CN116113631A - 一类氰基化合物、其制备方法及用途 - Google Patents

一类氰基化合物、其制备方法及用途 Download PDF

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CN116113631A
CN116113631A CN202280005454.0A CN202280005454A CN116113631A CN 116113631 A CN116113631 A CN 116113631A CN 202280005454 A CN202280005454 A CN 202280005454A CN 116113631 A CN116113631 A CN 116113631A
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CN116113631B (zh
Inventor
蒋翔锐
许叶春
张磊砢
苏海霞
张秋萌
赵文峰
尚卫娟
沈敬山
肖庚富
蒋华良
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Hainan Simcere Pharmaceutical Co ltd
Shanghai Institute of Materia Medica of CAS
Wuhan Institute of Virology of CAS
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Shanghai Institute of Materia Medica of CAS
Wuhan Institute of Virology of CAS
Simcere Pharmaceutical Co Ltd
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Priority to CN202311097958.2A priority Critical patent/CN117209555A/zh
Priority to CN202311114591.0A priority patent/CN117209556A/zh
Publication of CN116113631A publication Critical patent/CN116113631A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

提供了式I所示化合物、其外消旋体、对映异构体、非对映异构体及其药学上可接受的盐，以及其在预防或治疗由冠状病毒和/或小RNA病毒感染引起的相关疾病中的用途。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN202280005454.0A 2021-09-30 2022-09-29 一类氰基化合物、其制备方法及用途 Active CN116113631B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202311097958.2A CN117209555A (zh) 2021-09-30 2022-09-29 一类氰基化合物、其制备方法及用途
CN202311114591.0A CN117209556A (zh) 2021-09-30 2022-09-29 一类氰基化合物、其制备方法及用途

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CN2021111682324 2021-09-30
CN202111168232 2021-09-30
CN202210973184 2022-08-15
CN2022109731844 2022-08-15
PCT/CN2022/122384 WO2023051657A1 (zh) 2021-09-30 2022-09-29 一类氰基化合物、其制备方法及用途

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CN202311097958.2A Division CN117209555A (zh) 2021-09-30 2022-09-29 一类氰基化合物、其制备方法及用途

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CN (3) CN117209556A (zh)
AU (1) AU2022357033A1 (zh)
CA (1) CA3230035A1 (zh)
TW (1) TW202328145A (zh)
WO (1) WO2023051657A1 (zh)

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TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020198062A1 (en) * 2019-03-22 2020-10-01 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
US11124497B1 (en) * 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201817714A (zh) * 2016-08-30 2018-05-16 英商葛蘭素史密斯克藍智慧財產權有限公司 抑制3c及3cl蛋白酶之化合物及其使用方法
CN109134419A (zh) * 2017-06-15 2019-01-04 国科维思（北京）药物研究有限公司 一种2,2-二甲基-1,3-二氧戊环类衍生物、其制备方法和用途
CN113181339B (zh) * 2020-01-29 2022-02-22 中国科学院上海药物研究所 一种醛基类化合物的药物用途
IL295612A (en) * 2020-02-14 2022-10-01 Nlc Pharma Ltd Preparations for the treatment of corona
US11123329B1 (en) * 2020-03-23 2021-09-21 Vicore Pharma Ab Use of angiotensin II type 2 receptor agonist
CN112778310A (zh) * 2020-04-20 2021-05-11 中国科学院上海药物研究所 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020198062A1 (en) * 2019-03-22 2020-10-01 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
CN113795249A (zh) * 2019-03-22 2021-12-14 艾其林医药公司 用于治疗补体介导的病症的药物化合物
US11124497B1 (en) * 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof

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CN117209556A (zh) 2023-12-12
CA3230035A1 (en) 2023-04-06
AU2022357033A1 (en) 2024-03-21
KR20240054338A (ko) 2024-04-25
CN116113631B (zh) 2023-09-26
TW202328145A (zh) 2023-07-16
WO2023051657A1 (zh) 2023-04-06
CN117209555A (zh) 2023-12-12

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