CN116134034A - 四氢异喹啉衍生物及其应用 - Google Patents
四氢异喹啉衍生物及其应用 Download PDFInfo
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- CN116134034A CN116134034A CN202180063084.1A CN202180063084A CN116134034A CN 116134034 A CN116134034 A CN 116134034A CN 202180063084 A CN202180063084 A CN 202180063084A CN 116134034 A CN116134034 A CN 116134034A
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- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000013026 undiluted sample Substances 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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Abstract
一系列四氢异喹啉衍生物及其晶型，具体公开了式(VII)所示化合物、其晶型及其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (39)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011000192 | 2020-09-22 | ||
| CN2020110001928 | 2020-09-22 | ||
| CN202110187630 | 2021-02-08 | ||
| CN2021101876304 | 2021-02-08 | ||
| CN202110251658 | 2021-03-08 | ||
| CN202110251658X | 2021-03-08 | ||
| CN2021105290227 | 2021-05-14 | ||
| CN202110529022 | 2021-05-14 | ||
| CN202110802850 | 2021-07-15 | ||
| CN2021108028503 | 2021-07-15 | ||
| PCT/CN2021/119445 WO2022063094A1 (zh) | 2020-09-22 | 2021-09-18 | 四氢异喹啉衍生物及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116134034A true CN116134034A (zh) | 2023-05-16 |
Family
ID=80844905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180063084.1A Pending CN116134034A (zh) | 2020-09-22 | 2021-09-18 | 四氢异喹啉衍生物及其应用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230365558A1 (zh) |
| EP (1) | EP4219461A1 (zh) |
| CN (1) | CN116134034A (zh) |
| WO (1) | WO2022063094A1 (zh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6838465B2 (en) * | 2000-05-11 | 2005-01-04 | Banyu Pharmaceutical Co., Ltd. | N-acyltetrahydroisoquinoline derivatives |
| JP2016505000A (ja) * | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| DK2935222T3 (en) | 2012-12-21 | 2019-01-07 | Epizyme Inc | PRMT5 INHIBITORS AND APPLICATIONS THEREOF |
| CN108570059B (zh) * | 2017-03-09 | 2022-02-08 | 中国科学院上海药物研究所 | 一种具有prmt5抑制活性的化合物及其制备和应用 |
| KR20200092346A (ko) * | 2017-11-24 | 2020-08-03 | 주빌런트 에피스크라이브 엘엘씨 | Prmt5 억제제로서의 헤테로사이클릭 화합물 |
-
2021
- 2021-09-18 WO PCT/CN2021/119445 patent/WO2022063094A1/zh unknown
- 2021-09-18 CN CN202180063084.1A patent/CN116134034A/zh active Pending
- 2021-09-18 US US18/245,551 patent/US20230365558A1/en active Pending
- 2021-09-18 EP EP21871464.0A patent/EP4219461A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4219461A1 (en) | 2023-08-02 |
| US20230365558A1 (en) | 2023-11-16 |
| WO2022063094A1 (zh) | 2022-03-31 |
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