CN116236491B - 鼠李糖在制备用于治疗或预防神经退行性疾病的药物中的用途、药物组合物及其应用 - Google Patents
鼠李糖在制备用于治疗或预防神经退行性疾病的药物中的用途、药物组合物及其应用 Download PDFInfo
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| PCT/CN2023/109720 WO2024022468A1 (fr) | 2022-07-29 | 2023-07-28 | Utilisation de rhamnose dans la préparation d'un médicament pour le traitement ou la prévention de maladies neurodégénératives, composition pharmaceutique et son utilisation |
| TW112128432A TW202404616A (zh) | 2022-07-29 | 2023-07-28 | 鼠李糖在製備用於治療或預防神經退行性疾病的藥物中的用途、藥物組合物及其應用 |
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| TW (1) | TW202404616A (fr) |
| WO (1) | WO2024022468A1 (fr) |
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| CN116236491B (zh) * | 2022-07-29 | 2024-02-20 | 上海东西智荟生物医药有限公司 | 鼠李糖在制备用于治疗或预防神经退行性疾病的药物中的用途、药物组合物及其应用 |
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| CN102091088A (zh) * | 2010-06-13 | 2011-06-15 | 华中科技大学 | 米邦塔仙人掌多糖在防治慢性神经退行性疾病中的应用 |
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|---|---|---|---|---|
| SU1734751A1 (ru) * | 1989-08-07 | 1992-05-23 | Научно-производственное объединение "Аэрозоль" | Крем дл кожи лица |
| DE112005001269T5 (de) * | 2005-04-26 | 2008-05-29 | Versitech Ltd. | Polysaccharidextrakt aus Lycium barbarum als neuroprotektives Mittel gegen ß-Amyloidpeptidneurotoxizität |
| CN116236491B (zh) * | 2022-07-29 | 2024-02-20 | 上海东西智荟生物医药有限公司 | 鼠李糖在制备用于治疗或预防神经退行性疾病的药物中的用途、药物组合物及其应用 |
-
2023
- 2023-02-15 CN CN202310124122.0A patent/CN116236491B/zh active Active
- 2023-07-28 TW TW112128432A patent/TW202404616A/zh unknown
- 2023-07-28 WO PCT/CN2023/109720 patent/WO2024022468A1/fr unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091088A (zh) * | 2010-06-13 | 2011-06-15 | 华中科技大学 | 米邦塔仙人掌多糖在防治慢性神经退行性疾病中的应用 |
Non-Patent Citations (4)
| Title |
|---|
| "Ferulic Acid in Animal Models of Alzheimer’s Disease:A Systematic Review of Preclinical Studies;Er-Jin Wang等;《Cells》;第10卷;第1-19页，尤其是第12页第2-3段 * |
| Gas Chromatography Time-Of-Flight Mass Spectrometry (GC-TOF-MS)-Based Metabolomics for Comparison of Caffeinated and Decaffeinated Coffee and Its Implications for Alzheimer’s Disease;Kai Lun Chang等;《PloS one》;第9卷(第8期);第1-7页，尤其是第5页右栏第3段 * |
| Kai Lun Chang等.Gas Chromatography Time-Of-Flight Mass Spectrometry (GC-TOF-MS)-Based Metabolomics for Comparison of Caffeinated and Decaffeinated Coffee and Its Implications for Alzheimer’s Disease.《PloS one》.2014,第9卷(第8期),第1-7页，尤其是第5页右栏第3段. * |
| Neuroprotective potential of chrysin: Mechanistic insights and therapeutic potential for neurological disorders;Awanish Mishrai等;《Molecules》;第26卷;第1-20页，尤其是第1页摘要，第11页"4.1" * |
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| Publication number | Publication date |
|---|---|
| WO2024022468A1 (fr) | 2024-02-01 |
| CN116236491A (zh) | 2023-06-09 |
| TW202404616A (zh) | 2024-02-01 |
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