CN116098288A - Notoginseng radix oral liquid for lowering blood pressure and its preparation method - Google Patents

Notoginseng radix oral liquid for lowering blood pressure and its preparation method Download PDF

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CN116098288A
CN116098288A CN202310244768.2A CN202310244768A CN116098288A CN 116098288 A CN116098288 A CN 116098288A CN 202310244768 A CN202310244768 A CN 202310244768A CN 116098288 A CN116098288 A CN 116098288A
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oral liquid
notoginseng
pseudo
ginseng
water
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张云生
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Yunnan Jinqi Pharmaceuticals Co ltd
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Yunnan Jinqi Pharmaceuticals Co ltd
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Abstract

The invention discloses a pseudo-ginseng oral liquid for reducing blood pressure and a preparation method thereof, and relates to the technical field of oral liquid. The invention adopts fresh notoginseng fibrous roots as raw materials, extracts active ingredients such as notoginsenoside and the like after superfine grinding, and prepares the extract into notoginseng oral liquid, the prepared notoginseng oral liquid has remarkable antihypertensive activity, and the main active ingredients of the notoginseng oral liquid are notoginsenoside, have obvious advantages in the aspects of resisting hypoxia, aging, resisting hypoxia and improving human immunity, are harmless to health, are convenient to take, and can provide very good choices for hypertension groups. In addition, compared with the common notoginseng root (main root) serving as a raw material, the prepared notoginseng oral liquid has better antihypertensive activity, and superfine grinding can greatly promote dissolution of active ingredients such as notoginsenoside and the like, and the antihypertensive activity of the prepared notoginseng oral liquid is better than that of the prepared notoginseng oral liquid which is not prepared by a superfine grinding process.

Description

Notoginseng radix oral liquid for lowering blood pressure and its preparation method
Technical Field
The invention belongs to the technical field of oral liquid, and particularly relates to a pseudo-ginseng oral liquid for reducing blood pressure and a preparation method thereof.
Background
Notoginseng is a herb of the perennial family and is widely used in Yunnan, guangxi and Sichuan provinces. Saponins are the main physiologically active ingredients contained in pseudo-ginseng, and the content of each pseudo-ginseng is about 12%. Up to 20 dammarane type tetracyclic triterpene saponins can be separated from the whole plant of the pseudo-ginseng in medicine so far, pharmacological analysis of modern medicine shows that the pseudo-ginseng has obvious advantages in various aspects, such as anti-hypoxia, aging, hypoxia tolerance and improvement of human immunity, and the total saponins (PNS) and partial monomeric saponins have obvious advantages in blood system, heart brain system, immune system, nervous system, substance metabolism and the like. The study shows that the total saponins of panax notoginseng can dilate blood vessels and reduce blood pressure, especially reduce diastolic blood pressure.
The journal literature ("Panax notoginseng triol saponins combined with antihypertensive therapy for preventing hypertensive cerebral apoplexy", zhao Zhan, journal of hypertension, volume 14, 7) discusses the effect of Panax notoginseng triol saponins on preventing spontaneous cerebral apoplexy based on hypertension, and found that the blood pressure level of fosinopril, fosinopril+Panax notoginseng triol saponins groups was lower than that of physiological saline groups after 2 weeks of administration. The incidence of stroke in rats in the notoginseng triol saponin, fosinopril + notoginseng triol saponin and normal saline groups was 23.3%, 13.3%, 10% and 50% respectively, with significant differences between the incidence of stroke and normal saline groups in each treatment group (P<0.05 A) is provided; the average area of the focus of apoplexy is (1888.6 + -912.5), (2578.7 + -1873.9), (1633.6 + -1025.1) and (3802.6 + -1221.1) μm 2 Wherein the notoginseng triol saponin group and the fosinopril + notoginseng triol saponin group are significantly different from the physiological saline group (P<0.05). Conclusion that both the notoginseng triol saponin and the angiotensin converting enzyme inhibitor can reduce the cerebral apoplexy incidence rate of rats with renal vascular hypertension, and the combined use of the notoginseng triol saponin and the angiotensin converting enzyme inhibitor can also reduce the severity of the cerebral apoplexy.
Patent (CN 111405851A) discloses a pseudo-ginseng health food and a preparation method and application thereof, which adopts pseudo-ginseng flower freeze-dried powder and pseudo-ginseng stem and leaf freeze-dried powder as raw materials, protects the biological activity of the active ingredients of pseudo-ginseng flowers and pseudo-ginseng stem and leaf, and protects the easily-oxidized substances contained in the pseudo-ginseng flowers and the pseudo-ginseng stem and leaf. Through the proportion adjustment of the notoginseng flowers and the notoginseng stems and leaves, the notoginseng flowers and the notoginseng stems and leaves play a synergistic effect, and have the effects of reducing pressure and blood lipid, clearing heat and detoxicating, refreshing, tonifying qi, resisting aging, soothing the nerves and improving the immunity of organisms. Mixing with adjuvants, and reasonably blending the pharmacology and food to make the food with the help of the medicine and the medicine help the food, so as to achieve the effects of preventing, treating diseases and strengthening body, and be easily accepted by patients. The existing resources are fully utilized, the application of the pseudo-ginseng flowers and the pseudo-ginseng stems and leaves is expanded, a health food which has homology of medicine and food and is convenient to eat is added for the existing food market, and meanwhile, a plurality of traditional foods have health care effects.
The invention discloses a pseudo-ginseng flower and branch composition (CN 108835639A), which is prepared from 30-50% of pseudo-ginseng flowers and 50-70% of pseudo-ginseng stems and leaves by weight percent through pretreatment, extraction, concentration, drying or non-drying, and the prepared pseudo-ginseng flower and branch composition has the faint scent of pseudo-ginseng, unique flavor, can solve the problems of constipation, excessive internal heat and the like, has certain effects of regulating hypertension and hyperlipidemia, can calm the liver and improve eyesight, lose weight, diminish inflammation, stop bleeding, relieve pain and strengthen human immunity, can be directly drunk as a beverage, can be used in foods and cooking, can also be added into various foods as a food additive, and can meet the requirements of the market on nutrition and taste.
Patent (CN 107753551A) discloses a composition with blood pressure reducing function, which is prepared from the following raw materials in parts by weight: pseudo-ginseng: 1-10 parts of pseudo-ginseng flower: 2-12 parts of kudzuvine root: 1-15 parts of eucommia ulmoides: 2-12 parts of radix notoginseng and flos notoginseng, and extracting with alcohol to obtain an alcohol extract and filter residues; extracting cortex Eucommiae and radix Puerariae with ethanol, filtering, and extracting with water to obtain water extractive solution; respectively vacuum concentrating, drying and pulverizing the ethanol extract and the water extract to obtain ethanol extract dry extract powder and water extract dry extract powder; mixing the ethanol extract dry extract powder and the water extract dry extract powder. The obtained composition is compatible with the whole formula, has the function of synergistically reducing blood pressure, is safe and effective, has no toxic or side effect after long-term administration, and can be eaten for a long time.
Therefore, many researches on using the biological active ingredients of the pseudo-ginseng for reducing blood pressure exist in the prior art, but the prior art still fails to provide a health care product which can effectively reduce blood pressure and is convenient to take and takes the pseudo-ginseng as a raw material. Therefore, the notoginseng oral liquid health food with the blood pressure reducing effect prepared by taking the notoginseng as the raw material is provided, and has important significance in the field of medical health care.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides a pseudo-ginseng oral liquid for reducing blood pressure and a preparation method thereof. The invention adopts the fibrous root of pseudo-ginseng as the raw material, and the active ingredients such as pseudo-ginseng saponin and the like are extracted after superfine grinding, and the extract is prepared into pseudo-ginseng oral liquid. The preparation method comprises the steps of superfine grinding the raw materials to a specific mesh number, extracting active ingredients such as notoginsenoside and the like, and greatly promoting the dissolution of the active ingredients such as the notoginsenoside and the like, wherein the antihypertensive activity of the prepared pseudo-ginseng oral liquid is better than that of the pseudo-ginseng oral liquid prepared by a non-superfine grinding process. In addition, compared with the common notoginseng root (main root) serving as a raw material, the notoginseng oral liquid prepared by the invention has better antihypertensive activity.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
in a first aspect, the invention provides a preparation method of a pseudo-ginseng oral liquid for reducing blood pressure, which comprises the following steps:
1) Taking clean radix Notoginseng fibrous root, superfine pulverizing to 200-1000 mesh, leaching with ethanol, filtering the leaching solution to obtain ethanol extract and residue;
2) Decocting the residue with water, filtering, concentrating the filtrate, precipitating with ethanol, and filtering to obtain water extractive solution;
3) Mixing the ethanol extract obtained in step 1) with the water extract obtained in step 2), recovering ethanol, adding appropriate amount of water, stirring, standing overnight, and filtering to obtain Notoginseng radix fibrous root extract;
4) Diluting Notoginseng radix fibrous root extract with purified water, or mixing with adjuvants, diluting with purified water, packaging, capping, sterilizing, inspecting, and packaging to obtain Notoginseng radix oral liquid for lowering blood pressure.
The invention adopts the fibrous root of the pseudo-ginseng as the raw material, and compared with the common pseudo-ginseng (main root) as the raw material, the prepared pseudo-ginseng oral liquid has better antihypertensive activity. The active ingredients such as notoginsenoside are extracted after the raw materials are subjected to superfine grinding to a specific mesh number, so that the dissolution of the active ingredients such as the notoginsenoside can be greatly promoted, and the antihypertensive activity of the prepared notoginsen oral liquid is better than that of the notoginsen oral liquid prepared by a superfine grinding process.
The superfine grinding mesh is too small (the particle size is too large), so that the dissolution of active ingredients in the fibrous roots of the pseudo-ginseng cannot be well promoted, and the prepared pseudo-ginseng oral liquid is not beneficial to exerting the blood pressure reducing function; the superfine grinding of the particles (with too small particle size) can cause a large amount of all components to be dissolved out, and the impurity content in the extracted active components is too high, so that the prepared pseudo-ginseng oral liquid is not beneficial to exerting the blood pressure reducing function.
Preferably, the fibrous root of pseudo-ginseng is selected from fresh fibrous root of pseudo-ginseng and/or dry fibrous root of pseudo-ginseng.
Preferably, the ethanol leaching process of step 1) is as follows: adding 60% -90% ethanol 5-15 times of fibrous root weight, soaking and extracting at normal temperature for 10-40 hr, and leaching for 1-3 times.
Preferably, the process of decocting step 2) with water is as follows: adding water 2-4 times the weight of the filter residue, and decocting for 0.5-2 hr for 1-3 times.
Preferably, the concentration and alcohol precipitation process in the step 2) is as follows: concentrating to relative density of 1.05-1.10 at 80deg.C, adding 2-3 times of 95% ethanol, stirring, and standing for 24 hr.
Preferably, in the step 3), water which is 2-4 times of the total volume of the alcohol extract and the water extract is added; filtering with 100-200 mesh sieve.
Preferably, step 4) is performed by adding 1-3 times the volume of the extract of fibrous root of Panax notoginseng with water.
Preferably, the sterilization process in step 4) is: sterilizing at 121deg.C for 20-40 min.
Preferably, the auxiliary materials in the step 4) are other traditional Chinese medicine extracts or ingredients for both medicine and food.
In a second aspect, the application also provides a pseudo-ginseng oral liquid for reducing blood pressure, which is prepared by the preparation method.
In a third aspect, the application also provides an application of the notoginseng oral liquid for reducing blood pressure in preparing health care products with blood pressure reducing effect.
Compared with the prior art, the invention has the following beneficial effects:
1. the notoginseng oral liquid prepared by the invention has remarkable antihypertensive activity, has the main active ingredient of notoginsenoside, has obvious advantages in the aspects of resisting hypoxia, aging and hypoxia and improving human immunity, is harmless to health, is convenient to take, and can provide very good choices for hypertensive people.
2. The invention adopts the fibrous root of the pseudo-ginseng as the raw material, and compared with the common pseudo-ginseng (main root) as the raw material, the prepared pseudo-ginseng oral liquid has better antihypertensive activity. The active ingredients such as notoginsenoside are extracted after the raw materials are subjected to superfine grinding to a specific mesh number, so that the dissolution of the active ingredients such as the notoginsenoside can be greatly promoted, and the antihypertensive activity of the prepared notoginsen oral liquid is better than that of the notoginsen oral liquid prepared by a superfine grinding process.
Detailed Description
It is to be noted that the raw materials used in the present invention are all common commercial products, and the sources thereof are not particularly limited.
Fresh fibrous root of pseudo-ginseng and main root of fresh pseudo-ginseng: the Wenshan notoginseng is purchased from the Wenshan notoginseng market in Yunnan province.
Example 1
Preparation of notoginseng oral liquid for reducing blood pressure
Step 1): taking clean fresh pseudo-ginseng fibrous roots, superfine grinding the fresh pseudo-ginseng fibrous roots to 200 meshes, adding 80% ethanol which is 10 times the weight of the fibrous roots, soaking and extracting the fibrous roots for 35 hours at normal temperature, and filtering the leaching liquor to obtain an alcohol extracting solution and filter residues;
2) Decocting the residue in water for 1 hr, filtering, concentrating the filtrate to relative density of 1.10 at 80deg.C, cooling, adding 95% ethanol 3 times the volume of the concentrated solution, stirring, standing for 24 hr, and filtering to obtain water extractive solution;
3) Mixing the ethanol extract obtained in step 1) with the water extract obtained in step 2), recovering ethanol, adding water 4 times the volume of the Notoginseng radix fibrous root extract, stirring, standing overnight, and filtering with 200 mesh sieve to obtain Notoginseng radix fibrous root extract;
4) Diluting Notoginseng radix fibrous root extract with 1.5 times of purified water, packaging, capping, sterilizing at 121deg.C for 30 min, inspecting with lamp, and packaging to obtain Notoginseng radix oral liquid for lowering blood pressure.
Example 2
Preparation of notoginseng oral liquid for reducing blood pressure
Step 1): taking clean fresh radix Notoginseng fibrous roots, superfine pulverizing to 1000 meshes, adding 85% ethanol 8 times of fibrous roots, soaking and extracting at normal temperature for 2 times, extracting for 15 hr each time, mixing the leaching solutions, and filtering the leaching solutions to obtain ethanol extract and filter residues;
2) Decocting the residue with water for 2 times each for 0.5 hr, filtering, mixing filtrates, concentrating to relative density of 1.10 at 80deg.C, cooling, adding 95% ethanol 2.5 times of the concentrated solution, stirring, standing for 24 hr, and filtering to obtain water extractive solution;
3) Mixing the ethanol extract obtained in step 1) with the water extract obtained in step 2), recovering ethanol, adding water 3 times the volume of the Notoginseng radix fibrous root extract, stirring, standing overnight, and filtering with 150 mesh sieve to obtain Notoginseng radix fibrous root extract;
4) Diluting Notoginseng radix fibrous root extract with 2 times of purified water, packaging, capping, sterilizing at 121deg.C for 30 min, inspecting with light, and packaging to obtain Notoginseng radix oral liquid for lowering blood pressure.
Example 3
Preparation of notoginseng oral liquid for reducing blood pressure
Step 1): taking clean fresh pseudo-ginseng fibrous roots, superfine grinding the fresh pseudo-ginseng fibrous roots to 600 meshes, adding 80% ethanol which is 12 times the weight of the fibrous roots, soaking and extracting at normal temperature for 30 hours, mixing the leaching liquor, and filtering the leaching liquor to obtain an alcohol extraction liquor and filter residues;
2) Decocting the residue in water for 2 hr, filtering, concentrating the filtrate to relative density of 1.10 at 80deg.C, cooling, adding 95% ethanol 3 times the volume of the concentrated solution, stirring, standing for 24 hr, and filtering to obtain water extractive solution;
3) Mixing the ethanol extract obtained in step 1) with the water extract obtained in step 2), recovering ethanol, adding water 4 times the volume of the Notoginseng radix fibrous root extract, stirring, standing overnight, and filtering with 200 mesh sieve to obtain Notoginseng radix fibrous root extract;
4) Diluting Notoginseng radix fibrous root extract with 1.5 times of purified water, packaging, capping, sterilizing at 121deg.C for 30 min, inspecting with lamp, and packaging to obtain Notoginseng radix oral liquid for lowering blood pressure.
Comparative example 1
Example 1 was repeated except that fresh Notoginseng radix was used as the main root.
Comparative example 2
Example 1 was repeated except that the fresh ginseng fibrous roots were ultrafine crushed to 1100 mesh.
Comparative example 3
Example 1 was repeated except that the fibrous roots of fresh notoginseng were superfine-ground to 100 mesh.
Test examples
Hypotensive test in primary hypertensive rats
Sample: 70 male primary hypertensive rats of 12 weeks of age and body weight (400+ -20 g) were selected.
The feeding method comprises the following steps: the rats were kept in a room with a constant temperature of 24 ℃,12 h illumination and 12h darkness, and were fed with food and water ad libitum for 1 week. Rats were randomly divided into 7 groups of 10 animals, each group was subjected to gastric lavage with the oral liquid of examples 1 to 3 and comparative examples 1 to 3, distilled water (blank group) and captopril, and the samples were subjected to one-time gastric lavage by oral gavage, each rat was subjected to gastric lavage twice daily, wherein the amounts of the oral liquid of examples 1 to 3 and comparative examples 1 to 3 were 10ml/kg per gastric lavage, and the systolic blood pressure of the rats after 1, 4, 7, 10 weeks and 2 weeks of withdrawal were measured with a rat blood pressure measuring instrument, and each rat was subjected to measurement 3 times, and the results are shown in Table 1.
Table 1 influence of notoginseng oral liquid on blood pressure (systolic blood pressure after administration) (mean ± standard deviation, mmHg, n=10)
Figure BDA0004125537010000051
Note that: * Indicating p <0.05, with significant differences compared to the blank.
As seen from table 1, the systolic blood pressure of the rats in the blank group remained substantially balanced and did not change much. The captopril group can obviously reduce the blood pressure of rats, the systolic pressure reaches about 110mmHg of the minimum value after 10 weeks of treatment, and the blood pressure obviously rises after 2 weeks of drug withdrawal and is kept at about 120 mmHg. The oral liquids of examples 1-3 were administered for 1-10 weeks with a gradual decrease in blood pressure, to a degree less than that of captopril group, and the systolic blood pressure slightly exceeded 120mmHg after 10 weeks of administration, but the blood pressure did not rise after 2 weeks of withdrawal, and remained at about 120 mmHg. The oral liquid of comparative examples 1-3 was administered for 1-10 weeks, the blood pressure was slowly decreased, the systolic pressure was between 140-150mmHg after administration for 10 weeks, and the blood pressure was raised after stopping administration for 2 weeks.
Comparing captopril group with examples 1-3, it can be seen that the pseudo-ginseng oral liquid prepared by the invention can also effectively reduce blood pressure, the reduction degree is not as good as captopril, but no rebound is generated after drug withdrawal, and other harm to the body is avoided because the blood pressure reduction process is mild.
Comparing example 1 with comparative example 1, it can be seen that the prepared oral liquid has significantly better antihypertensive activity and no rebound after stopping the drug, compared with the fresh radix Notoginseng fibril as the raw material.
As can be seen from the comparison of the example 1 and the comparative examples 2-3, the prepared oral liquid has better antihypertensive activity and no rebound after stopping the medicine.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.

Claims (10)

1. The preparation method of the pseudo-ginseng oral liquid for reducing blood pressure is characterized by comprising the following steps of:
1) Taking clean radix Notoginseng fibrous root, superfine pulverizing to 200-1000 mesh, leaching with ethanol, filtering the leaching solution to obtain ethanol extract and residue;
2) Decocting the residue with water, filtering, concentrating the filtrate, precipitating with ethanol, and filtering to obtain water extractive solution;
3) Mixing the ethanol extract obtained in step 1) with the water extract obtained in step 2), recovering ethanol, adding appropriate amount of water, stirring, standing overnight, and filtering to obtain Notoginseng radix fibrous root extract;
4) Diluting Notoginseng radix fibrous root extract with purified water, or mixing with adjuvants, diluting with purified water, packaging, capping, sterilizing, inspecting, and packaging to obtain Notoginseng radix oral liquid for lowering blood pressure.
2. The method of claim 1, wherein the fibrous root of pseudo-ginseng is selected from fresh fibrous root of pseudo-ginseng and/or dry fibrous root of pseudo-ginseng.
3. The method of claim 1, wherein the ethanol leaching process of step 1) is: adding 5-15 times of 60% -90% ethanol by weight, soaking and extracting at normal temperature for 10-40 hours, and leaching for 1-3 times.
4. The preparation method as claimed in claim 1, wherein the process of decocting step 2) with water comprises: adding water 2-4 times the weight of the filter residue, and decocting for 0.5-2 hr for 1-3 times.
5. The method according to claim 1, wherein the concentration and alcohol precipitation processes in step 2) are as follows: concentrating to relative density of 1.05-1.10 at 80deg.C, adding 2-3 times of 95% ethanol, stirring, and standing for 24 hr.
6. The method according to claim 1, wherein water is added in the total volume of the alcohol extract and the water extract in the step 3) in an amount of 2 to 4 times; filtering with 100-200 mesh sieve.
7. The method of claim 1, wherein step 4) is performed by adding 1-3 times the volume of the extract of fibrous root of Panax notoginseng with water; the sterilization process in the step 4) is as follows: sterilizing at 121deg.C for 20-40 min.
8. The method of claim 1, wherein the auxiliary materials in step 4) are other Chinese medicinal extracts or ingredients for both medicine and food.
9. A blood pressure-reducing pseudo-ginseng oral liquid prepared by the preparation method according to any one of claims 1 to 8.
10. The use of the antihypertensive pseudo-ginseng oral liquid prepared by the preparation method according to any one of claims 1 to 8 or the antihypertensive pseudo-ginseng oral liquid according to claim 9 in the preparation of health care products with antihypertensive effect.
CN202310244768.2A 2023-03-15 2023-03-15 Notoginseng radix oral liquid for lowering blood pressure and its preparation method Pending CN116098288A (en)

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Publication number Priority date Publication date Assignee Title
CN106109952A (en) * 2016-07-11 2016-11-16 吕其镁 Medicine for blood fat reducing and preparation method thereof
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