CN116173150A

CN116173150A - Traditional Chinese medicine preparation for treating anxiety and preparation method thereof

Info

Publication number: CN116173150A
Application number: CN202310406229.4A
Authority: CN
Inventors: 王宏伟
Original assignee: Tianjin Wuqing Aikang Traditional Chinese Medicine Hospital
Current assignee: Tianjin Wuqing Aikang Traditional Chinese Medicine Hospital
Priority date: 2023-04-17
Filing date: 2023-04-17
Publication date: 2023-05-30

Abstract

The invention discloses a traditional Chinese medicine preparation for treating mental anxiety and a preparation method thereof, and the traditional Chinese medicine preparation for treating mental anxiety comprises the following medicine raw materials: the Chinese medicinal preparation has the beneficial effects of strengthening spleen, eliminating dampness, soothing liver, regulating qi, reducing internal heat and soothing nerves, is suitable for treating tension, anxiety, difficulty in falling asleep, insomnia, hypomnesis and fatigue weakness, has obvious curative effect and no side effect, is common and easy to obtain, can realize gradual alleviation and treatment of the symptoms by the relative compatibility of the medicinal raw materials, can be prepared into the medicament forms of ointment, powder and oral liquid according to the use requirement, has rich use modes, and can flexibly select the medicament forms according to the symptoms of users.

Description

Traditional Chinese medicine preparation for treating anxiety and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation for treating mental anxiety and a preparation method thereof.

Background

In the prior art, anxiety disorder is the most common one of mental diseases in the social population, and generalized anxiety is a clinically common type, which is characterized by chronic anxiety, easy recurrence and difficult cure. The quality of life and mental life of the patient are seriously affected, the heart lifting bladder and tension which lack definite objects and specific contents are taken as main symptoms, and the symptoms of autonomic nerve, muscle tension and restlessness of the patient are accompanied, so that the patient and family members feel pain. Generalized anxiety disorder is common, affects 3% -5% of the population in 1 year, is twice as much as men in women, is often related to stress, usually starts in children or teenagers, but can also start at any age, and due to stress, anxiety can cause insomnia in patients, and the clinical manifestations of insomnia are difficulty in falling asleep, deep sleep, easy wakefulness, early wakefulness, dreaminess, fatigue or lack of wakefulness after wakefulness, daytime sleepiness, etc. Insomnia affects human health, affects society's normal life, and long-term insomnia is more likely to cause organism immunity decline, and various diseases prevalence improves greatly, adopts western medicines to treat insomnia or tension and anxiety in prior art mostly, and western medicine sedative is only passive control or forced sleep in treating insomnia, can not improve sleep quality, and chemical sedative has great toxic and side effects to nerves and viscera, is unsuitable for long-term use.

The application number is: 201611268998.9 Chinese patent invention discloses a Chinese and western compound medicine for treating generalized anxiety disorder and a preparation method thereof, belonging to the technical field of medicines; the medicine comprises the following raw materials: radix codonopsis pilosulae, huixin grass, polygala tenuifolia, sleeping dish, snow mountain forest, lily, pseudo-ginseng, shizandra berry, perilla leaf, spina date seed, dwarf lilyturf tuber, bergamot leaf, bitter orange flower, ginger-flavored grass, etizolam, flurazepam and carbamazepine. However, the Chinese and western compound medicine for treating the generalized anxiety disorder and the preparation method thereof are prepared by matching Chinese medicine raw materials with western medicine components, wherein the western medicine components possibly generate certain interference on the medicine efficacy of the Chinese medicine raw materials, the preparation method is complex, the required process is complex, the medicine form is single, and the medicine form cannot be adjusted.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine preparation for treating mental anxiety and a preparation method thereof.

In order to achieve the above purpose, the technical scheme provided by the invention is as follows:

a traditional Chinese medicine preparation for treating mental anxiety, which comprises the following medicinal raw materials: coptis root, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, radix bupleuri, radix scutellariae and purified pinellia tuber.

The traditional Chinese medicine comprises the following raw materials in parts by weight:

and adding the components on the basis of the above:

2.5 to 3.5 portions of pilose asiabell root.

And adding the components on the basis of the above:

2.5 to 3.5 portions of raw licorice.

And adding the components on the basis of the above:

1.5 to 2.5 portions of ginger.

/>

a preparation method of a traditional Chinese medicine preparation for treating mental anxiety adopts the above raw materials for carrying out the following steps:

A. weighing: weighing Coptidis rhizoma, poria, fructus Aurantii Immaturus, radix Paeoniae alba, pericarpium Citri Tangerinae, ramulus Cinnamomi, caulis Bambusae in Taenia, bupleuri radix, scutellariae radix, purified pinellia Tuber, radix Codonopsis, glycyrrhrizae radix, and rhizoma Zingiberis recens, mixing, and pulverizing into powder;

B. soaking: soaking the medicinal powder prepared in the step A for 12 hours;

C. decocting: 2, decocting the liquid medicine prepared in the step B for 2 times;

D. clarifying: c, carrying out precipitation clarification operation on the liquid medicine prepared in the step C;

E. filtering the liquid medicine prepared in the step D to obtain a medicament in a supernatant state;

F. concentrating: concentrating the supernatant-state medicament prepared in the step E;

G. and (3) carrying: and F, filling the liquid medicine prepared in the step F to obtain the medicament in the form of oral liquid.

1) Weighing: weighing Coptidis rhizoma, poria, fructus Aurantii Immaturus, radix Paeoniae alba, pericarpium Citri Tangerinae, ramulus Cinnamomi, caulis Bambusae in Taenia, bupleuri radix, scutellariae radix, purified pinellia Tuber, radix Codonopsis, glycyrrhrizae radix, and rhizoma Zingiberis recens, mixing, and pulverizing into powder;

2) Extracting: extracting the medicinal powder prepared in the step 1), discarding medicinal residues after the extraction is completed, and extracting mixed medicinal liquid;

3) And (3) filtering: filtering the mixed liquid medicine, and storing the filtrate;

4) And (3) concentration: concentrating the filtrate obtained in the step 3) in vacuum to obtain a medicament in a fluid extract state, and refrigerating and retaining part of the medicament in the fluid extract state;

5) And (3) drying: drying the remaining fluid extract state medicament in the step 4) to obtain a dry extract state medicament, namely medicament raw powder;

6) And (5) filling: and (3) filling the raw powder of the medicament prepared in the step (5) to obtain the medicament in a capsule form.

b. soaking: soaking the medicinal powder prepared in the step a for 12 hours;

e. and (3) filtering: filtering the liquid medicine prepared in the step d to obtain a medicament in a fluid extract state;

f. concentrating: concentrating the fluid extract-state medicament prepared in the step e;

g. and (3) collecting paste: performing paste collecting operation on the medicament prepared in the step f;

h. and (3) carrying: and (c) filling the paste prepared in the step (g) to obtain the paste-shaped medicament.

The beneficial effects of the invention are as follows:

the traditional Chinese medicine composition has the effects of strengthening spleen, eliminating dampness, soothing liver, regulating qi, reducing internal heat and soothing nerves, is suitable for symptoms of tension, anxiety, difficulty in falling asleep, insomnia, hypomnesis and fatigue weakness, has obvious curative effect, has no side effect, is common and easy to obtain, can realize gradual alleviation and treatment of the symptoms through the relative compatibility of the raw materials, can be prepared into the dosage forms of paste, powder and oral liquid according to the use requirement, has rich use modes, and can flexibly select the dosage forms according to the symptoms of users.

Drawings

FIG. 1 is a flow chart of a sixth preparation method of the embodiment of the invention;

FIG. 2 is a flow chart of a seventh preparation method of the embodiment of the invention;

FIG. 3 is a flow chart of a method for preparing a eighth embodiment of the present invention.

Detailed Description

The invention is described in further detail below with reference to the accompanying drawings,

embodiment one:

wherein, the weight portion ratio of coptis chinensis, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, bupleurum, baical skullcap root and purified pinellia tuber is as follows: 2:5:5:5:5:3:3:4:3:3.

Embodiment two:

the following are added on the basis of the first embodiment:

2.5 to 3.5 portions of pilose asiabell root.

Wherein, the weight parts of coptis chinensis, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, radix bupleuri, radix scutellariae, purified pinellia tuber and radix codonopsis are as follows: 2:5:5:5:5:3:3:4:3:3:3.

Embodiment III:

and (3) adding the following components on the basis of the second embodiment:

2.5 to 3.5 portions of raw licorice.

Wherein, the weight parts of coptis chinensis, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, radix bupleuri, radix scutellariae, purified pinellia tuber, dangshen and raw liquorice are as follows: 2:5:5:5:5:3:3:4:3:3:3:3.

Embodiment four:

and (3) adding the following components on the basis of the third embodiment:

1.5 to 2.5 portions of ginger.

Wherein, the weight parts of coptis chinensis, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, radix bupleuri, radix scutellariae, purified pinellia tuber, dangshen and raw liquorice are as follows: 2:5:5:5:5:3:3:4:3:3:3:3:2.

Fifth embodiment:

a traditional Chinese medicine preparation for treating mental anxiety comprises the following medicinal raw materials in parts by weight:

example six:

B. soaking: soaking the medicinal powder prepared in the step A for 12 hours;

The taking method of the oral liquid-shaped medicament in the scheme comprises the following steps: the sixth preparation method of the invention is carried out twice a day, one bag at a time and half an hour after breakfast and supper every day, and the flow chart is shown in figure 1.

Embodiment seven:

The method for taking the capsule-shaped medicament in the scheme comprises the following steps: the seventh preparation method of the embodiment of the invention is taken twice a day, one granule at a time and half an hour after breakfast and supper every day, and the flow chart is shown in figure 2.

Example eight:

b. soaking: soaking the medicinal powder prepared in the step a for 12 hours;

The administration method of the paste form medicament in the present embodiment is as follows: the eight preparation methods of the embodiment of the invention are carried out twice a day, one bag at a time and taken half an hour after breakfast and supper every day, and the flow chart of the eight preparation methods is shown in figure 3.

Clinical typical cases:

case one: huang Mou A, 17 years old, senior high school students are faced with college entrance, the pressure is higher, the study performance is worse, family members exert pressure on the students in daily talking, so that the psychological pressure is higher, the study progress is influenced by anxiety and tension psychological factors in the school study process, the performance is further influenced, vicious circle is generated, the symptoms of difficulty in falling asleep, insomnia and fatigue weakness appear, the oral liquid medicament in the sixth embodiment is taken from 5 months in 2020 to 5 months in 2021, the tension and anxiety emotion are effectively relieved, the classroom state is improved, and the study performance is obviously improved.

Case two: zhao Mou women, 22 years old and college students, i.e. graduate, have not found the favorite employment direction, other peers have started working, serious anxiety state appears, and insomnia is caused for a long time, the mental state is absentmindedly, the life state falls into dilemma, the capsule medicament in the seventh embodiment is taken from the 3 rd 6 th year 2021 to the 12 th 9 th year 2021, the mental state is effectively adjusted, the anxiety symptom is relieved, the insomnia phenomenon disappears, and proper work is successfully found.

Case three: guo Mou A, 46A, off duty workers and enterprise judges are taken as the only income source in home, serious stress and anxiety are generated in the face of the reality of lost business, so that the sudden anxiety and irritability are caused, the suspicious mind, insomnia and dreaminess, hypomnesis and fatigue are generated in the surrounding environment, the family life is seriously influenced, the paste medicament in the eighth embodiment is taken from 9/8/2020 to 12/2021, the psychological quality is improved, the heart gradually changes to peace, the insomnia phenomenon disappears, and the family life is restored to be normal.

Case four: zhou Mou, girl, 33 years old, white collar, company management layer, busy work for a long time, private time is less, face family members to marrie, and suffer from high-intensity work, under the stress of two aspects, anxiety state appears, sleep difficulty appears, insomnia and memory decline appear, the cream formula medicament in the embodiment eight is taken from 2021 to 2022 to 10, insomnia disappears, anxiety state is relieved, and the relationship between families and work can be coordinated.

The traditional Chinese medicine preparation has the characteristics of raw materials, dialectical medication, formula principle and efficacy:

coptis root: bitter taste, cold property, entering heart, spleen, stomach, gall and large intestine channel, has the effects of clearing heat and drying dampness, purging fire and detoxifying, and is mainly used for treating damp-heat distention and fullness, vomiting and acid regurgitation, damp-heat diarrhea, high-heat unconsciousness, vexation and insomnia, blood heat and vomiting and epistaxis, carbuncle, furuncle and sore, conjunctival congestion and toothache, diabetes, eczema, damp sore and ear canal purulence, treating damp-heat blocking middle energizer, stomach and abdomen distention and fullness, nausea and vomiting, stomach heat and vomiting, hypochondrium distending pain caused by liver fire invading stomach, vomiting and acid and spleen deficiency-cold, vomiting acid water, purging fire and detoxifying, and clearing heat and purging heart channel excess fire, can be used for treating coma and dysphoria caused by heart fire excess, clearing heat and drying dampness, and purging fire and detoxifying, and treating furuncle and toxin, and can be used for treating thirst and hunger syndrome, kidney yin deficiency, heart fire and stomach excess fire and drying and toxin.

Poria cocos: sweet and bland taste, mild nature, and good effect in inducing diuresis to alleviate edema, excreting dampness, invigorating spleen, and calming heart, and can be used for treating edema, phlegm-fluid retention, spleen deficiency diarrhea, palpitation, and insomnia.

Immature bitter orange: bitter, pungent and sour taste, warm nature, and entering spleen, stomach and large intestine channels, has the effects of breaking qi and removing food retention, resolving phlegm and removing stuffiness, and is mainly used for treating gastrointestinal stagnation, damp-heat diarrhea, chest obstruction, chest stuffiness, qi stagnation chest hypochondriac pain and postpartum abdominal pain.

White peony root: bitter taste, sour, slightly cold nature, liver and spleen meridian entering, and has the effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang, and is mainly used for treating blood deficiency and sallow complexion, irregular menstruation, spontaneous sweat, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache dizziness, incoordination between liver and spleen, chest, hypochondrium and abdomen pain, limb contracture pain, liver yang hyperactivity, headache dizziness, and has the effects of suppressing sweating.

Dried orange peel: the Chinese medicinal composition has the effects of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm, and is mainly used for treating spleen and stomach qi stagnation syndrome, vomit, hiccup, damp phlegm, cold phlegm cough and chest stuffiness, xin Hangwen is general, has the effects of promoting qi circulation, relieving pain, strengthening spleen and regulating middle warmer, is bitter and warm and dry, so qi stagnation in cold dampness obstruction is most suitable, is fragrant and is good for regulating qi-flowing machine, regulating middle energizer to enable ascending and descending in order, can dry dampness and phlegm, can warm and resolve cold phlegm, and is pungent and bitter to enable lung to release and relieve cough, and is a key medicament for treating phlegm, xin Hangwen is general, enters lung and goes away chest stuffiness, and can promote qi to promote arthralgia and relieve pain.

Ramulus Cinnamomi: pungent and sweet in flavor, warm in nature, entering bladder, heart and lung meridians, has the effects of inducing sweat to relieve exterior syndrome, dispelling cold to relieve pain, activating yang to promote qi flow, warming and activating meridians, and calming the pulse to reduce qi, and is mainly used for treating common cold due to wind-cold, pain symptoms such as congealing cold and blood stasis, phlegm retention, water storage syndrome and palpitation.

Bamboo shavings: sweet in taste, slightly cold in nature, enters lung, stomach, heart and gallbladder meridians, has the effects of clearing heat and resolving phlegm, relieving restlessness and arresting vomiting, and is mainly used for treating phlegm-heat cough, phlegm-heat in gallbladder, palpitation, restlessness and insomnia, apoplexy and phlegm-disturbance, tongue strength and aphasia, stomach heat vomiting, pernicious vomiting and fetal movement.

Bupleurum root: bitter and pungent taste, slight cold nature, entering liver and gallbladder meridians, and has the effects of relieving exterior syndrome and fever, soothing liver and relieving depression, and lifting yang qi, and is mainly used for treating exterior syndrome and fever, shaoyang syndrome, liver depression and qi stagnation, qi deficiency sinking, organ prolapse and fever and malaria, and is good at dispelling evil and relieving exterior and fever and dispelling evil of shaoyang half exterior and half interior, pungent and bitter and purging, good in treating liver qi, soothing liver and relieving depression, and lifting spleen and stomach qi for clearing yang.

Radix Scutellariae Baicalensis: bitter in taste, cold in nature, entering lung, gall, spleen, stomach, large intestine and small intestine channels, has the effects of clearing heat and drying dampness, purging fire and removing toxin, stopping bleeding and preventing abortion, is mainly used for treating damp-heat, summer-heat dampness, chest distress and vomiting, damp-heat distention and fullness, jaundice and diarrhea, cough with lung heat, high fever polydipsia, blood heat and vomiting, carbuncle and sore toxin, fetal movement disorder, bitter and cold in nature, has the functions of clearing heat and drying dampness, clearing lung heat and stomach and damp-heat of large intestine, especially has the effects of clearing upper-heat and damp-heat, clearing lung heat and upper Jiao Shire, and is suitable for treating cough and phlegm thick, cough and asthma with lung heat, cough and excessive phlegm with lung heat and cough, clearing heat and stopping bleeding with the effect of cooling blood, and treating hematemesis and epistaxis due to excessive fire and other bleeding syndromes, metrorrhagia, and can be used for treating carbuncle and sore toxin due to excessive fire and heat toxin, heat and stasis pain, and has the effects of clearing heat and preventing fetal movement due to deficiency of heat and fetal movement.

Purified pinellia tuber: pungent taste, warm nature, entering spleen and stomach meridians, has the effects of drying dampness and resolving phlegm, calming adverse-rising energy and relieving vomiting, and relieving stuffiness and resolving masses, and is mainly used for treating cold phlegm, vomiting, regurgitation, cough and asthma with excessive phlegm, fullness in chest and diaphragm, phlegm syncope and headache, dizziness and insomnia, and carbuncle swelling.

Radix codonopsis pilosulae: the Chinese medicinal composition has the effects of tonifying spleen and lung, promoting fluid production and nourishing blood, and is mainly used for treating spleen and stomach weakness, lung deficiency, asthma and cough, body fluid injury and thirst, blood deficiency and weakness, contains sterols, codonopsis pilosula glycosides, codonopsis pilosula polysaccharides, codonopsis pilosula lactones, alkaloids, inorganic elements, amino acids and trace elements, and has the effects of reducing blood sugar, improving learning and memory functions, enhancing SOD activity of organisms, resisting anoxia, resisting radiation, resisting cancer, resisting inflammation and easing pain.

Raw licorice: the traditional Chinese medicine has the effects of tonifying spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, and relieving spasm and pain, and harmonizing various medicines, is mainly used for treating weakness of spleen and stomach, lassitude and debilitation, palpitation and shortness of breath, cough and excessive phlegm, epigastric and abdominal spasm and pain, carbuncle and swelling and sore toxin, and relieving drug toxicity and intensity, and contains glycyrrhizic acid, mannitol and glucose.

Ginger: pungent taste, warm nature, entering lung, spleen and stomach meridians, has the effects of relieving exterior syndrome, dispelling cold, warming middle energizer, arresting vomiting, warming lung, relieving cough and detoxifying, and is mainly used for treating wind-cold common cold: pungent and warm-dispersing and unblocking, can induce sweat to relieve exterior syndrome, dispel wind and dispel cold, but has weaker action, so it is suitable for wind-cold type common cold light syndrome; spleen-stomach cold syndrome: can warm middle energizer and dispel cold, and has effects of dispelling cold, stimulating appetite, relieving pain and arresting vomiting for patients with cold invasion of middle energizer or gastric abscess due to deficiency-cold of spleen and stomach; vomiting due to stomach cold: pungent and warm in property and free from obstruction, can warm stomach and dispel cold, harmonize middle energizer and reduce adverse flow of qi, has good vomiting stopping effect, is called as "vomiting family holy medicine", and can treat various vomiting with compatibility of symptoms; cough due to lung cold: pungent and warm in nature, dispersing pathogen, warming lung and expelling cold, resolving phlegm and relieving cough, and can be used for cough due to lung cold, no matter there is exogenous wind-cold or excessive phlegm and less phlegm.

Working principle:

the formula of the tranquillizing liquid is composed of coptis chinensis, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, radix bupleuri, radix scutellariae, purified pinellia tuber, radix codonopsis pilosulae, raw liquorice and ginger, wherein the tranquillizing liquid is prepared from cold-property coptis chinensis, white paeony root, bamboo shavings, radix bupleuri and radix scutellariae, warm immature bitter orange, dried orange peel, cassia twig, purified pinellia tuber and ginger, and the raw liquorice is supplemented with the poria cocos, radix codonopsis pilosulae and raw liquorice which are flat in property, so that the traditional Chinese medicine preparation has obvious curative effect and no side effect, can play roles of strengthening spleen and eliminating dampness, soothing liver and regulating qi, and removing fire and tranquillizing, has the advantages of flexible selection of medicament forms according to symptoms of patients, abundant use modes, simple preparation method and convenience in production.

The traditional Chinese medicine composition has the beneficial effects of strengthening spleen, eliminating dampness, soothing liver, regulating qi, reducing pathogenic fire and soothing nerves, is suitable for symptoms of tension, anxiety, difficulty in falling asleep, insomnia, hypomnesis and fatigue, has obvious curative effect and no side effect, is common and easy to obtain, can realize gradual alleviation and treatment of the symptoms by the relative compatibility of the raw materials, can be prepared into the dosage forms of ointment, powder and oral liquid according to the use requirement, has rich use modes, and can flexibly select the dosage forms according to the symptoms of users.

The foregoing describes one embodiment of the present invention in detail, but the description is only a preferred embodiment of the present invention and should not be construed as limiting the scope of the invention. All equivalent changes and modifications within the scope of the present invention are intended to be covered by the present invention.

Claims

1. The traditional Chinese medicine preparation for treating the mental anxiety is characterized by comprising the following raw materials: coptis root, poria cocos, immature bitter orange, white paeony root, dried orange peel, cassia twig, bamboo shavings, radix bupleuri, radix scutellariae and purified pinellia tuber.

2. The traditional Chinese medicine preparation for treating mental anxiety according to claim 1, which is characterized by comprising the following medicine raw materials in parts by weight:

3. the traditional Chinese medicine preparation for treating mental anxiety according to claim 2, wherein the traditional Chinese medicine preparation is added on the basis of the following steps:

2.5 to 3.5 portions of pilose asiabell root.

4. The Chinese medicinal preparation for treating anxiety according to claim 3, wherein the following components are added on the basis of the above steps:

2.5 to 3.5 portions of raw licorice.

5. The traditional Chinese medicine preparation for treating mental anxiety according to claim 4, wherein the following components are added on the basis of the above components:

1.5 to 2.5 portions of ginger.

6. The traditional Chinese medicine preparation for treating mental anxiety according to claim 5, which is characterized by comprising the following medicine raw materials in parts by weight:

7. a method for preparing a traditional Chinese medicine preparation for treating mental anxiety, which is characterized by comprising the following steps of:

B. soaking: soaking the medicinal powder prepared in the step A for 12 hours;

8. A method for preparing a traditional Chinese medicine preparation for treating mental anxiety, which is characterized by comprising the following steps of:

9. A method for preparing a traditional Chinese medicine preparation for treating mental anxiety, which is characterized by comprising the following steps of:

b. soaking: soaking the medicinal powder prepared in the step a for 12 hours;