CN116139241A - 治疗不孕不育及习惯性流产的中药组合物及其制备方法 - Google Patents
治疗不孕不育及习惯性流产的中药组合物及其制备方法 Download PDFInfo
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- CN116139241A CN116139241A CN202111397962.1A CN202111397962A CN116139241A CN 116139241 A CN116139241 A CN 116139241A CN 202111397962 A CN202111397962 A CN 202111397962A CN 116139241 A CN116139241 A CN 116139241A
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Abstract
本发明属于医药领域，尤其是一种治疗不孕不育及习惯性流产的中药组合物及其制备方法，针对现有的治疗不孕不育的药物大多效果较差，不能从根本上解决肝肾不足问题，现提出如下方案，其包括以下重量份的原料：女贞子11‑15份、墨旱莲6‑9份、枸杞子12‑16份、桑葚9‑11份、半夏9‑13份、砂仁6‑11份、黄芩10‑15份、大枣8‑11份、生姜12‑16份、沙苑子13‑17份、杜仲14‑18份、菟丝子9‑10份、黄精8‑12份、山萸肉7‑9份、人参9‑12份、黄芪8‑14份、山药11‑16份、熟地13‑15份、阿胶8‑11份、蛇床子6‑9份、茯苓8‑13份、党参7‑9份、白术8‑10份、当归9‑11份、紫苏10‑12份，本发明可以滋补肝肾，从根本上解决肝肾不足问题，同时可以健脾、益气、安胎，疗效好，无副作用。
Description
技术领域
本发明涉及医药领域，尤其涉及一种治疗不孕不育及习惯性流产的中药组合物及其制备方法。
背景技术
不孕不育一般指不孕症。不孕的医学定义为一年以上未采取任何避孕措施，性生活正常而没有成功妊娠。主要分为原发不孕及继发不孕。原发不孕为从未受孕；继发不孕为曾经怀孕以后又不孕，习惯性流产是指连续3次或3次以上自然流产者称为习惯性流产。每次流产往往发生在同一妊娠月份，其流产过程与一般流产相同，近年国际上把习惯性流产称为复发性流产。根据习惯流产时间性，分为早期习惯流产或晚期习惯流产。早期习惯性流产指在妊娠12周以前发生流产，一般多与遗传因素、母内分泌失调及免疫学因素等有关；晚期习惯性流产指在妊娠12周以后发生流产，常为子宫颈内口松弛所致。或者多由于刮宫或扩张宫颈所引起的子宫颈口损伤，少数可能于先天性发育异常、畸形，血型不合及母患疾病等因素有关，常见的崩漏、经闭、胎动不安、滑胎、不孕等大都由肝肾不足所致。
现有的治疗不孕不育的药物大多效果较差，不能从根本上解决肝肾不足问题，因此我们提出了治疗不孕不育及习惯性流产的中药组合物及其制备方法，用来解决上述问题。
发明内容
本发明的目的是为了解决现有技术中存在治疗不孕不育的药物大多效果较差，不能从根本上解决肝肾不足问题的缺点，而提出的治疗不孕不育及习惯性流产的中药组合物及其制备方法。
本发明提出的治疗不孕不育及习惯性流产的中药组合物，包括以下重量份的原料：女贞子10-16份、墨旱莲5-10份、枸杞子11-17份、桑葚8-12份、半夏9-13份、砂仁6-11份、黄芩10-15份、大枣8-11份、生姜12-16份、沙苑子12-18份、杜仲13-19份、菟丝子8-11份、黄精7-13份、山萸肉6-10份、人参8-13份、黄芪7-15份、山药10-17份、熟地12-16份、阿胶7-12份、蛇床子5-10份、茯苓7-14份、党参6-10份、白术7-11份、当归8-12份、紫苏9-13份。
优选的，包括以下重量份的原料：女贞子11-15份、墨旱莲6-9份、枸杞子12-16份、桑葚9-11份、半夏10-12份、砂仁7-10份、黄芩11-14份、大枣9-10份、生姜13-15份、沙苑子13-17份、杜仲14-18份、菟丝子9-10份、黄精8-12份、山萸肉7-9份、人参9-12份、黄芪8-14份、山药11-16份、熟地13-15份、阿胶8-11份、蛇床子6-9份、茯苓8-13份、党参7-9份、白术8-10份、当归9-11份、紫苏10-12份。
优选的，包括以下重量份的原料：女贞子13份、墨旱莲7份、枸杞子14份、桑葚10份、半夏11份、砂仁8份、黄芩12份、大枣9份、生姜14份、沙苑子14份、杜仲15份、菟丝子9份、黄精10份、山萸肉8份、人参10份、黄芪10份、山药13份、熟地14份、阿胶9份、蛇床子8份、茯苓10份、党参8份、白术9份、当归10份、紫苏11份。
本发明还提出了治疗不孕不育及习惯性流产的中药组合物的制备方法，包括以下步骤：
S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行处理，制得原料粉；
S2：将原料粉放入混合设备内，加水搅拌均匀，制得混合物；
S3：混合物进行干燥，磨粉，制得粉料；
S4：将粉料装入胶囊内，制得治疗不孕不育及习惯性流产的中药组合物。
优选的，所述S1中，对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉。
优选的，所述S2中，先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌20-30min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌30-60min,搅拌速度为300-400r/min。
优选的，所述S3中，混合物进行干燥，干燥温度为30-60℃，干燥完成后将干燥物放入磨粉设备内进行磨粉，粉料进行筛分制得粉料。
优选的，所述S4中，对粉料进行计量，将计量后的粉料装入胶囊内。
优选的，所述S3中，将混合物放入干燥箱内，进行加热干燥，干燥时通过水份检测仪对混合物所含水份进行检测，当到达需要的值时，停止加热，取出混合物，冷却，磨粉时，将混合物放入磨粉设备内，通过粉碎辊对混合物进行初步粉碎，然后通过研磨辊对碎料再次粉碎，最后通过筛网进行筛分。
优选的，所述S2中，加水时，通过流量传感器对水流量进行监测，通过电磁阀对水的流速进行控制，当水量达到预定量时，电磁阀关闭。
本发明的有益效果是：
紫苏：理气宽中、止痛、安胎；女贞子滋补肝肾；墨旱莲滋补肝肾，凉血止血；枸杞子滋补肝肾、益精明目；桑葚补血滋阴、生津润燥；半夏降逆止呕，消痞散结；砂仁脾胃气滞，腹痛痞胀；黄芩清热燥湿、安胎；大枣养胃健脾，益血滋补；沙苑子温补肝肾；杜仲补肝肾、强筋骨、安胎；菟丝子具有补益肝肾，安胎；黄精补气养阴、健脾、润肺、益肾；山萸肉补益肝肾、轻身强力；人参大补元气、复脉固脱、补脾益肺、生津安神；黄芪补气固表；山药补脾养胃、生津益肺、补肾涩精；熟地补血滋阴，益精填髓；生姜解表散寒，温中止呕，温肺止咳；阿胶补血，滋阴，润肺；蛇床子温肾壮阳；茯苓利水渗湿、健脾宁心；党参补中益气、健脾益肺；白术健脾、益气、安胎；当归补血活血、调经止痛、润肠通便；
本发明可以滋补肝肾，从根本上解决肝肾不足问题，同时可以健脾、益气、安胎，疗效好，无副作用。
具体实施方式
下面结合具体实施例对本发明作进一步解说。
实施例一
本发明提出了治疗不孕不育及习惯性流产的中药组合物，包括以下重量份的原料：女贞子10份、墨旱莲5份、枸杞子11份、桑葚8份、半夏9份、砂仁6份、黄芩10份、大枣9份、生姜14份、沙苑子12份、杜仲13份、菟丝子8份、黄精7份、山萸肉6-份、人参8份、黄芪7份、山药10份、熟地12份、阿胶7份、蛇床子5份、茯苓7份、党参6份、白术7份、当归8份、紫苏9份；
其制备方法包括以下步骤：
S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉；
S2：先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌20min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌30min,搅拌速度为300r/min，制得混合物；
S3：将混合物放入干燥箱内，进行加热干燥，干燥时通过水份检测仪对混合物所含水份进行检测，当到达需要的值时，停止加热，取出混合物，冷却，干燥温度为30℃，干燥完成后将干燥物放入磨粉设备内进行磨粉，粉料进行筛分制得粉料；
S4：对粉料进行计量，将粉料装入胶囊内，制得治疗不孕不育及习惯性流产的中药组合物。
实施例二
本发明提出了治疗不孕不育及习惯性流产的中药组合物，包括以下重量份的原料：女贞子13份、墨旱莲7份、枸杞子14份、桑葚10份、半夏11份、砂仁8份、黄芩12份、大枣10份、生姜15份、沙苑子14份、杜仲15份、菟丝子9份、黄精10份、山萸肉8份、人参10份、黄芪10份、山药13份、熟地14份、阿胶9份、蛇床子8份、茯苓10份、党参8份、白术9份、当归10份、紫苏11份；
其制备方法包括以下步骤：
S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉；
S2：先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌25min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌45min,搅拌速度为350r/min，制得混合物；
S3：将混合物放入干燥箱内，进行加热干燥，干燥时通过水份检测仪对混合物所含水份进行检测，当到达需要的值时，停止加热，取出混合物，冷却，干燥温度为45℃，干燥完成后将干燥物放入磨粉设备内进行磨粉，粉料进行筛分制得粉料；
S4：对粉料进行计量，将粉料装入胶囊内，制得治疗不孕不育及习惯性流产的中药组合物。
实施例三
本发明提出了治疗不孕不育及习惯性流产的中药组合物，包括以下重量份的原料：女贞子15份、墨旱莲9份、枸杞子16份、桑葚11份、半夏12份、砂仁10份、黄芩14份、大枣11份、生姜16份、沙苑子17份、杜仲18份、菟丝子10份、黄精12份、山萸肉9份、人参12份、黄芪14份、山药16份、熟地15份、阿胶11份、蛇床子9份、茯苓13份、党参9份、白术10份、当归11份、紫苏12份。
S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉；
S2：先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌29min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌58min,搅拌速度为400r/min，制得混合物；
S3：将混合物放入干燥箱内，进行加热干燥，干燥时通过水份检测仪对混合物所含水份进行检测，当到达需要的值时，停止加热，取出混合物，冷却，干燥温度为60℃，干燥完成后将干燥物放入磨粉设备内进行磨粉，粉料进行筛分制得粉料；
S4：对粉料进行计量，将粉料装入胶囊内，制得治疗不孕不育及习惯性流产的中药组合物。
实施例四
本发明提出了治疗不孕不育及习惯性流产的中药组合物，包括以下重量份的原料：女贞子16份、墨旱莲10份、枸杞子17份、桑葚12份、半夏13份、砂仁11份、黄芩15份、大枣11份、生姜16份、沙苑子18份、杜仲19份、菟丝子11份、黄精13份、山萸肉10份、人参13份、黄芪15份、山药17份、熟地16份、阿胶12份、蛇床子10份、茯苓14份、党参10份、白术11份、当归12份、紫苏13份；
其制备方法包括以下步骤：
S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉；
S2：先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌30min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌60min,搅拌速度为400r/min，制得混合物；
S3：将混合物放入干燥箱内，进行加热干燥，干燥时通过水份检测仪对混合物所含水份进行检测，当到达需要的值时，停止加热，取出混合物，冷却，干燥温度为60℃，干燥完成后将干燥物放入磨粉设备内进行磨粉，粉料进行筛分制得粉料；
S4：对粉料进行计量，将粉料装入胶囊内，制得治疗不孕不育及习惯性流产的中药组合物。
对比例一
与实施例一不同之处在于：包括以下重量份的原料：女贞子10份、桑葚8份、半夏9份、砂仁6份、黄芩10份、大枣9份、生姜14份、沙苑子12份、杜仲13份、菟丝子8份、黄精7份、山萸肉6份、人参8份、黄芪7份、山药10份、熟地12份、阿胶7份、蛇床子5份、茯苓7份、党参6份、白术7份、当归8份、紫苏9份；其制备方法包括以下步骤：S1：对女贞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉；S2：先将女贞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌20min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌30min,搅拌速度为300r/min，制得混合物，其余与实施例一相同。
对比例二
与实施例一不同之处在于：包括以下重量份的原料：女贞子10份、墨旱莲5份、枸杞子11份、桑葚8份、黄芩10份、大枣9份、生姜14份、沙苑子12份、杜仲13份、菟丝子8份、黄精7份、山萸肉6-份、人参8份、黄芪7份、山药10份、熟地12份、阿胶7份、蛇床子5份、茯苓7份、党参6份、白术7份、当归8份、紫苏9份；其制备方法包括以下步骤：S1：对女贞子、墨旱莲、枸杞子、桑葚、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉；S2：先将女贞子、墨旱莲、枸杞子、桑葚、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌20min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌30min,搅拌速度为300r/min，制得混合物；其余与实施例一相同。
对比例三
与实施例一不同之处在于：包括以下重量份的原料：女贞子10份、墨旱莲5份、枸杞子11份、桑葚8份、半夏9份、砂仁6份、黄芩10份、大枣9份、生姜14份、沙苑子12份、杜仲13份、菟丝子8份、黄精7份、山萸肉6-份、人参8份、黄芪7份、山药10份、熟地12份、阿胶7份、蛇床子5份、茯苓7份、党参6份、白术7份；其制备方法包括以下步骤：S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术进行清洗，烘干，粉碎，筛分，制得原料粉；S2：先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌20min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术，加入完成后继续搅拌30min,搅拌速度为300r/min，制得混合物；其余与实施例一相同。
试验例一
将实施例一、二、三、四和对比例一、二、三提出的中药组合物作为试验样品，给患者服用后，对其疗效进行试验，肝肾回到正常状态所用天数如下：
| 实施例 | 一 | 二 | 三 | 四 |
| 时间 | 14 | 13 | 15 | 14 |
| 对比例 | 一 | 二 | 三 | |
| 时间 | 20 | 21 | 20 |
本发明的治疗不孕不育及习惯性流产的中药组合物，可以滋补肝肾，从根本上解决肝肾不足问题，同时可以健脾、益气、安胎，疗效好，无副作用。
治疗不孕不育及习惯性流产的中药组合物检验结果如下表：
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (10)
1.治疗不孕不育及习惯性流产的中药组合物，其特征在于，包括以下重量份的原料：女贞子10-16份、墨旱莲5-10份、枸杞子11-17份、桑葚8-12份、半夏9-13份、砂仁6-11份、黄芩10-15份、大枣8-11份、生姜12-16份、沙苑子12-18份、杜仲13-19份、菟丝子8-11份、黄精7-13份、山萸肉6-10份、人参8-13份、黄芪7-15份、山药10-17份、熟地12-16份、阿胶7-12份、蛇床子5-10份、茯苓7-14份、党参6-10份、白术7-11份、当归8-12份、紫苏9-13份。
2.根据权利要求1所述的治疗不孕不育及习惯性流产的中药组合物，其特征在于，包括以下重量份的原料：女贞子11-15份、墨旱莲6-9份、枸杞子12-16份、桑葚9-11份、半夏10-12份、砂仁7-10份、黄芩11-14份、大枣9-10份、生姜13-15份、沙苑子13-17份、杜仲14-18份、菟丝子9-10份、黄精8-12份、山萸肉7-9份、人参9-12份、黄芪8-14份、山药11-16份、熟地13-15份、阿胶8-11份、蛇床子6-9份、茯苓8-13份、党参7-9份、白术8-10份、当归9-11份、紫苏10-12份。
3.根据权利要求1所述的治疗不孕不育及习惯性流产的中药组合物，其特征在于，包括以下重量份的原料：女贞子13份、墨旱莲7份、枸杞子14份、桑葚10份、半夏11份、砂仁8份、黄芩12份、大枣9份、生姜14份、沙苑子14份、杜仲15份、菟丝子9份、黄精10份、山萸肉8份、人参10份、黄芪10份、山药13份、熟地14份、阿胶9份、蛇床子8份、茯苓10份、党参8份、白术9份、当归10份、紫苏11份。
4.治疗不孕不育及习惯性流产的中药组合物的制备方法，其特征在于，包括以下步骤：
S1：对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行处理，制得原料粉；
S2：将原料粉放入混合设备内，加水搅拌均匀，制得混合物；
S3：混合物进行干燥，磨粉，制得粉料；
S4：将粉料装入胶囊内，制得治疗不孕不育及习惯性流产的中药组合物。
5.根据权利要求4所述的治疗不孕不育及习惯性流产的中药组合物的制备方法，其特征在于，所述S1中，对女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、生姜、沙苑子、杜仲、菟丝子、黄精、山萸肉、人参、黄芪、山药、熟地、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏进行清洗，烘干，粉碎，筛分，制得原料粉。
6.根据权利要求4所述的治疗不孕不育及习惯性流产的中药组合物的制备方法，其特征在于，所述S2中，先将女贞子、墨旱莲、枸杞子、桑葚、半夏、砂仁、黄芩、大枣、沙苑子、杜仲、菟丝子、黄精、山萸肉加入到搅拌设备内，搅拌20-30min，然后依次加入人参、黄芪、山药、熟地、生姜、阿胶、蛇床子、茯苓、党参、白术、当归、紫苏，加入完成后继续搅拌30-60min,搅拌速度为300-400r/min。
7.根据权利要求4所述的治疗不孕不育及习惯性流产的中药组合物的制备方法，其特征在于，所述S3中，混合物进行干燥，干燥温度为30-60℃，干燥完成后将干燥物放入磨粉设备内进行磨粉，粉料进行筛分制得粉料。
8.根据权利要求4所述的治疗不孕不育及习惯性流产的中药组合物的制备方法，其特征在于，所述S4中，对粉料进行计量，将计量后的粉料装入胶囊内。
9.根据权利要求4所述的治疗不孕不育及习惯性流产的中药组合物的制备方法，所述S3中，将混合物放入干燥箱内，进行加热干燥，干燥时通过水份检测仪对混合物所含水份进行检测，当到达需要的值时，停止加热，取出混合物，冷却，磨粉时，将混合物放入磨粉设备内，通过粉碎辊对混合物进行初步粉碎，然后通过研磨辊对碎料再次粉碎，最后通过筛网进行筛分。
10.根据权利要求4所述的治疗不孕不育及习惯性流产的中药组合物的制备方法，所述S2中，加水时，通过流量传感器对水流量进行监测，通过电磁阀对水的流速进行控制，当水量达到预定量时，电磁阀关闭。
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