and transform heat, and the modern pharmacology proves that the lonicera japonica leaves have good antiviral effect; bergenia crassifolia has the effects of moistening lung and relieving cough and moistening dryness; cordyceps militaris has effects of invigorating lung and kidney, relieving cough and stopping bleeding, and improving immunity; bitter apricot kernel, semen Armeniacae amarum moistens and relieves cough and asthma, enters the lung meridian and leads to the meridian. The medicines are used together to relieve exterior syndrome, clear interior, invigorate spleen, resolve phlegm, moisten lung and relieve cough, and are used for patients who are in line with the symptoms of light coronavirus infection and common cold wind-cold dampness and dryness in the diagnosis and treatment scheme of coronavirus infection (tenth edition of trial). Symptoms are aversion to cold and fever (body temperature <38.5 ℃), muscle soreness, dry cough, cough with little phlegm, difficult phlegm, sore throat, itching throat, pale mouth or anorexia, anorexia and debilitation, nasal obstruction and nasal discharge or even hyposmia, red or pale red tongue, yellow greasy or white greasy coating, and superficial and tight or rapid pulse.
The traditional Chinese medicine formula preparation is used for treating the symptoms of light and common cold wind-cold dampness, the treatment course is 5-7 days, the curative effect is observed after 7-10 days, the symptoms disappear to be healed, the symptoms are improved or reduced to be effective, and the symptoms are not improved or reduced to be ineffective, wherein 56 patients suffering from light and common cold wind-cold dampness are treated, 51 cases of the cure and effective patients are treated, and the effective rate is 91%; 23 patients with common cold with dampness and dryness are treated, 22 cases with cure and effectiveness are treated, and the effective rate is 95%; the following typical cases are detailed:
age diagnosis curative effect for name, sex and age
Light recovery from new coronavirus infection in men 40
Korean 47 novel coronavirus infection is light and effective
course-Male 57 novel light recovery from coronavirus infection
Novel 64-gene coronavirus infection light cure
Male 65 novel light recovery from coronavirus infection
Light cure of new type coronavirus infection for men 39
Light and effective coronavirus infection of Zhang Xnu 87
Light cure of new type 36 coronavirus infection
Light recovery from new coronavirus infection for men 12
Light cure of novel coronavirus infection in men 65
King-male 38 novel coronavirus infection light-duty efficacy
Light recovery from new type coronavirus infection for male 55
Deng 55 novel coronavirus infection light cure
Man 39 common cold wind-cold dampness syndrome recovery
Hu 61 common cold wind-cold dryness syndrome recovery
Plum 41 new coronavirus infection is slightly ineffective.

Claims (3)

1. A light traditional Chinese medicine formula preparation for treating novel coronavirus infection is characterized in that: the raw materials and the weight ratio are respectively as follows: 2 parts of night cold threo, 2 parts of eucheuma, 1 part of Chinese fevervine, 1 part of tartary buckwheat, 1 part of rhodiola rosea, 1 part of lonicera japonica leaves, 1 part of bergenia, 1 part of cordyceps militaris and 0.75 part of bitter apricot kernel.
2. A preparation method of a novel light traditional Chinese medicine formula preparation for treating coronavirus infection is characterized by comprising the following steps: it comprises the following steps:
step one: 2 parts of night hansu, 2 parts of eucheuma, 1 part of Chinese fevervine, 1 part of tartary buckwheat, 1 part of rhodiola rosea, 1 part of lonicera japonica, 1 part of bergenia, 1 part of cordyceps militaris and 0.75 part of bitter apricot kernel are put into a pulverizer to be pulverized into more than 120 meshes, and the mixture powder is obtained through a seventh sieve for standby;
step two: and (3) subpackaging 6g of the mixed powder obtained in the step one per small bag, and packaging the subpackaged powder into polyethylene plastic bags for sealing.
3. The method of preparing a light-duty traditional Chinese medicine formulation for treating novel coronavirus infection according to claim 2, wherein: the mixed powder is matched with corresponding pharmaceutical excipients to be prepared into capsules, tablets, pills, medicinal granules and granules, and each bag is packaged into 6 g.
CN202310070991.XA 2023-02-07 2023-02-07 Light traditional Chinese medicine formula preparation for treating novel coronavirus infection and preparation method thereof Pending CN116236550A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112089805A (en) * 2020-10-20 2020-12-18 贵州理工学院 Application of herba Polygoni Multiflori radix volatile oil in preparing medicine and daily chemical product
CN113476523A (en) * 2020-02-04 2021-10-08 石家庄以岭药业股份有限公司 Application of traditional Chinese medicine composition in preparation of medicine for improving fever, cough and weakness of novel coronavirus infected pneumonia patients

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113476523A (en) * 2020-02-04 2021-10-08 石家庄以岭药业股份有限公司 Application of traditional Chinese medicine composition in preparation of medicine for improving fever, cough and weakness of novel coronavirus infected pneumonia patients
CN112089805A (en) * 2020-10-20 2020-12-18 贵州理工学院 Application of herba Polygoni Multiflori radix volatile oil in preparing medicine and daily chemical product

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
许金国;等: "加拿大一枝黄花与一枝黄花解热镇痛抗炎作用比较", 《辽宁中医药大学学报》, vol. 13, no. 2 *

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