CN106109952A - Medicine for blood fat reducing and preparation method thereof - Google Patents
Medicine for blood fat reducing and preparation method thereof Download PDFInfo
- Publication number
- CN106109952A CN106109952A CN201610541925.6A CN201610541925A CN106109952A CN 106109952 A CN106109952 A CN 106109952A CN 201610541925 A CN201610541925 A CN 201610541925A CN 106109952 A CN106109952 A CN 106109952A
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- Prior art keywords
- extract
- radix notoginseng
- powder
- ethanol
- herba dendrobii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of medicine for blood fat reducing, being made up of Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, extract of panax notoginseng saponins mixing, described Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, the quality proportioning of extract of panax notoginseng saponins be: 38~42: 38~42: 13~17: 3~7.The present invention utilizes above-mentioned each component to carry out compatibility, makes each function mutually promote, not only has no side effect patient, and has preferable therapeutic effect, takes effect substantially, and treatment cycle is short.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, a kind of medicine for blood fat reducing and preparation side thereof
Method.
Background technology
Hyperlipemia be due to lipid metabolism or operating abnormal make cholesterol, triglyceride and low density lipoprotein, LDL too high and
A kind of disease that density lipoprotein is too low and causes.Research shows, hyperlipemia is to cause hypertension, hyperglycemia and tremulous pulse medicated porridge sample
The inducement of the diseases such as hardening, coronary heart disease, pancreatitis.Mainly by bad dietary habit, environmental factors, lack physical training, essence
God anxiety, emotional activity etc. are caused.Medicine for blood fat reducing is unsatisfactory the most clinically, there is also human body simultaneously
Certain side effect, treatment cycle is long, weak effect.
Summary of the invention
It is an object of the invention to provide a kind of patient is had no side effect, lipid-lowering effect substantially, instant effect for dropping blood
The medicine of fat, overcomes the deficiencies in the prior art.
The medicine for blood fat reducing of the present invention, it is characterised in that: carried by Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii
Taking thing, extract of panax notoginseng saponins mixing composition, described Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, Radix Notoginseng are total
The quality proportioning of saponin extract is: 38~42: 38~42: 13~17: 3~7.
Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, the quality proportioning of extract of panax notoginseng saponins are preferably: 8
: 8: 3: 1, dosage form is hard capsule or tablet or powder.
For the preparation method of the medicine of blood fat reducing, step is as follows:
(1), selected Radix Notoginseng, dust removal roguing, it is standby that micronizing to 200 mesh makes Radix Notoginseng powder;
(2), preparation Radix Notoginseng crude polysaccharide extract and extract of panax notoginseng saponins
A, Radix Notoginseng is put in extraction pot, with the ethanol extraction twice of concentration 72%;
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Notoginseng, heats with jacket steam, and steam pressure is 0.1Mpa,
Heating 30 minutes, backflow limit, limit is heated, and in making tank, temperature is unanimous between the higher and lower levels, when in extraction pot, feed temperature rises to 80 DEG C of stoppings and adding
Heat, keeps in tank 80 DEG C of constant temperature two hours, and then extracted tank bottoms 120 eye mesh screens of extracting solution filter, then through filter 140 mesh sieve
Net filtration, is transported to storage tank with stainless steel pump stand-by;
Ethanol addition is that inventory is for the second time: 6 liters/1 kilogram Radix Notoginseng, after adding ethanol, ibid walks operation;Twice second
Alcohol extract merges stand-by;
B, in extraction pot with the Radix Notoginseng after ethanol extraction again with purified water extraction twice;
Wherein extraction purification water addition is for the first time: material in 8 liters/1 kilogram tank, uses jacket steam after adding purified water
Being heated to 95 DEG C, be incubated 3 hours, extracted tank bottoms 120 eye mesh screens of extracting solution filter, then filter through filter 140 eye mesh screen, use
It is stand-by that stainless steel pump is transported to storage tank;
The addition of extraction purification water is for the second time: material in 6 liters/1 kilogram tank, is heated to 95 DEG C, is incubated 2 hours, filter
Liquid processes and ibid walks;Twice aqueous extract merges stand-by;
C, twice aqueous extract obtaining b step carry out concentrating under reduced pressure, are concentrated into the 1/8 of original volume, add 95%
Ethanol reaches 80% to solution ethanol concentration, stir, static 24 hours, remove supernatant recovered alcohol, collect
Precipitation is completely dissolved by purified water again, and the post-heating that stirs to 60 DEG C and keeps constant temperature 1 hour, and gained solution uses sheet frame mistake again
Filter filters, and discards filtering residue, filtrate is transported to storage tank stand-by;
D, the filtrate obtaining c step carry out concentrating under reduced pressure, and being concentrated into density is 1.20g/cm3, dense to obtain after concentrating
Contracting cream is vacuum dried, and makes dry cream moisture < 5%, collects dry cream, pulverizes, and packaging obtains Radix Notoginseng crude polysaccharide extract;
E, a walks twice alcohol extract carrying out vacuum-concentrcted, being concentrated into density is 1.20g/cm3, condensed cream is entered
Row vacuum drying, makes dry cream moisture < 5%, collects dry cream, pulverizes, and packaging obtains extract of panax notoginseng saponins;Radix Notoginseng total arasaponins carries
Take ginsenoside Rg1 and Rb1 summation content in thing and reach 30%;(wherein Rg1 content >=17%, Rb1 content >=13%)
(3), Herba Dendrobii extract is prepared
Utilize ultrasonic extracting process, Herba Dendrobii is crushed to 40 mesh, ultrasonic frequency 60KHz, Extracting temperature 55 DEG C,
Each 45 minutes of extraction time;Extraction purification water addition is for the first time: 10 liters/1 kilogram dendrobium officinale powder;Second time is extracted pure
Changing water addition is: 8 liters/1 kilogram dendrobium officinale powder;Extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out reducing pressure dense
Contracting, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture < 5%, pulverize, packaging, obtain stone
Dry measure used in former times extract;Extraction ratio is 5%, and in extract, dendrobium polysaccharide content is 12%.
(4), by Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, extract of panax notoginseng saponins by 38~42: 38
~42: 13~17: 3~7 mass proportioning or 8: 8: 3: 1 mass proportioning mix homogeneously, it is prepared as hard capsule or tablet or powder,
Medicine for blood fat reducing.
The component dendrobium polysaccharide of the medicine for blood fat reducing of the present invention has regulation effect, energy to the Developmental and Metabolic Disorder of lipid
Substantially reduce blood lipid level, for fatty liver, atherosclerosis etc., there is preventive effect, to hyperlipemia and Atherosclerosis
Change and have certain preventive and therapeutic effect, hyperlipidemia rats dysbolism of blood fat is had regulation effect, it is possible to effectively alleviate
The steatosis of hyperlipemia liver organization.Dendrobium polysaccharide can expand blood vessel, effectively facilitates human body raw to various nutrient substance, dimension
Element and the absorption of mineral, improve metabolism, improves the physiological function of each organ of health.To promoting circulation, expand blood vessel, fall
Low cholesterol and triglyceride have positive effect.
The effect of Radix Notoginseng powder: Radix Notoginseng powder can stop intestinal absorption fat, can reduce total lipid level, and content of triglyceride is bright
Aobvious reduction, arteries fat deposit reduces, and has triglyceride and serum total cholesterol effect in reduction blood.
Radix Notoginseng crude polysaccharide extract have suppression lipid absorption enhancement lipid metabolic conversion, antagonism thrombin induction from
Fibrinogen is to fibrinous conversion, and activates urokinase, promotes fibrinous dissolving, is described as cleaning the street of blood vessel
Husband.
In extract of panax notoginseng saponins, Rg1 has stronger lipoid peroxidization resistant, can significantly reduce blood fat and lipid
Peroxidation Product malonaldehyde, plays the effect reducing blood fat.
The present invention utilizes above-mentioned each component to carry out compatibility, makes each function mutually promote, not only has no side effect patient, and
Having preferable therapeutic effect, take effect substantially, treatment cycle is short.
Detailed description of the invention
The medicine for blood fat reducing of the present invention, total by Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, Radix Notoginseng
Saponin extract mixing composition, Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, the quality of extract of panax notoginseng saponins
Proportioning is: 38 or 40 or 42: 38 or 40 or 42: 13 or 15 or 17: 3 or 5 or 7.
Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, the quality proportioning of extract of panax notoginseng saponins are preferably: 8
: 8: 3: 1, dosage form is hard capsule or tablet or powder.
For the preparation method of the medicine of blood fat reducing, step is as follows:
(1), selected Radix Notoginseng, dust removal roguing, it is standby that micronizing to 200 mesh makes Radix Notoginseng powder;
(2), preparation Radix Notoginseng crude polysaccharide extract and extract of panax notoginseng saponins
A, Radix Notoginseng is put in extraction pot, with the ethanol extraction twice of concentration 72%;
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Notoginseng, heats with jacket steam, and steam pressure is 0.1Mpa,
Heating 30 minutes, backflow limit, limit is heated, and in making tank, temperature is unanimous between the higher and lower levels, when in extraction pot, feed temperature rises to 80 DEG C of stoppings and adding
Heat, keeps in tank 80 DEG C of constant temperature two hours, and then extracted tank bottoms 120 eye mesh screens of extracting solution filter, then through filter 140 mesh sieve
Net filtration, is transported to storage tank with stainless steel pump stand-by;
Ethanol addition is that inventory is for the second time: 6 liters/1 kilogram Radix Notoginseng, after adding ethanol, ibid walks operation;Twice second
Alcohol extract merges stand-by;
B, in extraction pot with the Radix Notoginseng after ethanol extraction again with purified water extraction twice;
Wherein extraction purification water addition is for the first time: material in 8 liters/1 kilogram tank, uses jacket steam after adding purified water
Being heated to 95 DEG C, be incubated 3 hours, extracted tank bottoms 120 eye mesh screens of extracting solution filter, then filter through filter 140 eye mesh screen, use
It is stand-by that stainless steel pump is transported to storage tank;
The addition of extraction purification water is for the second time: material in 6 liters/1 kilogram tank, is heated to 95 DEG C, is incubated 2 hours, filter
Liquid processes and ibid walks;Twice aqueous extract merges stand-by;
C, twice aqueous extract obtaining b step carry out concentrating under reduced pressure, are concentrated into the 1/8 of original volume, add 95%
Ethanol reaches 80% to solution ethanol concentration, stir, static 24 hours, remove supernatant recovered alcohol, collect
Precipitation is completely dissolved by purified water again, and the post-heating that stirs to 60 DEG C and keeps constant temperature 1 hour, and gained solution uses sheet frame mistake again
Filter filters, and discards filtering residue, filtrate is transported to storage tank stand-by;
D, the filtrate obtaining c step carry out concentrating under reduced pressure, and being concentrated into density is 1.20g/cm3, dense to obtain after concentrating
Contracting cream is vacuum dried, and makes dry cream moisture < 5%, collects dry cream, pulverizes, and packaging obtains Radix Notoginseng crude polysaccharide extract;
E, a walks twice alcohol extract carrying out vacuum-concentrcted, being concentrated into density is 1.20g/cm3, condensed cream is entered
Row vacuum drying, makes dry cream moisture < 5%, collects dry cream, pulverizes, and packaging obtains extract of panax notoginseng saponins;Radix Notoginseng total arasaponins carries
Take ginsenoside Rg1 and Rb1 summation content in thing and reach 30%;(wherein Rg1 content >=17%, Rb1 content >=13%)
(3), Herba Dendrobii extract is prepared
Utilize ultrasonic extracting process, Herba Dendrobii is crushed to 40 mesh, ultrasonic frequency 60KHz, Extracting temperature 55 DEG C,
Each 45 minutes of extraction time;Extraction purification water addition is for the first time: 10 liters/1 kilogram dendrobium officinale powder;Second time is extracted pure
Changing water addition is: 8 liters/1 kilogram dendrobium officinale powder;Extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out reducing pressure dense
Contracting, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture < 5%, pulverize, packaging, obtain stone
Dry measure used in former times extract;Extraction ratio is 5%, and in extract, dendrobium polysaccharide content is 12%.
(4), by Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, extract of panax notoginseng saponins by 38~42: 38
~42: 13~17: 3~7 mass proportioning or 8: 8: 3: 1 mass proportioning mix homogeneously, it is prepared as hard capsule or tablet or powder,
Medicine for blood fat reducing.
The present invention utilizes above-mentioned each component to carry out compatibility, makes each function mutually promote, not only has no side effect patient, and
Having preferable therapeutic effect, take effect substantially, treatment cycle is short.
Application example: Mr. Zhao, 34 years old, company enterprise planning supervisor, to bend over one's desk working for a long time, family of accompanying a guest, 2015 in health check-up
Finding, blood triglyceride, cholesterol exceed normal value, and have severe fatty liver, and body fat severe overweight belongs to Mild Obesity, body
Fat exceeds standard, hyperlipidemia, fatty liver, has the high risk factor suffering from coronary heart disease.Through making rational planning for exercise program and cooperation takes this
The medicine of invention, checks after 6 days again, and being clearly better all occurs in institute's Testing index, and Mr.'s Zhao mental status is also restored to
In the past.
Mr. An, life in 1976, salesman.Once sleep in July, 2014 and feel dizzy, the most weak.At that time
Thinking stays up late does not has a rest, and has a rest and the most also takes it seriously.But it is often accompanied by dizziness, dizzy, uncomfortable in chest time in later half a year
Sensation.After remove examination in hospital, blood fat is the most higher, has had influence on hepatic and renal function.Lipid lowerers is taken, after 1 year by doctor's advice requirement
Blood lipids index has declined, but after drug withdrawal, old trouble is just violated immediately.After listen friend to say this product is preferably tried takes one
After Yue, health has clear improvement, and situation dizzy, dizzy, uncomfortable in chest is not the most recommitted, the dizzy headache etc. the most often having
Sensation all also light without, health, after adhering to three months, the symptom such as have a dizzy spell thoroughly disappears, and body weight also has subtracted,
Livelihood restoration is normal.
Mr. Yu, 1963, corporate department was responsible for.2015 year health check-up blood fat three are higher, T-CHOL is 6.97,
Low-density lipoprotein cholesterol is 3.42, triglyceride is 2.79, and exercise is failed to hold, and the cycle is longer, DeGrain.Company
Exploitation blood fat reducing new product, like to try and see effect, illustratively quantity is taken, go after two months hospital through row Blood routine examination,
Blood fat T-CHOL is down to 5.60, low-density lipoprotein cholesterol is down to 2.55, triglyceride is down to 1.80, basic is just recovering
Often.
Claims (3)
1. the medicine for blood fat reducing, it is characterised in that: by Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, three
Seven total saponin extracts mixing compositions, described Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, Radix Notoginseng total arasaponins carry
The quality proportioning taking thing is: 38~42: 38~42: 13~17: 3~7.
Medicine for blood fat reducing the most according to claim 1, it is characterised in that: Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract,
Herba Dendrobii extract, the quality proportioning of extract of panax notoginseng saponins be: 8: 8: 3: 1, and dosage form is hard capsule or tablet or powder.
The preparation method of the medicine for blood fat reducing the most according to claim 1 and 2, it is characterised in that: step is as follows:
(1), selected Radix Notoginseng, dust removal roguing, it is standby that micronizing to 200 mesh makes Radix Notoginseng powder;
(2), preparation Radix Notoginseng crude polysaccharide extract and extract of panax notoginseng saponins
A, Radix Notoginseng is put in extraction pot, with the ethanol extraction twice of concentration 72%;
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Notoginseng, heats with jacket steam, and steam pressure is 0.1Mpa, heating
30 minutes, backflow limit, limit was heated, and in making tank, temperature is unanimous between the higher and lower levels, when in extraction pot, feed temperature rises to 80 DEG C of stopping heating, protected
Holding in tank 80 DEG C of constant temperature two hours, then extracted tank bottoms 120 eye mesh screens of extracting solution filter, then through filter 140 eye mesh screen mistake
Filter, is transported to storage tank with stainless steel pump stand-by;
Ethanol addition is that inventory is for the second time: 6 liters/1 kilogram Radix Notoginseng, after adding ethanol, ibid walks operation;Twice ethanol carries
Take liquid and merge stand-by;
B, in extraction pot with the Radix Notoginseng after ethanol extraction again with purified water extraction twice;
Wherein extraction purification water addition is for the first time: material in 8 liters/1 kilogram tank, heats with jacket steam after adding purified water
To 95 DEG C, being incubated 3 hours, extracted tank bottoms 120 eye mesh screens of extracting solution filter, then filter through filter 140 eye mesh screen, with stainless
It is stand-by that steel is pumped into storage tank;
The addition of extraction purification water is for the second time: material in 6 liters/1 kilogram tank, is heated to 95 DEG C, is incubated 2 hours, at filtrate
Reason ibid walks;Twice aqueous extract merges stand-by;
C, twice aqueous extract obtaining b step carry out concentrating under reduced pressure, are concentrated into the 1/8 of original volume, add the ethanol of 95%
Reaching 80% to solution ethanol concentration, stir, static 24 hours, remove supernatant recovered alcohol, collect precipitation
Being completely dissolved by purified water, the post-heating that stirs to 60 DEG C and keeps constant temperature 1 hour, and gained solution uses flame filter press more again
Filter, discard filtering residue, filtrate is transported to storage tank stand-by;
D, the filtrate obtaining c step carry out concentrating under reduced pressure, and being concentrated into density is 1.20g/cm3, the condensed cream obtained after concentrating is entered
Row vacuum drying, makes dry cream moisture < 5%, collects dry cream, pulverizes, and packaging obtains Radix Notoginseng crude polysaccharide extract;
E, a walks twice alcohol extract carrying out vacuum-concentrcted, being concentrated into density is 1.20g/cm3, condensed cream is carried out vacuum
It is dried, makes dry cream moisture < 5%, collect dry cream, pulverize, packaging, obtain extract of panax notoginseng saponins;
(3), Herba Dendrobii extract is prepared
Utilize ultrasonic extracting process, Herba Dendrobii is crushed to 40 mesh, ultrasonic frequency 60KHz, Extracting temperature 55 DEG C, extracts
Each 45 minutes of time;Extraction purification water addition is for the first time: 10 liters/1 kilogram dendrobium officinale powder;Extraction purification water for the second time
Addition is: 8 liters/1 kilogram dendrobium officinale powder;Extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out concentrating under reduced pressure, dense
Being reduced to density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture < 5%, pulverize, packaging, obtain Herba Dendrobii and extract
Thing;
(4), by Radix Notoginseng powder, Radix Notoginseng crude polysaccharide extract, Herba Dendrobii extract, extract of panax notoginseng saponins by 38~42: 38~42:
13~17: 3~7 mass proportionings or 8: 8: 3: 1 mass proportioning mix homogeneously, be prepared as hard capsule or tablet or powder, must be used for
The medicine of blood fat reducing.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107997170A (en) * | 2017-11-30 | 2018-05-08 | 江苏康缘药业股份有限公司 | A kind of composition with hypolipemic function and preparation method thereof |
CN111821330A (en) * | 2019-04-19 | 2020-10-27 | 香港大学 | Application of water extract of notoginseng in preparing blood fat reducing product |
CN116098288A (en) * | 2023-03-15 | 2023-05-12 | 云南金七制药有限公司 | Notoginseng radix oral liquid for lowering blood pressure and its preparation method |
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CN1366933A (en) * | 2001-01-22 | 2002-09-04 | 杨孟君 | Nano Qiyeshen'an preparation medicine and preparation method |
CN102308988A (en) * | 2011-07-08 | 2012-01-11 | 云南普洱思松科贸有限责任公司 | Dendrobium health product having function of human body immunization enhancement |
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2016
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1366933A (en) * | 2001-01-22 | 2002-09-04 | 杨孟君 | Nano Qiyeshen'an preparation medicine and preparation method |
CN102308988A (en) * | 2011-07-08 | 2012-01-11 | 云南普洱思松科贸有限责任公司 | Dendrobium health product having function of human body immunization enhancement |
Non-Patent Citations (1)
Title |
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田鲁等: "三七多糖调控蛋白激酶C-η及蛋白激酶C-ζ表达改善2型糖尿病大鼠肾功能的研究", 《新乡医学院学报》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107997170A (en) * | 2017-11-30 | 2018-05-08 | 江苏康缘药业股份有限公司 | A kind of composition with hypolipemic function and preparation method thereof |
CN107997170B (en) * | 2017-11-30 | 2021-04-20 | 江苏康缘药业股份有限公司 | Composition with blood fat reducing function and preparation method thereof |
CN111821330A (en) * | 2019-04-19 | 2020-10-27 | 香港大学 | Application of water extract of notoginseng in preparing blood fat reducing product |
CN116098288A (en) * | 2023-03-15 | 2023-05-12 | 云南金七制药有限公司 | Notoginseng radix oral liquid for lowering blood pressure and its preparation method |
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Application publication date: 20161116 |